Article
Immunology
Yongcan Wu, Demei Huang, Xiaomin Wang, Caixia Pei, Wei Xiao, Fei Wang, Zhenxing Wang
Summary: Pre-treatment with PLD alleviates lung inflammation and injury induced by LPS, reduces inflammatory cytokine levels, modulates oxidative stress-related factors in lung tissue, and inhibits the activation of NLRP3 and NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Yung Hyun Choi, Cheol Park, Cheng-Yung Jin, Chang-Hee Kang, Mi-Hwa Lee, Gi-Young Kim
Summary: The study demonstrates that Fisetin inhibits the activation of the NLRP3 inflammasome by TLR4/MD2 pathway, leading to the elimination of damaged mitochondria through p62-dependent mitophagy.
Article
Chemistry, Medicinal
Shan Han, Siyuan Li, Jilang Li, Jia He, Qin-Qin Wang, Xiang Gao, Shilin Yang, Jingjing Li, Renyikun Yuan, Guoyue Zhong, Hongwei Gao
Summary: Acute kidney injury (AKI) is a common clinical condition with high incidence and mortality rates. This study found that Hederasaponin C (HSC) has a protective effect against lipopolysaccharide (LPS)-induced renal inflammation by inhibiting the expression of TLR4 and the activation of NF-kappa B and PIP2 signaling pathways, as well as suppressing the activation of the NLRP3 inflammasome.
PHYTOTHERAPY RESEARCH
(2023)
Article
Surgery
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu
Summary: The research demonstrated that LYRM03 could decrease the severity of lung injury and inflammation induced by LPS by inhibiting the release of various inflammatory factors and regulating the activity of proteins like NF-κB.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Huiping Wu, Ying Wang, Haiyan Fu, Lili Ji, Na Li, Dan Zhang, Longxiang Su, Zhansheng Hu
Summary: The study aimed to investigate the potential neuroprotective effects of Maresin1 (MaR1) on microglia-induced neuroinflammation in sepsis-induced cognitive impairment and explore its anti-inflammatory mechanism. The results showed that MaR1 significantly ameliorated cognitive dysfunction and inhibited neuroinflammation by suppressing the activations of NLRP3 and TLR4-NF-κB signal pathways.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Wenhua Gan, Xiaohe Li, Yunyao Cui, Ting Xiao, Rui Liu, Ming Wang, Yiying Wei, Mengqi Cui, Shanfa Ren, Kaiyue Helian, Wen Ning, Honggang Zhou, Cheng Yang
Summary: The study revealed that pinocembrin could alleviate lung inflammatory response induced by LPS and BLM by regulating the TLR4-NF-kappa B signaling pathway and inhibiting the activation and assembly of NLRP3 inflammasomes. These findings provide insights into the anti-inflammatory mechanisms of pinocembrin and can guide future research in this area.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Anmao Li, Lei Gu, Chunyan He, Yishi Li, Mingyu Peng, Jiaxin Liao, Rui Xiao, Li Xu, Shuliang Guo
Summary: This study evaluates the role of GATA6 in NF-κB-mediated NLRP3 inflammasome activation and pyroptosis after tracheal injury. The results show that GATA6 promotes NLRP3 inflammasome activation and epithelial pyroptosis, and promotes epithelial-mesenchymal transition and fibrotic repair through the regulation of the NF-κB/NLRP3 pathway. Overall, GATA6 is a potential therapeutic target for tracheal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Xiao-Dan Bao, Yu-Yao Zu, Bi-Xu Wang, Mei-Ya Li, Fu-Sheng Jiang, Chao-Dong Qian, Fang-Mei Zhou, Zhi-Shan Ding
Summary: This study focused on the effect of coelonin on PM2.5-induced macrophage damage. It was found that coelonin could alleviate cell damage and reduce the production of inflammatory cytokines by suppressing TLR4/NF-kappa B/COX-2 signaling pathway and NLRP3 inflammasome activation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Yingying Fan, Jian Wang, Zhihui Feng, Ke Cao, Jiankang Liu, Hao Xu
Summary: The combination therapy of hydrogen and oxygen shows a superior protective effect on acute lung injury, with hydrogen playing a more important role in inflammatory and anti-apoptosis mechanisms, while oxygen improving hypoxia in the body.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Dang Wan-tai, Xu Dan, Zhou Jing-guo
Summary: This study suggests that berberine can alleviate gout inflammation in patients by regulating the TLR4-NF-kappa B signaling pathway and NLRP3 inflammasome expression.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Immunology
Zixi Chen, Mengzhe Zhang, Yunzhi Zhao, Wenjuan Xu, Fenfen Xiang, Xiaoxiao Li, Tao Zhang, Rong Wu, Xiangdong Kang
Summary: The NLRP3 inflammasome plays a crucial role in inflammatory responses, and hydrogen sulfide contributes to uterine quiescence by inhibiting the TLR4/NF-kappa B signaling pathway and downstream NLRP3 inflammasome activation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tatsuma Sakaguchi, Fusao Sumiyama, Masaya Kotsuka, Masahiko Hatta, Terufumi Yoshida, Mikio Hayashi, Masaki Kaibori, Mitsugu Sekimoto
Summary: Levosimendan has a protective effect on the liver and improves survival in a rat model of acute liver failure by inhibiting inflammatory mediators and cytokines, as well as suppressing the activation of NF-kappa B.
Article
Medicine, Research & Experimental
Yanke Lin, Shuai Wang, Lu Gao, Ziyue Zhou, Zemin Yang, Jingpan Lin, Shujing Ren, Huijie Xing, Baojian Wu
Summary: The study highlights the crucial role of Platr4 in experimental steatohepatitis, acting to inactivate the Nlrp3 inflammasome by intercepting NF-kappa B signaling, making it a potential target for ameliorating the pathological conditions of steatohepatitis.
Article
Microbiology
Shiyan Chen, Yanan Li, Bingxin Chu, Lanxin Yuan, Ning Liu, Yaohong Zhu, Jiufeng Wang
Summary: The study demonstrated that Lactobacillus johnsonii L531 alleviated Salmonella Typhimurium induced damage to intestinal epithelial cells by inhibiting the activation of inflammatory signaling pathways and reducing the expression of pro-inflammatory cytokines.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)