Article
Biophysics
Zicheng Lu, Tingting Liu, Xujiao Zhou, Yi Yang, Yanxiang Liu, Hong Zhou, Shanhong Wei, Zimeng Zhai, Yuqing Wu, Fan Sun, Zifei Wang, Tie Li, Jiaxu Hong
Summary: Dry eye disease (DED) is a common chronic eye disease that requires fast and reliable tools for diagnosis and monitoring. This study developed a biosensor based on silicon nanowire-based field-effect transistor (SiNW FET) for the quantitative measurement of MMP-9 in human tears. The biosensor demonstrated high agreement with enzyme-linked immunosorbent assay (ELISA) and showed good diagnostic sensitivity and specificity in real-world clinical settings.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Medicine, General & Internal
Ha Rim So, Jiwon Baek, Ji Young Lee, Hyun Seung Kim, Man Soo Kim, Eun Chul Kim
Summary: This study aims to evaluate the expression of matrix metalloproteinase-9 (MMP-9) in dry eyes treated with 0.05% cyclosporin A and 3.0% diquafosol tetrasodium. The study found that MMP-9 expression and grade were lower after treatment with cyclosporin than after treatment with diquafosol in dry eye disease. Anti-inflammatory treatment can decrease ocular MMP-9 levels in dry eye disease.
ANNALS OF MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang, Meng Ren
Summary: The hybrid hydrogel dressing developed for localized delivery of MMP-9 siRNA showed significant reduction in MMP-9 expression and improved diabetic wound closure in diabetic rats. The dressing exhibited negligible cytotoxicity in vitro and sustained release of siMMP-9 for up to 7 days. This delivery system offers a platform for in vivo delivery of siRNA for the treatment of various diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Ophthalmology
Tsung-Chuan Ho, Nai-Wen Fan, Shu- Yeh, Show-Li Chen, Yeou-Pin Tsao
Summary: This study demonstrates the potential efficacy of a PEDF-derived short peptide 29-mer in treating dry eye disease by reducing inflammation and preventing its development.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katharina Sommer, Heike Jakob, Caroline Reiche, Dirk Henrich, Jasmina Sterz, Johannes Frank, Ingo Marzi, Anna Lena Sander
Summary: Epoxyeicosatrienoic acids (EET) can accelerate diabetic skin wound healing by promoting neoangiogenesis, contributing to the resolution of the initial inflammatory reaction, and facilitating the crucial transition from the inflammatory to proliferative phase in wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Alexander Areesanan, Sven Nicolay, Morris Keller, Amy Marisa Zimmermann-Klemd, Olivier Potterat, Carsten Grundemann
Summary: The Malva sylvestris flower extract and its fractions show potential in reducing oxidative stress, promoting wound healing, and inhibiting cytokine secretion, indicating possible therapeutic effects for dry eye disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Ching Chen, Liang-Yu Lin, Jaw-Wen Chen, Ting-Ting Chang
Summary: This study found that CXCL5 levels were increased in type 2 DM patients. Inhibition of CXCL5 can promote neovascularization and wound healing. Therefore, CXCL5 may be a potential therapeutic target for vascular complications of diabetes mellitus.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Engineering, Biomedical
Zijian Shao, Tianyu Yin, Jinbo Jiang, Yang He, Tao Xiang, Shaobing Zhou
Summary: A self-adaptive multifunctional hydrogel with self-healing property and injectability has been developed for treating diabetic wounds. The hydrogel can react with high glucose and hydrogen peroxide to alleviate oxidative stress and release drugs. In animal experiments, the hydrogel accelerates angiogenesis and wound closure. This self-adaptive multifunctional hydrogel shows potential for the treatment of diabetic wounds.
BIOACTIVE MATERIALS
(2023)
Review
Ophthalmology
Alireza Shoari, Mozhgan Rezaei Kanavi, Mohammad Javad Rasaee
Summary: Dry eye syndrome (DES) is a multifactorial condition that affects the glands and surface of the eye, with uncontrolled activity of MMP-9 leading to epithelial desquamation. Inhibition of MMP-9 has been proposed as a therapeutic target for DES, with novel pharmaceutical compounds designed to improve symptoms and restore tear production.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Miki Hata-Mizuno, Yuichi Uchino, Miki Uchino, Shigeto Shimmura, Yoko Ogawa, Kazuo Tsubota, Kazuno Negishi
Summary: This study found a positive correlation between gal-3 concentration in tears and the severity of dry eye disease, as well as a negative correlation with tear film break-up time and Schirmer's test. The detection rate of gal-3C in tears was closely associated with the severity of dry eye disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Chemical
Prima F. Hillman, Chaeyoung Lee, Sang-Jip Nam
Summary: Wound healing is challenging in clinical settings and requires proper management. Acute wound healing involves cell divisions, formation of extracellular matrix, and the release of growth factors and cytokines. Factors like infection and inflammation can delay healing, and natural products have shown potential in promoting wound healing. This review discusses the research on wound healing activities of natural microbial products, aiming to contribute to the development of better wound treatments.
Article
Biochemistry & Molecular Biology
Ning Li, Aiyan Zhan, Yiguo Jiang, Hongzhuo Liu
Summary: The designed MMP-responsive hydrogel loaded with deferoxamine promoted angiogenesis and accelerated wound healing in diabetic foot ulcers by increasing the expression of hypoxia-inducible factor-1 alpha.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemical Research Methods
Heng-Cong Luo, Kai-Jin Mai, En Liu, Hui Chen, Yi-Juan Xie, Yong-Xiong Zheng, Rong Lin, Li-Ming Zhang, Ying Zhang
Summary: This study demonstrates the potential of a Dextran-PAMAM/siMMP-9 complex as a gene carrier for downregulating MMP-9 expression in diabetic foot ulcers. The complex effectively accelerated wound healing in diabetic rat models, indicating its promising regenerative capabilities for improving DFU healing.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Fisheries
Diana Ceballos-Francisco, Nuria Garcia-Carrillo, Alberto Cuesta, Maria Angeles Esteban
Summary: This study utilized ultrasound technology to observe the skin healing process in gilthead seabream after experimental wounds. The results demonstrated the utility of ultrasound for evaluating real-time biological processes in fish and provided new insights into the repair of external injuries in aquatic vertebrates.
JOURNAL OF FISH DISEASES
(2021)
Article
Ophthalmology
Christina Scelfo, Reem H. ElSheikh, Muhammad M. Shamim, Javaneh Abbasian, Alireza Ghaffarieh, Abdelrahman M. Elhusseiny
Summary: Glaucoma often accompanies ocular surface disease, which is caused by long-term use of pressure-lowering medications, active ingredients in the medications, and the glaucoma itself. In order to manage glaucoma or ocular hypertension patients, reducing the toxicity of eye drops and providing specific treatment for those with ocular surface disease is crucial.
CURRENT EYE RESEARCH
(2023)
Review
Ophthalmology
Fayrouz Aboalazayem, Abdelrahman M. Elhusseiny, Yasmine M. El Sayed
Summary: GATT is an innovative minimally invasive glaucoma surgery that increases aqueous drainage by incising the inner wall of Schlemm's canal, leading to a reduction in intraocular pressure and demonstrating favorable results in various types of glaucoma.
CURRENT EYE RESEARCH
(2023)
Editorial Material
Ophthalmology
Abdelrahman M. Elhusseiny, Abid Haseeb, Ayman G. Elnahry
Summary: This case report demonstrates improvement of treatment-resistant GA-associated ICS through prolonged dietary modifications and vitamin supplementation. It highlights the importance of educating parents about the value of dietary modifications for patients with GA.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Victoria Ly, Abdelrahman M. Elhusseiny, Ahmed B. Sallam
Summary: This study evaluated the clinical characteristics and visual outcomes of ocular syphilis in HIV-positive and negative patients. The results showed that posterior uveitis was the most common ophthalmic feature, and neurosyphilis was relatively high in both groups. There were no significant differences in laterality, presence of concurrent rash, RPR titers, and visual acuity between the two groups.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Abdelrahman M. Elhusseiny, Mohamed K. Soliman, Ahmed F. Shakarchi, Yousef A. Fouad, Yit C. Yang, Ahmed B. Sallam
Summary: This study compared the visual outcomes and rates of intraoperative complications between combined cataract extraction and pars plana vitrectomy (combined group) and sequential surgery (sequential group). The results showed that the postoperative visual acuity was worse in the combined group and there was a higher rate of posterior capsular rupture. However, the differences in visual improvement between the two groups decreased with longer follow-up time.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Review
Ophthalmology
Fatemeh Tavakkoli, Taher K. Eleiwa, Abdelrahman M. Elhusseiny, Mukesh Damala, Amit K. Rai, Kasra Cheraqpour, Mohammad H. Ansari, Mohammad Doroudian, Saeed H. Keshel, Mohammad Soleimani, Ali R. Djalilian, Virender S. Sangwan, Vivek Singh
Summary: The limbal stem cells niche is a microenvironment that provides and regulates the limbal epithelial stem cells. Disturbing this environment can lead to ocular surface aberrations. It is important to explore therapeutic strategies for restoring the functions of the limbal stem cells niche, especially due to the shortage of donor tissue for corneal transplantation.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Taher K. Eleiwa, Ibrahim A. Elsaadani, Abdelrahman M. Elhusseiny
Article
Multidisciplinary Sciences
Yasmine M. El Sayed, Abdelrahman M. Elhusseiny, Ghada I. Gawdat, Amanne F. Esmael, Hala M. Elhilali
Summary: This study aimed to determine the prevalence and clinical characteristics of childhood glaucoma among patients in an Egyptian children's hospital. The results showed that primary congenital glaucoma was the most common type of glaucoma in Egypt, and a significant proportion of patients had a history of parental consanguinity.
Article
Ophthalmology
Patrick C. Staropoli, Harsh Moolani, Abdelrahman M. Elhusseiny, Harry W. Flynn, William E. Smiddy
Summary: The purpose of this study was to identify the long-term rate of fellow eye full-thickness macular hole (FTMH) development. The results showed that the rate of FTMH in the fellow eye increases during long-term follow-up and may stabilize after 6 years.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Abdelrahman M. Elhusseiny, Reem M. Aboulhassan, Yasmine M. El Sayed, Ghada I. Gawdat, Hala M. Elhilali
Summary: A study evaluated the one-year outcomes of GATT in PCG patients with prior glaucoma surgery. The results showed significant reduction in intraocular pressure (IOP), with 85.7% achieving complete success and 14.2% achieving qualified success. No further glaucoma procedures were required, and no serious complications were reported.
CASE REPORTS IN OPHTHALMOLOGICAL MEDICINE
(2023)
Article
Ophthalmology
Abdelrahman M. Elhusseiny, Isdin Oke, Jean Adomfeh, Muhammad Z. Chauhan, Deborah K. VanderVeen
Summary: This study examined the association between neighborhood environment factors and outcomes of childhood glaucoma. The findings suggest that neighborhood environment quality may be an important predictor of outcomes in childhood glaucoma.
OPHTHALMOLOGY GLAUCOMA
(2023)
Editorial Material
Ophthalmology
Abdelrahman M. Elhusseiny, Lauren Hennein, Deborah K. VanderVeen
Summary: This is a case study about the successful treatment of an infant eye disease using intracameral and intravitreal bevacizumab. The case suggests a potential role for bevacizumab in the management of PFV, but further research is needed to confirm these findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Abdelrahman M. Elhusseiny, Mohamed M. Khodeiry, Richard K. Lee, Tarek Shaarawy, Salman Waqar, Mohamed S. Sayed
Summary: This study retrospectively observed the early experience with the use of the Paul glaucoma implant in children with refractory glaucoma. The results showed that the implant effectively reduced intraocular pressure without any postoperative complications. Larger studies with longer follow-up are needed to confirm these encouraging results.
CLINICAL OPHTHALMOLOGY
(2023)