Article
Biophysics
Ya Tao, Xin Zhao, XiaoPan Liu, PeiJia Wang, YinMo Huang, RuoNan Bo, MingJiang Liu, JinGui Li
Summary: This study developed a stable nanoemulsion loaded with ARS using a double emulsification solvent volatilisation method. The results demonstrated that CPA nanoemulsion had suitable characteristics for drug release and effectively relieved symptoms of UC in a mouse model. The study also found that CPA could specifically target colonic tissue and alleviate UC.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Shaojie Yin, Liuhui Li, Ya Tao, Jie Yu, Simin Wei, Mingjiang Liu, Jingui Li
Summary: Artesunate can protect against ulcerative colitis by inhibiting excessive ER stress, which helps to preserve intestinal barrier integrity and reduce inflammation. This protective effect is achieved through modulation of ER stress signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongyu Xiao, Hailun Li, Yifan Wen, Dongxu Jiang, Shumin Zhu, Xueling He, Qingping Xiong, Jie Gao, Shaozhen Hou, Song Huang, Lian He, Jian Liang
Summary: TFP shows significant therapeutic effects on DSS-induced UC model by inhibiting inflammation and restoring intestinal barrier and mucus barrier function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Bingyu Wang, Zhiqiang Gong, Jingyu Zhan, Lei Yang, Quanyu Zhou, Xingxing Yuan
Summary: Xianglian pill (XLP) has been found to alleviate DSS-induced acute colitis in mice by inhibiting pro-inflammatory cytokines secretion, repairing intestinal epithelial barrier dysfunction, enhancing autophagy, and blocking the activation of the PI3K/Akt/mTOR pathway. Blocking autophagy attenuated the protective effects of XLP on colitis, suggesting that the underlying mechanism may involve Xianglian pill promoting autophagy by blocking the activation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao
Summary: Salidroside, a glycoside extracted from Rhodiola rosea L., was found to ameliorate dextran sulfate sodium (DSS)-induced colitis by modulating the gut microbiota. Salidroside treatment inhibited colitis symptoms in mice, including colon length, histology, disease activity index (DAI) score, and macrophage levels in the intestine. In a fecal microbiota transplantation (FMT) study, fecal samples from Salidroside-treated mice significantly alleviated colitis symptoms in recipient mice, indicating the importance of gut microbiota in the therapeutic effect. Salidroside and FMT both influenced the structure and abundance of the gut microbiota, with decreased relative abundance of Turicibacter, Alistipes, Romboutsia, and increased relative abundance of Lactobacillus. The anti-inflammatory effect of Salidroside was dependent on the presence of gut microbiota, as evidenced by its disappearance in antibiotic-treated mice. Salidroside could be a promising functional food for colitis treatment.
Article
Gastroenterology & Hepatology
Chunxiao Li, Yu Xu, Tengjiao Gao, Shunyao Zhang, Zhe Lin, Shaobo Gu, Yi Fang, Xin Yuan, Siyi Yu, Qi Jiang, Zhongze Lou, Xiuming Zhang, Jie Zhang, Qiaoyan Wu, Mengli Gu, Xiaoyun Ding, Jing Sun, Yi Chen
Summary: This study found that ruxolitinib significantly alleviated ulcerative colitis by inhibiting nuclear factor kappa B-induced inflammation and apoptosis, as well as restoring epithelial barrier function via STAT3. This provides a new strategy for the treatment of ulcerative colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Plant Sciences
Xiaocui Deng, Yudan Wang, Lei Tian, Meilian Yang, Shuyue He, Yaping Liu, Afsar Khan, Yanping Li, Jianxin Cao, Guiguang Cheng
Summary: Anneslea fragrans is traditionally used as a folk medicine in China, Vietnam and Cambodia for treating various conditions. This study found that its aqueous-methanol extract has therapeutic effects on ulcerative colitis in mice by inhibiting inflammation through modulation of specific pathways and maintaining intestinal barrier function.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aurora Mazzei, Grazia Serino, Alessandro Romano, Emanuele Piccinno, Viviana Scalavino, Anna Maria Valentini, Raffaele Armentano, Roberta Schiavone, Gianluigi Giannelli, Tiziano Verri, Amilcare Barca
Summary: SLC15A4/PHT1 has been identified as a key path marker of immune/autoimmune/inflammatory pathways in immune cells, and this study found its overexpression in the colonic epithelium of ulcerative colitis (UC) patients. In vitro experiments successfully mirrored the inflammatory onset in spontaneously differentiated enterocyte-like monolayers of Caco-2 cells specifically exposed to DSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Yuqi Wu, Yanfei Zheng, Xiaolu Wang, Ping Tang, Wenqian Guo, Han Ma, Anqi Zhang, Delong Li, Yuxin Xie, Chong-Zhi Wang, Haiqiang Yao, Jin-Yi Wan, Chun-Su Yuan
Summary: Ulcerative colitis (UC) has become a global epidemic, and the lack of an effective cure highlights the necessity and urgency to explore novel therapies. Sijunzi Decoction (SJZD), a classical Chinese herbal formula, has been comprehensively applied and clinically proven effective in treating UC. The therapeutic benefits of SJZD are attributed to its ability to restore microbiota homeostasis, improve intestinal barrier integrity, and modulate the biosynthesis of bile acids (BAs), especially tauroursodeoxycholic acid (TUDCA).
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhiwei Miao, Liping Chen, Hui Feng, Mingjia Gu, Jing Yan, Yi Xu, Bai Ye
Summary: The study found that BTW significantly suppressed intestinal inflammation in UC mice, potentially through regulating the balance of Th17/Treg cells and restoring the intestinal epithelial barrier.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jiapei Cai, Jiuxi Liu, Peng Fan, Xue Dong, Kunpeng Zhu, Xiaobo Liu, Naisheng Zhang, Yongguo Cao
Summary: Dioscin, a natural steroid saponin derived from plants of the genus Dioscoreaceae, shows protective effects on DSS-induced colitis in mice by reducing disease activity, maintaining intestinal barrier function, and inhibiting excessive inflammation. It may be a promising candidate for future ulcerative colitis therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Xiaodong Li, Xia Wu, Qi Wang, Weilv Xu, Qingwei Zhao, Nana Xu, Xingjiang Hu, Ziqi Ye, Songxia Yu, Jian Liu, Xuelin He, Fushan Shi, Qiao Zhang, Weifen Li
Summary: The study found that sanguinarine (SAN) has a therapeutic effect on ulcerative colitis (UC) by blocking the NLRP3-(Caspase-1)/IL-1 beta pathway and improving intestinal microbial dysbiosis.
Article
Biochemistry & Molecular Biology
Meishan Yue, Jialu Huang, Xiaolan Ma, Peng Huang, Yisong Liu, Jianguo Zeng
Summary: This study found that PRO, an anti-inflammatory ingredient in Macleaya cordata, can alleviate inflammation symptoms and restore the intestinal barrier in DSS-induced colitis mice. PRO also regulates the composition of gut microbiota.
Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)