ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion

Multiple actin networks coordinate mechanotransduction at the immunological synapse

(2020) Daniel Blumenthal et al.   JOURNAL OF CELL BIOLOGY

Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis

(2019) Rhiannon Roberts et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment

(2019) Chunguang Ren et al.   DEVELOPMENTAL CELL

PTENα promotes neutrophil chemotaxis through regulation of cell deformability

(2019) Yunqiao Li et al.   BLOOD

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition

(2019) Katharine A. Michie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A tensile trilayered cytoskeletal endotube drives capillary-like lumenogenesis

(2019) Liakot A. Khan et al.   JOURNAL OF CELL BIOLOGY

Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration

(2019) Abigail Newe et al.   Frontiers in Immunology

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

(2019) Cédric Plutoni et al.   Nature Communications

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation

(2018) Yvonne T. Kschonsak et al.   JOURNAL OF CELL SCIENCE

Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration

(2018) Angela Rey-Gallardo et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology

(2018) Debasis Pore et al.   JOURNAL OF IMMUNOLOGY

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

(2018) Libing Mu et al.   Nature Communications

First Case of X-Linked Moesin Deficiency Identified After Newborn Screening for SCID

(2017) Ottavia M. Delmonte et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

(2017) Ephraim A. Ansa-Addo et al.   JOURNAL OF CLINICAL INVESTIGATION

The ERM Protein Moesin Regulates CD8+Regulatory T Cell Homeostasis and Self-Tolerance

(2017) Hiroki Satooka et al.   JOURNAL OF IMMUNOLOGY

Actin cortex architecture regulates cell surface tension

(2017) Priyamvada Chugh et al.   NATURE CELL BIOLOGY

ERM Proteins Play Distinct Roles in Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi

(2017) Éden R. Ferreira et al.   Frontiers in Microbiology

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite

(2017) Sang-Yeob Kim et al.   PLoS One

Moesin regulates neutrophil rolling velocity in vivo

(2016) Masanori Matsumoto et al.   CELLULAR IMMUNOLOGY

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin ( MSN ) gene

(2016) Chantal Lagresle-Peyrou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells

(2016) Harrison V. Prentice-Mott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Anatomy of Phagocytic and Immunological Synapses

(2016) Florence Niedergang et al.   Frontiers in Immunology

Leukocyte Chemoattractant Receptors in Human Disease Pathogenesis

(2015) Brian A. Zabel et al.   Annual Review of Pathology-Mechanisms of Disease

Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion

(2015) Gema Malet-Engra et al.   CURRENT BIOLOGY

Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering

(2015) Xiaodong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient

(2015) Xiaowen Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Ezrin Regulates Inflammation by Limiting B Cell IL-10 Production

(2015) Debasis Pore et al.   JOURNAL OF IMMUNOLOGY

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

(2015) Philip Vitorino et al.   NATURE

Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation

(2015) Nelio T. L. Rodrigues et al.   NATURE

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

(2015) Sayaka Ishihara et al.   Nature Communications

The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse

(2014) Kathryn Lagrue et al.   IMMUNOLOGICAL REVIEWS

Re-defining ERM function in lymphocyte activation and migration

(2014) Neetha Parameswaran et al.   IMMUNOLOGICAL REVIEWS

SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

(2014) Mickael Machicoane et al.   JOURNAL OF CELL BIOLOGY

Shaping the intestinal brush border

(2014) Scott W. Crawley et al.   JOURNAL OF CELL BIOLOGY

Ezrin and Moesin Function Together to Promote T Cell Activation

(2014) M. H. Shaffer et al.   JOURNAL OF IMMUNOLOGY

Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin

(2014) N. JayaNandanan et al.   Nature Communications

The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex

(2013) Sara Solinet et al.   JOURNAL OF CELL BIOLOGY

Spatial Coupling of JNK Activation to the B Cell Antigen Receptor by Tyrosine-Phosphorylated Ezrin

(2013) N. Parameswaran et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoids Induce Effector T Cell Depolarization via ERM Proteins, Thereby Impeding Migration and APC Conjugation

(2013) N. Muller et al.   JOURNAL OF IMMUNOLOGY

Ezrin Tunes the Magnitude of Humoral Immunity

(2013) D. Pore et al.   JOURNAL OF IMMUNOLOGY

Rab11 regulates cell–cell communication during collective cell movements

(2013) Damien Ramel et al.   NATURE CELL BIOLOGY

Ezrin and Moesin Are Required for Efficient T Cell Adhesion and Homing to Lymphoid Organs

(2013) Emily J. H. Chen et al.   PLoS One

Ezrin/Radixin/Moesin Proteins and Flotillins Cooperate to Promote Uropod Formation in T Cells

(2013) Sibylla Martinelli et al.   Frontiers in Immunology

Germinal center kinases in immune regulation

(2012) Hailei Yin et al.   Cellular & Molecular Immunology

Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking

(2012) Maria-Jesus Sanz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis

(2012) T. Hirata et al.   INTERNATIONAL IMMUNOLOGY

Ezrin-Radixin-Moesin-binding Sequence of PSGL-1 Glycoprotein Regulates Leukocyte Rolling on Selectins and Activation of Extracellular Signal-regulated Kinases

(2012) Caroline Spertini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Moesin, a Protein That Links Actin Cytoskeleton to the Plasma Membrane, Occurs by Phosphatidylinositol 4,5-bisphosphate (PIP2) Binding Sequentially to Two Sites and Releasing an Autoinhibitory Linker

(2012) Khadija Ben-Aissa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice

(2011) Y. Liu et al.   BLOOD

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

(2011) Bebhinn Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conformational Switching in Ezrin Regulates Morphological and Cytoskeletal Changes Required for B Cell Chemotaxis

(2011) Neetha Parameswaran et al.   JOURNAL OF IMMUNOLOGY

CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation

(2011) J. L. Cannon et al.   MOLECULAR BIOLOGY OF THE CELL

Ezrin Promotes Actin Assembly at the Phagosome Membrane and Regulates Phago-Lysosomal Fusion

(2011) Sabrina Marion et al.   TRAFFIC

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

(2010) Y. Wang et al.   DEVELOPMENT

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse

(2010) Rémi Lasserre et al.   EMBO JOURNAL

Essential Role of Ubiquitin and TSG101 Protein in Formation and Function of the Central Supramolecular Activation Cluster

(2010) Santosha Vardhana et al.   IMMUNITY

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Tethering of Intercellular Adhesion Molecule on Target Cells Is Required for LFA-1-Dependent NK Cell Adhesion and Granule Polarization

(2010) C. C. Gross et al.   JOURNAL OF IMMUNOLOGY

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

(2010) Aya Takesono et al.   PLoS One

Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking

(2010) S. Koduru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

(2009) Ziv Shulman et al.   IMMUNITY

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

(2009) Jian-Jiang Hao et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of collective cell migration at a glance

(2009) O. Ilina et al.   JOURNAL OF CELL SCIENCE

Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin

(2009) G. P. Coffey et al.   JOURNAL OF CELL SCIENCE

Bringing up the rear: defining the roles of the uropod

(2009) Francisco Sánchez-Madrid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation

(2009) N. V. Belkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hunter to Gatherer and Back: Immunological Synapses and Kinapses as Variations on the Theme of Amoeboid Locomotion

(2008) Michael L. Dustin   Annual Review of Cell and Developmental Biology

Structural Basis for CD44 Recognition by ERM Proteins

(2008) Tomoyuki Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells

(2008) Sébastien Carreno et al.   JOURNAL OF CELL BIOLOGY

Structural Basis of the Cytoplasmic Tail of Adhesion Molecule CD43 and Its Binding to ERM Proteins

(2008) Yumiko Takai et al.   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal activation of Rac1 for engulfment of apoptotic cells

(2008) M. Nakaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA