期刊
IMMUNOTHERAPY
卷 11, 期 17, 页码 1491-1505出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2019-0113
关键词
eosinophilic asthma; indirect comparison; mepolizumab; network meta-analysis; reslizumab
类别
资金
- Teva Pharmaceuticals
Aim: A systematic literature review and network meta-analysis assessed the efficacy and safety of reslizumab 3.0 mg/kg and mepolizumab 100 mg. Materials & methods: Eligible studies evaluated reslizumab and mepolizumab in patients with inadequately-controlled severe eosinophilic asthma. Using a Bayesian network meta-analysis, 95% credible intervals and posterior probabilities were reported. Results: Of 19 indirect efficacy comparisons performed in base-case (Global Initiative for Asthma 4/5 patients with >= 2 exacerbations in the previous year) and overall populations, significant differences favoring reslizumab were observed for severe exacerbations, FEV1 at 4 weeks and eosinophil counts at 4, 16 and 24 weeks, with no other significant differences including risk of adverse events. Conclusion: Indirect comparison of reslizumab and mepolizumab largely showed no significant differences in efficacy or safety.
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