Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin

MicroRNA-145 overexpression attenuates apoptosis and increases matrix synthesis in nucleus pulposus cells

(2019) Jie Zhou et al.   LIFE SCIENCES

Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

(2019) Hai-Chao Dong et al.   INFLAMMATION

Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo

(2019) Haiming Jin et al.   INFLAMMATION

TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling

(2019) Xinghuo Wu et al.   INFLAMMATION

Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

(2019) Chen Xia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-inflammatory effects of Melatonin: a mechanistic review

(2018) Seyed Mohammad Nabavi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD

(2018) Zhenyu Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells

(2018) Ruijun He et al.   LIFE SCIENCES

Transcription factor 7-like 2 controls matrix degradation through nuclear factor κB signaling and is repressed by microRNA-155 in nucleus pulposus cells

(2018) Jianchao Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-κB pathway

(2018) Jun Zou et al.   BIOMEDICINE & PHARMACOTHERAPY

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy

(2018) Changgui Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice

(2018) Xiaoyu Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin and inflammation - story of a double-edged blade

(2018) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

(2018) Sai Ma et al.   Oxidative Medicine and Cellular Longevity

Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells

(2017) Yu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway

(2017) Zheng Li et al.   JOURNAL OF PINEAL RESEARCH

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

(2017) Jia Yi Guo et al.   Oncotarget

The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration

(2016) Pan Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling

(2016) Xiaofei Wang et al.   INFLAMMATION RESEARCH

Xylosyltransferase-1 Expression Is Refractory to Inhibition by the Inflammatory Cytokines Tumor Necrosis Factor α and IL-1β in Nucleus Pulposus Cells

(2015) Wei Ye et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

(2015) KANG XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Enhanced NLRP3, Caspase-1, and IL- 1β Levels in Degenerate Human Intervertebral Disc and Their Association with the Grades of Disc Degeneration

(2014) Zhong-Hua Chen et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

The lumbar intervertebral disc: From embryonic development to degeneration

(2013) Pauline Colombier et al.   JOINT BONE SPINE

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Visfatin/NAMPT: A Multifaceted Molecule with Diverse Roles in Physiology and Pathophysiology

(2012) Tuva B. Dahl et al.   Annual Review of Nutrition

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What Is the Source of Chronic Low Back Pain and Does Age Play a Role?

(2011) Michael J. DePalma et al.   PAIN MEDICINE

The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology

(2009) Michael A. Adams et al.   MATRIX BIOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Crucial role of visfatin/pre–B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis

(2008) Marjolaine Gosset et al.   ARTHRITIS AND RHEUMATISM

A systematic review of low back pain cost of illness studies in the United States and internationally

(2008) Simon Dagenais et al.   Spine Journal