期刊
EXPERIMENTAL AND APPLIED ACAROLOGY
卷 80, 期 2, 页码 257-268出版社
SPRINGER
DOI: 10.1007/s10493-019-00458-1
关键词
Borrelia burgdorferi; Inactivated expression vehicle; Ixodes scapularis; Peromyscus leucopus; Reservoir-targeted vaccine
类别
资金
- U.S. Biologic, Inc.
- Hatch Act funds
- Centers for Disease Control and Prevention [CK000182-03]
Blacklegged ticks (Ixodes scapularis) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice (Peromyscus leucopus) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were previously developed and successfully evaluated in laboratory and controlled field trials. A novel, inactivated RTV was developed to minimize regulatory and market challenges facing previous RTVs based on live bacterial or viral vehicles. Thirty-two residential properties in Redding, Connecticut, participated in a field trial of an orally delivered, inactivated RTV efficacy study (2015-2016). During the two-year vaccination period, a significant decrease in the percentage of B. burgdorferi-infected I. scapularis larvae parasitizing P. leucopus was observed, as was a significant reduction in the percentage of infected P. leucopus on RTV-treated properties when compared to control properties. This novel inactivated RTV was effective in reducing numbers of B. burgdorferi-infected I. scapularis and B. burgdorferi-infected P. leucopus on properties where it was distributed.
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