Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Multidisciplinary Sciences
Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, Hui Zheng
Summary: Studies indicate that microglial-specific autophagy, represented by Atg7, plays a crucial role in regulating lipid metabolism and neuroinflammation. Deletion of Atg7 in microglia leads to a proinflammatory status and exacerbates intraneuronal tau pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie, Kiran Bhaskar
Summary: The study revealed that genetic deletion of IL-10 exacerbates neuroinflammation and tau phosphorylation, leading to neurodegeneration. Loss of IL-10 activates microglia, enhances IL-6 expression, and results in increased phosphorylation of tau protein under acute systemic inflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Rinie Bajracharya, David Brici, Liviu-Gabriel Bodea, Phillip W. Janowicz, Jurgen Gotz, Rebecca M. Nisbet
Summary: The study compared the efficacy of tau-specific antibodies with different Fc-receptor binding affinities in reducing tau pathology and microgliosis in an AD mouse model. The results showed that the IgG1/kappa isoform had a better ability to reduce tau pathology and microgliosis, while the IgG2a/kappa isoform enhanced extracellular tau phagocytosis in vitro.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Neurosciences
Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Pina-Crespo, Huaxi Xu, Timothy Y. Huang
Summary: This study found that Trem2 deletion can enhance the spreading of tau in the brain of mice, leading to impaired synaptic function and memory. Furthermore, Trem2 deletion can strengthen the ability of microglia to transmit tau through exosomal vesicles.
MOLECULAR NEURODEGENERATION
(2022)
Review
Neurosciences
Guimei Zhang, Zicheng Wang, Huiling Hu, Meng Zhao, Li Sun
Summary: Alzheimer's disease is a common type of age-related dementia, where dysregulated microglia activity can lead to chronic neuroinflammation, promote pathological protein accumulation, and impair mitophagy. Targeting microglia may offer new therapeutic interventions for the disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Juan R. Perea, Marta Bolos, Raquel Cuadros, Esther Garcia, Vega Garcia-Escudero, Felix Hernandez, Roisin M. McManus, Michael T. Heneka, Jesus Avila
Summary: This study demonstrates that inhibiting p38 can attenuate the toxic effect of tau in microglia and enhance microglia-mediated tau phagocytosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Andrew G. Murchison
Summary: This article posits that amyloid deposition and increased permeability of the blood-brain barrier are early independent events in Alzheimer's disease pathophysiology, contributing to a distinct microglial activation phenotype. Downstream effects such as synapse phagocytosis and persistent glutamate signally through NMDA receptors lead to neurodegeneration and tau pathology. This hypothesis aims to shed light on unexplained temporal and spatial features of AD by drawing from multiple lines of evidence.
ALZHEIMERS & DEMENTIA
(2022)
Review
Immunology
Yijun Chen, Yang Yu
Summary: Alzheimer's Disease (AD) is mostly responsible for dementia, characterized by neuritic plaques and neurofibrillary tangles containing aggregated β-amyloid (Aβ) and hyperphosphorylated tau protein. Recent focus has been on disease-modifying therapy targeting Aβ, although the efficacy and long-term safety of such drugs are still controversial. Tau has gained attention as a therapeutic target due to its association with cognitive dysfunction. Inflammation, especially neuroinflammation, is linked to AD and tau pathology. Understanding the relationship between tau pathology and neuroinflammation will contribute to discovering therapeutic targets for AD and other tau-related diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wang
Summary: Tau protein hyperphosphorylation and NFTs formation are key features of AD, and DpdtpA can attenuate these processes by regulating the PI3K/AKT/GSK-36 signaling pathway. DpdtpA also reduces microglial activation and inflammatory responses induced by Tau, offering a potential treatment option for AD-associated neuroinflammation.
Article
Geriatrics & Gerontology
Zejie Zuo, Fangfang Qi, Zhiwei Xing, Lifang Yuan, Yunjie Yang, Zitian He, Lihua Zhou, Zhibin Yao
Summary: The study suggests that A beta immunotherapy may exacerbate vascular A beta-associated pathology in Alzheimer's disease, whereas BCG treatment can improve this condition and enhance the efficacy of A beta vaccine. BCG treatment not only enhances the phagocytosis of A beta but also alleviates pathological changes by recruiting protective monocytes.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Julia Klein, Xinyu Yan, Aubrey Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S. Honig, Adam M. Brickman, Yaakov Stern, D. P. Devanand, Seonjoo Lee, William C. Kreisl
Summary: Olfactory identification deficits are closely related to the extent of tau pathology and neuroinflammation, particularly in patients with amyloid pathophysiology. Amyloid positivity and cognitive status have independent effects on UPSIT performance. Low UPSIT performance may be a marker for AD pathophysiology in cognitively normal individuals.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Summary: The study investigated the effects of TREM2 deficiency on tau spreading using a mouse model and found that Trem2(-/-) mice showed attenuated tau pathology in multiple brain regions along with decreased microglial density. The reduced TREM2 signaling impaired microglia activation and their contribution to tau spreading. However, caution should be exercised before targeting TREM2 as a therapeutic entry point for Alzheimer's disease until its involvement in tau aggregation and propagation is better understood.
Article
Cell Biology
Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowik
Summary: This study demonstrates that aggregated PHF6 peptide upregulates NLRP3 inflammasome expression and induces IL-1β and IL-18 expression in HMC3 cells, as well as affecting other inflammation and microglial polarization markers. Furthermore, the aggregated PHF6 also influences Beclin-1 expression and autophagy in a time-dependent manner. Overall, the study provides insights into the complex interplay between Alzheimer's PHF6 peptide aggregation and microglial inflammation, polarization, and autophagy.
Article
Immunology
Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang, Jin-Tai Yu
Summary: This study found that interleukin-3 (IL-3) secreted by astrocytes is associated with soluble triggering receptor expressed on myeloid cells 2 (sTREM2) and mediates the correlation between A beta pathology and tau pathology in Alzheimer's disease (AD). IL-3 may play a crucial role in the spread from A beta pathology to tau pathology to cognitive impairment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M. Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson, Christer Betsholtz, Xing-Mei Zhang, Changlian Zhu, Martin Enge, Bertrand Joseph, Robert A. Harris, Klas Blomgren
Summary: A subpopulation of microglia lacking genetic modification and showing high CX3CR1 expression was identified in Cx3cr1(CreER-Eyfp/wt) mouse strain. This subpopulation escaped depletion and proliferated extensively after microglial depletion, eventually occupying a large proportion of microglial pool. Additionally, it was demonstrated that CX3CL1-CX3CR1 signaling regulates microglial repopulation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Yuping Chen, Xiaoyong Tao, Yan Wang, Shengjie Xu, Yanhua Yang, Jinming Han, Feng Qiu
Summary: Clinical symptoms of anti-AChR positive MG combined with Titin antibody were more severe and progressed faster than those in the AChR + LRP4 and AChR groups. Regardless of antibody status, all patients responded well to immunotherapy and had relatively good prognoses.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jing-xian Sun, Ke-ying Zhu, Yu-meng Wang, Dan-jie Wang, Mi-zhen Zhang, Heela Sarlus, Irene Benito-Cuesta, Xiao-qiang Zhao, Zao-feng Zou, Qing-yang Zhong, Yi Feng, Shuai Wu, Yan-qing Wang, Robert A. Harris, Jun Wang
Summary: The role of TRPV1 in demyelinating diseases has been investigated, and it has been found to be an important regulator in the context of demyelination. TRPV1 deficiency exacerbates motor dysfunction and demyelination, while TRPV1 agonist CAP improves behavioral performance and facilitates remyelination. The activation of TRPV1 enhances microglial function and promotes myelin debris clearance.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Yong Zhang, Qiuyan Weng, Tongzhou Hu, Xiaohan Shen, Jinming Han
Summary: This study explored the mechanism of Rhizoma drynariae in the treatment of osteonecrosis of the femoral head (ONFH) using network pharmacology and in vitro experiments. Predicted targets of Rhizoma drynariae and ONFH were identified and key targets were determined. A compound-target-pathway network was constructed to depict the interrelationship between Rhizoma drynariae and ONFH-associated signaling pathways. Results showed the potential role of Rhizoma drynariae in ONFH treatment.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2023)
Article
Oncology
Yingzhu Yang, Chiyuan Yu, Rongrong Fu, Shishan Xia, Haixiang Ni, Yujing He, Keying Zhu, Qian Sun
Summary: Recent studies suggest that children born via cesarean section have an increased risk of immune-mediated diseases later in life. This meta-analysis investigated the association between cesarean section and childhood leukemia, and found that cesarean section is associated with a higher risk of childhood leukemia, particularly acute lymphoblastic leukemia. Notably, elective cesarean section was found to significantly increase the risk of acute lymphoblastic leukemia.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Youmeng Wang, Juliane Schoebel, Jinming Han, Jan F. Kraemer, Theresa Toncar, Jacob Siegert, Thomas Penzel, Christoph Schoebel
Summary: This study explored the effectiveness of phrenic nerve stimulation (PNS) on central sleep apnea (CSA) in heart failure patients. The results showed that PNS treatment significantly decreased the apnea-hypopnea index and increased mean arterial oxygen saturation. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea.
SLEEP AND BREATHING
(2023)
Article
Oncology
Shuiling Jin, Ruihua Zhao, Chuang Zhou, Qian Zhong, Jianxiang Shi, Chang Su, Qinglong Li, Xiaoxing Su, Huabin Chi, Xu Lu, Guozhong Jiang, Renyin Chen, Jinming Han, Miao Jiang, Shishi Qiao, Jingjing Liu, Min Song, Lijie Song, Yabing Du, Zhiwei Chang, Meng Wang, Meilian Dong, Yali Zhong, Pu Yu, Xiaojian Zhang, Hong Zong
Summary: This study evaluated the feasibility and tolerability of sintilimab plus anlotinib as second-line treatment for advanced BTC patients and found that this regimen showed encouraging anti-tumor activity. Genomic profiling and gut microbiome were explored as potential biomarkers for this regimen.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Green & Sustainable Science & Technology
Wei Yu, Huiqin Huang, Xinyan Kong, Keying Zhu
Summary: Our paper analyzes the impact of digital inclusive finance on the financial performance of SMEs by studying listed companies in Shanghai and Shenzhen A-share SMEs. The results indicate that SMEs in areas with higher levels of digital inclusive finance have significantly better financial performance. Digital inclusive finance can facilitate innovative investment, reduce debt financing costs, and improve risk-taking ability, ultimately strengthening SMEs' financial performance. These findings contribute to academic research on digital inclusive finance and offer recommendations for government, banks, and SMEs to continue implementing digital inclusive finance policies.
Article
Oncology
Yuyuan Chen, Caixian Yu, Dedian Chen, Yiyin Tang, Keying Zhu, Rong Guo, Sheng Huang, Zheng Li, Lvjun Cen
Summary: The study aimed to explore a predictive nomogram model for invasive micropapillary carcinoma (IMPC) prognosis. A total of 1855 IMPC patients diagnosed after surgery between 2004 and 2014 were used to build and validate the nomogram. The nomogram accurately predicted overall survival and demonstrated good performance in predicting prognosis.
Article
Neurosciences
Yan Miao, Xiaoling Zhong, Shuangshuang Jia, Yang Bian, Jinming Han, Feng Qiu
Summary: The objective of this study was to explore the characteristics and dynamic evolution of cognitive impairment in patients with neuromyelitis optica spectrum disorder (NMOSD). The results showed that 64% of patients with acute NMOSD had cognitive dysfunction. Various cognitive function tests indicated significant differences between patients with acute NMOSD and the control group. During follow-up visits, significant differences in serum aquaporin-4 (AQP-4) antibody titers were still noted in NMOSD patients, while no significant differences were found in cognitive function as measured by the Montreal Cognitive Assessment (MoCA). Therefore, acute NMOSD patients experience significant cognitive decline.
Article
Immunology
Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang
Summary: Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the central nervous system (CNS). Microglia with aryl hydrocarbon receptor (AhR) play a crucial role in efficient remyelination and clearance of myelin debris. AhR deficiency in microglia impairs phagocytic function, exacerbates CNS inflammation, and inhibits effective remyelination. This study highlights the therapeutic potential of AhR in demyelinating diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Editorial Material
Clinical Neurology
Yuzhen Xu, Jinming Han, Wen-Jun Tu, John Zhang
FRONTIERS IN NEUROLOGY
(2023)
Article
Geosciences, Multidisciplinary
Keying Zhu, Rui Yan, Chao Xiong, Lin Zheng, Zeren Zhima, Xuhui Shen, Dapeng Liu, Yibing Guan, Chao Liu, Song Xu, Fangxian Lv, Feng Guo, Na Zhou
Summary: In this study, the annual/semi-annual variations of electron density (Ne) in the topside ionosphere were analyzed based on observations from Langmuir probe (LAP) onboard the China Seismo-Electromagnetic Satellite (CSES). The results showed that Ne exhibited different behaviors during daytime and nighttime, with a linear-saturation trend in daytime and a roughly linear trend at night. The analysis using morphological analysis and Morlet wavelet analysis revealed annual/semi-annual variations of Ne at around 500 km altitude, with dominant periods of 187 days and 374 days. The study also found that the dominant period of Ne changed from semi-annual to annual variation as the magnetic latitude increased.
FRONTIERS IN EARTH SCIENCE
(2023)
Article
Engineering, Geological
Shanchao Hu, Xuedong Zhou, Wenkai Ru, Jinming Han, Shihao Guo, Chenxi Zhang, Lei Yang
Summary: This study conducted unloading confining pressure tests on coal-rock combinations under three different pressure rates. The stress-strain curves of the combinations were observed, and their failure, deformation, and strength characteristics were analyzed. The results showed that the combinations exhibited obvious volume expansion due to simple shear failure of the coal during unloading of the confining pressure. The rock part started to damage with increasing confining pressure value and unloading rate. The fracture angle was proportional to the initial confining pressure and inversely proportional to the unloading confining pressure rate, while the fragmentation and intensity degree varied significantly under different test conditions.
GEOTECHNICAL AND GEOLOGICAL ENGINEERING
(2023)