Review
Medicine, General & Internal
Siying He, Peter A. Cistulli, Philip de Chazal
Summary: Obstructive sleep apnoea is a sleep disorder that can lead to cardiovascular disease and other complications. The traditional diagnostic parameter is insufficient for predicting cardiovascular disease, so new parameters and computational methods are needed to improve accuracy.
Article
Pediatrics
Niamh Catherine Galway, Barbara Maxwell, Michael Shields, Dara O'Donoghue
Summary: Nocturnal pulse oximetry using the McGill Oximetry Score (MOS) for obstructive sleep apnoea (OSA) screening may require more than one night to ensure accuracy. Recording three nights of oximetry can increase the screening yield for OSA, and lowering the time threshold to >= 4 hours may enhance the capability of nocturnal oximetry screening.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Multidisciplinary Sciences
Philipp Helmer, Philipp Rodemers, Sebastian Hottenrott, Robert Leppich, Maja Helwich, Ruediger Pryss, Peter Kranke, Patrick Meybohm, Bernd E. Winkler, Michael Sammeth
Summary: Blood oxygen saturation is an important clinical parameter for postoperative hospitalized patients. Current monitoring methods, such as arterial blood gas and pulse oximetry, are not suitable for long-term continuous monitoring. Recent technological advances in consumer-grade fitness trackers could potentially fill this gap, but their applicability and accuracy in hospitalized patients have not been well studied.
Article
Clinical Neurology
Kate Sutherland, Nadi Sadr, Yu Sun Bin, Kristina Cook, Hasthi U. Dissanayake, Peter A. Cistulli, Philip de Chazal
Summary: This study compared associations of different oximetry patterns with incident cardiovascular disease (CVD) in individuals with obstructive sleep apnea (OSA). The results showed that none of the oxygenation patterns were related to the development of CVD in OSA patients. However, there were some associations between certain oxygenation patterns and CVD risk in women. Further research is needed to determine if OSA phenotypes can be used to predict susceptibility to cardiovascular disease.
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Eric Mccollum, Salahuddin Ahmed, Arunangshu Roy, A. S. M. D. Ashraful Islam, Holly B. Schuh, Carina King, Shubhada Hooli, Mohammad Abdul Quaiyum, Amy Sarah Ginsburg, William Checkley, Abdullah H. Baqui, Tim Colbourn
Summary: The study recruited children aged 3-35 months with suspected pneumonia in outpatient settings in Bangladesh to determine the burden, mortality risk, and prognostic accuracy of death from hypoxaemia.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Changxiu Ma, Ying Zhang, Jiuyu Liu, Gengyun Sun
Summary: The study evaluated the new parameter AHT% for assessing nocturnal hypoxaemia and excessive daytime sleepiness in patients with obstructive sleep apnoea, comparing it with the traditional AHI. Results showed that AHT% was superior to AHI in predicting excessive daytime sleepiness and better reflected the clinical characteristics of patients with obstructive sleep apnoea.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Carina King, Beatiwel Zadutsa, Lumbani Banda, Everlisto Phiri, Eric McCollum, Josephine Langton, Nicola Desmond, Shamim Ahmad Qazi, Yasir Bin Nisar, Charles Makwenda, Helena Hildenwall
Summary: This study investigated the survival of children referred from primary care in Malawi and found that severe hypoglycemia and hypoxemia were associated with increased mortality. Pre-referral glucose treatment and improved management of hypoglycemia could reduce the high case fatality ratio in children with severe hypoglycemia. The morbidity and mortality burden of severe hypoxemia was high, and ways to improve hypoxemia identification and management are needed.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Otorhinolaryngology
Surendran Thavagnanam, Shih Ying H'ng, Anna Marie Nathan, Kah Peng Eg, Karuthan Chinna, Siti Hajar bte Turbirin, Jessie Anne de Bruyne
Summary: The study showed that using Nonin 3150 WristOx2 TM for overnight pulse oximetry is an accurate and reliable tool in diagnosing significant obstructive sleep apnea syndrome in children.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Miuni Athauda Arachchige, Joerg Steier
Summary: Obstructive Sleep Apnoea (OSA) is a common condition that can have a significant impact on physical and mental health, including an increased risk of cardiovascular diseases. Continuous Positive Airway Pressure (CPAP) therapy is the recommended treatment for moderate to severe OSA, but long-term adherence remains a challenge. There are alternative non-CPAP treatments available, such as lifestyle changes, surgical options, and nerve stimulation. When choosing long-term therapies, symptom control, patient-related outcomes, and long-term cardiovascular health should be prioritized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Peter G. Middleton
Summary: This review provides a summary of the interactions between pregnancy and breathing during sleep, and highlights the changes in respiratory function that can increase the incidence and severity of sleep-disordered breathing. The increased risk of snoring and obstructive sleep apnea hypopnea syndrome during pregnancy is discussed, and the potential impact of increasing obesity rates on sleep-disordered breathing in pregnant women is considered.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Cell Biology
James Saleeb-Mousa, Demitris Nathanael, Andrew M. Coney, Manish Kalla, Keith L. Brain, Andrew P. Holmes
Summary: Obstructive sleep apnoea (OSA) is associated with a higher risk of atrial fibrillation (AF), affecting its induction, maintenance, severity, and treatment. The current prevention method, continuous positive airway pressure (CPAP), has limited effectiveness due to poor compliance. Understanding the underlying mechanisms of arrhythmia in OSA can lead to the development of better therapies and treatment selection to complement CPAP. Chronic intermittent hypoxia (CIH) in OSA leads to long-term changes in ion channel currents, inflammation, and fibrosis, contributing to atrial remodeling and dysregulation of electrical function. Atrial stretch during apneas further promotes structural remodeling and affects calcium handling. This review provides a comprehensive overview of the mechanistic insights and their roles in arrhythmia.
Article
Clinical Neurology
Renata L. Riha, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, John Arthur Kvamme, Pavol Joppa, Jan Hedner
Summary: The study compared the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between OSA patients who had undergone tonsillectomy and those who had not. Patients who had undergone tonsillectomy presented with less severe OSA at the time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Article
Anesthesiology
Shobana Rajan, Sanchit Ahuja, Barak Cohen, Adriana Martin, Amanda Pursell, Chen Liang, Guangmei Mao, Ryu Komatsu, Ehab Farag, Daniel I. Sessler
Summary: There was no significant difference in the risk of postoperative stroke after non-neurological, noncarotid, and noncardiac surgeries between patients who used ACEIs or ARBs for a long time and those who did not.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Anesthesiology
Bhiken Naik, Kai Kuck, Leif Saager, Sachin Kheterpal, Karen B. Domino, Karen L. Posner, Anik Sinha, Ami Stuart, Chad M. Brummett, Marcel E. Durieux, Michelle T. Vaughn, Nathan L. Pace
Summary: This study retrospectively evaluated the variation and influencing factors of intraoperative opioid administration from 2012 to 2016 in different institutions. The results showed a decrease in the use of opioids during surgery over time, with variations in dose among different genders and procedure types. Furthermore, there was substantial variability in opioid use between institutions even when adjusting for multiple variables.
ANESTHESIA AND ANALGESIA
(2022)
Letter
Anesthesiology
Richard D. Urman, Ashish K. Khanna, Sergio D. Bergese, Wolfgang Buhre, Maria Wittmann, Morgan Le Guen, Frank J. Overdyk, Fabio Di Piazza, Leif Saager
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Anesthesiology
Richard D. Urman, Ashish K. Khanna, Sergio D. Bergese, Wolfgang Buhre, Maria Wittmann, Morgan Le Guen, Frank J. Overdyk, Fabio Di Piazza, Leif Saager
Summary: This study evaluated the variation in opioid administration characteristics and its association with respiratory depression events across different regions. Despite differences in opioid administration practices between Asia, Europe, and the United States, respiratory depression remains a common issue on general care floors. Continuous monitoring and the use of post-procedure tramadol or epidural opioids may help reduce the incidence of respiratory depression in patients receiving post-operative opioids.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Anesthesiology
J. Erlenwein, M. Maring, M. Emons, H. J. Gerbershagen, R. M. Waeschle, L. Saager, F. Petzke
Summary: Incidents in the context of acute pain management pose high risks for patients, often related to staff mistakes and lack of skills, due to time pressure, workload, and inadequate organization.
Article
Anesthesiology
Christian Reiterer, Barbara Kabon, Sven Halvorson, Daniel Sessler, Edward J. Mascha, Andrea Kurz
Summary: In this subanalysis of a previous trial, the effects of intraoperative goal-directed colloid administration and crystalloid administration on cardiac index and blood pressure were tested. The results showed that there were no clinically meaningful differences in the cardiac index or mean pressure variability between the two groups. The study suggests that colloids do not provide substantial hemodynamic benefit.
Article
Anesthesiology
Tetsuya Shimada, Edward J. Mascha, Dongsheng Yang, Mauro Bravo, Eva Rivas, Ilker Ince, Alparslan Turan, Daniel I. Sessler
Summary: This study aimed to evaluate whether intra-operative hypertension causes postoperative complications. The results showed that there was no clinically meaningful relationship between intra-operative systolic pressure and the composite of myocardial injury and mortality, or acute kidney injury, and there was no interaction with preoperative clinic blood pressure.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Correction
Critical Care Medicine
Silvia Coppola, Davide Chiumello, Mattia Busana, Emanuele Giola, Paola Palermo, Tommaso Pozzi, Irene Steinberg, Stefano Roli, Federica Romitti, Stefano Lazzari, Simone Gattarello, Michela Palumbo, Peter Herrmann, Leif Saager, Michael Quintel, Konrad Meissner, Luigi Camporota, John J. Marini, Stefano Centanni, Luciano Gattinoni
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Sandra Rossi, Maria Michela Palumbo, Nicola Sverzellati, Mattia Busana, Laura Malchiodi, Paolo Bresciani, Patrizia Ceccarelli, Emanuele Sani, Federica Romitti, Matteo Bonifazi, Simone Gattarello, Irene Steinberg, Paola Palermo, Stefano Lazzari, Francesca Collino, Massimo Cressoni, Peter Herrmann, Leif Saager, Konrad Meissner, Michael Quintel, Luigi Camporota, John J. Marini, Luciano Gattinoni
Summary: This study aimed to investigate the mechanisms of oxygenation response to proning and recruitment maneuvers in patients with COVID-19 pneumonia. The findings indicate that the balance between resolution of dorsal atelectasis and formation of ventral atelectasis may play a key role in determining oxygenation responses. Patients assessed during the third week showed higher levels of consolidated tissue, potentially leading to fibrotic-like changes in the lung over time.
INTENSIVE CARE MEDICINE
(2022)
Article
Engineering, Biomedical
Benjamin Simpson, Michael Burns, Robert P. Dick, Leif Saager
Summary: The study developed a system to measure tissue viscoelastic response during epidural needle placement, aiming to provide assistance to clinical providers. Results showed that the system can reliably detect when the needle is close to bone, but does not provide the expected 5mm warning distance. Further technical advances may enhance the system's utility in clinical settings.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2022)
Article
Anesthesiology
Clemens Miller, Anselm Braeuer, Thomas Asendorf, Marielle Ernst, Philipp von Gottberg, Juliane Richter, Leif Saager, Marcus Nemeth
Summary: This study aimed to determine the target depth of nasopharyngeal temperature probe insertion in children by measuring distances on magnetic resonance imaging. The results showed that height had the strongest correlation with insertion depth, and a formula of 40.8 + height [cm] x 0.32 could achieve the target position in 67% of cases. Categorizing height ranges and corresponding insertion depths also achieved similar probabilities.
PEDIATRIC ANESTHESIA
(2022)
Article
Physiology
Federica Romitti, Mattia Busana, Maria Michela Palumbo, Matteo Bonifazi, Lorenzo Giosa, Francesco Vassalli, Alessandro Gatta, Francesca Collino, Irene Steinberg, Simone Gattarello, Stefano Lazzari, Paola Palermo, Ahmed Nasr, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Onnen Moerer, Leif Saager, Luigi Camporota, John J. Marini, Michael Quintel, Konrad Meissner, Luciano Gattinoni
Summary: The extent of ventilator-induced lung injury may be related to the intensity of mechanical ventilation. This study found that using a mechanical power of 3 J/min during mechanical ventilation led to better anatomical variables compared to using 7 J/min and 12 J/min, although the physiological values were worse.
PHYSIOLOGICAL REPORTS
(2022)
Article
Anesthesiology
Gausan Ratna Bajracharya, Wael Ali Sakr Esa, Guangmei Mao, Steve Leung, Barak Cohen, Kamal Maheshwari, Hermann P. Kessler, Emre Gorgun, Daniel I. Sessler, Alparslan Turan
Summary: This study investigated the effect of regional analgesia on postoperative infections in patients undergoing colorectal surgery. The results showed no significant difference in the occurrence of serious infections between patients with regional analgesia and patients with IV-PCA. Therefore, regional analgesia should not be chosen as a postoperative analgesic technique to reduce infections.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Mark D. Neuman, Rui Feng, Susan S. Ellenberg, Frederick Sieber, Daniel I. Sessler, Jay Magaziner, Nabil Elkassabany, Eric S. Schwenk, Derek Dillane, Edward R. Marcantonio, Diane Menio, Sabry Ayad, Manal Hassan, Trevor Stone, Steven Papp, Derek Donegan, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Ann Tierney, Lakisha J. Gaskins, Annamarie D. Horan, Trina Brown, James Dattilo, Jeffrey L. Carson
Summary: Results from the study showed that spinal anesthesia led to more severe pain in the first 24 hours after surgery and higher prescription analgesic use at 60 days compared to general anesthesia, but satisfaction was similar between the two groups.
ANNALS OF INTERNAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Linda C. Cummings, Chen Liang, Edward Mascha, Leif Saager, Zachary L. Smith, Sekar Bhavani, John J. Vargo, Kenneth C. Cummings
GASTROINTESTINAL ENDOSCOPY
(2021)
