期刊
FEBS JOURNAL
卷 287, 期 8, 页码 1478-1495出版社
WILEY
DOI: 10.1111/febs.15222
关键词
HIF; hypoxia; metabolism; sepsis
资金
- Agency for Innovation of Science and Technology in Flanders (IWT)
- Research Council of Ghent University (GOA Program)
- Research Foundation Flanders (FWO Vlaanderen)
- COST Action [BM1402]
- Interuniversity Attraction Poles Program of the Belgian Science Policy [IAP-VI-18]
Sepsis is a highly heterogeneous syndrome that is caused by an imbalanced host response to infection. Despite huge investments, sepsis remains a contemporary threat with significant burden on health systems. Vascular dysfunction and elevated oxygen consumption by highly metabolically active immune cells result in tissue hypoxia during inflammation. The transcription factor hypoxia-inducible factor-1a (HIF1 alpha), and its family members, plays an important role in cellular metabolism and adaptation to cellular stress caused by hypoxia. In this review, we discuss the role of HIF in sepsis. We show possible mechanisms by which the inflammatory response activated during sepsis affects the HIF pathway. The activated HIF pathway in turn changes the metabolism of both innate and adaptive immune cells. As HIF expression in leukocytes of septic patients can be directly linked with mortality, we discuss multiple ways of interfering with the HIF signaling pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据