Review
Immunology
Paolo Miotto, Rita Sorrentino, Stefano De Giorgi, Roberta Provvedi, Daniela Maria Cirillo, Riccardo Manganelli
Summary: Bacterial drug resistance poses a serious threat to human health, with tuberculosis being a high-risk infection due to limited drugs available against Mycobacterium tuberculosis. Drug resistance in bacteria is often caused by point mutations in drug targets, but changes in transcriptional regulation post-drug exposure also play a significant role and should be further explored for potential new drug targets and intervention strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priscilla E. Day-Walsh, Bryony Keeble, Gothai Pirabagar, Samuel J. Fountain, Paul A. Kroon
Summary: Junctional adhesion molecules (JAMs) play important roles in virus infection and inflammation. This study found that JAM-B is expressed in leukocytes and is regulated through multiple pathways, including the NF-kappa B pathway at the transcriptional level and the ubiquitin-proteosome pathway at the post-translational level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
William Agbemafle, Min May Wong, Diane C. Bassham
Summary: This review summarizes key regulatory mechanisms for modulating autophagy through post-translational modification or transcriptional regulation. Plants activate cellular responses to adapt to changing environmental conditions, one of which is autophagy, where cellular components are delivered to the vacuole for degradation. Autophagy is activated by various conditions, and the pathways controlling its activation are being elucidated. However, there is still much to discover regarding how these factors work together to properly modulate autophagy in response to specific signals.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Oncology
Kurt Sartorius, Samuel O. Antwi, Anil Chuturgoon, Lewis R. Roberts, Anna Kramvis
Summary: This review paper investigates the potential of RNA interference (RNAi) as a therapeutic option for HCC and explores various RNAi technologies. It outlines three primary strategies of RNAi interventions and discusses challenges such as chemical and delivery problems, targeting issues, and immune reactions.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiani Liang, Margot Chirikjian, Utpal B. Pajvani, Alberto Bartolome
Summary: The expression of MafA, a key transcription factor, is decreased in type 2 diabetes, leading to beta-cell dysfunction. Understanding the regulatory factors of MafA expression may help identify potential therapeutic targets for improving beta-cell function.
Article
Biochemical Research Methods
Mark Jayson Cortez, Hyukpyo Hong, Boseung Choi, Jae Kyoung Kim, Kresimir Josic
Summary: This study proposes a non-Markovian, hierarchical Bayesian inference framework for quantifying the variability of cellular processes within and across cells in a population. By using a delayed birth-death process, the proposed hierarchical framework is shown to be robust and leads to improved estimates compared to its non-hierarchical counterpart when applied to in silico and experimental data. The mean delays in protein production are reported to be larger than previously thought, with a coefficient of variation of around 0.2 across the population, and not strongly correlated with protein production or growth rates.
Article
Chemistry, Applied
Liping Sun, Jingtian Huo, Jieya Liu, Jiayi Yu, Jialing Zhou, Chongde Sun, Yue Wang, Feng Leng
Summary: Anthocyanins play crucial roles in plant resistance, human health, and fruit coloring, making them highly valued. This review extensively covers the functions, classifications, distributions, biosynthesis, decoration, transportation, transcriptional regulation, DNA methylation, and post-translational regulation of anthocyanins in fruits.
Review
Plant Sciences
Qiuxin Kan, Qing Li
Summary: Transposons are mobile DNA sequences that can influence gene expression. Recent studies have shown that transposon insertions can affect RNA processing, RNA stability, protein translation, and protein stability. This article will describe the diverse mechanisms by which transposons can impact gene expression at the post-transcriptional and translational levels.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luyi Cheng, Elise N. White, Naomi L. Brandt, Angela M. Yu, Alan A. Chen, Julius B. Lucks
Summary: The study investigates the structure and function of the Bacillus subtilis yxjA purine riboswitch and suggests a potential mechanism whereby ligand binding induces conformational changes in RNA structures. The results provide insight into how RNA functions in gene regulation.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Oncology
Le Yu, Ian J. Davis, Pengda Liu
Summary: Ewing sarcoma is a malignant pediatric bone cancer characterized by unique gene fusions, with EWSR1-FLI1 being the most prevalent. The understanding of regulatory mechanisms and potential therapeutic approaches for targeting EWSR1-FLI1 in Ewing sarcoma is still insufficient. This review provides a summary of up-to-date knowledge on the subject, aiming to identify knowledge gaps and propose new therapeutic directions.
Article
Environmental Sciences
Xiaoyu Wang, Hao Wu, Lvjing Wang, Yihan Wang, Xuejun Wang, Haixia Wang, Zhenmei Lu
Summary: This study revealed the comprehensive intracellular responses of Sphingomonas melonis TY to hyperosmotic stress, showing upregulation of sensing systems, stress response regulators, transport systems, and redox-stress response systems. It also found a decrease in cellular concentration of c-di-GMP, leading to damage to flagellar assembly and biofilm formation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Seung Ryul Han, Chang Ho Lee, Ji Young Im, Ju Hyun Kim, Ji Hyun Kim, Sung Jin Kim, Young Woo Cho, Eunkyung Kim, Youngah Kim, Ji-Ho Ryu, Mi Ha Ju, Jin Sook Jeong, Seong-Wook Lee
Summary: The study proposes a new antiHCC approach using adenovirus-mediated enhancement of ribozymes and miR-122a regulation to achieve efficient and selective anticancer effects in HCC patients while minimizing hepatotoxicity.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Plant Sciences
Xiao Li, Yi-Ying Lin, Jia-Yi Tan, Kang-Lun Liu, Xiao-Ling Shen, Ying-Jie Hu, Rui-Yi Yang
Summary: LAF was found to inhibit YAP by suppressing its transcriptional and post-translational levels, resulting in significant proliferation suppression in HeLa, MDA-MB-231, SW480, and PC3 cells. The expression of 14-3-3 sigma was remarkably increased, leading to decreased YAP nuclear localization.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Oncology
Sergio Pedraza-Arevalo, Alejandro Ibanez-Costa, Ricardo Blazquez-Encinas, Miguel R. Branco, Mari C. Vazquez-Borrego, Aura D. Herrera-Martinez, Eva Venegas-Moreno, Raquel Serrano-Blanch, Alvaro Arjona-Sanchez, Maria A. Galvez-Moreno, Marta Korbonits, Alfonso Soto-Moreno, Manuel D. Gahete, Marika Charalambous, Raul M. Luque, Justo P. Castano
Summary: The study revealed a direct correlation between SSTR5 and SSTR5-AS1 in pituitary and pancreatic neuroendocrine tumors. Differential methylation of CpG islands was observed in somatotropinomas compared with normal pituitaries. Silencing of SSTR5-AS1 in PanNETs cell lines led to downregulation of SSTR5 expression and altered cell aggressiveness features.
MOLECULAR ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Chenyi Li, Tian Jiang, Michelle Li, Yusong Zou, Yajun Yan
Summary: This review focuses on recent advances in fine-tuning gene expression at the DNA, RNA, and protein levels to improve microbial biosynthesis of natural products. Commonly used regulatory toolsets in each level are discussed, and perspectives for future direction in this area are provided.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Multidisciplinary Sciences
Yusuke Kato
Article
Multidisciplinary Sciences
Yusuke Kato
Article
Biochemical Research Methods
Yusuke Kato
ACS SYNTHETIC BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Satoshi Ueno, Kohtaro Kusaka, Yasushi Tamada, Masaomi Minaba, Hong Zhang, Pi-Chao Wang, Yusuke Kato
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2008)
Article
Microbiology
Satoshi Ueno, Kohtaro Kusaka, Yasushi Tamada, Hong Zhang, Masaomi Minaba, Yusuke Kato
Article
Microbiology
Melody Tsai, Ryosuke L. Ohniwa, Yusuke Kato, Sayaka L. Takeshita, Toshiko Ohta, Shinji Saito, Hideo Hayashi, Kazuya Morikawa
Article
Fisheries
Masaomi Minaba, Satoshi Ueno, Ajitha Pillai, Yusuke Kato
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2009)
Article
Microbiology
Satoshi Ueno, Masaomi Minaba, Yuji Nishiuchi, Misako Taichi, Yasushi Tamada, Toshimasa Yamazaki, Yusuke Kato
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2011)
Article
Biotechnology & Applied Microbiology
Satoshi Tomisawa, Eri Hojo, Yoshitaka Umetsu, Shinya Ohki, Yusuke Kato, Mitsuhiro Miyazawa, Mineyuki Mizuguchi, Masakatsu Kamiya, Yasuhiro Kumaki, Takashi Kikukawa, Keiichi Kawano, Makoto Demura, Tomoyasu Aizawa
Review
Biochemistry & Molecular Biology
Yusuke Kato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Yusuke Kato
Summary: The study introduced a novel growth controller regulated by an unnatural amino acid, which inhibited the growth of Escherichia coli without causing rapid bacterial death. This system demonstrated target specificity, environmental noise resistance, and titratability. By optimizing the anticodon sequence of tRNA(pyl), the most effective growth control was achieved.
Article
Biochemistry & Molecular Biology
Yusuke Kato
Summary: A protocol was developed for plasmid curing and exchange using a novel counter-selectable marker pylS(ZK)-pylT in Escherichia coli, which proved to be effective in both processes. The study demonstrated successful plasmid curing and exchange, highlighting the potential scalability and versatility of counter-selectable markers based on PylRS-tRNA(pyl).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biology
Yusuke Kato, Chunbo Lou
Article
Biochemistry & Molecular Biology
Masaomi Minaba, Susumu Ichiyama, Katsura Kojima, Mamiko Ozaki, Yusuke Kato