Article
Rehabilitation
Marte Stine Einstad, Pernille Thingstad, Stian Lydersen, Mari Gunnes, Ingvild Saltvedt, Torunn Askim
Summary: This study investigated whether cognition and physical performance, both separately and combined, at 3 months post stroke predict change in instrumental activities of daily living (IADL) up to 18 months, and whether different paths of IADL could be identified by different scenarios defined by combinations of high and low scores on physical performance and cognition.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Surgery
Carl A. Beyer, James P. Byrne, Sarah A. Moore, Nathaniel R. McLauchlan, Joao B. Rezende-Neto, Thomas J. Schroeppel, Christopher Dodgion, Kenji Inaba, Mark J. Seamon, Jeremy W. Cannon
Summary: Initial management failure of traumatic hemothorax is common and highly variable across trauma centers. Assessing patient selection for a given management strategy and center-level practices represent opportunities to improve outcomes from traumatic hemothorax.
Article
Dermatology
Marieke E. C. van Winden, Ewald M. Bronkhorst, M. Birgitte Visch, Gertruud A. M. Krekels, Simone van der Geer, Godelieve W. J. A. Damen, Avital Amir, Katja K. H. Aben, Marie-Jeanne J. P. Gerritsen, Peter C. M. van de Kerkhof, Elke M. G. J. de Jong, Satish F. K. Lubeek
Summary: This study evaluated predictors of treatment burden, outcomes, and survival in older patients with BCC aged 70 years and above in the head and neck area. Results showed that factors associated with higher treatment burden included iADL dependency, female sex, complications, larger tumor diameter, and polypharmacy. Early intervention for robust patients or those experiencing symptoms was beneficial based on the data.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Charlotte B. van Lee, Nina Kouloubis, Marlies Wakkee, Nicole W. J. Kelleners-Smeets, Ruud G. L. Nellen, Annik van Rengen, Hanke C. de Vijlder, Leon C. C. Wijne, Tamar Nijsten, Renate R. van den Bos
Summary: This prospective study investigated the rate and characteristics of incomplete excision of squamous cell carcinoma (cSCC) in a dermatological setting. The results showed that the risk of incomplete excision of cSCC is low in a cohort dominated by low-risk cSCCs. Most incompletely excised cSCCs were high-risk types and the incompleteness was almost always at the deep margins. Therefore, special attention should be paid to the deep margins when dealing with high-risk cSCC, and microscopic surgery may be considered.
DERMATOLOGIC SURGERY
(2022)
Article
Dermatology
Vicenc Rocamora, Laura Crespi, Marta Ferran, Mar Llamas-Velasco, Elena del Alcazar, Jose M. Carrascosa, Emma Beltran, Ana Urruticoechea-Arana, Jose Luis Lopez Estebaranz, David Vidal, Josep Riera, Lourdes Rodriguez, Susana Armesto, Josep M. Fernandez, Gloria Aparicio, Silvia Perez, Saray Porcar, Encarna Montesinos, Fernando Gallardo
Summary: This study evaluated the effectiveness and tolerability of Guselkumab in the treatment of psoriatic arthritis in clinical practice. The results showed that Guselkumab effectively controlled both joint and skin manifestations. No new safety concerns were found, and the majority of patients continued the treatment after 2 years of follow-up.
DERMATOLOGIC THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Anne Katherine Gribble, Carmen Sayon-Orea, Maira Bes-Rastrollo, Stefanos N. Kales, Ryutaro Shirahama, Miguel Angel Martinez-Gonzalez, Alejandro Fernandez-Montero
Summary: A study on a Mediterranean population found a positive association between daily siesta longer than 30 minutes and the development of metabolic syndrome, while there was no significant difference in risk between those averaging less than 30 minutes of siesta and those not taking siesta. Additionally, siesta duration of less than 15 minutes may reduce the risk of metabolic syndrome.
Article
Medicine, General & Internal
Hongxuan Zhang, Xiaoting Wang, Wanhong Yin, Hongmin Zhang, Lixia Liu, Pan Pan, Ying Zhu, Wei Huang, Zhiqun Xing, Bo Yao, Cui Wang, Tianlai Lin, Rongguo Yu, Xiuling Shang
Summary: This study aims to clarify the relationship between the ultrasound phenotype of septic cardiomyopathy and the prognosis of patients with sepsis, in order to provide evidence for early identification and intervention. Data from clinical measurements and echocardiographic measurements will be collected and analyzed to determine the prevalence of each phenotype and its association with prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Hideaki Sakuramoto, Kensuke Nakamura, Akira Ouchi, Saiko Okamoto, Shinichi Watanabe, Keibun Liu, Yasunari Morita, Hajime Katsukawa, Toru Kotani
Summary: This study investigated the current practice and barriers to the implementation of mobilization in ICU. The main barriers to mobilization in ICU were circulatory instability and physician's order for postoperative bed rest. Rehabilitation programs were initiated later and were less intense for unplanned admission patients compared to elective surgical patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Hsien-Yi Chiu, Ying-Ming Chiu, Nien-Feng Chang Liao, Ching-Chi Chi, Tsen-Fang Tsai, Chang-Yu Hsieh, Tsu-Yi Hsieh, Kuo-Lung Lai, Tsu-Man Chiu, Nan-Lin Wu, Rosaline Chung-yee Hui, Chaw-Ning Lee, Ting-Shun Wang, Po-Hua Chen, Chao-Chun Yang, Yu-Huei Huang
Summary: This study found that patients with psoriasis receiving biologics are at risk of HBV and HCV reactivations, especially those who are HBsAg and HBeAg positive and undergoing tumor necrosis factor-alpha-inhibitor therapy. Antiviral prophylaxis was effective in reducing the risk of HBV reactivation. No predictors were significantly associated with HCV reactivation.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Yayoi Tada, Akimichi Morita, Keiichi Yamanaka, Michihiro Kono, Shinichi Imafuku, Yukari Okubo, Fumikazu Yamazaki, Taisuke Kawamura, Asako Itakura, Mamitaro Ohtsuki
Summary: This study evaluated the long-term retention rate and effectiveness of Secukinumab in patients with psoriasis in Japan. The results showed a retention rate of 78.0% at week 52. Psoriasis Area and Severity Index significantly improved at week 52. This study provides clinical insights into psoriasis treatment strategies.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yuxiong Jiang, Ying Li, Dawei Huang, Xiaoyuan Zhong, Qian Yu, Yanhua Liang, Lin Dang, Chengzhi Lv, Binjiang Lin, Furen Zhang, Yunsheng Liang, Jiajing Lu, Yuling Shi
Summary: This study aimed to assess the impact of complete skin clearance (CSC) on quality of life (QoL) improvements and identify clinical parameters as predictors of CSC response in psoriasis patients treated with ixekizumab. The study found that CSC has a significant impact on QoL improvements. Female patients were more likely to achieve CSC response, while previous biologic treatment and joint affected were significantly associated with less CSC response.
Article
Oncology
Heidemarie Haller, Petra Voiss, Holger Cramer, Anna Paul, Mattea Reinisch, Sebastian Appelbaum, Gustav Dobos, Georg Sauer, Sherko Kummel, Thomas Ostermann
Summary: This study aims to identify predictors of short- and long-term response to integrative breast cancer treatment in women through collecting data and exploring influencing factors. The research includes various predictors such as study center, histologic cancer and comorbidity data, psychological status, etc., and will use multivariable prediction models for analysis.
Article
Dermatology
Florence Assan, Florence Tubach, Hugo Arlegui, Manuelle Viguier, Marie Beylot-Barry, Alain Dupuy, Nathalie Beneton, Pascal Joly, Denis Jullien, Emmanuel Mahe, Carle Paul, Marie-Aleth Richard, Herve Bachelez, Caroline Giboin, Olivier Chosidow, Emilie Sbidian
Summary: This study compared obese and non-obese patients in terms of first-line biologic therapy for psoriasis, finding that obese patients had shorter drug survival mainly due to inefficacy.
Article
Critical Care Medicine
Harry Magunia, Simone Lederer, Raphael Verbuecheln, Bryant Joseph Gilot, Michael Koeppen, Helene A. Haeberle, Valbona Mirakaj, Pascal Hofmann, Gernot Marx, Johannes Bickenbach, Boris Nohe, Michael Lay, Claudia Spies, Andreas Edel, Fridtjof Schiefenhoevel, Tim Rahmel, Christian Putensen, Timur Sellmann, Thea Koch, Timo Brandenburger, Thorsten Brenner, Marc Berger, Kai Zacharowski, Elisabeth Adam, Matthias Posch, Onnen Moerer, Christian S. Scheer, Daniel Sedding, Markus A. Weigand, Falk Fichtner, Carla Nau, Florian Praetsch, Thomas Wiesmann, Christian Koch, Gerhard Schneider, Tobias Lahmer, Andreas Straub, Andreas Meiser, Manfred Weiss, Bettina Jungwirth, Frank Wappler, Patrick Meybohm, Johannes Herrmann, Nisar Malek, Oliver Kohlbacher, Stephanie Biergans, Peter Rosenberger
Summary: This study aimed to develop a machine learning model to stratify patient risk and predict ICU survival and outcomes for COVID-19 patients. By using Explainable Boosting Machine analysis, the study identified predictive factors such as age, inflammatory and thrombotic activity, and severity of ARDS at ICU admission. These findings can assist in the treatment and management of critically ill COVID-19 patients.
Article
Dermatology
Linda Davidson, Juul M. P. A. Van den Reek, Florence Van Hunsel, Elke M. G. J. De Jong, Bart Jan Kullberg
Summary: This study analyzed spontaneous safety reports to identify associations between different biologics and bacterial skin or herpesvirus infections. The results showed that ustekinumab was strongly associated with bacterial skin infections, while infliximab showed the strongest association with herpes simplex and Epstein-Barr virus infections. All biologics were positively associated with bacterial skin infections, herpes simplex, and herpes zoster.
ACTA DERMATO-VENEREOLOGICA
(2022)
Letter
Dermatology
M. E. C. van Winden, F. M. Klosters, M. Hamaker, M. G. Olde Rikkert, P. C. M. van de Kerkhof, E. M. G. J. de Jong, S. F. K. Lubeek
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Mirjam J. Schaap, Susanne C. E. Broekhuis, Saskia Spillekom-van Koulil, Hans M. M. Groenewoud, Elke M. G. J. de Jong, Marieke M. B. Seyger
Summary: The study found that young psoriasis patients and parents primarily aim to clear lesions and itch with effective and safe treatment. However, differences in specific characteristics and preferences exist based on age, gender, and current treatment method.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Marloes. E. Van Muijen, Sarah E. Thomas, Hans M. M. Groenewoud, Marisol E. Otero, Paul M. Ossenkoppele, Marcellus D. Njoo, Sharon R. P. Dodemont, Else N. Kop, Maartje A. M. Berends, Marjolein I. A. Koetsier, Johannes M. Mommers, John E. M. Korver, Ron A. Tupker, Marjolein S. De Bruin-Weller, Lizelotte J. M. T. Weppner-Parren, Bas Peters, Marloes M. Kleinpenning, Astrid L. A. Kuijpers, W. Peter Arnold, Paula P. M. Van Lumig, Juul M. P. A. Van den Reek, Elke M. G. J. De Jong
Summary: Real-world evidence comparing the effectiveness of different biologic therapies for psoriasis shows that adalimumab, ustekinumab, secukinumab, ixekizumab, and guselkumab are more effective in reducing PASI scores and achieving PASI90 than etanercept. Ixekizumab and guselkumab have higher probabilities of achieving PASI90 than other treatments. The proportions of patients reaching PASI90/75 are lower in real-world studies compared to randomized controlled trials.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Elke L. M. Ter Haar, Eline E. Ten Bruin, Ewald M. Bronkhorst, Rinke J. Borgonjen, Marloes M. Kleinpenning, Else N. Kop, M. Birgitte Visch, Peter C. M. Van De Kerkhof, Elke M. G. J. De Jong, Satish F. K. Lubeek
Summary: This multicentre retrospective study examined the safety of systemic therapy in older adults with psoriasis and analyzed predictors for adverse events. The study found that increasing age was associated with a higher incidence of adverse events, while comorbidity, polypharmacy, and treatment type were not related to adverse event occurrence. Causality assessment showed that serious adverse events were rare and manageable in clinical practice, indicating a reassuring safety profile for systemic antipsoriatic therapy in this population.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Mirjam J. Schaap, Finola M. Bruins, Noa Johanna Maria van den Brink, Kadri Orro, Hans M. M. Groenewoud, Elke M. G. J. de Jong, Ellen H. van den Bogaard, Marieke M. B. Seyger
Summary: The study found significant differences in markers measured by TAP in pediatric psoriasis patients, with substantial variability over time but no clear correlation with disease severity.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Dermatology
Kevin V. Kwee, Jean-Luc Murk, Qiqi Yin, M. Birgitte Visch, Linda Davidson, Elke M. G. J. de Jong, Juul M. P. A. van den Reek, Milan Tjioe
Summary: The study aimed to estimate the prevalence of SARS-CoV-2 infection in psoriasis patients, compare infection rates among different treatment groups, and describe severe COVID-19 cases. The findings suggest that the risk of SARS-CoV-2 infection is not increased for psoriasis patients using biologics or non-biologic systemic therapy compared to other treatments.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Dermatology
Tamara W. Van Hal, Michelle L. M. Mulder, Mark H. Wenink, Frank H. J. Van Den Hoogen, Jake S. F. Maurits, Marcel C. Pasch, Juul M. P. A. Van Den Reek, Elke M. G. J. De Jong
Summary: In this study, researchers used data from the DAPPER study to identify predictive variables for concomitant psoriatic arthritis and created a referral tool based on these variables, with an area under the curve of 0.82. This referral tool could assist dermatologists in identifying psoriasis patients with concomitant psoriatic arthritis.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
L. S. van der Schoot, J. J. Janssen, M. T. Bastiaens, A. de Boer-Brand, C. Christiaansen-Smit, D. N. H. Enomoto, R. Hovingh, R. A. Tupker, M. M. B. Seyger, L. M. Verhoef, J. M. P. A. van den Reek, E. M. G. J. de Jong
Summary: Implementation of protocolized biologic dose reduction can increase patient uptake of treatment, with additional staff support, extra consultation time, education for healthcare providers and patients, and effective tools such as a feasible protocol leading to more patients on biologic dose reduction.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Letter
Dermatology
Inge M. G. J. Bronckers, Elke M. G. J. de Jong, Celia A. J. Michielsens, Hans M. M. Groenewoud, Peter C. M. van de Kerkhof, Marieke M. B. Seyger
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Astrid M. van Huizen, Gayle E. van der Kraaij, Celine I. Busard, Wouter Ouwerkerk, Juul M. P. A. van den Reek, Stef P. Menting, Errol P. Prens, Theo Rispens, Annick de Vries, Elke M. G. J. de Jong, Jo Lambert, Martijn B. A. van Doorn, Phyllis I. Spuls
Summary: This study compared the long-term effectiveness and safety of the combination of methotrexate and adalimumab with adalimumab monotherapy in patients with moderate to severe plaque type psoriasis. The results showed a trend towards longer drug survival in the combination therapy group, but no significant difference was found compared to the monotherapy group. Similar conclusions were drawn regarding the efficacy, safety, pharmacokinetics, and immunogenicity of the drugs. Overall, combination therapy may have a better effect in individual patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Dermatology
Sarah E. Thomas, Juul M. P. A. Van den Reek, Marieke M. B. Seyger, Elke M. G. J. de Jong
Summary: In this study, the researchers aimed to synthesize the various definitions of super-responders in psoriasis literature and evaluate their impact on the composition of the super-responder group.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Sarah E. Thomas, Juul M. P. A. Van den Reek
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
L. S. van der Schoot, L. M. Verhoef, I. van Ee, F. P. A. H. van Oort, A. H. Pieterse, M. M. B. Seyger, E. M. G. J. de Jong, J. M. P. A. van den Reek
Summary: This study aimed to explore patients' perspectives towards dose reduction of biologics for psoriasis. Patients perceived benefits of dose reduction including minimizing medication use, lowering risks of adverse effects, and lowering healthcare costs. However, they also expressed concerns about the potential loss of disease control. Addressing patients' concerns, fulfilling information needs, providing the possibility of resuming standard dose, and involving patients in decision-making are important when considering biologic dose reduction.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)