期刊
EUROPEAN JOURNAL OF OPHTHALMOLOGY
卷 31, 期 2, 页码 584-591出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1120672120902027
关键词
Diabetic retinopathy; diabetic choroidopathy; choroidal neovascular membrane
This study investigates the clinical and angiographic characteristics of choroidal neovascularization in patients with diabetic retinopathy, revealing a low prevalence rate with a significant role of diabetic choroidopathy in the formation of choroidal neovascularization in diabetic retinopathy eyes.
Background: To report the clinical and angiographic characteristics of choroidal neovascularization in patients with diabetic retinopathy. Methods: Patients of type 2 diabetes mellitus with presence of choroidal neovascularization in at least one eye were retrospectively analyzed. The study eyes were divided into three groups based on presence (active or scarred) or absence of choroidal neovascularization (fellow eyes). Imaging characteristics of active choroidal neovascularization were recorded using optical coherence tomography, fluorescein, and indocyanine angiography. Central macular thickness, subfoveal choroidal thickness, and large choroidal vessel layer thickness were compared at baseline and final visit. Results: Our study reports the prevalence rate of choroidal neovascularization in eyes with diabetic retinopathy (0.27%; 36 out of 13,382 eyes). A total of 64 eyes of 32 patients (age, mean +/- standard deviation: 68.5 +/- 9.3 years) with baseline visual acuity of 0.69 +/- 0.69 logarithm of minimum angle of resolution (Snellen equivalent 20/100) were included. Nonproliferative diabetic retinopathy (57 eyes) comprised the majority followed by proliferative diabetic retinopathy (7 eyes). Eyes with choroidal neovascularization (36, 56.25%) included both active (25) and scarred (11) choroidal neovascularization, with bilateral choroidal neovascularization in 4 patients. Type 1 choroidal neovascularization was the most common subtype of choroidal neovascularization on optical coherence tomography. Common etiologies for active choroidal neovascularization included age-related macular degeneration (3; 12%), myopia (1; 4%), and inflammatory choroidal neovascularization secondary to chorioretinitis (1; 4%). In the remaining 20 eyes, choroidal neovascularization formation was primarily due to diabetic choroidopathy. Conclusion: The prevalence of choroidal neovascularization in eyes with diabetic retinopathy is very low, with a lower prevalence of age-related macular degeneration. Diabetic choroidopathy plays a significant role in formation of choroidal neovascularization in eyes with diabetic retinopathy.
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