Article
Chemistry, Multidisciplinary
Md Abdullah Shamim, Ayaz Shahid, Pabitra K. Sardar, Steven Yeung, Jeremiah Reyes, Jenny Kim, Cyrus Parsa, Robert Orlando, Jeffrey Wang, Kristen M. Kelly, Frank L. Meyskens, Bradley T. Andresen, Ying Huang
Summary: The R-carvedilol enantiomer, which does not bind to beta-adrenergic receptors, exhibits skin cancer preventive activity. Transfersomes loaded with R-carvedilol were prepared and characterized. These transfersomes showed slower drug release but significantly enhanced skin drug permeation and retention compared to the free drug.
Article
Pharmacology & Pharmacy
Md Abdullah Shamim, Steven Yeung, Ayaz Shahid, Mengbing Chen, Jeffrey Wang, Preshita Desai, Cyrus Parsa, Robert Orlando, Frank L. Meyskens, Kristen M. Kelly, Bradley T. Andresen, Ying Huang
Summary: This study characterized a topical delivery system based on transfersome (T-CAR) for preventing UV-induced skin cancer. The T-CAR gel showed promising results in reducing skin edema, tumor incidence, and expression of cancer-related markers without significant systemic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Ayaz Shahid, Mengbing Chen, Carol Lin, Bradley T. T. Andresen, Cyrus Parsa, Robert Orlando, Ying Huang
Summary: The study evaluated the effects of carvedilol on the lung toxicity, inflammation, and carcinogenesis induced by B(a)P and its metabolite BPDE. Carvedilol inhibited the malignant transformation of human bronchial epithelial cells and attenuated the activation of ELK-1, AhR/XRE, and NF-kappa B induced by B(a)P. In mouse models, carvedilol effectively inhibited lung toxicity, inflammation, and histopathologic abnormalities induced by B(a)P, and attenuated lung tumor development.
Article
Oncology
Wiebke Schloermann, Christoph Horlebein, Sabine M. M. Huebner, Elisa Wittwer, Michael Glei
Summary: The aim of this study was to investigate the contribution of reactive oxygen species (ROS) to the chemopreventive effects of fermentation supernatants (FS) of different dietary fibers and butyrate as a fermentation metabolite. The results showed that butyrate and FS significantly decreased cell growth and increased ROS levels. These findings suggest that ROS may play a role in the growth inhibitory and apoptotic effects of butyrate and FS.
Article
Biochemistry & Molecular Biology
Sergi Casabella-Ramon, Veronica Jimenez-Sabado, Carmen Tarifa, Sandra Casellas, Tien Tina Lu, Paloma Izquierdo-Castro, Ignasi Gich, Marcel Jimenez, Antonino Ginel, Jose M. Guerra, S. R. Wayne Chen, Raul Benitez, Leif Hove-Madsen
Summary: A hallmark of atrial fibrillation is excessive spontaneous calcium release events, which can be mimicked by beta 1- or beta 2-adrenergic stimulation. The study found that beta 2-adrenergic stimulation alone can stimulate phosphorylation of the ryanodine receptor (RyR2) and enhance spontaneous calcium release. The non-selective beta-blocker carvedilol, particularly the R-enantiomer, can reverse these effects.
Article
Integrative & Complementary Medicine
Yuan-Ye Dang, Hua Luo, Yong-Mei Li, Yang Zhou, Xiu Luo, Shui-Mu Lin, Shou-Ping Liu, Simon Ming-Yuen Lee, Chu-Wen Li, Xiao-Yan Dai
Summary: Curcumin prevents As3+-induced cell transformation by activating the Nrf2 signaling pathway and inducing autophagy.
Article
Medicine, General & Internal
Soo Jin Kim, Han Su Park, Pil Moon Kang, Bong Joon Kim, Hyun Su Kim, Jung Ho Heo, Taek Sang Kim, Sung Il Im
Summary: The use of carvedilol is associated with a lower incidence of arrhythmic events in BPH patients and a decreased occurrence of urologic events compared to non-carvedilol beta-blockers in long-term follow-up.
Article
Biochemistry & Molecular Biology
Chandan Muddahally Naganna, K. Yogendra Prasad, V. P. Mahendra, P. Ganesan, Ravi Kumar
Summary: The study found that vanillic acid can protect the viability and function of pancreatic beta-cells under oxidative stress conditions, while enhancing insulin secretion. This may be achieved through the activation of the Erk1/2 signaling pathway, increased expression of antioxidant enzymes, and reduced expression of apoptotic markers. These results demonstrate the potential therapeutic value of vanillic acid in preventing oxidative stress-related diseases such as diabetes.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Logan Ganzen, Mee Jung Ko, Mengrui Zhang, Rui Xie, Yongkai Chen, Liyun Zhang, Rebecca James, Jeff Mumm, Richard M. van Rijn, Wenxuan Zhong, Chi Pui Pang, Mingzhi Zhang, Motokazu Tsujikawa, Yuk Fai Leung
Summary: The study aimed to identify drugs for the treatment of retinitis pigmentosa by screening on a zebrafish model, finding that carvedilol could improve visual motor response and increase rod cell number in RP patients.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Marta Alvarez Nadal, Elizabeth Romelia Viera Ramirez, Maria Garcia Vallejo, Irene Martin Capon, Milagros Fernandez Lucas
Summary: The study found that the use of beta-blockers in hemodialysis patients is associated with a higher risk of hypotension and decreased vascular refilling. Carvedilol use was found to impair vascular refilling, possibly due to its nonselective action and reduced dialyzability.
CARDIORENAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Vanessa Duarte Ortiz, Rayane Brinck Teixeira, Patrick Turck, Giana Blume Corssac, Adriane Bello-Klein, Alexandre Luz de Castro, Alex Sander da Rosa Araujo
Summary: This study aimed to compare the influence of carvedilol and thyroid hormones (TH) on inflammatory and HIF-1 alpha proteins and on cardiac haemodynamics in the infarcted heart. The results showed that thyroid hormones can reduce inflammation and increase HIF-1 alpha levels, protecting the infarcted heart.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Luigi Pistelli, Clementina Sansone, Arianna Smerilli, Marco Festa, Douglas M. Noonan, Adriana Albini, Christophe Brunet
Summary: The study found that marine microalgae are a valuable and eco-sustainable source of pigments that can be used for photochemoprevention. Certain marine pigments can effectively reduce UV-induced damage in melanoma model cells and regulate intracellular reactive oxygen species and nitric oxide levels, thereby intervening in signaling pathways associated with cancer induction.
Article
Medicine, General & Internal
Jae-Wook Lee, Pham Xuan Thuy, Hae-Kyoung Han, Eun-Yi Moon
Summary: DEHP, commonly used phthalates in plastics, influences tumorigenesis by enhancing TB4 expression, primary cilia formation and ROS production. The growth of tumor cells is correlated with intracellular ATP changes and might be controlled through the TB4-H2O2 axis. TB4 could serve as a novel bio-marker to predict the risk of DEHP on tumor growth.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Editorial Material
Pharmacology & Pharmacy
Samuel Legeay, Sebastien Faure
Summary: When using the combination of gliclazide and carvedilol, it is important to reinforce the self-monitoring of blood glucose levels and remind the patient how to quickly adjust blood sugar levels by mouth.
ACTUALITES PHARMACEUTIQUES
(2022)
Article
Biochemistry & Molecular Biology
Virginia Albinana, Lucia Recio-Poveda, Pilar Gonzalez-Peramato, Luis Martinez-Pineiro, Luisa Maria Botella, Angel M. Cuesta
Summary: This study investigates the effects of ADRB2 blockers on the inflammatory response and metabolism in VHL-ccRCC cells. The results show that ADRB2 blockade reduces oxidative stress levels and stabilizes the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)