Review
Health Care Sciences & Services
Sean R. O'Connor, Frank Kee, David R. Thompson, Margaret E. Cupples, Michael Donnelly, Neil Heron
Summary: This study evaluated the quality of apps for supporting lifestyle change following a TIA or 'minor' stroke, finding that only a small number of apps met the criteria and that overall quality was low. Further development and testing of accessible, user-designed, and evidence-informed digital interventions are needed for this population.
Review
Medicine, General & Internal
Kailash Krishnan, Zhe Kang Law, Jatinder S. Minhas, Philip M. Bath, Thompson G. Robinson, Nikola Sprigg, Akash Mavilakandy, Timothy J. England, David Eveson, Amit Mistri, Jesse Dawson, Jason P. Appleton
Summary: Acute stroke is a leading cause of disability and mortality, necessitating urgent evaluation and treatment. This review examines four antiplatelet treatments for non-cardioembolic stroke prevention and highlights gaps in the evidence for potential future trials.
Article
Clinical Neurology
Aoibhin Clarke, Catriona Reddin, Robert Murphy, Martin J. O'Donnell
Summary: The study aimed to determine whether prior use of antiplatelet therapy affects the effectiveness of dual antiplatelet therapy in patients with acute minor ischaemic stroke or transient ischaemic attack. The results showed that there was no significant difference in the effectiveness of dual antiplatelet therapy between patients with and without prior aspirin therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Environmental Sciences
Neil Heron, Sean R. O'Connor, Frank Kee, David R. Thompson, Neil Anderson, David Cutting, Margaret E. Cupples, Michael Donnelly
Summary: This study developed the 'Brain-Fit' app for individuals who have experienced TIA or minor stroke, aiming to maximize user engagement and sustainability by exploring usability and relevance perceptions. Through scoping reviews and focus groups, barriers and facilitators to the use of digital interventions were identified, leading to the creation of guiding principles, behavioral analysis, and an explanatory logic model for the intervention. Feedback from participants was used to optimize the app, including simplifying goal setting and data entry sections, with further studies needed to evaluate efficacy and cost-effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Zhihao Lei, Shuanglin Li, Hongye Feng, Yupeng Lai, Yanxia Zhou, Chao Li, Lijie Ren
Summary: This study aimed to develop and validate a prognostic nomogram for patients with minor stroke and TIA, which demonstrated favorable predictive accuracy. The nomogram has the potential to impact clinical decision-making.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Xin Qiu, Yongbo Zhang, Hongqiu Gu, Yingyu Jiang, Yuesong Pan, Yong Jiang, Xia Meng, Yilong Wang, Xingquan Zhao, Hao Li, Xiujie Wang, Yongjun Wang, Zixiao Li, CHANCE Investigators
Summary: This study investigated the association between CYP2B6 polymorphisms and the efficacy of clopidogrel in patients with minor stroke or transient ischemic attack. The results showed no significant difference in the efficacy of aspirin plus clopidogrel compared with aspirin alone, regardless of the presence of CYP2B6 polymorphisms. Therefore, both carriers and noncarriers of CYP2B6 polymorphisms may benefit from aspirin plus clopidogrel treatment for secondary stroke prevention.
Article
Health Care Sciences & Services
Nicole Freene, Hannah Wallett, Allyson Flynn, Elisabeth Preston, Shahla Cowans, Christian Lueck, Theophile Niyonsenga, Itismita Mohanty, Rachel Davey
Summary: This study aims to evaluate the effectiveness and implementation of a traditional exercise-based cardiovascular rehabilitation program for people with TIA or mild stroke. The study will recruit 140 participants and use a randomized controlled trial design. Multiple outcome measures, including the distance completed in the 6-minute walk test, will be collected. Implementation outcomes will be assessed using the RE-AIM framework.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Clinical Neurology
Marta Olive-Gadea, David Cano, Marc Rodrigo-Gisbert, Marian Muchada, Estefania Montiel, Maria Baladas, Ester Sanchez-Gavilan, Carolina Paredes, Alvaro Garcia-Tornel, Marta Rubiera, Manuel Requena, Marc Ribo, Carlos A. Molina
Summary: Patient-reported outcome measures (PROMs) provide valuable information for assessing the long-term outcomes of stroke patients. This study used a mobile app to evaluate PROMs in patients with minor stroke or transient ischemic attack and found a correlation between patient-reported outcomes and clinician-assessed outcomes, although some differences were observed.
Article
Medicine, General & Internal
Birgit Maria Vahlberg, Erik Lundstrom, Staffan Eriksson, Ulf Holmback, Tommy Cederholm
Summary: The study evaluated the effects of mobile phone text-messaging exercise instructions on body composition, cardiometabolic risk markers, and self-reported health at 3 months after stroke. The results showed no clear effect of daily mobile phone-delivered training instructions on body composition, cardiovascular biochemical risk factors, or self-perceived health. Further research is needed to evaluate secondary prevention efforts in larger populations after recent stroke.
Article
Clinical Neurology
Jing Jing, Yue Suo, Anxin Wang, Yingting Zuo, Yong Jiang, Liping Liu, Xingquan Zhao, Yilong Wang, Zixiao Li, Hao Li, Xia Meng, Yongjun Wang
Summary: Large artery stenosis and infarction number independently predict 1-year stroke recurrence in low- to moderate-risk patients with TIA or MIS stratified by the ABCD(2) score system.
Article
Chemistry, Multidisciplinary
Hosam Aljihani, Fathy Eassa, Khalid Almarhabi, Abdullah Algarni, Abdulaziz Attaallah
Summary: The study discusses utilizing blockchain technology to enhance the immutability and reliability of attack detection systems, addressing the challenges faced by current attack detection techniques. By designing standalone behavior-based attack detection techniques that integrate blockchain functionalities, the detection systems become more reliable in distributed software systems.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Fulvio Pomero, Eleonora Galli, Marta Bellesini, Lorenzo Maroni, Alessandro Squizzato
Summary: Early administration of P2Y12 inhibitors plus aspirin in patients with acute non-cardioembolic minor ischemic stroke or TIA reduced the incidence of ischemic stroke recurrence, impacting more significantly than the increased bleeding risk and influencing patients' quality of life by reducing disabling stroke.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Huihui Liu, Jing Jing, Anxin Wang, Qin Xu, Xia Meng, Hao Li, Zixiao Li, Yongjun Wang
Summary: This study compared the risk of stroke recurrence and the responses to dual antiplatelets with ticagrelor-aspirin versus clopidogrel-aspirin between patients with posterior circulation infarct (PCI) and those with anterior circulation infarct (ACI). The study found that the risk of stroke recurrence was similar between PCI and ACI patients, and ticagrelor-aspirin was superior to clopidogrel-aspirin in reducing the risk of stroke in both PCI and ACI patients within 90 days.
Article
Clinical Neurology
Jesse Dawson, Yannick Bejot, Louisa M. Christensen, Gian Marco De Marchis, Martin Dichgans, Guri Hagberg, Mirjam R. Heldner, Haralampos Milionis, Linxin Li, Francesca Romana Pezzella, Martin Taylor Rowan, Cristina Tiu, Alastair Webb
Summary: The European Stroke Organisation (ESO) guideline provides evidence-based recommendations on pharmacological management for the prevention of recurrent stroke and other important outcomes after ischaemic stroke or transient ischaemic attack. The guideline covers areas such as blood pressure, diabetes mellitus, lipid levels, and antiplatelet therapy, aiming to reduce the long-term risk of recurrent stroke.
EUROPEAN STROKE JOURNAL
(2022)
Article
Clinical Neurology
Cristina Hobeanu, Philippa C. Lavallee, Hugo Charles, Julien Labreuche, Gregory W. Albers, Louis R. Caplan, Geoffrey A. Donnan, Jose M. Ferro, Michael G. Hennerici, Carlos A. Molina, Peter M. Rothwell, Philippe Gabriel Steg, Pierre-Jean Touboul, Shinichiro Uchiyama, Eric Vicaut, K. S. Lawrence Wong, Pierre Amarenco
Summary: The study revealed a significant burden of disability in patients with transient ischaemic attack or minor ischemic stroke at 5 years, with most predictors being modifiable risk factors. Regular physical activity before the index event was associated with a significantly reduced risk of disability at 5 years.
Article
Economics
Leonie Heron, Mark A. Tully, Frank Kee, Ciaran O'Neill
Summary: This study used econometric analysis to assess the associations between objectively measured physical activity levels and future inpatient days and costs in adults in the UK Biobank study. The findings suggest that increasing physical activity levels in the UK may reduce inpatient hospitalisations and costs, especially in women and lower-income groups.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Oncology
Ebonee N. Butler, Cindy Ke Zhou, Michael Curry, Una McMenamin, Christopher Cardwell, Marie C. Bradley, Barry Graubard, Michael B. Cook
Summary: This study found an inverse association between testosterone therapy (TT) and the risk of distant-stage prostate and colorectal cancers, but a positive association with distant-stage melanoma. These findings suggest a potential role for TT in the etiology of these cancers or the presence of residual confounding.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Lee Smith, Jae Il Shin, Louis Jacob, Guillermo F. Lopez Sanchez, Felipe Schuch, Mark A. Tully, Hans Oh, Nicola Veronese, Pinar Soysal, Laurie Butler, Yvonne Barnett, Ai Koyanagi
Summary: This study aimed to examine the association between food insecurity and physical multimorbidity in older adults from LMICs. The findings revealed that food insecurity was associated with a higher risk of multimorbidity.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Lee Smith, Jae Il Shin, Guillermo F. Lopez Sanchez, Felipe Schuch, Mark Tully, Yvonne Barnett, Laurie Butler, Damiano Pizzol, Nicola Veronese, Pinar Soysal, Karel Kostev, Louis Jacob, Ai Koyanagi
Summary: This study investigated the association between multimorbidity and sarcopenia in a sample of older adults from six LMICs. The findings suggest that targeting individuals with multimorbidity may help prevent sarcopenia.
Article
Geriatrics & Gerontology
Lee Smith, Jae Il Shin, Guillermo F. Lopez Sanchez, Karel Kostev, Louis Jacob, Mark A. Tully, Laurie Butler, Yvonne Barnett, Nicola Veronese, Pinar Soysal, Adel S. Abduljabbar, Josep Maria Haro, Ai Koyanagi
Summary: This study examined the association between physical multimorbidity and suicidal ideation or suicide attempts among older adults in low- and middle-income countries (LMICs), as well as the mediating factors. The results showed a significant association between physical multimorbidity and suicidal ideation or suicide attempts, with pain/discomfort, sleep/energy, and mobility limitations mediating the relationship.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Family Studies
Susan Lagdon, Lucia Klencakova, Dirk Schubotz, Ciaran Shannon, Mark A. Tully, Cherie Armour, Julie-Ann Jordan
Summary: Coercive control and related research have made significant progress, but there is currently a lack of evidence on young people's knowledge and understanding of coercive control. A 2020 survey in Northern Ireland found that only 16% of 16-year olds had heard of coercive control and knew what it meant. The study also revealed gender disparities in awareness, with females being less likely to have heard of coercive control.
JOURNAL OF CHILD & ADOLESCENT TRAUMA
(2023)
Article
Clinical Neurology
Louis Jacob, Lee Smith, Karel Kostev, Hans Oh, Razak M. M. Gyasi, Guillermo F. Lopez F. Sanchez, Tae-Jin Song, Mark A. A. Tully, Josep Maria Haro, Dong Keon Yon, Jae Il Shin, Ai Koyanagi
Summary: Little is known about the relationship between food insecurity and sleep problems in low- and middle-income countries, while the mediators of this association are largely unknown. Therefore, we investigated the association between food insecurity and insomnia-related symptoms in six low- and middle-income countries, and the potential mediators of this relationship.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Geriatrics & Gerontology
Lee Smith, Guillermo F. Lopez Sanchez, Nicola Veronese, Pinar Soysal, Masoud Rahmati, Louis Jacob, Karel Kostev, Josep Maria Haro, Abdullah Ahmed Alghamdi, Laurie Butler, Yvonne Barnett, Helen Keyes, Mark A. Tully, Jae Shin, Ai Koyanagi
Summary: This study examined the longitudinal relationship between dynapenic abdominal obesity (DAO) and future fall risk in middle-aged and older individuals from Ireland. The results showed that individuals with DAO at baseline had a higher likelihood of falls occurring during the 2-year follow-up period. Interventions to prevent or reverse DAO may be beneficial for reducing fall risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lee Smith, Guillermo F. Lopez Sanchez, Damiano Pizzol, Masoud Rahmati, Dong Keon Yon, Andrew Morrison, Jasmine Samvelyan, Nicola Veronese, Pinar Soysal, Mark A. Tully, Laurie Butler, Yvonne Barnett, Jae Il Shin, Ai Koyanagi
Summary: This study aimed to examine the association between unclean cooking fuel use and gait speed in older adults, and found that using unclean cooking fuel was significantly associated with slower gait speed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Urology & Nephrology
Damiano Pizzol, Guillermo F. Lopez Sanchez, Petre Cristian Ilie, Alessandro Bertoldo, Mike Trott, Mark A. Tully, Jason J. Wilson, Nicola Veronese, Pinar Soysal, Anne Carrie, Simona Ippoliti, Luke Pratsides, Sam Shah, Ai Koyanagi, Laurie Butler, Yvonne Barnett, Christopher Parris, Rosie Lindsay, Lee Smith
Summary: Premature ejaculation is a common male condition with varying prevalence estimates worldwide. Due to the lack of clear definition and understanding of its pathophysiology, treatment remains challenging. This systematic review aims to evaluate non-pharmacological treatment modalities for premature ejaculation to inform clinical practice and patients.
TRENDS IN UROLOGY & MENS HEALTH
(2023)
Review
Geriatrics & Gerontology
Lee Smith, Guillermo F. Lopez Sanchez, Pinar Soysal, Mark A. Tully, Ai Koyanagi
Summary: Unclean cooking fuel use is associated with multiple mental and physical health outcomes in older adults, likely driven by inflammation and oxidative stress. Further research is needed to understand the pathways and eliminate the use of unclean cooking fuels globally.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Psychiatry
Lee Smith, Guillermo F. Lopez Sanchez, Hans Oh, Masoud Rahmati, Mark A. Tully, Dong Keon Yon, Laurie Butler, Yvonne Barnett, Graham Ball, Jae Il Shin, Ai Koyanagi
Summary: Food insecurity is associated with higher odds of depressive symptoms among adolescents in low- and middle-income countries. Addressing food insecurity may help prevent depression in this population.
PSYCHIATRY RESEARCH
(2023)
Article
Nutrition & Dietetics
Lee Smith, Guillermo F. Lopez F. Sanchez, Mark A. Tully, Louis Jacob, Karel Kostev, Hans Oh, Laurie Butler, Yvonne Barnett, Jae Il Shin, Ai Koyanagi
Summary: This study examined the trends of food insecurity among school-going adolescents aged 12-15 years from 31 countries. The prevalence of food insecurity varied in different countries, with both increasing and decreasing trends observed. It is crucial to take global action to address this issue and achieve the Sustainable Development Goal 2.
Article
Psychiatry
Helena F. Moura, Lisia von Diemen, Rugero A. Bulzing, Jacob Meyer, Igor Grabovac, Guillermo F. Lopez-Sanchez, Kabir P. Sadarangani, Mark A. Tully, Lee Smith, Felipe B. Schuch
Summary: This study examined alcohol use and perceived change in alcohol consumption among Brazilians during the COVID-19 pandemic, as well as their associations with depressive, anxiety, and co-occurring depressive and anxiety symptoms. The findings showed that 68.5% of participants reported alcohol consumption during the pandemic, with 22.7% reporting increased alcohol use. Alcohol consumption was associated with anxiety and depressive symptoms. The study highlights the importance of actively monitoring and assessing the risks of alcohol use and consumption.
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2023)
Review
Geriatrics & Gerontology
Pinar Soysal, Nicola Veronese, Simona Ippoliti, Damiano Pizzol, Anne Marie Carrie, Simina Stefanescu, Guillermo F. Lopez-Sanchez, Yvonne Barnett, Laurie Butler, Ai Koyanagi, Louis Jacob, Ramy Abou Ghaydya, David Sheyn, Adonis K. Hijaz, Jose M. Oliva-Lozano, Jose M. Muyor, Mike Trott, Andreas Kronbichler, Igor Grabovac, Mark A. Tully, Lin Yang, Jimin Hwang, Jong Yeob Kim, Seoyeon Park, Junmin Song, Jae Il Shin, Petre-Cristian Ilie, Lee Smith
Summary: This study aimed to assess the health outcomes associated with Urinary Incontinence (UI) and evaluate the quality and strength of these associations through an umbrella review and integrated meta-analyses. The results showed that UI was strongly associated with female sexual dysfunction, depression, and anxiety, while the evidence of other adverse outcomes such as poorer quality of life, higher mortality, falls, pressure ulcers, diabetes, arthritis, fecal incontinence, and frailty was weak.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
