Article
Behavioral Sciences
Rebecca J. Wilson, Margaret R. Bell, Katherine R. Giordano, Serena Seyburn, Dorothy A. Kozlowski
Summary: Although concussions are extensively studied, subconcussions, which have higher frequency, have received less attention in neurotrauma research. This study established a subconcussion model and investigated the sex differences in the behavioral responses to repeated subconcussions. The results showed that repeat subconcussions can lead to behavioral impairments similar to or worse than those caused by a single concussion, and females and males exhibit distinct patterns of deficits.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Editorial Material
Physics, Multidisciplinary
Savannah Garmon
Summary: Imposing PT-symmetry and pseudo-Hermitian symmetry on an electric circuit with non-reciprocal couplings leads to a complex morphology of degenerate eigenvalues, which may open up new possibilities in sensing and dynamical engineering.
Editorial Material
Behavioral Sciences
Marcus O. Harrington, Scott A. Cairney
Summary: Sleep deprivation impairs top-down inhibitory control networks, leading to intrusive thoughts and emotion dysregulation, resulting in a vicious cycle of insomnia, persistent unwanted thoughts, and heightened anxiety, ultimately increasing the risk of mental illness.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Cell Biology
Irene L. Llorente, Yuan Xie, Jose A. Mazzitelli, Emily A. Hatanaka, Jessica Cinkornpumin, David R. Miller, Ying Lin, William E. Lowry, S. Thomas Carmichael
Summary: Research shows that hiPSC-GEPs cells, derived from hiPSC-neural progenitor cells, have the potential to differentiate into astrocytes and promote brain repair when transplanted after WMS in mice.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
M. A. Shevchenko, M. A. Karpov, A. D. Kudryavtseva, D. V. Rozinskii, N. V. Tcherniega, S. F. Umanskaya
Summary: The development of new methods for generating pulsed electromagnetic microwave radiation, especially with optical pumping, is actively being researched. This paper proposes and experimentally demonstrates a new method for photonic generation of microwave electromagnetic radiation based on the oscillation of charged submicron particles at their own acoustic frequency, utilizing laser radiation in the optical range and the Raman mechanism to effectively build up acoustic vibrations.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Boris P. Yakimov, Anna A. Rubekina, Alexander Ya. Zherebker, Gleb S. Budylin, Victor O. Kompanets, Sergey Chekalin, Yuri G. Vainer, Afraa A. Hasan, Eugene N. Nikolaev, Victor V. Fadeev, Irina Perminova, Evgeny A. Shirshin
Summary: The mechanism of formation of the optical properties of dissolved organic matter and humic substances is still a challenging problem. Heterogeneous systems of chromophores that result from the oxidation of simple aromatic species can reproduce humic-like optical properties. This research provides insights into the photophysics of dissolved organic matter and humic substances.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Shuwen Jiang, Luke Carroll, Lars M. Rasmussen, Michael J. Davies
Summary: Disulfide bonds are crucial for protein structure, especially in extracellular environments. Recent studies have shown variations in the reaction rates of disulfides with oxidants, potentially forming thiosulfinates. Photo-oxidation reactions could lead to the formation of glutathionylated proteins, indicating a novel pathway for signaling molecules production.
Article
Plant Sciences
Ningning Wang, Shiyan Wang, Fan Qi, Yingkai Wang, Yujie Lin, Yiming Zhou, Weilong Meng, Chunying Zhang, Yunpeng Wang, Jian Ma
Summary: Plant polyploidization is an effective strategy for plants to maintain their adaptive advantage in response to environmental variation. This study compared the responses of an autotetraploid rice and its diploid donor plant to saline stress, and found that the autotetraploid rice exhibited higher tolerance and different physiological and gene expression patterns compared to the diploid rice. These findings provide important insights into the mechanisms underlying the enhanced performance of polyploid plants in response to salt stress.
Article
Multidisciplinary Sciences
Ketaki Ganti, Anish Bagga, Silvia Carnaccini, Lucas M. Ferreri, Ginger Geiger, C. Joaquin Caceres, Brittany Seibert, Yonghai Li, Liping Wang, Taeyong Kwon, Yuhao Li, Igor Morozov, Wenjun Ma, Juergen A. Richt, Daniel R. Perez, Katia Koelle, Anice C. Lowen
Summary: This study investigates the intra-host dynamics of influenza virus reassortment and finds that reassortment is prevalent in swine, ferrets, and guinea pigs, but less frequent in swine. Tissue-specific differences in reassortment are observed in ferrets, with more reassortants detected in the nasal tract compared to the lower respiratory tract. The study also highlights the impact of spatial compartmentalization on the evolution and transmission of viral variants.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lydie Leung, Matthew J. Timm, John C. Polanyi
Summary: The study observed the sequential 'knock-on' of F-atom products propagating along a 1D fluorocarbon line on Cu(110), with hot F-atoms traveling in six successive 'to-and-fro' cycles resembling the motion of a macroscopic Newton's cradle.
CHEMICAL COMMUNICATIONS
(2021)
Article
Neurosciences
Peter Goettle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Kury
Summary: The research highlights that HERV-W ENV protein inhibits OPC maturation and remyelination, and improving TLR4 surface expression can rescue these deficits. Specific substances like C20 and L48H437 show promise in this process.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Aline Barbosa Maia, Flavia Lima Ribeiro-Gomes, Caroline Cristhiani Tavares de Lima Gress, Guilherme Loureiro Werneck, Diogo Onofre Souza, Roberto Farina Almeida, Claudio Tadeu Daniel-Ribeiro
Summary: The study suggests that immunization with immunogens that induce type 2 immune responses may reverse cognitive and behavioral impairments associated with malaria. This finding highlights the potential importance of researching and developing vaccines for the treatment and prevention of post-malaria sequelae.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern
Summary: The human placenta is an additional site of primitive haematopoiesis, where placental erythro-myeloid progenitors (PEMPs) generate HBC-like cells lacking expression of HLA-class II. This is mediated through epigenetic silencing of the CIITA gene, which regulates HLA-class II expression.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Carly M. Krull, Haiyi Li, Amit Pathak
Summary: The nucleocytoplasmic transport of E-M factors plays a role in regulating cellular epithelial-mesenchymal states. By inhibiting nuclear export, researchers found that soft substrates increase collective migration of cells while stiffer substrates reduce migration. This suggests that nuclear export inhibition disrupts cell migration and leads to loss of cell-cell coordination.
Article
Neurosciences
Nikolaus R. Wagner, Jessica L. MacDonald
Summary: This study explores the role of the epigenetic regulator CITED2 in the development of the neocortex. Cited2 conditional knockout mice exhibit reduced proliferation of intermediate progenitor cells, decreased thickness of the superficial layers, and dysregulation of neuronal connectivity in the neocortex. Behavioral experiments show altered behaviors in Cited2 cKO mice during neonatal and adult stages.
Article
Biochemistry & Molecular Biology
Reona Wada, Shun Fujinuma, Hirokazu Nakatsumi, Masaki Matsumoto, Keiichi Nakayama
Summary: Mechanistic target of rapamycin complex 1 (mTORC1) is a serine-threonine kinase activated by extracellular signals, regulating various biological processes. PBX2 was identified as a novel target dephosphorylated downstream of mTORC1. The phosphorylation of PBX2 is regulated by the antagonistic actions of glycogen synthase kinase 3 (GSK3) and protein phosphatase 1 (PP1).
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Oncology
Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya, Junichi Takahashi, Keisuke Kosai, Seiichiro Takao, Yushi Motomura, Kuniaki Sato, Qingjiang Hu, Atsushi Fujii, Hiroaki Wakiyama, Taro Tobo, Hiroki Uchida, Keishi Sugimachi, Kohei Shibata, Tohru Utsunomiya, Shogo Kobayashi, Hideshi Ishii, Takanori Hasegawa, Takaaki Masuda, Yusuke Matsui, Atsushi Niida, Tomoyoshi Soga, Yutaka Suzuki, Satoru Miyano, Hiroyuki Aburatani, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Keiichi I. Nakayama, Teppei Shimamura, Tatsuhiro Shibata, Koshi Mimori
Summary: This study analyzed the genomic, transcriptomic, proteomic, and metabolomic profiles of intrahepatic cholangiocarcinoma (ICC) samples, revealing the presence of multiple genomic alterations and metabolic pathway changes. The identified ICC-specific metabolic pathway could potentially be targeted for new therapeutic interventions.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I. Nakayama
Summary: This study established a syngeneic orthotopic transplantation model in mice based on intestinal cancer organoids, and revealed that quiescent p57(+) CSCs play a significant role in cancer relapse and are resistant to chemotherapy. Ablation of p57(+) CSCs suppressed tumor regrowth after chemotherapy, suggesting p57(+) CSCs as a promising therapeutic target for malignant intestinal cancer.
Article
Developmental Biology
Takayuki Mitsuhashi, Satoko Hattori, Kimino Fujimura, Shinsuke Shibata, Tsuyoshi Miyakawa, Takao Takahashi
Summary: Valproic acid (VPA) is an antiepileptic drug that inhibits epileptic activity of neurons mainly through sodium channel inhibition and GABA transaminase inhibition. It also inhibits histone deacetylases, leading to epigenetic modifications of stem/progenitor cell characteristics and affecting fetal development. Clinical studies have shown that VPA exposure in utero increases the risk of autistic features and intellectual disabilities in children. A study on mice revealed that in utero VPA exposure led to abnormal social interaction, cognitive changes, hypersensitivity to pain/heat, and impaired locomotor activity, resembling symptoms of autism spectrum disorder in humans.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shohei Iida, Hirotaka Shoji, Fumihiro Kawakita, Takehisa Nakanishi, Yoshiaki Matsushima, Makoto Kondo, Koji Habe, Hidenori Suzuki, Tsuyoshi Miyakawa, Keiichi Yamanaka
Summary: Intense itching reduces the quality of life and is associated with psychiatric conditions. This study used a dermatitis mouse model to evaluate psychiatric symptoms and found that Lcn2 is closely associated with anxiety symptoms, but anxiety and depression caused by chronic skin inflammation may be irreversible. Active control of skin inflammation is essential for preventing anxiety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Katsuhiko Takahashi, Hitoshi Amano, Tomohiko Urano, Minqi Li, Meiko Oki, Kazuhiro Aoki, Norio Amizuka, Keiichi I. Nakayama, Keiko Nakayama, Nobuyuki Udagawa, Nobuaki Higashi
Summary: The study found that p57(Kip2) plays an important role in bone development and is associated with the vitamin D receptor (VDR). 1,25-(OH)(2)VD3 can promote the differentiation of osteoblasts by regulating p57(Kip2), and simultaneously reduce the generation of osteoclasts.
Article
Multidisciplinary Sciences
Chisa Shiraishi, Akinobu Matsumoto, Kazuya Ichihara, Taishi Yamamoto, Takeshi Yokoyama, Taisuke Mizoo, Atsushi Hatano, Masaki Matsumoto, Yoshikazu Tanaka, Eriko Matsuura-Suzuki, Shintaro Iwasaki, Shouji Matsushima, Hiroyuki Tsutsui, Keiichi I. Nakayama
Summary: This study reveals that the RPL3L-encoded ribosomal protein specifically expressed in heart and skeletal muscle affects translation elongation dynamics, and its deficiency impairs cardiac contractility in mice. The results provide insights into the mechanisms and physiological relevance of tissue-specific translational regulation.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama
Summary: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder that can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The transcription factor FOXK1 plays a key role in hepatic lipid metabolism by suppressing lipid catabolism. Inhibition of FOXK1 has shown promising results in improving hepatic steatosis, inflammation, fibrosis, and tumorigenesis, making it a potential therapeutic strategy for NAFLD-NASH and HCC.
Article
Neurosciences
Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie, Keizo Takao
Summary: GlyR alpha 4 subunit is mainly expressed in the hindbrain and midbrain of mice, and has lower expression in other regions of the brain. The expression of GlyR alpha 4 increases during brain development. Mutant mice with Glra4 deficiency show changes in startle response, social behavior, and anxiety-like behavior.
Article
Psychiatry
Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa
Summary: The study suggests that changes in brain pH, expressed as pH, are associated with various neuropsychiatric disorders. The expression patterns of pH-associated genes in these disorders were analyzed in human patients and mouse models, showing abnormal expression levels. Furthermore, astrocytes were identified as the cell type with the highest acidity-related gene expression. These findings indicate that the expression pattern of pH-associated genes may serve as a surrogate for pH changes in brain cells and provide insights into the pathophysiology of neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Kanae Yumimoto, Shigeaki Sugiyama, Saori Motomura, Daisuke Takahashi, Keiichi I. Nakayama
Summary: ROS poses a risk for the transition of vertebrates from aquatic to terrestrial life, and how ancestral organisms adapted to such ROS exposure has remained a mystery. By studying the evolution of Keap1 gene, researchers found that the duplication of Keap1 gene in fish and the lower affinity of Keap1B for Cul3 contributed to robust Nrf2 induction in response to ROS exposure. Mutation of mammalian Keap1 to resemble zebrafish Keap1A resulted in an attenuated Nrf2 response and increased sensitivity to ultraviolet radiation. These findings suggest that the molecular evolution of Keap1 was essential for adaptation to terrestrial life.
Article
Biochemistry & Molecular Biology
Yashuang Ping, Kenji Ohata, Kenji Kikushima, Takumi Sakamoto, Ariful Islam, Lili Xu, Hengsen Zhang, Bin Chen, Jing Yan, Fumihiro Eto, Chiho Nakane, Keizo Takao, Tsuyoshi Miyakawa, Katsuya Kabashima, Miho Watanabe, Tomoaki Kahyo, Ikuko Yao, Atsuo Fukuda, Koji Ikegami, Yoshiyuki Konishi, Mitsutoshi Setou
Summary: As an important neurotransmitter, glutamate functions in the majority of excitatory synapses in the human brain. The metabolic pathway of glutamate is complex, and the exact role of glutamate pool in neurons remains unclear. This study utilized Ttll1 and Ttll7 knockout mice to investigate the impact of tubulin polyglutamylation on neuronal behavior. Matrix-assisted laser desorption/ionization (MALDI) Imaging mass spectrometry (IMS) analysis revealed increased levels of glutamate in the brains of knockout mice, suggesting that tubulin polyglutamylation by TTLLs acts as a reservoir of glutamate in neurons and modulates other glutamate-related amino acids.
Article
Biology
Atsuki Kawamura, Masaaki Nishiyama
Summary: Deletion of the autism-related gene Chd8 in mice leads to changes in the expression of activity-dependent genes in postmitotic neurons, but does not impact seizure susceptibility or memory formation. These findings provide insights into the transcriptional regulation role of CHD8 in postmitotic neurons and the adult brain, and suggest that disruption of this function may contribute to ASD pathogenesis associated with CHD8 haploinsufficiency.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Shintaro Funasaki, Atsushi Hatano, Hirokazu Nakatsumi, Daisuke Koga, Osamu Sugahara, Kanae Yumimoto, Masaya Baba, Masaki Matsumoto, Keiichi I. Nakayama
Summary: CD4(+)CD8(+) double-positive (DP) thymocytes undergo positive or negative selection based on the strength of TCR stimulation. Phosphoproteome analysis revealed that high-affinity peptide ligands induce phosphorylation of p90 ribosomal protein kinase (RSK) at Thr562. This phosphorylation triggers RSK translocation to the nucleus, where it phosphorylates the nuclear receptor Nur77, promoting its mitochondrial translocation for apoptosis induction.
Article
Biochemistry & Molecular Biology
Shigeaki Sugiyama, Kanae Yumimoto, Shun Fujinuma, Keiichi Nakayama
Summary: This study compared 10 CCR2 antagonists and found that MK0812 is the most potent inhibitor. It also demonstrated the efficacy of MK0812 in reducing lung metastasis in a mouse model.
JOURNAL OF BIOCHEMISTRY
(2023)