Article
Cardiac & Cardiovascular Systems
Ali A. Al-Mubarak, Niels Grote Beverborg, Navin Suthahar, Ron T. Gansevoort, Stephan J. L. Bakker, Daan J. Touw, Rudolf A. de Boer, Peter van der Meer, Nils Bomer
Summary: This study aims to investigate the relationship between serum selenium levels and the risk of mortality and new-onset heart failure. The results show that high selenium levels are associated with reduced mortality and incidence of new-onset heart failure in non-smokers.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Medical Laboratory Technology
Zheng Qin, Qinbo Yang, Mei Yang, Mei Han, Yuqin Xiong, Ruoxi Liao, Baihai Su
Summary: The study showed that serum leptin concentration is associated with cardiovascular events and all-cause death in maintenance hemodialysis patients, and may impact the development of left ventricular hypertrophy and peripheral vascular disease.
CLINICA CHIMICA ACTA
(2021)
Article
Nutrition & Dietetics
Mesut Gumussoy, Volkan Atmis, Ahmet Yalcin, Remzi Bahsi, Seher Yigit, Sinan Ari, Haydar Can Dokuyan, Melih Gaffar Gozukara, Kamile Silay
Summary: This study evaluated the relationship between Malnutrition-sarcopenia syndrome (MSS) and all-cause mortality in hospitalised older Turkish people over two years. The results showed that MSS, sarcopenia, sarcopenia with malnutrition risk, and malnutrition groups were independently associated with higher mortality rates. MSS group had the highest hazard ratio and the worst survival curve among the study groups. Measures to prevent both sarcopenia and malnutrition are needed to reduce adverse health outcomes such as mortality in hospitalized older individuals.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Chih-Yun Chang, Chia-Lin Lee, Wei-Ju Liu, Jun-Sing Wang
Summary: This study investigated the relationship between adherence to the Mediterranean diet and all-cause and cardiovascular mortality in heart failure patients. The findings suggest that adherence to the Mediterranean diet is not associated with a lower risk of all-cause and cardiovascular mortality. A lower intake of red/processed meat was found to be associated with a higher risk of mortality, which requires further investigation.
Article
Cardiac & Cardiovascular Systems
Dineo Mpanya, Turgay Celik, Eric Klug, Hopewell Ntsinjana
Summary: This study aims to demonstrate the utility of machine learning in predicting all-cause mortality in heart failure patients in LMIC. Six supervised machine learning algorithms were trained using data from 500 consecutive heart failure patients. The support vector machines (SVM) algorithm performed the best and successfully predicted all-cause mortality with modest accuracy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nils Bomer, Mario G. Pavez-Giani, Frederik E. Deiman, Annet N. Linders, Martijn F. Hoes, Christiane L. J. Baierl, Silke U. Oberdorf-Maass, Rudolf A. de Boer, Herman H. W. Sillje, Eugene Berezikov, Warner S. Simonides, B. Daan Westenbrink, Peter van der Meer
Summary: In this study, we identified DIO2 as a member of the fetal-gene-program and a key regulator of mitochondrial function in human cardiomyocytes. Silencing DIO2 resulted in increased reactive oxygen species, impaired activation of the mitochondrial unfolded protein response, severely impaired mitochondrial respiration and reduced cellular viability. Our results suggest a key position of human DIO2 as a regulator of mitochondrial function in human cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Syed Baseeruddin Alvi, Divya Sridharan, Shridhar K. Sanghvi, Muhamad Mergaye, Uzair Ahmed, Sarah K. Mikula, Harpreet Singh, Mahmood Khan
Summary: This study demonstrates the potential of polydopamine nanoparticles (PDA-NPs) as a bioactive agent to enhance contractility and beat propagation of cardiomyocytes. PDA-NPs improve mitochondrial bioenergetics and have cardiotonic effects on the heart. In addition, they can modulate the genetic expression of cardiomyocytes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Joan Weston, Andrew L. Clark
Summary: This prospective cohort study aimed to compare the short-term prognostic value of 9 commonly used malnutrition tools in patients with chronic heart failure. The study found that most tools were independently associated with worse morbidity and mortality in patients with CHF, with serum albumin providing comparable prognostic information to simple or multidimensional malnutrition tools.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Ting-Yu Chou, Wei-Ju Liu, Chia-Lin Lee, Jun-Sing Wang
Summary: This study investigated the association of adherence to the DASH diet with all-cause mortality in patients with heart failure. The findings suggest that a higher DASH score is not associated with all-cause mortality in patients with heart failure.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Giosafat Spitaleri, Elisabet Zamora, German Cediel, Pau Codina, Evelyn Santiago-Vacas, Mar Domingo, Josep Lupon, Javier Santesmases, Crisanto Diez-Quevedo, Maria Isabel Troya, Maria Boldo, Salvador Altimir, Nuria Alonso, Beatriz Gonzalez, Antoni Bayes-Genis
Summary: Differences in long-term all-cause and cardiovascular mortality in heart failure outpatients were assessed based on the etiology of heart failure. Dilated cardiomyopathy had the lowest risk of all-cause death, while drug-induced cardiomyopathy had the highest risk. However, almost all etiologies had a lower risk of cardiovascular death than ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Yoshikuni Obata, Naoya Kakutani, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shingo Takada, Taisuke Ono, Takeshi Sota, Yoshiharu Kinugasa, Masashige Takahashi, Hisashi Matsuo, Ryuichi Matsukawa, Ichiro Yoshida, Isao Yokota, Kazuhiro Yamamoto, Miyuki Tsuchihashi-Makaya
Summary: Inadequate calorie intake is associated with worse clinical outcomes in stable outpatients with chronic HF, including higher risks of all-cause death and HF-related hospitalization. Further studies with direct measurements of dietary calorie intake and total energy expenditure are needed to clarify this relationship.
Article
Cardiac & Cardiovascular Systems
Christoph Ahlgrim, Florian Seiler, Philipp Birkner, Simon Schoechlin, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser
Summary: This study found that PV expansion is a relevant predictor of long-term all-cause mortality in compensated CHF patients. PV expansion can be identified through hematocrit values, and it is unclear whether it can be targeted with diuretic therapy.
CLINICAL CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Haibo Gao, Wei Li, Yifei Wang, Xuemei Zhao, Liuxin Li, Hongwei Zheng, Boheng Zhang, Shouling Wu, Qi Zhang
Summary: Weight reduction before and after the diagnosis of heart failure is an independent risk factor for increased all-cause mortality.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
A. Driscoll, H. Romaniuk, D. Dinh, J. Amerena, A. Brennan, D. L. Hare, D. Kaye, J. Lefkovits, S. Lockwood, C. Neil, D. Prior, C. M. Reid, L. Orellana
Summary: This study developed a risk prediction model (AUS-HF model) using routinely collected measures at point of care to predict 30-day all-cause re-hospitalisation or death among patients admitted with acute heart failure. The model demonstrated moderate accuracy and good calibration, making it a valuable tool for informing follow-up decisions after hospitalisation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jack B. Lopuszynski, Alicia J. Downing, Colleen M. Finley, Maliha Zahid
Summary: An observational study of HFpEF patients in three hospitals revealed multiple independent predictors of all-cause mortality, including age, serum albumin level, NT-proBNP concentration, and E/e' value. These factors can be easily applied in a clinical setting to assess mortality risk in HFpEF patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Frits A. Boom, Paul P. H. Le Brun, Judith M. Ris, Tjitske Veenbaas, Daan Touw
Summary: The systematic and science-based reduction of non-sterility risks can be achieved by using a checklist and template for risk assessment and control. The study highlights the importance of yearly audits in reducing the risk of non-sterility. Microbiological controls are crucial for ensuring product quality, but may not be as useful in assessing the risk of non-sterility.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Cardiac & Cardiovascular Systems
Eva M. Boorsma, Jozine M. Ter Maaten, Kevin Damman, Bart J. van Essen, Faiez Zannad, Dirk J. van Veldhuisen, Nilesh J. Samani, Kenneth Dickstein, Marco Metra, Gerasimos Filippatos, Chim C. Lang, Leong Ng, Stefan D. Anker, John G. Cleland, Pierpaolo Pellicori, Ron T. Gansevoort, Hiddo J. L. Heerspink, Adriaan A. Voors, Johanna E. Emmens
Summary: Albuminuria is common in patients with heart failure and is associated with clinical symptoms and biomarkers of congestion. It is also related to the severity and prognosis of heart failure.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Milton Packer, John G. F. Cleland
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Medical Laboratory Technology
Sjanene Marfil, Anne-Grete Maertson, Marlous Toren-Wielema, Coretta Leer-Buter, Elisabeth. H. Scholvinck, Jan-Willem C. Alffenaar, Daan. J. Touw, Marieke G. G. Sturkenboom
Summary: Ganciclovir therapeutic drug monitoring (TDM) in 12 treatment episodes showed significant variability in both trough concentration and area under the 24-hour concentration-time curve (AUC24), both within and between individuals. Subtherapeutic concentrations were found in 30% of the treatment episodes, despite adequate valganciclovir dosing. However, a decrease in viral load was still observed. These findings highlight the importance of evaluating target concentrations and assessing the applicability of ganciclovir TDM in children.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, John G. F. Cleland, Nicolas Girerd, Pierpaolo Pellicori, Mark R. Hazebroek, Job Verdonschot, Timothy J. Collier, Johannes Petutschnigg, Andrew L. Clark, Jan A. Staessen, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: The study investigated the effect of spironolactone on QRS duration in patients with stage B HFpEF. Spironolactone was found to significantly reduce the QRS duration after 9 months of treatment, indicating improved myocardial electrical activation. This effect was not associated with changes in LV mass or volume.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
George Markousis-Mavrogenis, Waldemar B. Minich, Ali A. Al-Mubarak, Stefan D. Anker, John G. F. Cleland, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Nilesh J. Samani, Faiez Zannad, Marco Metra, Petra Seemann, Antonia Hoeg, Patricio Lopez, Dirk J. van Veldhuisen, Rudolf A. de Boer, Adriaan A. Voors, Peter van der Meer, Lutz Schomburg, Nils Bomer
Summary: The study examined the importance of autoantibodies against adrenergic/muscarinic receptors in heart failure. The findings suggest that anti-beta 1 AABs are independently associated with HF rehospitalization, while other AABs are mainly related to comorbidities and medication use.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, Timothy Collier, Anne Pizard, Jens Bjoerkman, Javed Butler, Andrew Clark, John G. Cleland, Christian Delles, Javier Diez, Arantxa Gonzalez, Mark Hazebroek, Jennifer Ho, Anne-Cecile Huby, Shih-Jen Hwang, Roberto Latini, Beatrice Mariottoni, Alexandre Mebazaa, Pierpaolo Pellicori, Naveed Sattar, Peter Sever, Jan A. Staessen, Job Verdonschot, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: This study identified protein biomarkers associated with new-onset heart failure in three independent cohorts. The inclusion of these biomarkers in addition to clinical risk factors improved the prediction of heart failure risk. The B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide were found to be particularly relevant in predicting heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Infectious Diseases
D. Abraham Van den Born, Anne-Grete Martson, Anette Veringa, Nieko C. Punt, Tjip S. Van der Werf, Jan-Willem C. Alffenaar, Marieke G. G. Sturkenboom, Daan J. Touw
Summary: This study investigated the effect of inflammation on the metabolism of voriconazole and found that C-reactive protein (CRP) was the only significant covariate. The final pharmacokinetic model, which included CRP as a covariate, can be applied in clinical care.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Pien Rawee, Daan Kremer, Ilja M. M. Nolte, Henri G. D. Leuvenink, Daan J. J. Touw, Martin H. H. De Borst, Stephan J. L. Bakker, Mark R. R. Hanudel, Michele F. F. Eisenga
Summary: Heavy metal exposure has been linked to an increased risk of chronic kidney disease (CKD) and its progression. Iron deficiency, another common problem in CKD patients, is hypothesized to play a crucial role in the damaging effects of heavy metal exposure. Iron receptors upregulated by iron deficiency may lead to increased uptake of heavy metals in the intestine, while iron deficiency may also contribute to the retention of heavy metals in the kidney. Iron supplementation might be a strategy to combat these detrimental processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Koen W. Streng, Hans L. Hillege, Jozine M. ter Maaten, Dirk J. van Veldhuisen, Kenneth Dickstein, Nilesh J. Samani, Leong L. Ng, Marco Metra, Gerasimos S. Filippatos, Piotr Ponikowski, Faiez Zannad, Stefan D. Anker, Peter van der Meer, Chim C. Lang, Adriaan A. Voors, Kevin Damman
Summary: A study found that the causes of renal dysfunction differ between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). The study measured various urinary markers reflecting different nephron segments in heart failure patients and found that HFpEF patients showed more evidence of tubular damage and/or dysfunction, especially when glomerular function was preserved.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Javed Khan, Fraser J. Graham, Gabriele Masini, Antonio Iaconelli, Jocelyn M. Friday, Chim C. Lang, Pierpaolo Pellicori
Summary: This review discusses strategies for early identification and objective management of congestion in heart failure patients. Using ultrasound to combine echocardiography with assessment of great veins, lungs, and kidneys can aid in recognizing and quantifying congestion, which is still difficult and subjective to manage.
CURRENT CARDIOLOGY REPORTS
(2023)
Letter
Cardiac & Cardiovascular Systems
Vincenzo C. C. Leo, Syed Kazmi, Jack Brownrigg, Marzieh Araghi, Harpreet S. S. Sarna, Pierpaolo Pellicori, Joe Cuthbert, John G. F. Cleland, Andrew L. L. Clark
Article
Infectious Diseases
Esther M. Hollander, Eline L. van Tuinen, Elisabeth H. Scholvinck, Klasien A. Bergman, Arno R. Bourgonje, Valentina Gracchi, Martin C. J. Kneyber, Daan J. Touw, Paola Mian
Summary: Although aminoglycosides are commonly used in neonates and children, the effectiveness of current dosing regimens in achieving target concentrations is unclear. This single-center cohort study evaluated the target attainment of gentamicin in neonates and children. The study found that a significant percentage of patients did not reach the target trough and peak concentrations, indicating a need for additional parameters to improve target attainment.
Letter
Respiratory System
Anne M. Akkerman-Nijland, Bart L. Rottier, Joanne Holstein, Rik L. J. Winter, Daniel J. Touw, Onno W. Akkerman, Gerard H. Koppelman
Letter
Cardiac & Cardiovascular Systems
Alberto Guarnaccia, Gianfranco Sinagra, John G. F. Cleland