Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Fisheries
Renjie Chang, Weiwei Zheng, Qiang Luo, Guiliang Liu, Tianjun Xu, Yuena Sun
Summary: The study revealed that miR-148-1-5p functions as a negative regulator in immune responses by targeting the IRAK1 gene and modulating the NF-kappa B signaling pathway in miiuy croaker.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kun Wu, Guoquan Tao, Ting Xu, Yuanyuan An, Xiangyou Yu, Yi Wang, Shaochuang Wang, Wen Guo, Long Ma
Summary: Liver ischemia-reperfusion (I/R) injury is a common pathological phenomenon with unclear mechanisms. This study focused on the role of miR-497b-5p in liver I/R injury, showing its involvement in regulating inflammatory factors and cell apoptosis. Additionally, miR-497b-5p may activate the NF-κB pathway to promote liver I/R injury, while the overexpression of MED1 and TIMP2 could alleviate the damage.
Article
Biochemistry & Molecular Biology
Heejoo Kim, Hwee Won Ji, Hyeon Woo Kim, Sung Hwan Yun, Jae Eun Park, Sun Jung Kim
Summary: The research revealed that Rg3 regulates the expression of lncRNA ATXN8OS and miR-424-5p in MCF-7 cancer cells, impacting cell proliferation and apoptosis, and subsequently affecting the expression of oncogenic target genes.
Article
Medicine, Research & Experimental
Qinglan Wang, Feng Zhang, Yang Lei, Ping Liu, Chenghai Liu, Yanyan Tao
Summary: The study investigated the effects and mechanism of miR-322/424 in liver fibrosis, revealing that miR-322/424 plays a crucial role in targeting Cullin2 and enhancing HIF-1 alpha-mediated hepatic angiogenesis. The results showed that miR-322/424 levels were increased in liver cirrhosis patients and animal models, with its agonist exacerbating fibrosis while the antagonist had the opposite effect.
Article
Multidisciplinary Sciences
Zhengri Lu, Mengen Deng, Genshan Ma, Lijuan Chen
Summary: This study aimed to investigate the role and mechanisms of TRIM38 in myocardial ischemia/reperfusion (I/R) injury. The results showed that TRIM38 expression can alleviate inflammatory responses and oxidative stress, inhibit apoptosis, and attenuate cellular injury by suppressing the TAK1/NF-kappa B pathway activity.
Article
Cell Biology
Zi-Zhen Zhang, Jiao-Jiao Chen, Wen-Yi Deng, Xiao-Hua Yu, Wei-Hua Tan
Summary: CTRP1 inhibits cholesterol efflux and promotes macrophage lipid accumulation through the miR-424-5p/FoxO1/ABCA1 signaling pathway, providing a novel mechanistic insight into its proatherosclerotic action.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Pharmacology & Pharmacy
Xiao Xiao, Rong Ai, Y. Tian, Ning Mi, W. Liu, S. Cheng, Na Qian, X. Zhu
Summary: The study demonstrated that microRNA-140-5p has a protective effect on valproate-induced autistic rats, alleviating death, malformation, and weight loss induced by valproate while improving learning and memory abilities.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Huan Wang, Xiaomin Huang, Pengfei Xu, Xuejing Liu, Zihao Zhou, Fuhua Wang, Jingyi Li, Yuhui Wang, Xunde Xian, George Liu, Wei Huang
Summary: This study found that ApoC3 worsens the progression of early-stage DN by activating the renal TLR2/NF-KB pathway, which is partially independent of HTG.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Oncology
Ravinder Reddy Gaddam, Young-Rae Kim, Julia S. Jacobs, Jin-Young Yoon, Qiuxia Li, Angela Cai, Hamsitha Shankaiahgari, Barry London, Kaikobad Irani, Ajit Vikram
Summary: This study reveals that miR-204 regulates cardiac hypertrophy development and overexpression of miR-204 can inhibit the development of cardiac dysfunction caused by hypertrophy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Zheng Zhou, Yu Chen
Summary: This study aims to investigate the effects of long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the biological phenotypes of nasopharyngeal carcinoma (NPC) cells and its related mechanisms. The results showed that SNHG1 was upregulated while miR-424-5p was downregulated in NPC tissues and cells. SNHG1 promotes the proliferation, invasion, and migration of NPC cells by repressing miR-424-5p expression.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Cell Biology
Pengling Wang, Tianli Zhang, Nan Jiang, Kun Wang, Liping Feng, Ting Liu, Xingsheng Yang
Summary: This study identifies PDIA6 as a significant player in endometrial cancer, promoting malignant behavior of cancer cells through regulation of the TGF-beta pathway and modulation by the TRPM2-AS/miR-424-5p axis. Therefore, PDIA6 may be a potential target for endometrial cancer therapy.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Chi Pan, Shanshan Shao, Yawen Gu, Qingtao Ni
Summary: The study revealed that miR-93-5p targeted EphA4 in triple-negative breast cancer through the NF-kappa B pathway. However, radiation therapy prevented tumor progression by inhibiting the miR-93-5p/EphA4/NF-kappa B pathway. The expression levels of miR-93-5p were found to be higher in clinical patients.
Article
Cell Biology
Yuquan Wang, Zhengmin Xu, Xiaoli Wang, Jiankang Zheng, Lihan Peng, Yunfei Zhou, Yongyan Song, Zhan Lu
Summary: The study identified miR-503-5p as a pro-atherosclerotic factor in atherosclerosis, mediating communication between macrophages, HCAECs, and HCASMCs via EVs. MiR-503-5p reduced the proliferative and angiogenic abilities of HCAECs while enhancing the proliferative and migrating abilities of HCASMCs. It also upregulated inflammatory cytokines and adhesion molecules by downregulating Smad family members 1, 2, and 7 in HCAECs and HCASMCs. Inhibition of miR-503-5p reduced atherosclerotic lesion formation in aortic tissue of atherosclerotic mice.