期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms21010258
关键词
ncRNA; miRNAs; lncRNAs; circRNAs; ESCC
资金
- National Natural Science Foundation of China [81472232, 81970726, 81672433, 81970551, 81370537]
- Fundamental Research Funds for the Central Universities
- Research projects on biomedical transformation of China-Japan Friendship Hospital [PYBZ1803]
- Henan Provincial Natural Science Foundation [182300410323, 182300410316]
- Program for Science & Technology Innovation Talents in Universities of Henan Province (HASTIT) [13HASTIT024]
- Plan for Scientific Innovation Talent of Henan Province
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据