Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Anjali Srivastava, Bhawna Tomar, Divyansh Sharma, Srikanta Kumar Rath
Summary: Chronic kidney disease (CKD) permanently changes the function and structure of the kidney over time and is often characterized by glomerular filtration defect or proteinuria lasting longer than three months. Mitochondrial dysfunction is a common response to CKD damage, leading to altered mitochondrial shape, increased oxidative stress, and decreased biogenesis and ATP generation. This article summarizes the recent advancements in understanding the involvement of mitochondrial remodeling in CKD and emphasizes the importance of understanding mitochondrial biology for developing effective treatment options.
Article
Multidisciplinary Sciences
Elisa Bernardes Monteiro, Natalia Alvarenga Borges, Mariana Monteiro, Angela de Castro Resende, Julio Beltrame Daleprane, Christophe Olivier Soulage
Summary: The aim of this study was to evaluate the protective effects of a phenolic-rich Acai seed extract (ASE) in mice with kidney failure. The results showed that ASE improved renal dysfunction and fibrosis through its antioxidant activity and modulation of the TGF-beta 1 pathway.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Giorgia Magliocca, Pasquale Mone, Biagio Raffaele Di Iorio, August Heidland, Stefania Marzocco
Summary: This review provides an overview of the effect of short-chain fatty acids (SCFAs) on CKD-associated inflammation and oxidative stress, based on pre-clinical and clinical evidence. In patients with chronic kidney disease (CKD), there is a significant alteration in the gut microbiota, resulting in reduced production of beneficial bacterial metabolites. However, SCFAs have been shown to have beneficial effects in modulating inflammation and oxidative stress in CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Idalina Beirao, Rui Alves, Luis Belo, Alice Santos-Silva
Summary: The global prevalence of chronic kidney disease (CKD) is rising, highlighting the need for earlier biomarkers to improve patient prognosis. Research has identified a range of promising early CKD biomarkers, which still require further validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Nabil Foudi, Maeva Palayer, Marie Briet, Anne-Sophie Garnier
Summary: Chronic kidney disease (CKD) poses a high cardiovascular risk due to arterial remodeling and stiffness; uremic toxins affect vascular smooth muscle cell function; low-grade inflammation may contribute to cardiovascular complications in CKD patients despite traditional risk factor management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Ana Sanchez, Cristina Contreras, Joaquin Carballido-Rodriguez, Dolores Prieto
Summary: An epidemiological relationship between urolithiasis and cardiovascular diseases has been reported. Endothelial dysfunction is associated with both conditions. Oxidative stress is a key factor in the development of endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Biochemistry & Molecular Biology
Eva Harlacher, Julia Wollenhaupt, Constance C. F. M. J. Baaten, Heidi Noels
Summary: Patients with chronic kidney disease (CKD) are at a highly increased risk of cardiovascular complications. This study systematically reviewed literature on CKD-associated endothelial dysfunction, revealing the role of inflammation, oxidative stress, leukocyte migration, and thrombosis in CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Peter Stenvinkel, Glenn M. Chertow, Prasad Devarajan, Adeera Levin, Sharon P. Andreoli, Sripal Bangalore, Bradley A. Warady
Summary: Despite recent advances in the management of chronic kidney disease (CKD), morbidity and mortality rates in these patients remain high. Chronic inflammation, oxidative stress, hypoxia, senescence, and mitochondrial dysfunction are now recognized as key factors in the etiology and progression of CKD. Various mechanisms, such as NF-KB and Nrf2-mediated gene transcription, regulate the inflammatory response in CKD, impacting glomerular filtration rate (GFR) decline and eventual progression to end-stage kidney disease (ESKD) in various kidney diseases.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, Carol A. Pollock
Summary: Chronic kidney disease is a global public health problem, and photobiomodulation therapy may be an innovative, non-pharmacological treatment option. Preliminary studies suggest that photobiomodulation therapy can improve the condition of patients with chronic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Radhia Hamdi, Amana Saadallah-Kallel, Slima Ferchichi-Trimeche, Raja Mokdad-Gargouri, Abdelhedi Miled, Bachir Benarba
Summary: The study found that DNA hypomethylation of the p66shc promoter in chronic renal failure patients is correlated with oxidative and inflammatory stress as well as disease stages.
Review
Biochemistry & Molecular Biology
Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim
Summary: Vitamin E supplementation significantly decreased inflammation and oxidative stress biomarkers in adult patients receiving hemodialysis, suggesting that it may help alleviate endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Gonzalez-Amor, Ana B. Garcia-Redondo, Inmaculada Jorge, Guillermo Zalba, Martina Becares, Maria J. Ruiz-Rodriguez, Cristina Rodriguez, Hugo Bermeo, Raquel Rodrigues-Diez, Francisco J. Rios, Augusto C. Montezano, Jose Martinez-Gonzalez, Jesus Vazquez, Juan Miguel Redondo, Rhian M. Touyz, Susana Guerra, Mercedes Salaices, Ana M. Briones
Summary: The study revealed that ISG15 plays a crucial role in vascular damage associated with hypertension by inducing oxidative stress and inflammation. The expression of ISG15 was positively correlated with high systolic and diastolic blood pressure as well as carotid intima-media thickness, while ISG15 knockout mice showed protection against hypertension and vascular damage.
CARDIOVASCULAR RESEARCH
(2022)
Article
Infectious Diseases
Paul Loubet, Linda Wittkop, Laetitia Ninove, Mathieu Chalouni, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Eric Thouvenot, Martine Laville, Bruno Laviolle, Jean-Daniel Lelievre, Jacques Morel, Stephanie Nguyen Quoc, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, Francois Vrtovsnik, Sophie Circosta, Laure Esterle, Axel Levier, Philippe Vanhems, Eric Tartour, Beatrice Parfait, Xavier de Lamballerie, Odile Launay
Summary: This study aimed to investigate the 1-month humoral response to two or three doses of mRNA COVID-19 vaccine in specific populations compared with healthy adults. The results showed a lower humoral response in the specific populations. However, the third dose of the vaccine had a positive effect on the immune response.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Critical Care Medicine
Justyna A. Karolak, Carrie L. Welch, Christian Mosimann, Katarzyna Bzdega, James D. West, David Montani, Melanie Eyries, Mary P. Mullen, Steven H. Abman, Matina Prapa, Stefan Graf, Nicholas W. Morrell, Anna R. Hemnes, Frederic Perros, Rizwan Hamid, Malcolm P. O. Logan, Jeffrey Whitsett, Csaba Galambos, Pawel Stankiewicz, Wendy K. Chung, Eric D. Austin
Summary: Over the past decade, the significance of the TBX4 gene in respiratory diseases has been recognized. TBX4 is associated with congenital disorders involving respiratory and skeletal structures, but its exact role in human development is not fully understood. Through human and animal studies, we discuss the developmental, tissue-specific, and pathological functions of TBX4, as well as review the published TBX4 variants that result in different disease phenotypes. We also outline future research directions to enhance our understanding of TBX4 function and the impact of TBX4 disruption on development.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Nutrition & Dietetics
Giorgina Barbara Piccoli, Tommy Cederholm, Carla Maria Avesani, Stephan J. L. Bakker, Vincenzo Bellizzi, Cristina Cuerda, Adamasco Cupisti, Alice Sabatino, Stephane Schneider, Massimo Torreggiani, Denis Fouque, Juan Jesus Carrero, Rocco Barazzoni
Summary: Increased life expectancy presents significant challenges to healthcare systems globally, including the rise in chronic kidney disease (CKD) and malnutrition-protein-energy wasting (PEW) in older adults, leading to poor clinical outcomes. A critical review paper by ESPEN and ERN-ERA aims to summarize key concepts in preventing and treating CKD progression and impaired nutritional status, and provide guidance on defining optimal protein and energy intake in varying CKD severity. Careful assessment and individualized approach are necessary, considering malnutrition-PEW status, kidney function, and patient preferences. Greater awareness and research are needed to improve nutritional care for this growing patient subgroup.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Benedicte Gaborit, Sara Fernandes, Paul Loubet, Laetitia Ninove, Anne Dutour, Bertrand Cariou, Muriel Coupaye, Karine Clement, Sebastien Czernichow, Claire Carette, Noemie Resseguier, Laure Esterle, Sabrina Kali, Marie Houssays, Xavier de Lamballerie, Linda Wittkop, Odile Launay, Martine Laville
Summary: Patients with diabetes and obesity have weaker immune responses to COVID-19 vaccines, especially one month after the second dose. Post-vaccination serological checks are necessary for these high-risk populations.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Urology & Nephrology
Maxime Espi, Xavier Charmetant, Cyrille Mathieu, Alexandre Lalande, Didier Decimo, Laetitia Koppe, Caroline Pelletier, Anne Ovize, Alexia Barbry, Emmanuel Morelon, Emilie Kalbacher, Denis Fouque, Olivier Thaunat
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nathan Mewton, Erwan Donal, Francois Picard, Francois Derimay, Daniel Grinberg, Delphine Maucort Boulch, Thomas Bochaton, Nicolas Piriou, Amelie De Lorgeril, Geraldine Samson, Frederic Rouleau, Benjamin Riche, Jean Noel Trochu
Summary: The study aimed to assess the distribution of primary and secondary heart failure events in a severe heart failure population and their association with 2-year all-cause mortality. The results showed that primary heart failure decompensations were three times more frequent than secondary decompensations, but both types had a similar impact on mortality risk. Patients with only primary or only secondary decompensation had a significantly increased risk of death.
AMERICAN HEART JOURNAL
(2023)
Article
Physiology
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurelle Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frederic Perros
Summary: Hereditary pulmonary veno-occlusive disease (hPVOD) is a severe autosomal recessive pulmonary hypertension caused by loss of function of the EIF2AK4 gene. Researchers generated rat models with biallelic Gcn2 mutation to study the molecular and cellular response of the lungs under amino acid deprivation. The study revealed that Gcn2-/- rats displayed increased apoptosis, overexpression of proinflammatory genes, and infiltration of inflammatory cells, suggesting a potential role of Gcn2 in immune homeostasis and hPVOD development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kossi D. Abalo, Sophie Malekzadeh-Milani, Sebastien Hascoet, Serge Dreuil, Tiphaine Feuillet, Cecilia Damon, Helene Bouvaist, Ivan Bouzguenda, Sarah Cohen, Claire Dauphin, Sylvie Di Filippo, Stephanie Douchin, Francois Godart, Patrice Guerin, Pauline Helms, Clement Karsenty, Bruno Lefort, Pierre Mauran, Caroline Ovaert, Jean-Francois Piechaud, Jean-Benoit Thambo, Choonsik Lee, Mark P. Little, Damien Bonnet, Marie-Odile Bernier, Estelle Rage
Summary: Pediatric patients with congenital heart disease who undergo cardiac catheterization (CC) may be exposed to low dose ionizing radiation (LDIR). However, this study found no increased risk of lympho-hematopoietic malignancies and lymphoma associated with LDIR in these patients.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Clinical Neurology
Paul Clottes, Nicolas Benech, Chloe Dumot, Sophie Jarraud, Hubert Vidal, Laura Mechtouff
Summary: Despite recent advances in stroke therapy, it remains a leading cause of disability and death, necessitating the identification of new therapeutic targets. Increasingly, dysbiosis of gut microbiota has been recognized as playing a detrimental role in cardiovascular diseases, including stroke. The metabolites produced by gut microbiota, such as trimethylamine-N-oxide, short chain fatty acids, and tryptophan, have been found to be key players. There is evidence linking gut microbiota alteration to cardiovascular risk factors, supported by preclinical studies. Additionally, observational studies have shown that stroke patients with altered gut microbiota experience more complications, larger infarct sizes, and worse clinical outcomes. Various microbiota-targeted strategies, including prebiotics/probiotics and inhibitors of metabolites, have been developed. However, the timing and endpoints of these studies have varied, resulting in different outcomes. Based on available evidence, it is believed that further research on microbiota-targeted strategies, in conjunction with conventional stroke care, should be conducted within three therapeutic time windows: primary prevention or secondary prevention to control cardiovascular risk factors, acute phase to minimize infarct size and systemic complications, and subacute phase to prevent recurrence and promote neurological recovery.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Emma Wischlen, Noemie Laverdure, Domitille Erard, Barbara Rohmer, Olivier Boillot, Remi Dubois, Alain Lachaux, Sophie Collardeau-Frachon, Valerie Hervieu, Jerome Dumortier
Summary: Post-transplantation evolution of progressive familial intrahepatic cholestasis type 2 patients can be complicated by antibody-induced bile salt export pump deficiency (AIBD). There is no consensus on its management. We describe a patient who presented two episodes, 9 years apart. The first episode was refractory to plasmapheresis and intravenous immunoglobulin (IVIG) started 2 months after AIBD onset, leading to graft loss. The second episode responded to plasmapheresis, IVIG and rituximab initiated less than 2 weeks after the beginning of symptoms, allowing for long-term recovery. This case suggests that intensive treatment with minimum delay after symptoms onset could sponsor a better evolution.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Bochaton, Nathan Mewton
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Gastroenterology & Hepatology
Sarah Duponchel, Lea Monnier, Jennifer Molle, Nadia Bendridi, Muhammad Rizwan Alam, Ahmed Gaballah, Boyan Grigorov, Alexander Ivanov, Marcel Schmiel, Margarete Odenthal, Michel Ovize, Jennifer Rieusset, Fabien Zoulim, Birke Bartosch
Summary: Chronic HCV infection causes cellular stress, fibrosis, and predisposes to hepatocarcinogenesis. Mitochondria play key roles in orchestrating stress responses. The study revealed that HCV proteins associate with mitochondria and alter the composition of mitochondrial subdomains, which are crucial for efficient viral replication.
Article
Biochemistry & Molecular Biology
Bruna Cadete Martins, Alexandre Coelho Soares, Fabiane Ferreira Martins, Angela de Castro Resende, Kim Ohanna Pimenta Inada, Vanessa Souza-Mello, Nathalia Moura Nunes, Julio Beltrame Daleprane
Summary: This study aimed to evaluate the preventive and therapeutic effects of coffee consumption on molecular changes and adipose tissue remodeling in a murine model of high-fat diet-induced obesity. The results showed that the coffee prevention group had lower body mass and a better distribution of adipose tissue compared to the high-fat group. Both groups that received coffee showed improved glucose metabolism and attenuated adipose tissue inflammation. Coffee consumption also attenuated hepatic steatosis and inflammation. Preventive coffee consumption associated with a high-fat diet ameliorates the metabolic profile related to the development of obesity and its comorbidities.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Critical Care Medicine
Pierre-Edouard Bollaert, Alexandra Monnier, Francis Schneider, Laurent Argaud, Julio Badie, Claire Charpentier, Ferhat Meziani, Michel Bemer, Jean-Pierre Quenot, Marie Buzzi, Herve Outin, Cedric Bruel, Laurent Ziegler, Sebastien Gibot, Jean-Marc Virion, Camille Alleyrat, Guillaume Louis, Nelly Agrinier
Summary: The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. However, the conservative strategy did not reduce mortality in these patients.
Article
Pediatrics
Tania Perrin, Pierre Pradat, Julie Larcade, Marion Masclef-Imbert, Blandine Pastor-Diez, Jean-Charles Picaud
Summary: This cohort study aimed to evaluate the impact of an individualised nutritional care approach combining standardised fortification with adjustable fortification on postnatal growth and body composition in extremely low birth weight (ELBW) infants. The study found that the individualised nutritional care approach prevented postnatal weight loss in most infants, limited length growth deficit, and supported excellent head circumference growth.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)