Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD‐L1 into extracellular vesicles

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells

(2019) Mingshui Chen et al.   BMC CANCER

PD-1/PD-L1 Pathway Mediates the Alleviation of Pulmonary Fibrosis by Human Mesenchymal Stem Cells in Humanized Mice

(2018) Ke Ni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

(2018) Helena J. Janse van Rensburg et al.   CANCER RESEARCH

Fatty acid synthase is required for profibrotic TGF-β signaling

(2018) Mi-Yeon Jung et al.   FASEB JOURNAL

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

(2018) Min Hwan Kim et al.   Cancer Immunology Research

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

(2018) Soumaya Kouidhi et al.   Frontiers in Immunology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis

(2018) Aina Martin-Medina et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

(2018) Lindsay J. Celada et al.   Science Translational Medicine

Fibronectin on the Surface of Extracellular Vesicles Mediates Fibroblast Invasion

(2018) Diptiman Chanda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

(2017) Maria Zena Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice

(2017) Yunyuan Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity

(2017) Ryu Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

(2017) Jeong-Han Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism

(2017) Jitka Soukupova et al.   Scientific Reports

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

(2016) Tomasz Szul et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Idiopathic pulmonary fibrosis and cancer: do they really look similar?

(2015) Carlo Vancheri   BMC Medicine

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Idiopathic pulmonary fibrosis and lung cancer

(2015) Katerina M. Antoniou et al.   CURRENT OPINION IN PULMONARY MEDICINE

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage

(2015) Colette Dezutter-Dambuyant et al.   OncoImmunology

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

(2015) Cindy Neuzillet et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Idiopathic Pulmonary Fibrosis: Evolving Concepts

(2014) Jay H. Ryu et al.   MAYO CLINIC PROCEEDINGS

Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases

(2013) Mahefatiana Andrianifahanana et al.   FASEB JOURNAL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms in Progressive Idiopathic Pulmonary Fibrosis

(2012) Mark P. Steele et al.   Annual Review of Medicine

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

TNF-α and TGF-β Counter-Regulate PD-L1 Expression on Monocytes in Systemic Lupus Erythematosus

(2012) Jing-Ni Ou et al.   Scientific Reports

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Non-Smad Transforming Growth Factor-β Signaling Regulated by Focal Adhesion Kinase Binding the p85 Subunit of Phosphatidylinositol 3-Kinase

(2011) Min Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Roles for Mammalian Target of Rapamycin Complexes in the Fibroblast Response to Transforming Growth Factor- 

(2008) R. A. Rahimi et al.   CANCER RESEARCH

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

(2008) C A Crane et al.   ONCOGENE

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE