Article
Neurosciences
Karl Schoknecht, Johannes Hirrlinger, Jens Eilers
Summary: Spreading depolarizations (SDs) occur frequently in acute cerebral injuries, characterized by breakdown of ion gradients leading to reduced extracellular sodium and increased extracellular potassium concentration. Astrocytic accumulation of fluorescein (Fluo) was found during SDs induced by elevated potassium concentration. Astrocytic Fluo accumulation and swelling were only prevented by inhibition of the sodium-potassium ATPase, suggesting its involvement in these processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Satoshi Yamada, Yoshiaki Suzuki, Eiva Bernotiene, Wayne R. Giles, Yuji Imaizumi, Hisao Yamamura
Summary: The study revealed that the swelling-activated Cl(-1) currents and regulatory volume decrease in human articular chondrocytes are regulated by CIC-3, and can be attenuated by DIDS and CIC-3 knockdown. Hypoosmotic stimulation triggers Ca2+ influx and PGE(2) release in OUMS-27 cells, which are reduced by DIDS and CIC-3 knockdown, suggesting an association of CIC-3 with cartilage degenerative diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
L. G. P. Bezerra, A. M. Silva, S. S. J. Moreira, C. M. P. de Souza, A. R. Silva
Summary: The use of fluorophores Hoechst 33342 and propidium iodide was established to evaluate the plasma membrane integrity of quail spermatozoa. The study also identified an adequate hypoosmotic solution for evaluating sperm membrane functionality. However, the hypoosmotic swelling test has little predictive value in this species.
BRITISH POULTRY SCIENCE
(2023)
Article
Cell Biology
Bosung Shim, Jesse A. Stokum, Mitchell Moyer, Natalya Tsymbalyuk, Orest Tsymbalyuk, Kaspar Keledjian, Svetlana Ivanova, Cigdem Tosun, Volodymyr Gerzanich, J. Marc Simard
Summary: The study found that the SGLT2 inhibitor canagliflozin can reduce brain swelling and have a positive effect in various models of cerebral ischemia, especially in large ischemic strokes, which may have important translational implications.
Article
Biochemistry & Molecular Biology
Takako Nishi, Katsuhiko Sakamoto, Ryota Matsuo
Summary: The effect of acute hypoosmotic stress on the neural response in Onchidium mollusk was studied. The results suggest the existence of compensatory mechanisms involving aquaglyceroporin and VRAC-like channels to maintain membrane potential under hypoosmotic conditions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Michal Levin, Noy Cohen
Summary: This work proposes a simple experimental method based on 3D-printing technologies to characterize the stress of stimuli-responsive hydrogels under spatial geometric constraints. The results reveal the swelling behavior and stress variation of hydrogels under different confinement conditions. These findings can optimize the performance of swelling-based systems and understand the stress generated under other stimuli.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Immunology
Ganggui Zhu, Xiaoyu Wang, Luxi Chen, Cameron Lenahan, Zaixiang Fu, Yuanjian Fang, Wenhua Yu
Summary: This article discusses the adverse consequences of oxidative stress and the role of glial cells in stroke. Glial cells are rapidly activated after stroke, generating large amounts of reactive oxygen species (ROS) that cause oxidative damage. Additionally, ROS regulate the function of glial cells in pathological processes such as neuroinflammation and blood-brain barrier damage. However, glial cells also protect the central nervous system from oxidative damage by synthesizing antioxidants and regulating the Nrf2 pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Margareth Sidarta, Luna Baruah, Michaela Wenzel
Summary: Mechanosensitive channels play a crucial role in maintaining osmotic balance and are involved in bacterial infections and antibiotic susceptibility. They have the potential to be interesting targets for antibacterial chemotherapy.
Article
Energy & Fuels
Yangzheng Cao, Huacui Wang, Binghe Liu, Jun Xu
Summary: A fully detailed three-dimensional swelling mechanical model considering the actual structure of the battery has been developed and validated through experiments. The model has been applied to investigate plate-constrained swelling and analyze the swelling force and stress distribution of each component. The results provide fundamental insights into the application of lithium-ion batteries.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Fisheries
Baosong Huang, Fubai Liu, Danyu Cao, Guiying Li, Kaiqi Lin, Jinfeng Li, Gang Shi, Jiandong Zhang, Bei Wang, Jiansheng Huang, Chuanhao Pan, Qian Ma, Gang Chen, Zhongliang Wang
Summary: This study investigated the miRNA transcriptome of cobia gills under normal and low salinity conditions, identifying numerous miRNAs associated with adaptation. Target gene analysis revealed metabolic pathways and signal transduction as the most affected pathways, indicating that cobia maintains osmotic balance and energy homeostasis by regulating miRNAs in these pathways to adapt to low salinity environments.
AQUACULTURE RESEARCH
(2021)
Article
Environmental Sciences
Yanqing Wei, Cuiran Liu, Youju Shu
Summary: The study evaluates the effects of external stress (sigma(v)) and compaction characteristics on the swelling characteristics of expansive clay. Experimental results show that the swelling pressure (p(s)) increases with increasing compaction dry density (rho(d)), but first increases then decreases with increasing compaction moisture content (w(0)). The p(s)-w and swelling strain (epsilon(s))-w relationships are bilinear, and the turning points (w(Sp) and w(Sv)) indicate the full saturation of micropores. The w(Sp) values are lower than the w(Sv) values and decrease slightly with increasing rho(d). The w(Sv) values are not sensitive to compaction characteristics but generally decrease with increasing external stress (sigma(v)).
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alex Evilevitch, Sophia Hohlbauch
Summary: This study investigated the mechanical response of the nucleus during the initial stage of herpesvirus infection by using atomic force microscopy. It was found that the chromatin becomes stiffer while the nuclear lamina becomes softer after the injection of viral DNA, which may contribute to maintaining nuclear integrity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Geological
Yongfu Xu, Hong-ri Zhang
Summary: This paper presents a new design method for soilbag-protected slopes in expansive soils based on the balance between soilbag friction and active lateral earth pressure. It emphasizes the importance of soilbag heap-up height and width in ensuring slope stability.
GEOTEXTILES AND GEOMEMBRANES
(2021)
Review
Behavioral Sciences
Rodrigo Orso, Kerstin Camile Creutzberg, Francisco Sindermann Lumertz, Erika Kestering-Ferreira, Bruna Alvim Stocchero, Mariana Kude Perrone, Veronica Begni, Rodrigo Grassi-Oliveira, Marco Andrea Riva, Thiago Wendt Viola
Summary: Exposure to stress during early development may lead to altered neurobiological functions. This may be due to the disruption of glial density and morphology, as observed in rodent studies. However, the effects on different glial cells appear to vary. Our meta-analysis shows that prenatal and early life stress can increase microglia density and decrease oligodendrocyte density in offspring. Additional findings include an increase in microglia soma size with early life stress. These effects are influenced by factors such as stress protocol, sex, age, and tissue type. The results highlight the importance of glial cell alterations in stress-induced dysfunctions throughout development.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Svyatoslav S. S. Sokolov, Marina M. M. Popova, Peter Pohl, Andreas Horner, Sergey A. A. Akimov, Natalia A. A. Kireeva, Dmitry A. A. Knorre, Oleg V. V. Batishchev, Fedor F. F. Severin
Summary: Yeast S. cerevisiae suppresses sterol biosynthesis in response to hyperosmotic stress. Lowering the sterol content increases water permeability of the cell membrane and may prevent membrane rupture.
Article
Clinical Neurology
Bao-Hua Chao, Feng Yan, Yang Hua, Jian-Min Liu, Ge Yang, Xun-Ming Ji, Bin Peng, Guo-Guang Zhao, Yong-Jun Wang, De-Zhi Kang, Yi-Long Wang, Jin-Sheng Zeng, Lan Chu, Tian-Xiao Li, Yu-Ming Xu, Ming Liu, Li He, Yun Xu, Jiang Wu, Min Lou, Wei Yue, Lei Cao, Wen-Jun Tu, Long-De Wang
Summary: The China Stroke Prevention Project Committee has been actively promoting stroke prevention and control in China. With over 8.3 million people screened and followed up from 2012 to 2018, the committee has helped establish 380 stroke centers in mainland China and improved stroke care quality through monitoring and reporting. Further nationwide promotion of the program is needed to continue the progress.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Endocrinology & Metabolism
Wenning Fu, Chao Wang, Li Zou, Heng Jiang, Mia Miller, Yong Gan, Shiyi Cao, Hongbin Xu, Jing Mao, Shijiao Yan, Wei Yue, Feng Yan, Qingfeng Tian, Zuxun Lu
Summary: This study found significant positive relationships between obesity indicators such as BMI, WC, LAP, VAI, and BAI with the risk of diabetes. Among these indices, WC had the strongest impact on diabetes prevalence, while BAI had the weakest impact.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Clinical Neurology
Jianfeng Zhuang, Yucong Peng, Chi Gu, Huihui Chen, Zheng Lin, Hang Zhou, Xiao Wu, Jianru Li, Xiaobo Yu, Yang Cao, Hanhai Zeng, Xiongjie Fu, Chaoran Xu, Peiyu Huang, Shenglong Cao, Chun Wang, Feng Yan, Gao Chen
Summary: Wogonin enhances phagocytosis, reduces inflammation, and oxidative stress, facilitating hematoma clearance and improving neurobehavioral recovery after ICH.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Xiongjie Fu, Hanhai Zeng, Jikuang Zhao, Guoyang Zhou, Hang Zhou, Jianfeng Zhuang, Chaoran Xu, Jianru Li, Yucong Peng, Yang Cao, Yin Li, Huaijun Chen, Lin Wang, Feng Yan, Gao Chen
Summary: The study shows that Dectin-1 plays a role in regulating microglia/macrophage phenotype and neuroinflammation after intracerebral hemorrhage, potentially contributing to functional recovery through the activation of the Syk/Card9/NF-kB pathway.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Wen-Jun Tu, Feng Yan, Bao-Hua Chao, Xun-Ming Ji, Longde Wang
Summary: Among stroke patients, admission to a designated SU was associated with modestly lower mortality at discharge, reduced probability of death, or being disabled at the end of follow-up.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hanhai Zeng, Xiongjie Fu, Jing Cai, Chenjun Sun, Mengyan Yu, Yucong Peng, Jianfeng Zhuang, Jingyin Chen, Huaijun Chen, Qian Yu, Chaoran Xu, Hang Zhou, Yang Cao, Libin Hu, Jianru Li, Shenglong Cao, Chi Gu, Feng Yan, Gao Chen
Summary: Neuroinflammation in patients with subarachnoid hemorrhage (SAH) is closely associated with poor prognosis, and neutrophil extracellular traps (NETs) play a key role in promoting inflammation. Inhibiting NET formation can attenuate the damage caused by neuroinflammation after SAH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Microbiology
Xiaobo Yu, Guoyang Zhou, Bo Shao, Hang Zhou, Chaoran Xu, Feng Yan, Lin Wang, Gao Chen, Jianru Li, Xiongjie Fu
Summary: Intracerebral hemorrhage (ICH) can disrupt gut microbiota balance, leading to changes in immune responses and neuroinflammation. Restoring a healthy microbiota can alleviate functional deficits and neuroinflammation after ICH.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Fangfang Zhao, Haiping Zhao, Junfen Fan, Rongliang Wang, Ziping Han, Zhen Tao, Yangmin Zheng, Feng Yan, Yuyou Huang, Lei Yu, Xu Zhang, Lianfeng Zhang, Yumin Luo, Yuanwu Ma
Summary: The study showed that knockout of miR-29a in rats aggravated neurological damage in experimental stroke rat models by promoting M1 microglial polarization and increasing glutamate release. MiR-29a-5p levels decreased in the blood and brain tissue of rat MCAO models, as well as in the peripheral blood of acute stroke patients. Additionally, miR-29a knockout enhanced infarct volume and showed M1 polarization of microglia in the MCAO rat brain.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Hanhai Zeng, Huaijun Chen, Min Li, Jianfeng Zhuang, Yucong Peng, Hang Zhou, Chaoran Xu, Qian Yu, Xiongjie Fu, Shenglong Cao, Jing Cai, Feng Yan, Gao Chen
Summary: The study revealed that NRBF2 has a protective effect on endoplasmic reticulum stress-associated neuroinflammation and oxidative stress after SAH by promoting autophagosome maturation through interactions with Rab7.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang, Feng Yan
Summary: Our study revealed that inhibiting P2X4R can promote neurofunctional recovery after ICH, transform pro-inflammatory microglia induced by ICH into an anti-inflammatory phenotype, and alleviate ICH-induced WMI. Additionally, TrkB blockage can reverse the protective effects of WMI, suggesting that P2X4R plays a crucial role in regulating WMI and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Hang Zhou, Libin Hu, Jianru Li, Wu Ruan, Yang Cao, Jianfeng Zhuang, Hangzhe Xu, Yucong Peng, Zhongyuan Zhang, Chaoran Xu, Qian Yu, Yin Li, Zhangqi Dou, Junwen Hu, Xinyan Wu, Xiaobo Yu, Chi Gu, Shenglong Cao, Feng Yan, Gao Chen
Summary: The study demonstrates the role of AXL in transforming astrocytes into a phagocytic phenotype after TBI through the AXL/STAT1/ABCA1 pathway, which helps limit neuroinflammation and improve neurological impairments. The findings provide a potential therapeutic target for TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Chaoran Xu, Huaijun Chen, Shengjun Zhou, Chenjun Sun, Xiaolong Xia, Yucong Peng, Jianfeng Zhuang, Xiongjie Fu, Hanhai Zeng, Hang Zhou, Yang Cao, Qian Yu, Yin Li, Libin Hu, Guoyang Zhou, Feng Yan, Gao Chen, Jianru Li
Summary: The pharmacological activation of RXR-alpha accelerates hematoma clearance, alleviates neurological dysfunction after ICH, and reduces neuroinflammation by repolarizing microglia/macrophages, indicating a promising therapeutic target for ICH.
NEUROSCIENCE BULLETIN
(2021)
Correction
Clinical Neurology
Xiongjie Fu, Hanhai Zeng, Jikuang Zhao, Guoyang Zhou, Hang Zhou, Jianfeng Zhuang, Chaoran Xu, Jianru Li, Yucong Peng, Yang Cao, Yin Li, Huaijun Chen, Lin Wang, Feng Yan, Gao Chen
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Wenzhen Li, Dajie Chen, Shuai Liu, Xiaojun Wang, Xiaojie Chen, Jiafeng Chen, Jing Ma, Fujian Song, Hui Li, Shijiao Yan, Xiaoxv Yin, Shiyi Cao, Yanhong Gong, Junan Liu, Wei Yue, Feng Yan, Chuanzhu Lv, Zhihong Wang, Zuxun Lu
Summary: After the update of the hypertension definition by the 2017 ACC/AHA guidelines, the prevalence of hypertension significantly increased, with newly labeled as hypertensive mainly seen in north China. Efforts should focus on improving health education, management, and interventions in the northern region.
Article
Cell Biology
Zeng Hanhai, Qin Bin, Zhou Shengjun, Li Jingbo, Guo Yinghan, Cai Lingxin, Cao Shenglong, Zhou Hang, Chen Huaijun, Zhuang Jianfeng, Peng Yucong, Fu Xiongjie, Yu Xiaobo, Tan Xiaoxiao, Li Jianru, Gu Chi, Yan Feng, Chen Gao
Summary: Neutrophils in peripheral blood were found to be higher in subarachnoid hemorrhage patients compared to healthy subjects. The presence of neutrophil extracellular traps released post-SAH could shift microglia towards a more proinflammatory phenotype, contributing to neuroinflammation and poor outcome.