Article
Environmental Sciences
Hai'e Xu, Wanshuang Cao, Hongliang Sun, Shougang Zhang, Pan Li, Surong Jiang, Caiyun Zhong
Summary: Studies have shown that DEHP induced significant hormetic effects at environmentally relevant concentrations (12 and 36 μg/L), leading to U-shaped or inverted U-shaped responses in gene expression levels related to stress response (CAT, GST, and MgGLYZ) and antioxidant enzyme activities (SOD and CAT). The metabolic profiles revealed that DEHP generally caused monophasic response in osmotic regulation (homarine) and biphasic response (hormesis) in energy metabolism (glucose, glycogen, and amino acids). These findings can assist in ecological risk assessment of DEHP and determination of hormetic dose responses.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Environmental Sciences
Diana C. Pacyga, Diana K. Haggerty, Megan Nicol, Melissa Henning, Antonia M. Calafat, Joseph M. Braun, Susan L. Schantz, Rita S. Strakovsky
Summary: Conception season, enrollment year, and several sociodemographic/lifestyle factors were found to be associated with biomarker profiles of phthalates and their replacements in pregnant women.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Kevin McNally, Craig Sams, Alex Hogg, George Loizou
Summary: A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate was developed to interpret the metabolism and biokinetics of DEHTP. The model was calibrated against the urinary excretion of metabolites. Significant quantitative differences in lymphatic uptake were observed compared to a similar model for di-(2-propylheptyl) phthalate. The in silico algorithm for predicting protein binding performed poorly, highlighting the caution needed when making predictions based on chemical properties.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Toxicology
V. Plichta, W. Voelkel, L. Fembacher, M. Woeckner, D. Nowak, H. Fromme
Summary: Phthalates and other plasticizers are found in high amounts in the indoor environment, making house dust a potential exposure source. This study investigated the oral bioavailability of phthalates and DINCH (R) in humans through ingestion of house dust. The results showed that high molecular weight phthalates, DINP, and DINCH (R) reached their maximum concentration in urine 2-19 hours after ingestion. It was also found that a daily intake of 50 mg of dust could significantly contribute to the overall plasticizer exposure, especially in toddlers.
TOXICOLOGY LETTERS
(2022)
Review
Environmental Sciences
Kyung Joo Lee, Kyungho Choi
Summary: In this systematic review, the authors examined the presence and potential effects of DINP and DIDP, two plasticizers used as alternatives to DEHP, in various environmental media, foods, consumer products, and human populations. The results indicate that DINP and DIDP are widely present in indoor environments, diets, and children's products. While the levels of DINP exposure were found to be relatively lower compared to DEHP, it still exhibited similar endocrine disruption potentials, particularly among males and pregnant women. There are knowledge gaps regarding the exposure of DIDP in the human population.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Reproductive Biology
Kijeong Yun, Kyunghee Ji
Summary: This study evaluated the effects of Di-(2-ethylhexyl) terephthalate (DEHTP) exposure on fertility, sex hormone levels, vitellogenin levels, and gene transcription along the hypothalamic-pituitary-gonad axis in zebrafish. Results showed that mean egg numbers were significantly reduced in the 30 and 300 & mu;g/L DEHTP groups. The adverse effects of DEHTP on hormones and gene transcripts were more prominent in males than in females.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Microbiology
Sean Ting-Shyang Wei, Yi-Lung Chen, Yu-Wei Wu, Tien-Yu Wu, Yi-Li Lai, Po-Hsiang Wang, Wael Ismail, Tzong-Huei Lee, Yin-Ru Chiang
Summary: DEHP, the most widely used plasticizer globally, accumulates in estuarine sediments and poses adverse effects on ecosystems and human health. Through integrated meta-omics approaches, it was found that DEHP biodegradation in estuarine sediments mainly depends on synergistic networks between denitrifying proteobacteria. The side chain hydrolysis of DEHP is identified as the rate-limiting step in its degradation process.
Article
Biotechnology & Applied Microbiology
Yen-Shun Hsu, Yung-Hsin Liu, Chu-Hsuan Lin, Chih-Hsuan Tsai, Whei-Fen Wu
Summary: Burkholderia sp. SP4, isolated from agricultural soils, exhibits a high degradation capability of di-2-ethylhexyl-phthalate (DEHP). It can degrade up to 99% of DEHP (300 mg l(-1)) within 48 h in minimal salt (MS) media without additional carbon source. The optimal conditions for DEHP degradation by SP4 are determined to be at 35°C and pH 6.0. Supplementation of certain compounds in the media enhances the degradation activity. Kinetic analyses reveal that SP4 degrades DEHP through a first-order reaction and has a better degradative activity compared to other known microbes. Metabolic intermediates of DEHP are identified for SP4, indicating a novel degradation pathway diverged from benzoate products. This study provides insight into a resilient DEHP-degradable bacterium and a new pathway for DEHP biodegradation, which can be applied in the removal of DEHP from various environments.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Jingyu Qu, Wei Xia, Xi Qian, Yongning Wu, Jingguang Li, Sheng Wen, Shunqing Xu
Summary: Despite being restricted by many authorities, di (2-ethylhexyl) phthalate (DEHP) is still widely detected in the environment and biospecimens. Exposure levels varied significantly between countries with children having the highest levels. While most hazard quotients were less than 1, the risk behind cannot be ignored. In the general population, DEHP exposure levels showed a downtrend over time, with efforts to reduce exposure still lacking on a global scale.
Article
Biochemistry & Molecular Biology
Liselott Kallsten, Radwa Almamoun, Paula Pierozan, Erik Nylander, Kalliroi Sdougkou, Jonathan W. Martin, Oskar Karlsson
Summary: This study found that di-n-butyl phthalate (DBP) exposure can lead to persistent effects on testosterone synthesis and spermatogenesis in adult male mice, resulting in decreased testosterone levels. The study also revealed increased levels of key cells and proteins, including steroidogenic enzymes, oxidative stress markers, and germ cell markers, in response to DBP exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
M. K. Dziobak, R. S. Wells, E. C. Pisarski, E. F. Wirth, L. B. Hart
Summary: This study evaluated exposure to phthalate metabolites in free-ranging bottlenose dolphins, finding that approximately 75% of the dolphins had detectable concentrations of at least one phthalate metabolite. Sex and age did not significantly affect the detection and concentration of phthalate metabolites.
Article
Cell Biology
Liselott Kallsten, Paula Pierozan, Jonathan W. Martin, Oskar Karlsson
Summary: The environmental contaminants DBP and MBP have been found to inhibit the synthesis of testosterone and other steroid hormones, with differences in their toxicological mechanisms. Additionally, DBP induces oxidative stress while MBP reduces protein oxidation.
Article
Biochemistry & Molecular Biology
Nicolas Kambia, Isabelle Severin, Amaury Farce, Laurence Dahbi, Thierry Dine, Emmanuel Moreau, Valerie Sautou, Marie-Christine Chagnon
Summary: DEHT, an alternative to DEHP, shows lower migration from PVC and lack of reprotoxicity. However, more data is needed to support the safety of its metabolites on thyroid system hormonal properties. Study findings suggest lack of interactions between DEHT metabolites and TRs, highlighting the potential benefits of DEHT.
Article
Biochemistry & Molecular Biology
Yoshifumi Horie, Miho Nomura, Babu Rajendran Ramaswamy, Hiroya Harino, Chee Kong Yap, Hideo Okamura
Summary: Water pollution caused by plasticizers is a severe environmental issue worldwide. This study investigated the effects of the nonphthalate bis(2-ethylhexyl) sebacate (DEHS) plasticizer on the gene expression levels of thyroid hormone-related, reproduction-related, and estrogen-responsive genes in Japanese medaka. The results showed that DEHS could disrupt the thyroid hormone-related gene expression and metabolism in fish, but did not have dose-dependent effects on the gene expression levels of other reproductive-related genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fabrizia Carli, Sabrina Tait, Luca Busani, Demetrio Ciociaro, Veronica Della Latta, Anna Paola Pala, Annalisa Deodati, Andrea Raffaelli, Filippo Pratesi, Raffaele Conte, Francesca Maranghi, Roberta Tassinari, Enrica Fabbrizi, Giacomo Toffol, Stefano Cianfarani, Cinzia La Rocca, Amalia Gastaldelli, LIFE PERSUADED Project Grp
Summary: Phthalates and bisphenol A (BPA) are commonly found in Italian women, with DEHP being higher in the south and BPA being higher in the north. Urban areas have higher BPA levels, while DEHP levels do not differ by region. The BPA intake is significantly lower than the temporary tolerable daily intake, and there is a positive correlation between DEHP and BPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Sonja A. Wrobel, Daniel Bury, Vladimir N. Belov, Jan M. Klenk, Bernhard Hauer, Heiko Hayen, Anderson J. Martino-Andrade, Holger M. Koch, Thomas Bruening, Heiko U. Kaefferlein
Summary: We have developed a specific and robust analytical method to analyze the most important neonicotinoids and their metabolites in human urine. The method was successfully validated and applied to quantify these compounds in individuals from the general population in Germany and pregnant women from Brazil with no known occupational exposures to neonicotinoids.
ANALYTICA CHIMICA ACTA
(2023)
Article
Oncology
Julie Abildgaard, Hein Vincent Stroomberg, A. Kirstine Bang, Jakob Albrethsen, Laura Smedegaard Kruuse, Anders Juul, Klaus Brasso, Andreas Roder, Niels Jorgensen
Summary: Men with high-risk, non-metastatic prostate cancer receive adjuvant androgen deprivation therapy (ADT) for at least 2 years according to Danish guidelines. It remains unclarified if patients regain the function of the pituitary-testis axis after cessation of ADT. Our study investigated the function of the pituitary-testis axis following adjuvant ADT and found that persistent testosterone deficiency (TD) is a common long-term consequence, equally distributed between pituitary and testicular dysfunction. The study emphasizes the necessity for systematic follow-up of full pituitary-testis axis function in patients receiving adjuvant ADT.
ENDOCRINE-RELATED CANCER
(2023)
Article
Obstetrics & Gynecology
A. H. Hansen, L. Priskorn, L. S. Hansen, E. Carlsen, U. N. Joensen, F. M. Jacobsen, C. F. S. Jensen, N. Jorgensen
Summary: This study aimed to investigate whether prior testicular torsion is associated with testicular function in young men from the general population. The results showed no differences in semen parameters between men who had experienced testicular torsion and controls. However, subtle alterations in reproductive hormones were observed, with higher FSH and lower inhibin B levels in men with prior testicular torsion. Follow-up studies are needed to assess any long-term consequences for fertility.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Hagai Levine, Niels Jorgensen, Anderson Martino-Andrade, Jaime Mendiola, Dan Weksler-Derri, Maya Jolles, Rachel Pinotti, Shanna H. Swan
Summary: This study reveals a significant decline in sperm count among men from all continents, with a more pronounced decrease observed post-2000. The decline in sperm count is not limited to North America-Europe-Australia, but also seen in South/Central America-Asia-Africa. Urgent research and action are needed to investigate the causes and prevent further disruption of male reproductive health.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Public, Environmental & Occupational Health
Antje Gerofke, Madlen David, Phillipp Schmidt, Joana Lobo Vicente, Jurgen Buekers, Liese Gilles, Ann Colles, Jos Bessems, Michiel Bastiaensen, Adrian Covaci, Elly Den Hond, Gudrun Koppen, Michelle Laeremans, Veerle J. Verheyen, Milena Cerna, Jana Klanova, Andrea Krskova, Martin Zvonar, Lisbeth E. Knudsen, Holger M. Koch, Tina Kold Jensen, Loic Rambaud, Margaux Riou, Nina Vogel, Catherine Gabriel, Spyros Karakitsios, Nafsika Papaioannou, Denis Sarigiannis, Reka Kakucs, Szilvia Kozepesy, Peter Rudnai, Tamas Szigeti, Fabio Barbone, Valentina Rosolen, Cedric Guignard, Arno C. Gutleb, Amrit Kaur Sakhi, Line Smastuen Haug, Beata Janasik, Danuta Ligocka, Milada Estokova, Lucia Fabelova, Branislav Kolena, Lubica Palkovicova Murinova, Ida Petrovicova, Denisa Richterova, Milena Horvat, Darja Mazej, Janja Snoj Tratnik, Agneta Annika Runkel, Argelia Castano, Marta Esteban-Lopez, Susana Pedraza-Diaz, Agneta Akesson, Sanna Lignell, Jelle Vlaanderen, Jan-Paul Zock, Greet Schoeters, Marike Kolossa-Gehring
Summary: Within the HBM4EU initiative, HBM indicators were developed to address key policy questions and support chemical policies. Result indicators provide information on chemical exposure in different demographic groups and allow comparisons to identify differences and inform policy measures. Impact indicators assess health risks by comparing exposure values to health-based guidance values, helping to identify relevant health issues and support risk management decisions.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nina Vogel, Phillipp Schmidt, Rosa Lange, Antje Gerofke, Amrit K. Sakhi, Line S. Haug, Tina Kold Jensen, Hanne Frederiksen, Tamas Szigeti, Zsofia Csako, Lubica Palkovicova Murinova, Miroslava Sidlovska, Beata Janasik, Wojciech Wasowicz, Janja Snoj Tratnik, Darja Mazej, Catherine Gabriel, Spyros Karakitsios, Fabio Barbonem, Valentina Rosolen, Loic Rambaud, Margaux Riou, Aline Murawski, Daan Leseman, Gudrun Koppen, Adrian Covaci, Sanna Lignell, Anna Karin Lindroos, Martin Zvonar, Lenka Andryskova, Lucia Fabelova, Denisa Richterova, Milena Horvatj, Tina Kosjekj, Denis Sarigiannis, Marios Maroulis, Susana Pedraza-Diaz, Ana Canas, Veerle J. Verheyen, Michiel Bastiaensen, Liese Gilles, Greet Schoeters, Marta Esteban-Lopez, Argelia Castano, Eva Govarts, Holger M. Kochx, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers for PVC and are associated with adverse effects on the reproductive system. The HBM4EU Aligned Studies have investigated the exposure to ten phthalates and the substitute chemical DINCH in European children and adolescents. The study provides detailed data on exposure levels and differences across European regions, as well as comparisons to biomonitoring guidance values.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nina Vogel, Hanne Frederiksen, Rosa Lange, Niels Jorgensen, Holger M. Koch, Till Weber, Anna-Maria Andersson, Marike Kolossa-Gehring
Summary: It has been observed over the past 25 years that exposure to certain phthalates can have negative effects on human health, such as disrupting the endocrine system. As a result, the EU implemented regulations which led to a decrease in production of restricted phthalates and an increase in the production of substitutes. A recent study examined the impact of these regulations on exposure patterns in two European populations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Letter
Endocrinology & Metabolism
Emmie N. Upners, Lars Lau Raket, Jorgen H. Petersen, Ajay Thankamony, Edna Roche, Guftar Shaikh, Jeremy M. W. Kirk, Hilary Hoey, Sten-A Ivarsson, Olle Soder, Anders Juul, Rikke Beck Jensen
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Mikkel Vilmand, Iben Have Beck, Niels Bilenberg, Anna-Maria Andersson, Anders Juul, Greet Schoeters, Henriette Boye, Hanne Frederiksen, Tina Kold Jensen
Summary: This study investigated the association between prenatal and concurrent exposure to phthalates and IQ in 7-year-old children. The results showed that high concentrations of metabolites of di(2-ethylhexyl) phthalate were associated with decreased IQ in children. This suggests that exposure to phthalates may be harmful to child neurodevelopment.
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Andre Madsen, Anders Juul, Lise Aksglaede
Summary: This study aimed to characterize the clinical profiles of prepubertal boys with Klinefelter syndrome (KS) and develop a novel biochemical classification model to identify KS before puberty. Retrospective longitudinal data from 15 prepubertal boys with KS and 1475 controls were used to train a machine learning model for the detection of KS. The study showed that applying machine learning models can improve the identification of prepubertal boys with KS.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Amanda Cleemann Wang, Casper P. Hagen, Trine Holm Johannsen, Andre Greger Madsen, Line Hartvig Cleemann, Peter Christiansen, Katharina M. Main, Anders Juul, Rikke Beck Jensen
Summary: Differentiation between girls with ICPP and PT can be supported by individual clinical and biochemical parameters. However, dimension reduction of clinical and hormonal profiles by PCA improved the diagnostic value, which in the future may support the diagnostic process as a supplement to the GnRH test in evaluation of pubertal disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Toxicology
Tatiana Zauer Curi, Marcella Tapias Passoni, Sara Emilia Lima Tolouei, Anderson Tadeu de Araujo Ramos, Samara Christina Franca de Almeira, Anna Beatriz Abreu Ferraz Scinskas, Renata Marino Romano, Jeane Maria de Oliveira, Katherinne Maria Spercoski, Ariany Carvalho dos Santos, Paulo Roberto Dalsenter, Holger Martin Koch, Anderson Joel Martino-Andrade
Summary: This study examined the reproductive effects of in utero/lactational exposure to a mixture of antiandrogenic phthalates. The results showed that the mixture had inhibitory effects on fetal testosterone production and reproductive organ development in rats, and induced antiandrogenic effects at the highest dose.
TOXICOLOGICAL SCIENCES
(2023)
Correction
Endocrinology & Metabolism
Anders Juul, Philippe Backeljauw, Michael Hojby, Masanobu Kawai, Rasmus Juul Kildemoes, Agnes Linglart, Nehama Zuckerman-Levin, Reiko Horikawa
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
R. Lindahl-Jacobsen, M. Tavlo Petersson, L. Priskorn, N. E. Skakkebaek, A. Juul, D. M. Kristensen, M. L. Eisenberg, T. K. Jensen
Summary: Prolonged time to pregnancy is associated with increased mortality in parents in a dose-response manner.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)