Article
Environmental Sciences
Cassidy Clarity, Jessica Trowbridge, Roy Gerona, Katherine Ona, Michael McMaster, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello-Frosch
Summary: The study found that female firefighters are more likely to be affected by chemical exposures compared to office workers, with a significant positive association between chemical exposures and telomere length. These results suggest potential mechanisms by which chemicals may impact carcinogenesis and other adverse health outcomes.
ENVIRONMENTAL HEALTH
(2021)
Article
Engineering, Environmental
Jessica Trowbridge, Roy Gerona, Michael McMaster, Katherine Ona, Cassidy Clarity, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello-Frosch
Summary: This study investigated the exposure to flame retardants among female firefighters and office workers, finding a specific FR compound associated with thyroid hormone levels in firefighters. Additionally, it revealed that intermediate body mass index and a college education were associated with higher FR levels.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Anna Birukov, Louise Bjorkholt Andersen, Marianne Skovsager Andersen, Julie H. Nielsen, Flemming Nielsen, Henriette Boye Kyhl, Jan Stener Jorgensen, Philippe Grandjean, Ralf Dechend, Tina Kold Jensen
Summary: The study found that exposure to PFAS in early pregnancy was associated with increased systolic and diastolic blood pressure in pregnant women, but no clear associations were found with preeclampsia or gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Paul E. Rosenfeld, Kenneth R. Spaeth, Linda L. Remy, Vera Byers, Stuart A. Muerth, Ryan C. Hallman, Jasmine Summers-Evans, Sofia Barker
Summary: Firefighters are at risk of exposure to PFASs, especially from AFFF. They have elevated serum levels of long-chain PFASs. Due to the persistence and bioaccumulation of PFAS chemicals, firefighters experience cumulative effects from AFFF exposure throughout their careers. Studies have shown an elevated risk of various cancers among firefighters due to PFAS exposure, necessitating further research.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Sheng-Han Lee, Wei-Chen Tseng, Zhi-Yi Du, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Guang-Wen Lien, Hao-Jan Liang, Hui-Ju Wen, Yue-Leon Guo, Pau-Chung Chen, Ching-Yu Lin
Summary: This study evaluated the impact of PFASs exposure on lipid changes in children, finding that children exposed to different levels of specific PFASs exhibited different lipid patterns, potentially related to hepatic lipid metabolism, metabolic disorders, and PFASs-membrane interactions.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jiaqi Yang, Hexing Wang, Hongyi Du, Hongji Fang, Minghui Han, Yuanping Wang, Linji Xu, Shuping Liu, Jianping Yi, Yue Chen, Qingwu Jiang, Gengsheng He
Summary: This study found that exposure to PFASs can disrupt estrogen homeostasis in pregnant women, with different PFASs showing varying effects on estrogen levels at different stages of pregnancy.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Endocrinology & Metabolism
Guoqi Yu, Fei Luo, Min Nian, Shuman Li, Bin Liu, Liping Feng, Jun Zhang
Summary: This study revealed that prenatal exposure to PFHxS was associated with an increased BDNF level in the umbilical blood, especially in male fetuses.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Katarina Rihackova, Ales Pindur, Klara Komprdova, Nina Palesova, Jiri Kohoutek, Petr Senk, Jana Navratilova, Lenka Andryskova, Ludmila Sebejova, Richard Hulek, Mazen Ismael, Pavel Cupr
Summary: The CELSPAC-FIREexpo biomonitoring study investigates the long-term effects of chemical exposure on firefighters' wellness and fitness. The study found that firefighters had significantly higher PFAS levels compared to the control group, and these levels were associated with their length of firefighting career, age, blood donation, and population size.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yu-Hsuan Shih, Annelise J. Blomberg, Louise Helskov Jorgensen, Pal Weihe, Philippe Grandjean
Summary: This study found significant associations between PFAS concentrations at 18 months, 5 years, and 9 years, and levels of leptin, leptin receptor, and resistin in children at age 9. There was limited evidence of a modification effect of sex on serum PFAS concentrations. The Bayesian kernel machine regression results consistently suggested significant effects of PFAS mixtures at 18 months, 5 years, and 9 years on adipokine concentrations at 9 years.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Clara Amalie Gade Timmermann, Marianne Skovsager Andersen, Esben Budtz-Jorgensen, Henriette Boye, Flemming Nielsen, Richard Christian Jensen, Signe Bruun, Steffen Husby, Philippe Grandjean, Tina Kold Jensen
Summary: This study found a positive association between increased serum-PFAS concentrations during early pregnancy and an increased risk of terminating breastfeeding after childbirth. However, there was no correlation between serum-PFAS concentrations and serum-prolactin concentrations. These findings are of public health importance given the global exposures to PFAS and the long-term health consequences they may have on breastfeeding ability.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Hui Wang, Fei Luo, Yu Zhang, Xuchen Yang, Shanyu Zhang, Jun Zhang, Ying Tian, Liqiang Zheng
Summary: This study aimed to investigate the association between prenatal exposure to Perfluoroalkyl substances (PFAS) and intelligence quotient (IQ) in children. The results showed no significant association between nine individual PFAS concentrations and child IQ, regardless of continuous or tertile analysis. Although there were inverse associations between certain individual PFAS and IQ, overall, PFAS mixture during early pregnancy was not associated with child IQ. Further research is needed to confirm or refute these results in other populations and to elucidate the potential neurotoxicology of PFAS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Yuqian Li, Xinyan Lu, Nanyang Yu, Aijing Li, Taifeng Zhuang, Letian Du, Song Tang, Wei Shi, Hongxia Yu, Maoyong Song, Si Wei
Summary: This study evaluated the associations between metabolites in maternal and cord serum and internal exposure to common PFASs. It identified multiple metabolites and pathways linked to PFAS exposure in pregnant women and fetuses, indicating the potential application of metabolome-wide association studies in studying toxic mechanisms of PFASs. Additional research is required to confirm causation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Hui Wang, Tai Ren, Na Zhang, Weiping Xia, Mi Xiang, Jinjun Ran, Jun Zhang
Summary: This study investigated the association between exposure to poly- and perfluoroalkyl substances (PFASs) during pregnancy and postpartum depression (PPD). The results showed that exposure to PFASs in early pregnancy was not associated with PPD at 6 weeks postpartum.
Article
Environmental Sciences
Johanna Inhyang Kim, Bung-Nyun Kim, Young Ah Lee, Choong Ho Shin, Yun-Chul Hong, Lise Dalgaard Dossing, Gustav Hildebrandt, Youn-Hee Lim
Summary: This study examined the association between early-childhood exposure to perfluoroalkyl substances (PFAS) and attention-deficit/hyperactivity disorder (ADHD) symptoms. Serum levels of six PFAS were measured in 521 children at the ages of 2 and 4 years, and the ADHD Rating Scale IV (ARS) was used to measure ADHD traits at 8 years of age. The study found that exposure to PFAS was associated with ADHD symptoms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Zhenzhen Xie, Jing Tan, Guanghong Fang, Honglei Ji, Maohua Miao, Yuan Tian, Hui Hu, Wencheng Cao, Hong Liang, Wei Yuan
Summary: Findings from this study suggest that prenatal exposure to multiple PFASs may have some effects on neurobehavioral development in children, but there is no clear evidence of negative effects. However, the modest associations found still suggest the potential developmental neurotoxicity of prenatal PFAS exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Kathryn M. Rodgers, Adrian Covaci, Giulia Poma, Kristin Knox, Joseph G. Allen, Jose Cedeno-Laurent, Ruthann A. Rudel, Robin E. Dodson
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2020)
Article
Multidisciplinary Sciences
Vincent Bessonneau, Roy R. Gerona, Jessica Trowbridge, Rachel Grashow, Thomas Lin, Heather Buren, Rachel Morello-Frosch, Ruthann A. Rudel
Summary: This study used Gaussian graphical models to explore associations between environmental chemicals and endogenous molecules in a cohort of California women firefighters and office workers, revealing various exposure-metabolite associations and generating new hypotheses relevant to disease causation. Additionally, findings from this study were confirmed through analysis of data from the National Health and Nutrition Examination Survey, showing a novel approach to discovering links between chemical exposures and biological processes with potential implications for disease development.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Cassidy Clarity, Jessica Trowbridge, Roy Gerona, Katherine Ona, Michael McMaster, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello-Frosch
Summary: The study found that female firefighters are more likely to be affected by chemical exposures compared to office workers, with a significant positive association between chemical exposures and telomere length. These results suggest potential mechanisms by which chemicals may impact carcinogenesis and other adverse health outcomes.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Arthur David, Jade Chaker, Elliott J. Price, Vincent Bessonneau, Andrew J. Chetwynd, Chiara M. Vitale, Jana Klanova, Douglas I. Walker, Jean-Philippe Antignac, Robert Barouki, Gary W. Miller
Summary: The use of high-resolution mass spectrometry to characterize the human internal chemical exposome provides unprecedented precision in investigating the environmental etiology of chronic diseases. However, improvements are needed in the flexibility, sensitivity, and automation of analytical techniques. Additionally, challenges exist in assessing the dynamic nature of the internal chemical exposome, establishing international collaboration, high level networking, and sustainable research infrastructure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Jessica Trowbridge, Roy Gerona, Michael McMaster, Katherine Ona, Cassidy Clarity, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello-Frosch
Summary: This study investigated the exposure to flame retardants among female firefighters and office workers, finding a specific FR compound associated with thyroid hormone levels in firefighters. Additionally, it revealed that intermediate body mass index and a college education were associated with higher FR levels.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanrong Su, Julia Santucci-Pereira, Nhi M. Dang, Joice Kanefsky, Vishnuprabha Rahulkannan, Meardey Hillegass, Shalina Joshi, Hafsa Gurdogan, Zhen Chen, Vincent Bessonneau, Ruthann Rudel, Jennifer Ser-Dolansky, Sallie S. Schneider, Jose Russo
Summary: Pubertal exposure to EDCs, such as BBP, PFOA, and ZAL, can have adverse effects on the endocrine system and mammary gland development in rats. The combination of PFOA and ZAL, in particular, has the most significant impact and may increase the risk of mammary tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Environmental Sciences
Ruthann A. Rudel, Bethsaida Cardona, Alexandre Borrel, Jennifer E. Kay
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Multidisciplinary Sciences
Elliott J. Price, Chiara M. Vitale, Gary W. Miller, Arthur David, Robert Barouki, Karine Audouze, Douglas I. Walker, Jean-Philippe Antignac, Xavier Coumoul, Vincent Bessonneau, Jana Klanova
Summary: The exposome concept encourages consideration of non-genetic factors that influence an individual's health, but different interpretations of the concept have led to confusion. A reattribution of the exposome and introduction of the term "functional exposomics" can provide a more integrable dataset for multiomics and systems biology research.
Article
Engineering, Environmental
Kristin E. Knox, Robin E. Dodson, Ruthann A. Rudel, Claudia Polsky, Megan R. Schwarzman
Summary: Consumer products serve as significant sources of harmful chemical exposure, but lack transparency in ingredient disclosure due to legal gaps. The California Air Resources Board (CARB) holds a unique dataset that identifies the impact of volatile organic chemicals (VOCs) from consumer products on smog formation, offering a partial solution. By analyzing CARB data, we highlighted the presence of chemicals regulated under Prop 65 and emphasized the need for reformulating or redesigning product categories to reduce human exposure and health risks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Jessica Trowbridge, Dimitri Abrahamsson, Garret D. Bland, Ting Jiang, Miaomiao Wang, June-Soo Park, Rachel Morello-Frosch, Marina Sirota, Harim Lee, Dana E. Goin, Marya G. Zlatnik, Tracey J. Woodruff
Summary: In this study, non-targeted analysis methods were used to quantify and investigate levels of nine chemicals in maternal and cord blood. The results showed that certain chemical exposures were associated with an increased risk of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Public, Environmental & Occupational Health
Jennifer E. Kay, Bethsaida Cardona, Ruthann A. Rudel, Laura N. Vandenberg, Ana M. Soto, Sofie Christiansen, Linda S. Birnbaum, Suzanne E. Fenton
Summary: Population studies have shown worrying trends in breast development, breastfeeding difficulties, and increased breast cancer rates in young women. Chemical exposures have been linked to these outcomes, with endocrine-disrupting chemicals often disrupting hormonal regulation. Current toxicological approaches are inadequate in detecting these effects, hindering our ability to identify harmful exposures to the breast and prevent them.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Meeting Abstract
Oncology
Vanessa Y. De la Rosa, Erik Lehnert, Marko Milanovic, Chris Vulpe, Ruthann A. Rudel
CANCER PREVENTION RESEARCH
(2020)
Meeting Abstract
Oncology
Jessica Helm, Andrea Hindman, Ruthann A. Rudel
CANCER PREVENTION RESEARCH
(2020)