Article
Biochemistry & Molecular Biology
Pablo Balino, Ricard Romero-Cano, Maria Muriach
Summary: Ethanol abuse and metabolic syndrome both have negative impacts on the central nervous system, but their combined effects have not been fully elucidated. This study aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Ethanol intake modulated the insulin response and impaired the oxidative status in the ob mouse brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Zhenxian Jia, Hongling Zhang, Ling Yu, Feng Qiu, Yiqing Lv, Jing Guan, Huiqing Gang, Jingwen Zuo, Tongzhang Zheng, Hongxiu Liu, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: This prospective cohort study found an association between prenatal lead exposure and increased risk of cognitive developmental delay (CDD) in children with high genetic risk. These findings suggest that prenatal lead exposure and genetic background may jointly contribute to an increased risk of CDD in children, indicating the possibility for an integrated strategy to assess CDD risk and improve children's cognitive ability.
Article
Engineering, Environmental
Joao Pedro Justiniano de Oliveira, Fernanda Neves Estrela, Aline Sueli de Lima Rodrigues, Abraao Tiago Batista Guimaraes, Thiago Lopes Rocha, Guilherme Malafaia
Summary: The study found that exposure to polylactic acid (PLA) biopolymers may lead to behavioral and biochemical changes in Danio rerio larvae, as well as their accumulation in the larvae. The results suggest that PLA biopolymers can affect animals' locomotor and exploration activities, leading to anxiety-like behavior.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Behavioral Sciences
Ngala Elvis Mbiydzenyuy, Sian Megan Joanna Hemmings, Lihle Qulu
Summary: This review article discusses the mechanisms underlying the influence of prenatal maternal stress on fetal neuroendocrine signaling, as well as the potential risks for aggressive behavior in offspring. It covers topics such as the maternal-placental-fetal interface, disruptions in the intrauterine environment, and epigenetic modifications of genes involved in aggressive behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biology
Suresh Kumar, Karishma Seem, Trilochan Mohapatra
Summary: Plants need to modulate their responses to drought stress in order to protect themselves. In this investigation, rice plants were subjected to drought stress and the effects were observed in subsequent generations. These findings are important for developing stress-tolerant crops and ensuring global food security.
Article
Plant Sciences
Runqiang Liu, Jingchong Li, Lei Zhang, Ta Feng, Zhiyong Zhang, Baohong Zhang
Summary: Difenoconazole exposure inhibits plant growth by reducing root and shoot development, decreasing chlorophyll biosynthesis, and inducing oxidative stress, ultimately leading to impaired wheat plant growth and development.
Review
Cell Biology
Dan C. Li, Elizabeth A. Hinton, Shannon L. Gourley
Summary: Meaningful social interactions are crucial for human well-being, and experiencing social isolation during adolescence can disrupt neurobiological processes necessary for adaptive adult behaviors. Research on rodents suggests that isolation during adolescence can lead to alterations in social, anxiety-like, cognitive, and decision-making behaviors in adulthood. Further investigation into the neurobiological mechanisms underlying these effects is crucial, especially in light of the recent increase in social deprivation due to the COVID-19 pandemic.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuta Komoike, Masato Matsuoka
Summary: This study provides direct experimental evidence of the adverse developmental effects of low-level lead (Pb) exposure, using a zebrafish model. The findings suggest that exposure to trace amounts of Pb can result in premature hatching, reduced body length, edema, and inflation defects in zebrafish larvae. Furthermore, the study reveals a transient increase in oxidative and endoplasmic reticulum stresses in Pb-exposed embryos. The results contribute to a better understanding of the total health effects of Pb exposure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vishnu N. Thakare, Sameer H. Lakade, Moreshwar P. Mahajan, Yogesh P. Kulkarni, Valmik D. Dhakane, Minal T. Harde, Bhoomika M. Patel
Summary: The amelioration of oxidative stress and enhancement of mono-amines in the brain are important mechanisms of protocatechuic acid (PCA) as an antidepressant. This study aimed to explore the potential antidepressant mechanisms of PCA in mice subjected to chronic unpredictable mild stress (CUMS). The results showed that PCA administration improved behavioral alterations, restored BDNF levels, and modulated oxidative stress response, cytokines systems, and antioxidant defense system in the mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Arushi Sandhu, Kajal Rawat, Vipasha Gautam, Antika Sharma, Anil Kumar, Lekha Saha
Summary: This study investigated the pharmacological effects of ibudilast in a prenatal valproic acid (VPA) model of autism spectrum disorder (ASD) in Wistar rats. The results showed that ibudilast significantly improved social interaction, spatial learning, anxiety, hyperactivity, and decreased nociceptive threshold, as well as reduced oxidative stress, inflammation, glial cell activation, and neuronal damage in the brain. In conclusion, ibudilast treatment restored crucial ASD-related behavioral abnormalities, potentially through neuroprotection.
Article
Environmental Sciences
Mariana F. Martins, Patricia G. Costa, Amanda da S. Guerreiro, Adalto Bianchini
Summary: Coastal elasmobranchs are vulnerable to chemical contaminants due to their life history characteristics and trophic positions. The effects of prenatal exposure to contaminants in embryos of the critically endangered Brazilian guitarfish were investigated. The study found that prenatal exposure to contaminants can impact the redox status in embryos and lead to oxidative damage.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Irene C. Mammarella, Sara Caviola, Serena Rossi, Elisabetta Patron, Daniela Palomba
Summary: The study examines the impact of stress levels on students' state mathematics anxiety while solving calculation problems. A computerized mathematical task was given to 165 fifth-graders in positive, negative, and control conditions. The negative condition was associated with negative emotional states, worries, and perceived lack of competence. The stress induced in the negative condition led to increased skin conductance and cardiac vagal withdrawal. The study emphasizes the importance of students' interpretation of mathematics-related experiences on their emotional, cognitive, and psychophysiological responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Toxicology
Rachael E. Rogers, Shuyi Chai, Andrew J. Pask, Deidre M. Mattiske
Summary: Over the past 50 years, significant decreases in fertility have been observed, with female conception rates dropping by 44% and male sperm counts decreasing by over 50%. This decrease can be attributed to increasing exposure to endocrine disrupting chemicals (EDCs), such as Diethylstilbestrol (DES). Women exposed to DES in utero experienced higher rates of infertility, pregnancy complications, and reproductive cancers, with evidence suggesting these effects may persist in future generations.
TOXICOLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Fanny-Linn H. Kraft, Ondi L. Crino, Katherine L. Buchanan
Summary: The study revealed that the paternal exposure to CORT treatment has an impact on the endocrine function of zebra finch offspring, but not on their body mass, size, or body condition. There was a correlation found in body mass and tarsus length between offspring and parent.
HORMONES AND BEHAVIOR
(2021)
Review
Biology
Vina D. L. Putra, Kristopher A. Kilian, Melissa L. Knothe Tate
Summary: This review discusses the biomechanical, biophysical, and biochemical factors that regulate cytoskeletal remodeling during tissue neogenesis for targeted tissue regeneration. It highlights the effects of cytoskeletal remodeling on stem cell mechanoadaptation and lineage commitment. The review also summarizes findings on cytoskeletal remodeling in tissue neogenesis and its relevance in guiding tissue regeneration, as well as methods for visualizing and measuring cytoskeletal remodeling and its effects on cell mechanics.
COMMUNICATIONS BIOLOGY
(2023)
Review
Genetics & Heredity
Garima Singh, Vikrant Singh, Marissa Sobolewski, Deborah A. Cory-Slechta, Jay S. Schneider
FRONTIERS IN GENETICS
(2018)
Article
Toxicology
Carolyn Klocke, Valeriia Sherina, Uschi M. Graham, Jakob Gunderson, Joshua L. Allen, Marissa Sobolewski, Jason L. Blum, Judith T. Zelikoff, Deborah A. Cory-Slechta
INHALATION TOXICOLOGY
(2018)
Article
Toxicology
Keith Morris-Schaffer, Alyssa K. Merrill, Candace Wong, Katrina Jew, Marissa Sobolewski, Deborah A. Cory-Slechta
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Article
Toxicology
Keith Morris-Schaffer, Alyssa Merrill, Katrina Jew, Candace Wong, Katherine Conrad, Katherine Harvey, Elena Marvin, Marissa Sobolewski, Gunter Oberdorster, Alison Elder, Deborah A. Cory-Slechta
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Article
Pathology
Deborah A. Cory-Slechta, Marissa Sobolewski, Elena Marvin, Katherine Conrad, Alyssa Merrill, Tim Anderson, Brian P. Jackson, Gunter Oberdorster
TOXICOLOGIC PATHOLOGY
(2019)
Article
Neurosciences
Matthew D. Rand, Katherine Conrad, Elena Marvin, Katherine Harvey, Don Henderson, Rabi Tawil, Marissa Sobolewski, Deborah A. Cory-Slechta
Review
Environmental Sciences
Deborah A. Cory-Slechta, Marissa Sobolewski, Gunter Oberdorster
Article
Toxicology
Timothy Anderson, Alyssa K. Merrill, Matthew L. Eckard, Elena Marvin, Katherine Conrad, Kevin Welle, Gunter Oberdorster, Marissa Sobolewski, Deborah A. Cory-Slechta
Summary: This study found that prolonged low-dose inhalation of paraquat can result in its deposition in various brain regions, leading to olfactory impairment, which is a prodromal feature of Parkinson's disease.
TOXICOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Alyssa K. Merrill, Timothy Anderson, Katherine Conrad, Elena Marvin, Tamarra James-Todd, Deborah A. Cory-Slechta, Marissa Sobolewski
Summary: Exposure to multiple EDCs during pregnancy may exacerbate metabolic health issues for women in later life, as indicated by this pilot study.
Article
Toxicology
Marissa Sobolewski, Katherine Conrad, Elena Marvin, Matthew Eckard, Calla M. Goeke, Alyssa K. Merrill, Kevin Welle, Brian P. Jackson, Robert Gelein, David Chalupa, Gunter Oberdorster, Deborah A. Cory-Slechta
Summary: This study suggests that exposure to ambient ultrafine particulate matter, particularly when combined with sulfur dioxide, may lead to neurotoxic effects in mice. The findings also highlight the potential vulnerability of females to these exposures. Further research is needed to validate these results in humans and determine the need for regulation of iron in air pollution for public health protection.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Deborah A. Cory-Slechta, Alyssa Merrill, Marissa Sobolewski
Summary: Air pollution is a complex mixture that exposes individuals to a lifelong exposure of gases, particulate matter, and contaminants. Studies increasingly associate air pollution with neurodevelopmental disorders and neurodegenerative diseases, supported by animal models. The shared mechanisms of inflammation, oxidative stress, and brain metal dyshomeostasis across these diseases highlight the need for future research to identify responsible contaminants and protect public health.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Behavioral Sciences
M. L. Eckard, K. Welle, M. Sobolewski, D. A. Cory-Slechta
Summary: Many studies have shown that time-based interventions can reduce impulsive behavior in rodents, but few studies have directly examined how these interventions affect impulsive action, whether the effects of intervention differ by sex, and how these interventions affect neurochemistry in areas related to decision-making and reward. This study aimed to investigate the effects of a fixed-interval intervention on adult male and female mice, and found that the intervention increased striatal serotonergic analytes in both sexes, but had limited effects on the frontal cortex. In terms of impulsive action, the intervention reduced delay resets and no-wait resets in male mice, but not in female mice. Overall, these findings suggest that time-based interventions may effectively reduce impulsive action in rodents, particularly in males, and that these interventions operate through serotonergic augmentation in the striatum.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Editorial Material
Neurosciences
Deborah A. Cory-Slechta, Marissa Sobolewski
Summary: A growing body of epidemiological evidence suggests that there is a link between air pollution and various brain disorders, indicating that these adverse effects may be caused by shared mechanisms among these disorders. Consequently, more stringent and targeted regulatory policies may be necessary to safeguard public health.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Neurosciences
M. L. Eckard, E. Marvin, K. Conrad, G. Oberdorster, M. Sobolewski, D. A. Cory-Slechta
Summary: Air pollution is a major threat to neurological health, causing developmental and degenerative disorders. Iron, a common metal in air pollution, can affect children's behavior. Exposure to iron aerosols can replicate the behavioral effects of air pollution, and the presence of sulfur dioxide can modulate these effects.