Article
Biochemistry & Molecular Biology
Yi Jiang, Ming Shen, Yuanyuan Chen, Yinghui Wei, Jingli Tao, Honglin Liu
Summary: Melatonin inhibits oxidative stress-induced mitophagy to promote granulosa cell survival. It suppresses PINK1 and Parkin pathway to maintain cell viability against oxidative damage, providing a potential therapeutic target for anovulatory disorders.
Article
Food Science & Technology
Jiehuan Xu, Lingwei Sun, Mengqian He, Shushan Zhang, Jun Gao, Caifeng Wu, Defu Zhang, Jianjun Dai
Summary: This study demonstrates that resveratrol can counteract the toxic effects of zearalenone during porcine oocyte maturation. Resveratrol improves mitochondrial dysfunction and damage by enhancing PINK1/Parkin-mediated mitophagy, thereby promoting embryonic development.
Article
Cell Biology
Lianzhi Mao, Huahuan Liu, Rongjun Zhang, Yudi Deng, Yuting Hao, Wenzhen Liao, Miaomiao Yuan, Suxia Sun
Summary: Warangalone was found to induce mitochondrial damage and decrease cell viability in breast cancer cells by increasing ROS production. Additionally, it activated mitophagy through upregulation of PINK1 and Parkin, leading to mitochondrial apoptosis. However, the protective effect of autophagy/mitophagy against Warangalone-induced mitochondrial apoptosis was also observed. In conclusion, a combination of Warangalone and autophagy/mitophagy inhibitors may be a potential treatment for breast cancer.
Article
Food Science & Technology
Miao Song, Jian Zhang, Siming Huo, Xuliang Zhang, Yilong Cui, Yanfei Li
Summary: Aluminium (Al) accumulation in the spleen leads to apoptosis, primarily through mitochondrial dyshomeostasis and the release of apoptosis-inducing factor (AIF). The role of phosphatase and tensin homolog (PTEN)-induced putative kinase1 (PINK1)/E3 ubiquitin ligase PARK2 (Parkin)-mediated mitophagy in AIF-mediated spleen apoptosis induced by Al is uncertain. In this study, AlCl3 administration resulted in PINK1/Parkin-mediated mitophagy, AIF release, and AIF-mediated spleen apoptosis. Parkin deficiency exacerbated mitochondrial damage, AIF release, and AIF-mediated spleen apoptosis induced by AlCl3. Our findings suggest that mitophagy and AIF-mediated spleen apoptosis are both caused by AlCl3, but mitophagy is protective in AIF-mediated apoptosis induced by AlCl3.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Bo Qian, Rong-Juan Jiang, Jia-Le Song, Chen-Qiang Wang
Summary: TDCPP-induced ferroptosis may be associated with its neurotoxicity, potentially through the PINK1/PARKIN-mediated mitophagy initiated by mitochondrial damage.
Article
Reproductive Biology
Jiehuan Xu, Lingwei Sun, Caifeng Wu, Shushan Zhang, Shiqiang Ju, Rong Rui, Defu Zhang, Jianjun Dai
Summary: The study reveals that vitrification causes mitochondrial dysfunction and mitophagy in porcine oocytes, affecting embryonic developmental potential. Mitochondrial dysfunction under oxidative stress can be restored by antioxidant α-tocopherol, improving mitochondrial homeostasis and alleviating mitophagy.
Article
Cell Biology
Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda
Summary: Macroautophagy/autophagy is a complex intracellular degradation process with many regulatory factors. This study identified BCAS3 and C16orf70 as novel proteins associated with the autophagosome formation site and demonstrated their regulatory roles in autophagic activity. The BCAS3-C16orf70 complex affects the recruitment of core autophagy proteins to the phagophore assembly site.
Article
Cell Biology
Chengyu Li, Chen Fu, Tong He, Zhaojun Liu, Jiaqi Zhou, Gang Wu, Honglin Liu, Ming Shen
Summary: This study demonstrates that FSH protects ovarian granulosa cells against hypoxic stress by activating the HIF-1α-GAS6-Axl-Akt pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yancheng Tang, Liming Wang, Tao Yi, Jun Xu, Jigang Wang, Jiang-Jiang Qin, Qilei Chen, Ka-Man Yip, Yihang Pan, Peng Hong, Yingying Lu, Han-Ming Shen, Hu-Biao Chen
Summary: This study demonstrates that the natural product magnolol can induce mitochondrial depolarization, excessive fragmentation, and increased reactive oxygen species production. Magnolol also induces mitophagy through positive feedforward loops and triggers cancer cell death via the intrinsic apoptosis pathway, leading to inhibition of tumor growth and prolonged survival in mice. Inhibition of mitophagy enhances the anticancer efficacy of magnolol, suggesting that targeting mitophagy may be a promising strategy for improving cancer therapy.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang, Xiaoying Tian, Yujie Zhu, Hao He
Summary: A new optical method, UPLaS, has been developed to precisely and noninvasively induce localized mitochondrial Ca2+ oscillations, which directly initiates the PINK1-Parkin pathway for mitophagy.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Xiaoyu Wang, Xiaomin Tian, Huilin Yan, Tingting Zhu, Hao Ren, Yufeng Zhou, Donghao Zhao, Dan Xu, Xinlei Lian, Liangxing Fang, Yang Yu, Xiaoping Liao, Yahong Liu, Jian Sun
Summary: This study investigated the potential damage of Salinomycin (SAL) in IPEC-J2 cells by studying the interplay between mitophagy and oxidative stress. The results showed that excessive SAL induced cell death, cell cycle arrest, and oxidative damage through the activation of the Nrf2/Keap1/HO-1 pathway. Additionally, SAL exposure also activated PINK1/Parkin-dependent mitophagy and reduced mitochondrial membrane potential. These findings suggest that targeting ROS/PINK1/Parkin-dependent mitophagy and oxidative stress could be a new protective mechanism against SAL-induced cell damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Shuangquan Wen, Li Wang, Chaofan Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Summary: Cadmium is an environmental pollutant with neurotoxicity. This study found that mitochondrial dysfunction leads to mitophagy and apoptosis, while inhibiting cyclosporine A exacerbates cell apoptosis. Similar results were observed in in vivo experiments. The study suggests that PINK1/Parkin-mediated mitophagy plays an important role in neuroprotection.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Fabienne C. Fiesel, Dominika Fricova, Caleb S. Hayes, Mathew A. Coban, Roman Hudec, Jenny M. Bredenberg, Benjamin J. Broadway, Briana N. Markham, Tingxiang Yan, Paige K. Boneski, Gabriella Fiorino, Jens O. Watzlawik, Xu Hou, Arthur M. McCarty, Laura J. Lewis-Tuffin, Jun Zhong, Benjamin J. Madden, Alban Ordureau, Heeseon An, Andreas Puschmann, Zbigniew K. Wszolek, Owen A. Ross, J. Wade Harper, Thomas R. Caulfield, Wolfdieter Springer
Summary: This study investigates the impact of single nucleotide variants in the activation loop of the PINK1 kinase on its enzymatic function. The G411A variant of PINK1 is found to significantly enhance Ub phosphorylation and promote PRKN activation and mitophagy, leading to increased neuronal viability under mitochondrial stress. The mechanism involves the stabilization of PINK1's kinase fold and a change in Ub conformation. These findings suggest that the G411A variant could have therapeutic potential for neuroprotection.
Editorial Material
Cell Biology
Zak Doric, Huihui Li, Ken Nakamura
Summary: This study summarizes recent findings enabled by a new platform for tracking individual mitochondria in neurons, outlining the steps of PINK1- and PRKN-dependent mitochondrial turnover, including the unexplored fates of mitochondria after fusion with lysosomes. These studies reveal unexpected mechanisms of mitochondrial quality control, which may contribute to the reliance of neurons on PINK1 under stress conditions.
Article
Cell Biology
Jens O. Watzlawik, Fabienne C. Fiesel, Gabriella Fiorino, Bernardo A. Bustillos, Zahra Baninameh, Briana N. Markham, Xu Hou, Caleb S. Hayes, Jenny M. Bredenberg, Nicholas W. Kurchaba, Dominika Fricova, Joanna Siuda, Zbigniew K. Wszolek, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Asheeta A. Prasad, Deniz Kirik, Howard S. Fox, Kelly L. Stauch, Matthew S. Goldberg, Wolfdieter Springer
Summary: This study investigates the basal activation levels of the PINK1-PRKN signaling pathway in vivo using rodent samples, patient-derived cells, and isogenic neurons. The findings highlight the age-dependent, brain region-specific, and cell type-specific effects of PINK1-PRKN signaling, which have significant implications for improving diagnosis, prognosis, and patient stratification in Parkinson's disease.
Review
Chemistry, Multidisciplinary
Xu Min, Zhou Baomei, Ding Yan, Du Shanshan, Su Mengke, Liu Honglin
Summary: This tutorial review comprehensively summarizes the synthesis strategies, characteristics, applications, challenges, and future perspectives of oligonucleotide-peptide complexes (OPCs). The article aims to boost researchers' interests in developing novel OPC synthesis techniques by providing a clear overview of the current situation and limitations in the field.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Chemistry, Analytical
Shanshan Du, Mengke Su, Chao Wang, Zhongxiang Ding, Yifan Jiang, Honglin Liu
Summary: This study develops a new liquid/liquid interfacial surface-enhanced Raman spectroscopy (SERS) strategy that allows for high-resolution analysis of lipid compounds and has the potential for trace-level identification.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yan Ding, Yu Zhang, Xiaoqi Shi, Lingling Liao, Qinghe Li, Tingmei Duan, Hao Jiang, ZhongXiang Ding, Hongyan Wang, Honglin Liu
Summary: A mild, cost-effective, and non-toxic strategy using iodide etching was developed to directly estimate the amount of DNA on gold nanoparticles (GNPs). This strategy allows for easy quantification of DNA using fluorescence recovery after incubation with the etching reagent. It offers a breakthrough in DNA quantification methods and has important applications in bio-detection assays and nanoparticle-based therapeutics.
ANALYTICAL METHODS
(2022)
Article
Cell Biology
Honglin Liu, Jiani Xie, Limin Fan, Yue Xia, Xia Peng, Jianhua Zhou, Xiaorong Ni
Summary: This study found that cryptotanshinone (CRY) can improve ovarian tissue damage caused by polycystic ovary syndrome (PCOS) by regulating ferroptosis. The specific mechanisms include modulation of oxidative stress, inflammation, and apoptosis signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Weilong Dai, Ke Liu, Rongyang Li, Yan Cao, Ming Shen, Jingli Tao, Honglin Liu
Summary: This study investigated the effect and underlying mechanism of Trillin on myoblast differentiation using a myoblast differentiation model established with mice C2C12 cell line in vitro. The results showed that Trillin significantly inhibited C2C12 differentiation in a dose-dependent manner and increased autophagy. Mechanistically, the activity of AKT/mTOR declined during the inhibition of differentiation by Trillin.
Article
Chemistry, Analytical
Wenxiang Cao, Honglin Liu, Yinjian Hang, Hongzhi Wang, Guodong Li
Summary: This research focuses on how to safely mine in close multi coal seams, especially for large-dip coal seams with complex geological and mechanical conditions. The study found that the overburden strata deform asymmetrically around the coal pillar, leading to non-uniform stress distribution on the floor of the coal pillar and ribs. The results provide a theoretical foundation for a reasonable layout and support technique for roadways in deep zone mining.
Article
Biochemistry & Molecular Biology
Baobao Chen, Mingtian Deng, Meng-Hao Pan, Shao-Chen Sun, Honglin Liu
Summary: In this study, the researchers found that fertilization-dependent ERK1/2 plays an important role in zygotic reprogramming and early embryonic development in mice. Inhibition of ERK1/2 led to abnormal accumulation of H3K9me2, 5mC, and its oxides, resulting in increased asymmetry of parental chromatin. Furthermore, the inhibition of ERK1/2 triggered abnormal localization of G9a and Tet3, leading to impaired paternal chromatin binding. The findings suggest that fertilization-dependent ERK1/2 regulates zygotic H3K9me2 and 5mC, contributing to the developmental competence of pre-implantation embryos.
CELL AND BIOSCIENCE
(2022)
Article
Cell Biology
Xinying Zhou, Hui Xu, Qianna Li, Qi Wang, Honglin Liu, Yingqi Huang, Yao Liang, Linmiao Lie, Zhenyu Han, Yaoxin Chen, Yulan Huang, Wenle Zhou, Qian Wen, Chaoying Zhou, Shengfeng Hu, Li Ma
Summary: Viperin plays a role in regulating the activation and function of dendritic cells during Mycobacterium tuberculosis infection, and this effect is mediated through NF-kappa B p65 activation pathway. Viperin deficiency enhances the phagocytic activity and clearance ability of dendritic cells against Mtb, and also enhances the interaction between dendritic cells and T cells.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Construction & Building Technology
Guopeng Fan, Naitian Zhang, Songtao Lv, Milkos Borges Cabrera, Jiang Yuan, Xianpeng Fan, Honglin Liu
Summary: The study investigates the correlation between the chemical composition and theological properties of neat asphalt after aging and rejuvenation. The results show that the rheological properties of the asphalt change with aging, but can be reversed by the addition of a regenerating agent. The study also discovers linear relationships among several rheological parameters through correlation analysis.
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Xinying Zhou, Zelin Zhang, Hui Xu, Bo Zhu, Lijie Zhang, Linmiao Lie, Yingqi Huang, Xialin Du, Honglin Liu, Yanfen Li, Yulan Huang, Shengfeng Hu, Chaoying Zhou, Qian Wen, Mailkel P. Pepplenbosch, Li Ma
Summary: Viperin protein is increased in abundance in patients with lymphatic and pulmonary tuberculosis (TB), and its deficiency reduces mycobacterium tuberculosis bacterial loads and enhances macrophage responses. Viperin promotes Mtb infection by inhibiting host innate immune responses in macrophages.
Article
Obstetrics & Gynecology
Jianhui Yang, Aitong Xu, YuMin Zhang, Jiahui Deng, Xuemei Lin, Lili Xie, Xiaochun Deng, Honglin Liu, Peishan Chen, Yuejun Huang
Summary: This study, which includes 345 pregnant women, explores the relationship between prenatal depression and small for gestational age (SGA) birth. The findings suggest that changes in methylation levels in the placenta may be involved in this relationship.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Environmental Sciences
Hengfang Wang, Honglin Liu, Tianhong Yang, Guanghui Lv, Wenjing Li, Yuncai Chen, Deyan Wu
Summary: This study elucidated the responses and potential functions of soil microbial communities during succession in alpine mining areas. The results showed that mining disturbance significantly reduced the relative abundance of archaea, while restoration increased bacterial network node connections and decreased archaeal network connections. The networks of microbial genes related to nitrogen and phosphorus cycle potential varied depending on the succession type.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Green & Sustainable Science & Technology
Guodong Li, Hongzhi Wang, Zhaoxuan Liu, Honglin Liu, Haitian Yan, Zenwei Liu
Summary: The gob-side entry retaining (GER) technique, a member of the pillarless coal mining system, is gaining popularity due to its high resource recovery rate and environmental benefits. The development of the modified high-water backfill material (MBM), which is mixed with aeolian sand, provides a cost-effective solution for coal operators in arid areas. The MBM exhibits high strength, adjustable setting time, and increased peak and residual strength with the addition of aeolian sand.
Article
Endocrinology & Metabolism
Fang Zhao, Quan-Wei Wei, Bo-Jiang Li, Qian-Nan Weng, Yi Jiang, Cai-Bo Ning, Kai-Qing Liu, Wang-Jun Wu, Hong-Lin Liu
Summary: The study found that long-term repeated ACTH administration significantly delayed the initiation of estrus and the pre-ovulatory LH peak in weaned sows, reduced the ovulation rate, affected the concentrations of estrogen and progesterone, and also decreased the mRNA expression of LHR in the corpus luteum.