Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: Cancer is a leading cause of death worldwide. Lung, prostate, and colorectal cancer are common in men, while breast and colorectal cancer have a high incidence in women. Improvements in detection methods, including imaging techniques, are important, but inflammatory and tumoral markers, as well as calculated scores, may also contribute to prognosis assessment. Current markers such as ESR, CRP, and CEACAM have been used for decades, but their diagnostic and prognostic value is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ivana Vecurkovska, Jana Maslankova, Vladimira Tomeckova, Jana Kat'uchova, Terezia Kiskova, Lucia Frohlichova, Maria Marekova, Marek Stupak
Summary: The determination of the tissue BDNF/MMP-9 ratio can be used as a prognostic biomarker for colorectal cancer. This ratio significantly decreases with the progression of the disease in living patients, but shows an opposite trend in deceased individuals. Lower BDNF/MMP-9 ratio levels may predict favorable prognosis in patients.
Review
Oncology
Zahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad, Enrico Mini
Summary: Colorectal cancer (CRC) is a common global cancer derived from polyps, with Matrix Metalloproteinases (MMPs) playing a critical role in its initiation and progression. The expression of various MMPs in CRC patients is associated with a poor prognosis, and although research has explored MMP inhibition and targeted therapy for CRC, there is still insufficient understanding of the role of MMPs in polyp malignancy.
Article
Biochemistry & Molecular Biology
Yuliang Cui, Wenpeng Shi, Kun Zhang, Zhengjun Hou, Yanyun Wang, WenHua Yan, Qinfeng Ma, Shicheng He, Junli Huang, Chenfei Lu, Yeqi Wang, Guixue Wang, Juhui Qiu
Summary: This study identified the distribution and hemodynamic parameters of hematopoietic endothelium in zebrafish embryos and revealed that the emergence of hematopoietic stem/progenitor cells (HSPCs) is controlled by low shear stress (LSS) through promoting macrophage accumulation and matrix metalloproteinase (MMP) expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Huayue Zhang, Miaomiao Wu, Hang Thu Ta, Zhi Ping Xu, Run Zhang
Summary: This review summarizes the development and application of sensors for the detection of MMPs in the past three years. These sensors are designed mainly based on the exploration of MMPs' molecular structure and enzymatic activity, aiming to better understand the roles of MMPs in disease progression and their potential in early diagnosis and treatment monitoring. The research hotspots, current challenges, and further research directions in this field are also discussed.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
Maria-Elpida Christopoulou, Eleni Papakonstantinou, Daiana Stolz
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Aleksandr Popov, Emma Kozlovskaya, Tatyana Rutckova, Olga Styshova, Aleksey Vakhrushev, Elena Kupera, Ludmila Tekutyeva
Summary: Recent research has shown that matrix metalloproteinase-generated functional proteins (MKs) can be a valuable source of nutrition and therapy, reducing the risk of serious diseases such as cancer. MKs have antitumor properties and can be used in combination therapy without toxic side effects. This review summarizes the data on the antitumor activity of MKs from various sources and discusses their potential and challenges in therapeutic use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Luying He, Qianming Kang, Ka Iong Chan, Yang Zhang, Zhangfeng Zhong, Wen Tan
Summary: In this study, we reviewed the immunomodulatory role of matrix metalloproteinases (MMPs) in colitis-associated cancer (CAC) and discussed relevant clinical applications. We analyzed over 300 pharmacological studies retrieved from PubMed and the Web of Science, focusing on MMPs, cancer, colitis, CAC, and immunomodulation. MMPs are involved in various processes in CAC, such as cell proliferation, cell differentiation, angiogenesis, ECM remodeling, and the inflammatory response. They also affect the immune system by modulating immune cell differentiation and activity, as well as the recruitment of macrophages and neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shriefa Almutairi, Hanin Moh'd Kalloush, Nour A. Manoon, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins in the extracellular matrix (ECM). They play a role in various biological processes and have become attractive therapeutic targets for cancer treatment.
Article
Obstetrics & Gynecology
Laura Governini, Camilla Marrocco, Bianca Semplici, Valentina Pavone, Giuseppe Belmonte, Stefano Luisi, Felice Petraglia, Alice Luddi, Paola Piomboni
Summary: The study compared the expression profiles of MMPs and TIMPs in the endometrium of women with and without type 3 leiomyomas, finding differential expression and localization of these proteins in leiomyoma patients, along with associations with key molecules involved in the inflammatory pathway.
FERTILITY AND STERILITY
(2021)
Article
Anatomy & Morphology
Xiaocheng Li, Zhengxia Wei, Yuhong Chen
Summary: This study demonstrates that CXCL12 overexpression enhances the function of EPCs and has positive effects on the recovery of aortic aneurysm.
Article
Pharmacology & Pharmacy
Andrea De Pieri, Keegan Ocorr, Kyle Jerreld, Mikkael Lamoca, Wolfgang Hitzl, Karin Wuertz-Kozak
Summary: This study successfully encapsulated resveratrol into poly(epsilon-caprolactone) microparticles to prolong and protect its release and activity. These microparticles showed no cytotoxicity and stimulated collagen deposition, while reducing inflammation and proteolysis.
Article
Chemistry, Medicinal
Yi Liu, Liyuan Lin, Haiyan Zheng, Yuan-Lin He, Yanmei Li, Chunxia Zhou, Pengzhi Hong, Shengli Sun, Yi Zhang, Zhong-Ji Qian
Summary: In this study, it was found that EAA, isolated and purified from coral symbiotic fungi, could inhibit tumor metastasis and invasion. Through cell experiments and protein analysis, it was discovered that EAA reduced the activity of MMPs and VEGF by regulating the phosphorylation of downstream MAPK, PI3K/AKT, and NF-kappa B pathways, thereby inhibiting the migration and invasion of tumor cells.
Article
Chemistry, Multidisciplinary
Matthew Drayton, Morgan A. Alford, Daniel Pletzer, Evan F. Haney, Yoan Machado, Haiming D. Luo, Christopher M. Overall, Jayachandran N. Kizhakkedathu, Robert E. W. Hancock, Suzana K. Straus
Summary: A novel PEG-HDP conjugate was designed targeting MMPs at sites of inflammation and infection, enhancing antimicrobial activity through enzymatic cleavage while improving biocompatibility, demonstrated by strong antibacterial efficacy in a mouse abscess model with high-density MRSA infection.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Sara Gouarderes, Aurelie Marches, Patricia Vicendo, Isabelle Fourquaux, Michel Simon, Nofel Merbahi, Laure Gibot
Summary: This study assessed the potential of direct CAP to remodel skin collagens, finding no significant changes in cell viability, pro-collagen I secretion, matrix metalloproteinases activity, and hydroxyproline content after treatment. The plasma-activated culture medium was shown to induce cell apoptosis and growth delay.
BIOELECTROCHEMISTRY
(2022)
