期刊
BREAST CARE
卷 11, 期 3, 页码 167-173出版社
KARGER
DOI: 10.1159/000447284
关键词
Breast cancer; Cyclin-dependent kinase; Palbociclib; Abemaciclib; Ribociclib
资金
- Lilly
- Novartis
- Pfizer
Clinical and preclinical data support a significant role for inhibitors of the cyclin-dependent kinases (CDKs) 4 and 6 in the treatment of patients with breast cancer. Recently, based on data showing improvement in progression-free survival, the use of palbociclib (Ibrance; Pfizer, Inc.) in combination with endocrine agents was approved to treat patients with hormone receptor-positive advanced disease. Importantly, 2 other CDK4/6 inhibitors, abemaciclib (LY2835219; Lilly) and ribociclib (LEE011; Novartis), are in the late stage of clinical development. In this review, we will focus on clinical data on these 2 new drugs, highlighting their differences compared to palbociclib in terms of single-agent activity, central nervous system penetration, and common adverse events. In addition, we will present the ongoing clinical trials and discuss future directions in the field. (C) 2016 S. Karger GmbH, Freiburg
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