Article
Public, Environmental & Occupational Health
Ziyao Huang
Summary: This study aimed to investigate the association between blood lead levels and blood pressure and hypertension. The results showed a positive association between blood lead levels and blood pressure, but no significant association with hypertension. Additionally, the association between blood lead levels and blood pressure remained significant in non-Hispanic white and black individuals.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Heng Wan, Bin Wang, Yuke Cui, Yuying Wang, Kun Zhang, Chi Chen, Fangzhen Xia, Lin Ye, Li Wang, Ningjian Wang, Yingli Lu
Summary: Low-level lead exposure may increase hepatic glucose production, leading to elevated blood glucose levels, as evidenced by studies on both humans and animals.
Article
Toxicology
Dragana Vukelic, Aleksandra Buha Djordjevic, Milena Andelkovic, Aleksandra Repic, Katarina Baralic, Marijana Curcic, Danijela Dukic-Cosic, Novica Boricic, Biljana Antonijevic, Zorica Bulat
Summary: The study aimed to simulate low-level lead exposure in an animal model and evaluate its reproductive adverse effects. Benchmarked dose-response modeling was performed based on collected data. Male Wistar rats were divided into seven groups (n = 6): one control group and six groups treated with different doses of lead. After 28 days of treatment, the rats were sacrificed and their blood and testes were analyzed for testosterone levels, essential metal levels, and histological changes. The results showed a dose-dependent decrease in serum testosterone levels and an increase in zinc levels in the testes, but no adverse effects on testicular histology were observed. These findings provide important information for the assessment of lead's impact on human health.
TOXICOLOGY LETTERS
(2023)
Article
Water Resources
Zhi Huang, Xiao-chen Yin, Ming Chen, Mei-ling Li, Bo Chen, Yu-ming Hu
Summary: Lead (Pb) is a potent environmental toxic metal. This study evaluated the relationships of dietary patterns with low-level Pb exposure in children from Hunan province of China. The study found that gender had a significant difference in blood lead levels (BLLs) among children, and the plant dietary pattern may be an important source of lead exposure.
EXPOSURE AND HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Yong Guo, Yu-Hong Deng, Hai-Jin Ke, Jie-Ling Wu
Summary: This study found a negative association between low-level lead exposure and iron status in Chinese children aged 0-5 years, indicating that lead exposure can lead to iron deficiency and anemia. The findings extended previous research to show that even low-level lead exposure can impact iron status in children.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Lars Barregard, Gerd Sallsten, Thomas Lundh, Johan Molne
Summary: This study found that even low levels of Cd exposure may cause mild tubular atrophy in the kidneys. There is also an association between kidney Hg and renal arteriosclerosis. The results are significant for understanding the effects of these toxic metals on the kidneys.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Jens Bertram, Christian Ramolla, Andre Esser, Thomas Schettgen, Nina Fohn, Thomas Kraus
Summary: Despite centuries of mining activities in Euskirchen, high lead concentrations in the soil still exist, posing a potential risk to residents. A human biomonitoring study involving 506 volunteers indicated that children living in the region have a higher lead exposure, with some exceeding the reference values. Factors such as age, sex, smoking, construction age of real estate, occupancy, and intensive contact with soil significantly affect the blood lead levels. Measures to reduce lead exposure include improving personal and domestic hygiene.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Gauri Desai, Zhongzheng Niu, Wei Luo, Seth Frndak, Amy L. Shaver, Katarzyna Kordas
Summary: The study found that the mixture of low-level lead, mercury, arsenic, and cadmium may be inversely associated with diastolic blood pressure in children, with no evidence of effects on other blood pressure measures. Longitudinal studies are needed to further understand the interactive effects of toxicants on children's blood pressure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Engineering, Environmental
Lingfei Shi, Jia Zhou, Jinjiang Dong, Faliang Gao, Wenyan Zhao
Summary: This study investigated the relationship between blood lead levels (BLLs) and homocysteine (Hcy) levels in US children and adolescents. The results showed that there was a positive association between low-level blood lead and Hcy levels. For every 1.0 μg/dL increase in BLLs, there was a 0.06 μmol/L elevation in Hcy levels. Additionally, a linear relationship between BLLs and Hcy levels was observed, with a stronger association in participants with lower serum folate levels.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Review
Environmental Sciences
Nahid Khoshnamvand, Nahid Azizi, Mohammad Sadegh Hassanvand, Mansour Shamsipour, Kazem Naddafi, Vahide Oskoei
Summary: This study investigated the blood lead levels in the general Iranian population with environmental exposure to lead. The results showed that the mean blood lead level in the Iranian population was higher than the recommended level by the US Centers for Disease Control and Prevention (CDC). Additionally, the study found that the mean blood lead levels were higher in men and adults compared to women and children.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Lily D. Yan, Vanessa Rouzier, Jean Lookens Pierre, Myung Hee Lee, Paul Muntner, Patrick J. Parsons, Alexandra Apollon, Stephano St-Preux, Rodolphe Malebranche, Gerard Pierre, Evens Emmanuel, Denis Nash, Justin Kingery, Kathleen F. Walsh, Caleigh E. Smith, Miranda Metz, Olga Tymejczyk, Marie Deschamps, Jean W. Pape, Daniel W. Fitzgerald, Margaret L. McNairy
Summary: This study found that there is widespread environmental lead exposure in urban Haiti, and higher lead levels are associated with higher blood pressure.
Article
Physiology
Maylla Ronacher Simoes, Bruna Fernandes Azevedo, Maria Jesus Alonso, Mercedes Salaices, Dalton Valentim Vassallo
Summary: This study found that lead exposure can increase the contraction response of mesenteric resistance arteries in rats to phenylephrine, while not significantly affecting relaxation induced by acetylcholine and sodium nitroprusside. Additionally, lead exposure increased the vascular expression of cyclooxygenase-2 (COX-2) protein, and specific COX-2 inhibitors were more effective in reducing the response to phenylephrine in treated rats. Furthermore, antagonists of EP1, TP, IP, and angiotensin II type 1 receptors only reduced vasoconstriction in lead-treated rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Dragana Javorac, Biljana Antonijevic, Milena Andelkovic, Aleksandra Repic, Petar Bulat, Aleksandra Buha Djordjevic, Katarina Baralic, Danijela Dukic-Cosic, Tamara Antonic, Zorica Bulat
Summary: Exposure to low doses of lead may affect hematological parameters and lipid profiles, as well as antioxidant enzymes, reactive oxygen species, and metal element levels in the body. Results from the study suggest that copper blood levels and superoxide dismutase activity are particularly sensitive indicators of lead toxicity at low levels of exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Hui Zhang, Hailong Li, Amanda Phipps Green, Ming Wang, Fei Yan, Maichao Li, Yuwei He, Wenyan Sun, Xuan Yuan, Jie Lu, Mingshu Sun, Tony R. Merriman, Changgui Li
Summary: This study investigated the association between low-level environmental exposure to Cd/Pb and gout status, and found that Cd and Pb levels were significantly higher in the gout flare group compared to control or intercritical groups. The results suggest that Cd and Pb may be risk factors for gout flare status.
Article
Environmental Sciences
Qiyue Tan, Yuebin Lv, Feng Zhao, Jinhui Zhou, Yang Yang, Yingchun Liu, Mingyuan Zhang, Feng Lu, Yuan Wei, Xin Chen, Ruizhi Zhang, Chen Chen, Bing Wu, Xiaochang Zhang, Chengcheng Li, Hongyuan Huang, Junfang Cai, Zhaojin Cao, Di Yu, John S. Ji, Shuhua Zhao, Xiaoming Shi
Summary: This study found that even low levels of arsenic exposure were associated with an increased risk of oxidative stress, showing a nonlinear dose-response relationship.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)