Targeting the Wnt signaling pathway: the challenge of reducing scarring without affecting repair
出版年份 2020 全文链接
标题
Targeting the Wnt signaling pathway: the challenge of reducing scarring without affecting repair
作者
关键词
-
出版物
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 29, Issue 2, Pages 179-190
出版商
Informa UK Limited
发表日期
2020-01-17
DOI
10.1080/13543784.2020.1718105
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Loss of Wnt Secretion by Macrophages Promotes Hepatobiliary Injury after Administration of 3,5-Diethoxycarbonyl-1, 4-Dihydrocollidine Diet
- (2019) An Jiang et al. AMERICAN JOURNAL OF PATHOLOGY
- Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations.
- (2019) Dustin Flanagan et al. CANCER RESEARCH
- Niclosamide alleviates pulmonary fibrosis in vitro and in vivo by attenuation of epithelial-to-mesenchymal transition, matrix proteins & Wnt/β-catenin signaling: A drug repurposing study
- (2019) Raju Boyapally et al. LIFE SCIENCES
- Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics
- (2019) Jerry Harb et al. Current Oncology Reports
- YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury
- (2019) Lara Planas-Paz et al. Cell Stem Cell
- Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
- (2019) Brian J. Pepe-Mooney et al. Cell Stem Cell
- Overexpression of miR-27b-3p Targeting Wnt3a Regulates the Signaling Pathway of Wnt/β-Catenin and Attenuates Atrial Fibrosis in Rats with Atrial Fibrillation
- (2019) Xiangwei Lv et al. Oxidative Medicine and Cellular Longevity
- Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis
- (2019) Guido Carpino et al. HEPATOLOGY
- Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
- (2018) Guido Carpino et al. AMERICAN JOURNAL OF PATHOLOGY
- Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12
- (2018) Büsra Öztürk Akcora et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma
- (2018) Madeline N. Hayes et al. Cell Stem Cell
- Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
- (2018) Thomas Funck-Brentano et al. JOURNAL OF ENDOCRINOLOGY
- Pimozide suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling pathway
- (2018) Yonggang Ren et al. LIFE SCIENCES
- A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
- (2018) Zvezdan Pavlovic et al. mAbs
- Utilizing ethacrynic acid and ciclopirox olamine in liver cancer
- (2018) Ahmad Al‑Dali et al. Oncology Letters
- ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
- (2018) Andreia V. Pinho et al. Nature Communications
- VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix
- (2017) Tammy N. Jessen et al. EXPERIMENTAL CELL RESEARCH
- Upregulated miR-29c suppresses silica-induced lung fibrosis through the Wnt/β-catenin pathway in mice
- (2017) X Wang et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
- (2017) Ying Wei et al. JOURNAL OF CLINICAL INVESTIGATION
- Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
- (2017) Fotios Sampaziotis et al. NATURE MEDICINE
- Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis
- (2017) Alexandre Vallée et al. Oncotarget
- Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
- (2017) Kelly L. Walton et al. Frontiers in Pharmacology
- Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct
- (2016) Bingfang Xu et al. DEVELOPMENTAL BIOLOGY
- The rationale for targeting TGF-β in chronic liver diseases
- (2016) Gianluigi Giannelli et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice
- (2016) Hirohisa Okabe et al. HEPATOLOGY
- Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide
- (2016) Valerie Fako et al. International Journal of Biological Sciences
- WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells
- (2016) LIANG XU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis
- (2016) Fengyun Xu et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
- (2016) Lara Planas-Paz et al. NATURE CELL BIOLOGY
- TGF-β: the master regulator of fibrosis
- (2016) Xiao-ming Meng et al. Nature Reviews Nephrology
- Wnt signaling in cancer
- (2016) T Zhan et al. ONCOGENE
- Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway
- (2016) Guido Carpino et al. PLoS One
- Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
- (2016) Subhrajit Saha et al. Nature Communications
- Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
- (2015) Meritxell Huch et al. CELL
- Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a
- (2015) Shuxia Wang et al. FASEB JOURNAL
- β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis
- (2015) Satdarshan Pal Monga GASTROENTEROLOGY
- WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited
- (2015) Luke Boulter et al. JOURNAL OF CLINICAL INVESTIGATION
- The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation
- (2015) Ana Sofia Rocha et al. Cell Reports
- Wnt CoreceptorLrp5Is a Driver of Idiopathic Pulmonary Fibrosis
- (2014) Anna P. Lam et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice
- (2014) Bernd Kinzel et al. DEVELOPMENTAL BIOLOGY
- Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size
- (2014) Sergio P. Acebron et al. MOLECULAR CELL
- Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum
- (2014) Dandan Zhu et al. Parasites & Vectors
- Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells
- (2014) Watcharin Loilome et al. TUMOR BIOLOGY
- Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity
- (2013) N. Escobedo et al. DEVELOPMENT
- Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling
- (2013) Weng Chuan Peng et al. PLoS One
- Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure
- (2012) Tamako Nishimura et al. CELL
- Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin
- (2012) M. F. Chacon-Heszele et al. DEVELOPMENT
- Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration
- (2012) Nian-Ling Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration
- (2012) B. B. Williams et al. JOURNAL OF CELL SCIENCE
- Wnt Pathway in Pulmonary Fibrosis in the Bleomycin Mouse Model
- (2012) Li Liu et al. JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
- (2012) Huai-Xiang Hao et al. NATURE
- Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
- (2012) Luke Boulter et al. NATURE MEDICINE
- Inhibitors/antagonists of TGF- system in kidney fibrosis
- (2012) M. Yanagita NEPHROLOGY DIALYSIS TRANSPLANTATION
- Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays
- (2012) Wu-Jun Xiong WORLD JOURNAL OF GASTROENTEROLOGY
- The Evolution of the Wnt Pathway
- (2012) T. W. Holstein Cold Spring Harbor Perspectives in Biology
- Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
- (2012) Alfiya Akhmetshina et al. Nature Communications
- Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
- (2011) Jun Wei et al. ARTHRITIS AND RHEUMATISM
- Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
- (2011) Atsuko Yanagida et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- β-catenin signaling
- (2011) Anna P. Lam et al. CURRENT OPINION IN RHEUMATOLOGY
- Disruption of planar cell polarity activity leads to developmental biliary defects
- (2011) Shuang Cui et al. DEVELOPMENTAL BIOLOGY
- Vangl2 Promotes Wnt/Planar Cell Polarity-like Signaling by Antagonizing Dvl1-Mediated Feedback Inhibition in Growth Cone Guidance
- (2011) Beth Shafer et al. DEVELOPMENTAL CELL
- Matrix Metalloproteinase-7 as a Surrogate Marker Predicts Renal Wnt/ -Catenin Activity in CKD
- (2011) W. He et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway
- (2010) Frédéric Trensz et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish
- (2010) Marion Ségalen et al. DEVELOPMENTAL CELL
- Ror2 is required for midgut elongation during mouse development
- (2010) Makiko Yamada et al. DEVELOPMENTAL DYNAMICS
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
- (2010) L. Grumolato et al. GENES & DEVELOPMENT
- Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver
- (2010) S. Lorenzini et al. GUT
- The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation
- (2010) Laura L. Yates et al. HUMAN MOLECULAR GENETICS
- The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
- (2010) Laura L. Yates et al. HUMAN MOLECULAR GENETICS
- Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
- (2010) Yan Gong et al. PLoS One
- PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis
- (2010) Jun Wei et al. PLoS One
- Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
- (2010) H. J. Snippert et al. SCIENCE
- Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis
- (2009) B. Gustafson et al. DIABETOLOGIA
- Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis
- (2009) W. He et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans
- (2008) Youngmi Jung et al. GASTROENTEROLOGY
- Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
- (2008) Scott L. Friedman PHYSIOLOGICAL REVIEWS
- Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
- (2007) Jason H. Cheng et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis
- (2007) Julie Bayle et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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