Article
Biochemistry & Molecular Biology
Ratul Datta Chaudhuri, Anirban Banik, Biswajit Mandal, Sagartirtha Sarkar
Summary: HIF-1α overexpression during MI reduces cardiomyocyte apoptosis by indirectly promoting HO-1-induced antioxidant response, which leads to decreased ROS accumulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tongtong Ma, Junjie Wu, Zhongqing Chen
Summary: This study investigates the role of circular RNAs (circRNAs) in sepsis-induced acute kidney injury (SAKI) and identifies circFkbp5/miR-760-3p/Tnf-alpha axis as potential therapeutic targets.
Article
Medicine, Research & Experimental
Yanke Lin, Shuai Wang, Lu Gao, Ziyue Zhou, Zemin Yang, Jingpan Lin, Shujing Ren, Huijie Xing, Baojian Wu
Summary: The study highlights the crucial role of Platr4 in experimental steatohepatitis, acting to inactivate the Nlrp3 inflammasome by intercepting NF-kappa B signaling, making it a potential target for ameliorating the pathological conditions of steatohepatitis.
Article
Biochemistry & Molecular Biology
Xiao-Yu Zhang, Zhuo-Chang Chen, Nan Li, Zhi-Hua Wang, Ya-Li Guo, Cui-Jie Tian, Dong-Jun Cheng, Xue-Yi Tang, Luo-Xian Zhang
Summary: Activated neutrophil-derived CRNDE is transferred to ASMCs through exosomes, activating the NF-kappa B pathway and promoting the proliferation and migration of ASMCs, which contributes to airway remodeling in asthma.
HUMAN MOLECULAR GENETICS
(2022)
Article
Multidisciplinary Sciences
Anika Witten, Leonie Martens, Ann-Christin Schaefer, Christian Troidl, Sabine Pankuweit, Ann-Kathrin Vlacil, Raghav Oberoi, Bernhard Schieffer, Karsten Grote, Monika Stoll, Birgit Markus
Summary: This study describes the specific characteristics of monocyte subset miRNA expression in patients with coronary artery disease and myocardial infarction, providing a basis for further functional analysis and the identification of new therapeutic targets for cardiovascular disease.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Zhiyu He, Xiaojun Zeng, Deke Zhou, Peiying Liu, Dunzheng Han, Lingling Xu, Tong Bu, Jinping Wang, Mengmeng Ke, Xiudi Pan, Yipeng Du, Hao Xue, Dongfeng Lu, Bihui Luo
Summary: This study identifies the novel ability of lncRNA Chaer in regulating cardiomyocyte apoptosis by promoting phosphorylation of AMPK in acute myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
X-P Cui, J-X Ye, H. Lin, H. Zhou, S. Ye, J-S Mu
Summary: This study found that the combination of edaravone and oxiracetam can inhibit neuronal apoptosis in rats with cerebral infarction by regulating the SIRT1/NF-kappa B signaling pathway, thereby exerting a neuroprotective effect.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Gao, Ying Zhang
Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.
MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Article
Immunology
Xiao-qin Qu, Qiong-feng Chen, Qiao-qing Shi, Qian-qian Luo, Shuang-yan Zheng, Yan-hong Li, Liang-yu Bai, Shuai Gan, Xiao-yan Zhou
Summary: PEBP4 plays an important role in LPS/D-GalN-induced acute liver injury, with its knockout exacerbating liver damage, inflammation, and apoptosis, mediated through the TLR4/NF-κB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rundong Jiang, Jiaqi Xu, Yuezhong Zhang, Xuanmeng Zhu, Jiachen Liu, Yurong Tan
Summary: Ligustrazine has been shown to inhibit the occurrence and development of ALI through multiple pathways, including reducing inflammatory cell infiltration, inhibiting the secretion of inflammatory factors, and decreasing cell pyroptosis and apoptosis. This provides a theoretical basis for the future use of ligustrazine in the treatment of ALI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qiuling Lin, Dingguo Zhang, Jian Zhang, Weixiang Luo, Zhenglei Xu, Jun Yao, Lisheng Wang
Summary: The incidence of ulcerative colitis (UC) in China has increased significantly. This study identified dysregulated lncRNA DLEU2 as a potential diagnostic biomarker and therapeutic target for UC. Through RNA sequencing, the expression of multiple lncRNAs and mRNAs was found to be significantly altered in the gut mucosa of UC patients. Mechanistically, DLEU2 exerts anti-inflammatory activity by inhibiting the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Barbara Di Francesco, Daniela Verzella, Daria Capece, Davide Vecchiotti, Mauro Di Vito Nolfi, Irene Flati, Jessica Cornice, Monica Di Padova, Adriano Angelucci, Edoardo Alesse, Francesca Zazzeroni
Summary: Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with a high need for new therapeutic options. Constitutive NF-kappa B activation has been reported in around 40% of AML patients, making targeting the NF-kappa B pathway an attractive strategy to treat AML.
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.