Article
Microbiology
Jose J. Rivera Rivas, Charles J. Czuprynski
Summary: Histophilus somni is a Gram-negative coccobacillus that causes diffuse vasculitis and intravascular thrombosis in cattle. Our study demonstrates that exposure to H. somni cells causes monocyte-derived macrophages to release microparticles with pro-coagulant activity, potentially amplifying thrombus formation.
VETERINARY MICROBIOLOGY
(2022)
Article
Hematology
Yohei Hisada, Kenison B. Garratt, Anaum Maqsood, Steven P. Grover, Tomohiro Kawano, Brian C. Cooley, Jonathan Erlich, Florian Moik, Matthew J. Flick, Ingrid Pabinger, Nigel Mackman, Cihan Ay
Summary: This study investigated the association of active Lys-PG in plasma and VTE in pancreatic cancer patients, as well as the impact of human pancreatic tumors expressing Lys-PG on venous thrombus resolution in mice. The results suggest that Lys-PG may contribute to the development of VTE in pancreatic cancer.
Review
Hematology
Regan Bucciol, Maha Othman
Summary: Cancer-associated thrombosis (CAT), such as venous thromboembolism (VTE), is a common complication in cancer patients, and breast cancer has been associated with increased VTE cases. Tissue factor (TF), a glycoprotein that triggers coagulation, is expressed and released by cancer cells, leading to a prothrombotic state. This review evaluated the use of procoagulant microparticles (MPTF) as a biomarker for thrombosis risk in breast cancer.
CURRENT OPINION IN HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Corinna Steidel, Fanny Ender, Achim Rody, Nikolas von Bubnoff, Frank Gieseler
Summary: This study discusses the potential causal role of tissue factor-bearing extracellular vesicles (TF+ EVs) released from tumor cells in the pathological coagulation status of ovarian cancer patients. Results show that EVs derived from ascites of ovarian cancer patients have significantly high TF activities and are associated with a high rate of VTE, suggesting a potential role in prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Johannes Thaler, Gerald Prager, Ingrid Pabinger, Cihan Ay
Summary: Using a modified plasma clot formation assay, we found an increased plasma clot formation rate and fibrin fiber thickness in pancreatic cancer patients compared to healthy controls. When a tissue factor blocking antibody was added, the clot formation rate decreased significantly in patients, fibrin fiber thickness decreased in patients and controls, the lag phase remained unchanged, and the time to peak fibrin generation increased in patients. These findings suggest the presence of a prothrombotic state in pancreatic cancer patients, dependent on tissue factor.
Review
Oncology
Yohei Hisada, Nigel Mackman
Summary: The TF-factor VIIa complex is a key initiator of blood coagulation, with tumors expressing TF and releasing TF-positive EVs into circulation. Levels of EVTF activity may serve as a biomarker for identifying patients at risk for thrombosis, and tumor-derived TF + EVs are associated with reduced survival in cancer patients. This suggests that EVTF activity could potentially be used as a prognostic biomarker for venous thrombosis and disseminated intravascular coagulation in cancer patients.
Article
Multidisciplinary Sciences
Jeremy G. T. Wurtzel, Sophia Lazar, Sonali Sikder, Kathy Q. Cai, Igor Astsaturov, Andrew S. Weyrich, Jesse W. Rowley, Lawrence E. Goldfinger
Summary: Platelet-derived miRNAs have been shown to modulate solid tumor growth by restructuring the tumor cell transcriptome, particularly in primary ectopic tumors.
Article
Oncology
Kathryn M. Muilenburg, Carly C. Isder, Prakash Radhakrishnan, Surinder K. Batra, Quan P. Ly, Mark A. Carlson, Michael Bouvet, Michael A. Hollingsworth, Aaron M. Mohs
Summary: Pancreatic cancer is difficult to resect completely. Fluorescence-guided surgery (FGS) can help achieve complete tumor resections by using contrast agents that target biomarkers expressed in malignant tissue. Mucins, a family of glycoproteins, are upregulated in pancreatic cancer and have the potential to serve as biomarkers for FGS. This review summarizes the biomarker traits of mucins and their potential use in FGS for pancreatic cancer.
Article
Medical Laboratory Technology
Mukulika Bose, Alexa Sanders, Chandrav De, Ru Zhou, Priyanka Lala, Sophia Shwartz, Bhaskar Mitra, Cory Brouwer, Pinku Mukherjee
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a major cause of cancer-related deaths in the United States. Surgical resection is the best treatment option, but only a small percentage of patients are eligible. Recurrence and metastasis are the main reasons for mortality. A monoclonal antibody named TAB004 has been developed to target tumor-associated MUC1 (tMUC1), which is expressed in over 80% of PDAs. Treatment with TAB004 has shown significant effects in reducing colony-forming potential in PDA cells and inducing cell death. The mechanism involves disruption of cellular integrity, activation of ER stress and anoikis, and inhibition of oncogenic signaling pathways. TAB004 also exhibited promising results in mouse models, indicating its potential as a prophylactic agent to prevent tumor relapse, metastasis, and increase the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Koelina Ganguly, Ashu Shah, Pranita Atri, Sanchita Rauth, Moorthy P. Ponnusamy, Sushil Kumar, Surinder K. Batra
Summary: This review provides a comprehensive understanding of the interplay between chemokines and mucinome in the stromal modulation and immune suppression of pancreatic cancer. It highlights the need for future studies to decipher the complexities of chemokine-mediated control and its potential application in prognostication and stratification of pancreatic cancer patients for immunotherapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Makoto Sano, Ryota Takahashi, Hideaki Ijichi, Kazunaga Ishigaki, Tomoharu Yamada, Koji Miyabayashi, Gen Kimura, Suguru Mizuno, Hiroyuki Kato, Hiroaki Fujiwara, Takuma Nakatsuka, Yasuo Tanaka, Jinsuk Kim, Yohei Masugi, Yasuyuki Morishita, Mariko Tanaka, Tetsuo Ushiku, Yousuke Nakai, Keisuke Tateishi, Yukimoto Ishii, Hiroyuki Isayama, Harold L. Moses, Kazuhiko Koike
Summary: PDAC is the deadliest cancer and frequently associated with CAT. This study found that inhibition of VCAM-1 can effectively treat PDAC and CAT in mice, leading to extended survival time. Increase of plasma ANP and sVCAM-1 may serve as diagnostic markers for CAT in PDAC.
Article
Biochemistry & Molecular Biology
Wa Cao, Meng-Yu Zhu, Seung-Hoon Lee, Su-Bin Lee, Hyung-Jin Kim, Byung-Ouk Park, Cheol-Hwan Yoon, Dipendra Khadka, Gi-Su Oh, Hyeok Shim, Tae-Hwan Kwak, Hong-Seob So
Summary: This study reveals that regulating cellular NAD(+) levels can alleviate thrombosis in tumor-bearing mice, potentially serving as a viable therapeutic approach for cancer-associated thrombosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jian Yang, Yongzheng Li, Zhaowei Sun, Hanxiang Zhan
Summary: This review summarizes recent advances in understanding the origin, distribution, and polarization of macrophages in pancreatic cancer, as well as their role in carcinogenesis and development, and potential therapeutic value. Macrophages play a crucial role in creating an immunosuppressive tumor microenvironment, ultimately facilitating tumor initiation and progression in pancreatic cancer.
Article
Biochemistry & Molecular Biology
Joy M. Davis, Binglu Cheng, Madeline M. Drake, Qiang Yu, Baibing Yang, Jing Li, Chunhui Liu, Mamoun Younes, Xiurong Zhao, Jennifer M. Bailey, Qiang Shen, Tien C. Ko, Yanna Cao
Summary: Chronic pancreatitis is a major risk factor for pancreatic ductal adenocarcinoma, but the mechanism by which CP promotes pancreatic oncogenesis remains unclear. Our study found that GREM1 expression by fibroblasts correlates with the development of PDAC and is associated with macrophages in the pancreatic tumor microenvironment. Gremlin 1 may play a role in promoting PDAC development and influencing macrophage phenotype.
Article
Oncology
Satoshi Kobayashi, Shiro Koizume, Tomoko Takahashi, Makoto Ueno, Ritsuko Oishi, Shuhei Nagashima, Yusuke Sano, Taito Fukushima, Shun Tezuka, Manabu Morimoto, Sho Nakamura, Hiroto Narimatsu, Wolfram Ruf, Yohei Miyagi
Summary: Tissue factor levels are an independent predictive factor for cancer-associated thromboembolism in patients with pancreatic cancer.
Article
Hematology
Paul G. Kemps, Jennifer Picarsic, Benjamin H. Durham, Zofia Helias-Rodzewicz, Laura Hiemcke-Jiwa, Cor van den Bos, Marianne D. van de Wetering, Carel J. M. van Noesel, Jan A. M. van Laar, Robert M. Verdijk, Uta E. Flucke, Pancras C. W. Hogendoorn, F. J. Sherida H. Woei-A-Jin, Raf Sciot, Andreas Beilken, Friedrich Feuerhake, Martin Ebinger, Robert Mohle, Falko Fend, Antje Bornemann, Verena Wiegering, Karen Ernestus, Tina Mery, Olga Gryniewicz-Kwiatkowska, Bozenna Dembowska-Baginska, Dmitry A. Evseev, Vsevolod Potapenko, Vadim V. Baykov, Stefania Gaspari, Sabrina Rossi, Marco Gessi, Gianpiero Tamburrini, Sebastien Heritier, Jean Donadieu, Jacinthe Bonneau-Lagacherie, Claire Lamaison, Laure Farnault, Sylvie Fraitag, Marie-Laure Jullie, Julien Haroche, Matthew Collin, Jackie Allotey, Majid Madni, Kerry Turner, Susan Picton, Pasquale M. Barbaro, Alysa Poulin, Ingrid S. Tam, Dina El Demellawy, Brianna Empringham, James A. Whitlock, Aditya Raghunathan, Amy A. Swanson, Mariko Suchi, Jon M. Brandt, Nabeel R. Yaseen, Joanna L. Weinstein, Irem Eldem, Bryan A. Sisk, Vaishnavi Sridhar, Mandy Atkinson, Lucas R. Massoth, Jason L. Hornick, Sanda Alexandrescu, Kee Kiat Yeo, Kseniya Petrova-Drus, Stephen Z. Peeke, Laura S. Munoz-Arcos, Daniel G. Leino, David D. Grier, Robert Lorsbach, Somak Roy, Ashish R. Kumar, Shipra Garg, Nishant Tiwari, Kristian T. Schafernak, Michael M. Henry, Astrid G. S. van Halteren, Oussama Abla, Eli L. Diamond, Jean-Francois Emile
Summary: ALK-positive histiocytosis is a rare and poorly characterized subtype of histiocytic neoplasm. This study provides the largest analysis of ALK-positive histiocytosis to date, describing the clinicopathologic and molecular characteristics of 39 cases. The study also highlights the robust responses observed in patients treated with ALK inhibition, particularly those with neurologic involvement.
Article
Pathology
Anne M. R. Schrader, Ruben A. L. de Groen, Rein Willemze, Patty M. Jansen, Koen D. Quint, Tom van Wezel, Ronald van Eijk, Dina Ruano, Cornelis P. Tensen, Esther Hauben, F. J. S. H. Woei-A-Jin, Anne M. Busschots, Anke van den Berg, Arjan Diepstra, Maarten H. Vermeer, Joost S. P. Vermaat
Summary: This study compared the COO classification of two different types of primary cutaneous B-cell lymphoma (PCDLBCL-LT and PCFCL-LC) and found that their classification results were different. PCFCL-LC was almost always classified as the GCB subtype, while the classification of PCDLBCL-LT was more heterogeneous. However, these different classification results were not associated with the expression of BCL2 and IgM, gene mutations, gene loss, or patient survival.
Article
Hematology
Mirian Brink, Frederik O. Meeuwes, Marjolein W. M. van der Poel, Marie Jose Kersten, Marielle Wondergem, Pim G. N. J. Mutsaers, Lara H. Bohmer, F. J. Sherida H. Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Wouter Plattel, Gerwin A. Huls, Joost S. P. Vermaat, Marcel Nijland
Summary: In patients aged <65 years with PTCL, the addition of etoposide and consolidation with ASCT improved overall survival rates, particularly in ALK(+) ALCL patients. ASCT consolidation was associated with improved survival rates in patients with ALCL, AITL, or PTCL, while the addition of etoposide did not show significant correlation with survival rates.
Review
Oncology
Fleur A. de Groot, Ruben A. L. de Groen, Anke van den Berg, Patty M. Jansen, King H. Lam, Pim G. N. J. Mutsaers, Carel J. M. van Noesel, Martine E. D. Chamuleau, Wendy B. C. Stevens, Jessica R. Placa, Rogier Mous, Marie Jose Kersten, Marjolein M. W. van der Poel, Thomas Tousseyn, F. J. Sherida H. Woei-a-Jin, Arjan Diepstra, Marcel Nijland, Joost S. P. Vermaat
Summary: This review summarizes the insights from gene-expression profiling studies on the background and origination of diffuse large B-cell lymphomas (DLBCL). By combining transcriptomics with genomics, proteomics, and patient characteristics, diagnostic classification, prognostication, and the development of new targeted therapeutic strategies in DLBCL can be improved.
Article
Clinical Neurology
Gael Vermeersch, Lies Laenen, Geraldine Lens, Kim C. M. van der Elst, Dietmar Rudolf Thal, Sander Jentjens, Philippe Demaerel, Tine Van Nieuwenhuyse, Elke Wollants, Nancy Boeckx, Nicolas Verhaert, Benedicte Dubois, Frank J. M. Kuppeveld, F. J. Sherida H. Woei-A-Jin
Summary: This study tracked the treatment of a patient with rituximab-induced echovirus 13 infection using intravenous immunoglobulins and fluoxetine, showing that fluoxetine was more effective in viral clearance.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Nico P. M. Smit, Fred P. H. T. M. Romijn, Vanessa J. J. van Ham, Esther Reijnders, Christa M. Cobbaert, L. Renee Ruhaak
Summary: Plasma anticoagulants affect the results of quantitative protein mass-spectrometry (QPMS) analysis of apolipoproteins. Heparin plasma shows comparable results to serum, whereas citrate plasma shows reduced concentrations that can be explained by dilution. EDTA-plasma shows reduced recovery due to altered proteolytic digestion efficiency.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Frederik O. Meeuwes, Mirian Brink, Marjolein W. M. Van Der Poel, Marie Jose Kersten, Marielle Wondergem, Pim G. N. J. Mutsaers, Lara Bohmer, Sherida Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Arjan Diepstra, Tjeerd J. F. Snijders, Wouter J. Plattel, Gerwin A. Huls, Joost S. P. Vermaat, Marcel Nijland
Summary: Although rituximab improved overall response rate (ORR) for patients with AITL, there was no significant impact on progression-free survival (PFS) and overall survival (OS).
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Sophie C. Hagenaars, Lennard J. M. Dekker, Bob Ravesteijn, Ronald L. P. van Vlierberghe, Fred P. H. T. M. Romijn, Linda Verhoeff, Arjen J. Witkamp, Karin E. Schenk, Kristien B. I. M. Keymeulen, Marian B. E. Menke-Pluijmers, Anneriet E. Dassen, Birgitta A. Kortmann, Jakob de Vries, Emiel J. T. Rutgers, Yuri E. M. van der Burgt, Elma Meershoek-Klein Kranenbarg, Christa M. Cobbaert, Theo M. Luider, Wilma E. Mesker, Rob A. E. M. Tollenaar
Summary: The TESTBREAST study aims to identify a novel panel of blood-based protein biomarkers for early breast cancer detection in moderate-to-high-risk women. Longitudinal measurements of protein levels in serum samples revealed a greater interpatient than intrapatient variability, and identified specific proteins associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vibeke K. J. Vergote, Gregor Verhoef, Ann Janssens, F. J. Sherida H. Woei-A-Jin, Annouschka Laenen, Thomas Tousseyn, Daan Dierickx, Christophe M. Deroose
Summary: Multiple studies have demonstrated the predictive value of pretreatment [F-18]FDG-PET/CT metabolic parameters in various lymphoma subtypes. However, there is limited research on the role of metabolic parameters in mantle cell lymphoma (MCL). In this retrospective study, we investigated the prognostic value of baseline metabolic tumor volume (MTV) and lesion dissemination in untreated MCL. We found that higher baseline MTV was associated with worse overall survival, progression-free survival, and disease-specific survival in univariate analysis. Furthermore, MTV was significantly associated with disease-specific survival in multivariate analysis. However, there was no correlation between lesion dissemination and outcome. Overall, these findings suggest that MTV is an important prognostic tool and can improve risk stratification for untreated MCL at staging.
LEUKEMIA & LYMPHOMA
(2023)
Letter
Oncology
Susanne Osanto, F. J. Sherida H. Woei-A-Jin, Minneke J. Coenraad, Nir Weijl, Mark C. Burgmans, Jacobus Burggraaf
Summary: This letter to the editor responds to comments made by Rizzo et al on the recently reported phase II study results of dovitinib therapy for hepatocellular carcinoma.
Article
Oncology
Anne M. R. Schrader, Ruben A. L. de Groen, Rein Willemze, Patty M. Jansen, Koen D. Quint, Arjen H. G. Cleven, Tom van Wezel, Ronald van Eijk, Dina Ruano, J. H. (Hendrik) Veelken, Cornelis P. Tensen, Karen J. Neelis, Laurien A. Daniels, Esther Hauben, F. J. S. H. (sherida) Woei-A-Jin, A. M. (Annemie) Busschots, Maarten H. Vermeer, Joost S. P. Vermaat
Summary: In this study, the genetic evolution of primary and relapsed/refractory disease in PCDLBCL-LT patients was investigated. The researchers found that the main driver alterations were persistently present in relapsed/refractory disease and identified novel alterations in relapsed cases. MYC rearrangements and HIST1H1E mutations were significantly associated with a worse prognosis. These findings suggest the potential for targeted therapies and molecular-based disease monitoring in this patient population.
Article
Medical Laboratory Technology
L. Renee Ruhaak, Fred P. H. T. M. Romijn, Ilijana Begcevic Brkovic, Zsusanna Kuklenyik, Julia Dittrich, Uta Ceglarek, Andrew N. Hoofnagle, Harald Althaus, Eduardo Angles-Cano, Stefan Coassin, Vincent Delatour, Liesbet Deprez, Ioannis Dikaios, Gerhard M. Kostner, Florian Kronenberg, Alicia Lyle, Urban Prinzing, Hubert W. Vesper, Christa M. Cobbaert, Int Federation Clinical Chem Lab Med Working Grp Apolipoproteins Mass Spect
Summary: In order to ensure the accuracy and reliability of medical results from in vitro diagnostic and in-house tests, a higher order reference measurement system traceable to endorsed reference measurement procedures and reference materials is needed. A candidate reference measurement procedure for serum apolipoprotein(a) [apo(a)] based on mass spectrometry was developed and provisionally validated. The method demonstrated accurate quantitation of serum apo(a) and fulfilled predefined analytical performance specifications.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauranne Van Assche, Bart Peeters, Anne Vorlat, Koen Monsieurs, Hein Heidbuchel, Marc J. Claeys
Summary: This study evaluates the safety and effectiveness of the 0-1h hs-cTn algorithm compared to the standard 0-3h cTn protocol for diagnosing AMI. The results show that the 0-1h hs-cTn protocol has a sensitivity of 100% and a negative predictive value of 100% for ruling out AMI.
Article
Oncology
Lize Vanaken, F. J. Sherida H. Woei-A-Jin, Rita Van Ginderdeuren, Christophe M. Deroose, Annouschka Laenen, Guy Missotten, Dietmar R. Thal, Oliver Bechter, Patrick Schoffski, Paul Clement
Summary: This study aimed to investigate the efficacy of immune checkpoint inhibitors (ICI) in patients with metastatic uveal melanoma (MUM). The results showed that ICI did not improve overall survival in MUM patients. Local treatment options may be more beneficial compared to ICI.
Article
Immunology
Saskia Bos, Liesbeth Daniels, Lucienne Michaux, Isabelle Vanden Bempt, Sascha Vermeer, F. J. Sherida H. Woei-A-Jin, Patrick Schoffski, Birgit Weynand, Raf Sciot, Sabine Declercq, Laurens J. Ceulemans, Laurent Godinas, Geert M. Verleden, Dirk E. Van Raemdonck, Lieven J. Dupont, Robin Vos
Summary: A 35-year-old woman who underwent bilateral lung transplantation developed vascular tumors of mixed donor origin, with the donor's previously diagnosed cerebral hemangioma believed to be a precursor lesion of the recipient's vascular malignancy.
FRONTIERS IN IMMUNOLOGY
(2022)