Article
Infectious Diseases
Chailat Maluangnon, Surat Tongyoo, Chairat Permpikul
Summary: This study compared the benefits of continuous and intermittent vancomycin infusion. Continuous infusion was found to achieve therapeutic targets faster and have fewer subtherapeutic episodes compared to intermittent infusion. However, there was no significant difference in treatment success, mortality, or incidence of acute kidney injury between the two methods.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Uwe Liebchen, Hanna Salletmeier, Simon Kallee, Christina Scharf, Lucas Huebner, Alexandra Weber, Michael Zoller
Summary: This study aimed to investigate the optimal loading doses of meropenem before continuous infusion in critically ill patients, recommending a loading dose of 0.5 g in extreme scenarios for better target attainment following continuous infusion.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Abdul Haseeb, Mayyasah Khalid Alqurashi, Areej Sultan Althaqafi, Jumana Majdi Alsharif, Hani Saleh Faidah, Mashael Bushyah, Amal F. Alotaibi, Mahmoud Essam Elrggal, Ahmad Jamal Mahrous, Safa S. Almarzoky Abuhussain, Najla A. Obaid, Manal Algethamy, Abdullmoin AlQarni, Asim A. Khogeer, Zikria Saleem, Muhammad Shahid Iqbal, Sami S. Ashgar, Aziz Sheikh
Summary: This systematic review evaluates the clinical safety and efficacy of vancomycin loading dose in critically ill patients. The results show that using a weight-based loading dose can more easily achieve the target therapeutic level without an increased risk of adverse drug reactions.
Article
Infectious Diseases
Jinhui Xu, Lufen Duan, Jiahui Li, Fang Chen, Xiaowen Xu, Jian Lu, Zhiwei Zhuang, Yifei Cao, Yunlong Yuan, Xin Liu, Jiantong Sun, Qin Zhou, Lu Shi, Lian Tang
Summary: This prospective interventional study compared the pharmacokinetic/pharmacodynamics (PK/PD) target attainment, therapeutic efficacy, and safety between critically ill patients receiving continuous infusion (CI) or intermittent infusion (II) of vancomycin during continuous venovenous hemofiltration (CVVH). The study also explored the correlations between effluent flow rate (EFR) and PK/PD indices.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
S. G. Passon, A. R. Schmidt, M. Wittmann, M. Velten, T. Baehner
Summary: Continuous infusion of ampicillin/sulbactam in critically ill patients showed therapeutic concentrations exceeding the minimum inhibitory concentration (MIC) breakpoint in all measurements and above the 4-fold MIC in the majority of analyses. However, patients with acute kidney injury had significantly higher serum concentrations, while impaired renal function and increased renal clearance affected drug levels.
Article
Multidisciplinary Sciences
Christina Medhat Naiim, M. M. Elmazar, Nagwa A. Sabri, Naglaa S. Bazan
Summary: This study compared the efficacy, safety, and cost-effectiveness between extended infusion and intermittent infusion of piperacillin/tazobactam in the treatment of gram-negative bacterial infections. The results demonstrated that extended infusion had shorter treatment duration and time to clinical success compared to intermittent infusion, and it was more cost-effective. Both regimens had comparable clinical and microbiological outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Romain Garreau, Benoit Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod, Florent Wallet, Arnaud Friggeri, Jean-Christophe Richard, Sylvain Goutelle
Summary: This study conducted population pharmacokinetic analysis to identify optimal loading and maintenance doses of vancomycin administered by continuous infusion in ICU patients. The model-driven approach suggested loading dose of 27.5 mg/kg of ideal body weight and maintenance dose ranging from 17.5 to 30 mg/kg depending on renal function. Simulations showed that approximately 55.8% of patients would achieve the target exposure with the suggested dosages.
Article
Pharmacology & Pharmacy
Julia E. Mohlmann, Matthijs van Luin, Esther V. Uijtendaal, Noel Zahr, Maaike A. Sikma
Summary: This study presents a case of using cefiderocol as continuous infusion to treat a critically ill patient with multidrug-resistant Pseudomonas aeruginosa infection. The results suggest that continuous infusion can achieve the desired drug concentrations for effective treatment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Chuhui Wang, Chao Zhang, Xiaoxiao Li, Sixuan Zhao, Na He, Suodi Zhai, Qinggang Ge
Summary: The study aimed to determine factors affecting pharmacokinetic profiles and optimal dosage regimens for critically ill patients undergoing CVVH. A two-compartment model with first-order elimination characterized vancomycin pharmacokinetics, with CL significantly correlated with UFR and albumin level. Recommended dosage regimens varied based on UFR and albumin levels, providing guidance for clinicians in choosing the optimal vancomycin dosage for these patients.
Article
Respiratory System
Jin Gu Yoon, Kyungmin Huh, You Min Sohn, Hyo Jung Park, Soo Jin Na, Kyeongman Jeon
Summary: A retrospective cohort study on patients with pneumonia treated with vancomycin found that the initial loading dose did not affect clinical outcomes or rapid achievement of pharmacological targets. There were no significant differences in microbiological efficacy, all-cause mortality, and incidence of acute kidney injury between the groups that received the loading dose and those that did not, suggesting that initial loading dose is not a key factor affecting treatment efficacy.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Endocrinology & Metabolism
Eileen R. Faulds, Andrew Boutsicaris, Lyndsey Sumner, Laureen Jones, Molly McNett, Keaton S. Smetana, Casey C. May, Elizabeth Buschur, Matthew C. Exline, Matthew D. Ringel, Kathleen Dungan
Summary: This study provides data to support the feasibility, accuracy, safety, and potential workload reduction of using CGM with a hybrid protocol in the ICU for patients with COVID-19 on IV insulin therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Infectious Diseases
Sarah Tournayre, Olivier Mathieu, Maxime Villiet, Noemie Besnard, Vincent Brunot, Delphine Daubin, Laura Platon, Philippe Corne, Kada Klouche, Romaric Larcher
Summary: This retrospective cohort study compares the plasma concentrations of meropenem achieved with continuous infusion and extended intermittent infusion in ICU patients, finding that continuous infusion is more effective in achieving the target concentration.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Infectious Diseases
Ligia-Ancuta Hui, Constantin Bodolea, Laurian Vlase, Elisabeta Ioana Hiriscau, Adina Popa
Summary: A judicious antibiotic therapy is essential for critically ill patients with sepsis and septic shock. Understanding the pharmacokinetics and pharmacodynamics of antibiotics, particularly linezolid, is crucial for achieving therapeutic goals and minimizing side effects in intensive care settings.
Article
Immunology
Xiangqing Song, Mi Han
Summary: This study evaluated the PK/PD exposure of vancomycin in MRSA bloodstream infections using different infusion modes. The results showed that the optimal two-step infusion (OTSI) mode had advantages in terms of both efficacy and safety, especially for patients with a creatinine clearance (CLcr) of >= 60 ml/min and isolates with an MIC of <= 2 mg/L.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Nicolas Garbez, Litaty C. Mbatchi, Emilio Maseda, Sonia Luque, Santiago Grau, Steven C. Wallis, Laurent Muller, Jeffrey Lipman, Jason A. Roberts, Jean-Yves Lefrant, Claire Roger
Summary: The study compared the pharmacokinetics of micafungin in patients receiving CVVH and CVVHDF, and concluded that a loading dose of 150 mg is required to achieve therapeutic effects for less susceptible Candida species.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Infectious Diseases
Maria Angeles Melendez-Carmona, Mikel Mancheno-Losa, Albert Ruiz-Sorribas, Irene Munoz-Gallego, Esther Viedma, Fernando Chaves, Francoise Van Bambeke, Jaime Lora-Tamayo
Summary: There is significant variability in the response of biofilm-embedded Staphylococcus aureus to levofloxacin and rifampicin. A lower range response, combined with other factors, could be responsible for treatment failure.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Thanh Van Do, Toshie Manabe, Giap Van Vu, Vuong Minh Nong, Yuji Fujikura, Dung Phan, Thach The Pham, Cuong Duy Do, Tra Thu Doan, Nguyen Trung Nguyen, Thai Quoc Nguyen, Thanh Van Dong, Chinh Quoc Luong, Hiroki Manabe, Dan Kambayashi, Anh Viet Hoang, Nhan Van Vu, Giang Kim Trinh, Son Ngoc Do, Takeshi Kamiya, Hirotaka Ohara, Chi Van Nguyen, Tuan Quoc Dang, Koichiro Kudo, Co Xuan Dao
Summary: This study focused on analyzing the mortality risk factors of COVID-19 cases caused by the Delta variant in Vietnam during the outbreak in August 2021. The results showed that unvaccinated patients accounted for 61.2% of non-survivors and 43.6% of survivors. The time from symptom onset to hospital admission was 8 days in non-survivors and 7 days in survivors. Among non-survivors, 90.2% developed acute respiratory distress syndrome (ARDS). Diabetes mellitus, respiration rate, oxygen saturation, vaccination status, time from symptom onset to admission, and older age were identified as risk factors for mortality.
Correction
Microbiology
Albert Ruiz-Sorribas, Herve Poilvache, Nur Hidayatul Nazirah Kamarudin, Annabel Braem, Francoise Van Bambeke
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Thi Hai Yen, Nguyen Ky Anh, Rannissa Puspita Jayanti, Nguyen Ky Phat, Dinh Hoa Vu, Jong-Lyul Ghim, Sangzin Ahn, Jae-Gook Shin, Jee Youn Oh, Nguyen Phuoc Long, Dong Hyun Kim
Summary: This study investigated the plasma metabolic profiles of tuberculosis (TB) patients and TB patients with type 2 diabetes mellitus (DM) using a multimodal metabolomics and lipidomics approach. Significant differences in biological processes and biomarkers were identified between TB and TB-DM, providing insights into the pathophysiology of TB-DM and potential improvements in TB treatment. The integration of multimodal metabolomics and lipidomics provides a comprehensive understanding of the metabolic changes associated with TB-DM, enhancing our knowledge of DM comorbidity in TB infection and contributing to the development of more effective treatment.
Review
Pharmacology & Pharmacy
Prakruti S. Rao, Nisha Modi, Nam-Tien Tran Nguyen, Dinh Hoa Vu, Yingda L. Xie, Monica Gandhi, Roy Gerona, John Metcalfe, Scott K. Heysell, Jan-Willem C. Alffenaar
Summary: Quantifying drug exposure is crucial for personalized dose adjustment in tuberculosis patients. Traditional methods using serum or plasma samples for drug monitoring have logistical challenges. Less invasive and lower cost tests using alternative biomatrices can improve feasibility.
CLINICAL PHARMACOKINETICS
(2023)
Article
Multidisciplinary Sciences
Tuan Anh Nguyen, Luu Dang Vu, Ton Duy Mai, Co Xuan Dao, Hung Manh Ngo, Hai Bui Hoang, Son Ngoc Do, Hao The Nguyen, Dung Thi Pham, My Ha Nguyen, Duong Ngoc Nguyen, Hien Thi Thu Vuong, Hung Dinh Vu, Dong Duc Nguyen, Linh Quoc Nguyen, Phuong Viet Dao, Thanh Dang Vu, Dung Tien Nguyen, Tuan Anh Tran, Trang Quynh Pham, Chi Van Nguyen, Anh Dat Nguyen, Chinh Quoc Luong
Summary: This study compared the accuracy of the PAASH, WFNS, and H&H scales in predicting the outcomes of patients with aneurysmal SAH. The results showed that all three scales had good predictive abilities for the 90-day poor outcome, with the PAASH scale performing better than the others.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Son Ngoc Do, Co Xuan Dao, Tuan Anh Nguyen, My Ha Nguyen, Dung Thi Pham, Nga Thi Nguyen, Dai Quang Huynh, Quoc Trong Ai Hoang, Cuong Van Bui, Thang Dinh Vu, Ha Nhat Bui, Hung Tan Nguyen, Hai Bui Hoang, Thuy Thi Phuong Le, Lien Thi Bao Nguyen, Phuoc Thien Duong, Tuan Dang Nguyen, Vuong Hung Le, Giang Thi Tra Pham, Giang Thi Huong Bui, Tam Van Bui, Thao Thi Ngoc Pham, Chi Van Nguyen, Anh Dat Nguyen, Jason Phua, Andrew Li, Chinh Quoc Luong
Summary: This study compared the accuracy of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Scores in predicting mortality among patients with sepsis in ICU settings in a low-income and middle-income country. The results found that the SOFA Score had better discriminatory ability for predicting ICU mortality compared to the APACHE II Score.
Article
Medicine, General & Internal
Tuan Anh Nguyen, Ton Duy Mai, Luu Dang Vu, Co Xuan Dao, Hung Manh Ngo, Hai Bui Hoang, Tuan Anh Tran, Trang Quynh Pham, Dung Thi Pham, My Ha Nguyen, Linh Quoc Nguyen, Phuong Viet Dao, Duong Ngoc Nguyen, Hien Thi Thu Vuong, Hung Dinh Vu, Dong Duc Nguyen, Thanh Dang Vu, Dung Tien Nguyen, Anh Le Ngoc Do, Quynh Thi Pham, Nhung Hong Khuat, Ninh Van Duong, Cong Chi Ngo, Son Ngoc Do, Hao The Nguyen, Chi Van Nguyen, Anh Dat Nguyen, Chinh Quoc Luong
Summary: This multicentre prospective cohort study investigated the impact of intracerebral haematoma (ICH) on outcomes in patients with aneurysmal subarachnoid haemorrhage (aSAH) and identified factors associated with ICH. The study found that ICH was present in 20.5% of aSAH patients and was significantly associated with poor outcomes and death. Independent factors associated with ICH included systolic blood pressure ≥140 mm Hg, higher World Federation of Neurosurgical Societies (WFNS) grades, and ruptured middle cerebral artery aneurysms.
Editorial Material
Infectious Diseases
Francoise Van Bambeke, Sebastian Wicha, Paul M. Tulkens, Markus Zeitlinger
Article
Infectious Diseases
My H. Pham, Le Thi Hoi, Mathew A. Beale, Fahad A. Khokhar, Nguyen Thi Hoa, Patrick Musicha, Grace A. Blackwell, Hoang Bao Long, Dang Thi Huong, Nguyen Gia Binh, Dao Xuan Co, Tran Giang, Cuong Bui, Hai Ninh Tran, James Bryan, Archie Herrick, Theresa Feltwell, Behzad Nadjm, Julian Parkhill, Hindrik Rogier van Doorn, Nguyen Vu Trung, Nguyen Van Kinh, Mili Estee Torok, Nicholas R. Thomson
Summary: A study in Hanoi, Vietnam, highlights the high prevalence of ESBL-positive carbapenem-resistant K pneumoniae in intensive care units. The study also reveals that the important resistance genes are carried broadly by patients entering the two hospitals directly or through referral.
Article
Rehabilitation
Dao Vu Do, Thi Hai Van Pham, Trang Linh Nguyen, Van Giap Vu, Xuan Co Dao
Summary: This study highlights the benefits of early rehabilitation in the ICU for COVID-19 patients, which can improve patient survival during their ICU stay. The analysis of data shows that early rehabilitation has a statistically significant improvement on exertion in patients who underwent at least 5 days of rehabilitation.
DISABILITY AND REHABILITATION
(2023)
Article
Infectious Diseases
K. P. Singh, A. C. C. Carvalho, R. Centis, L. D'Ambrosio, G. B. Migliori, S. G. Mpagama, B. C. Nguyen, R. E. Aarnoutse, A. Aleksa, R. van Altena, P. K. Bhavani, M. S. Bolhuis, S. Borisov, N. van't Boveneind-Vrubleuskaya, J. Bruchfeld, J. A. Caminero, I. Carvalho, J. G. Cho, L. Davies Forsman, M. Dedicoat, K. Dheda, K. Dooley, J. Furin, J. M. Garcia-Garcia, A. Garcia-Prats, A. C. Hesseling, S. K. Heysell, Y. Hu, H. Y. Kim, S. Manga, B. J. Marais, I. Margineanu, A-G. Martson, M. Munoz Torrico, H. M. Nataprawira, E. Nunes, C. W. M. Ong, R. Otto-Knapp, D. J. Palmero, C. A. Peloquin, A. Rendon, D. Rossato Silva, R. Ruslami, A. M. I. Saktiawati, P. Santoso, H. S. Schaaf, B. Seaworth, U. S. H. Simonsson, R. Singla, A. Skrahina, I. Solovic, S. Srivastava, S. L. Stocker, M. G. G. Stukenboom, E. M. Svensson, M. Tadolini, T. A. Thomas, S. Tiberi, J. Trubiano, Z. F. Udwadia, A. R. Verhage, D. H. Vu, O. W. Akkerman, J. W. C. Alffenaar, J. T. Denholm
Summary: This article presents clinical standards for the diagnosis and management of adverse effects (AE) to tuberculosis (TB) treatment. Eight clinical standards were identified, including counseling and evaluation for AE risk, assessment and management of AE, and training for healthcare workers. These standards aim to provide a consensus-based approach to minimize the impact of AE in TB treatment.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Multidisciplinary Sciences
Tuan Anh Nguyen, Ton Duy Mai, Luu Dang Vu, Co Xuan Dao, Hung Manh Ngo, Hai Bui Hoang, Tuan Anh Tran, Trang Quynh Pham, Dung Thi Pham, My Ha Nguyen, Linh Quoc Nguyen, Phuong Viet Dao, Duong Ngoc Nguyen, Hien Thi Thu Vuong, Hung Dinh Vu, Dong Duc Nguyen, Thanh Dang Vu, Dung Tien Nguyen, Anh Le Ngoc Do, Cuong Duy Nguyen, Son Ngoc Do, Hao The Nguyen, Chi Van Nguyen, Anh Dat Nguyen, Chinh Quoc Luong
Summary: The modified WFNS, WFNS, and H & H scales all showed good discriminatory abilities in predicting the prognosis of patients with aSAH. Among them, the modified WFNS scale had a better effect size in predicting poor outcomes compared to the WFNS and H & H scales.
Article
Medical Informatics
Ha N. Tran, Tien N. T. Nguyen, Ngan T. K. Tran, Ly T. Nguyen, Hoa D. Vu, Anh H. Nguyen, Nhung T. H. Trinh
Summary: Background: Antibiotics are commonly used medications that can cause adverse drug reactions. This study aimed to characterize and assess the preventability of spontaneously reported adverse drug reactions (ADRs) associated with antibiotics in Vietnam. Methods: We conducted a retrospective descriptive study using ADRs reported to the National Pharmacovigilance Database of Vietnam between June 2018 and May 2019. The leading causes and characteristics of preventable ADRs (pADRs) were identified and described. Results: A total of 6385 antibiotic-related reports were included. Beta-lactam antibiotics, mostly administered parenterally, were suspected in the majority of cases. The most commonly reported pADRs were allergic reactions, mainly involving the skin and subcutaneous tissue. Approximately 8.4% of all cases were associated with pADRs, with major causes including potentially inappropriate prescribing and re-administration of antibiotics causing prior allergy/allergies. Conclusion: ADRs related to antibiotic use accounted for more than half of the spontaneously reported ADRs in Vietnam. Approximately one in every ten reported cases was associated with a preventable ADR. The majority of pADRs can be prevented through improvements in antibiotic prescribing practices.
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2023)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)