Review
Clinical Neurology
Ambra Stefani, Birgit Hoegl
Summary: Nightmare disorder and isolated sleep paralysis are common REM sleep disorders that can cause distress. Nightmare disorder is related to emotion regulation and hyperarousal, with imagery rehearsal therapy being an effective nonmedication treatment; isolated sleep paralysis may result from REM atonia persisting into wakefulness, and therapy mainly involves avoiding predisposing factors.
Article
Clinical Neurology
Regis Lopez, Sofiene Chenini, Lucie Barateau, Anna-Laura Rassu, Elisa Evangelista, Beatriz Abril, Julien Fanielle, Nicolas Vitello, Isabelle Jaussent, Yves Dauvilliers
Summary: The study found that sleep-related head jerks are common in the general population, but their clinical significance is unclear. Severe symptomatic forms of SRHJ may be categorized as a new sleep-related movement disorder, distinct from RBD and periodic leg movements.
Article
Clinical Neurology
Jiri Nepozitek, Canan Unalp, Simona Dostalova, Petr Dusek, David Kemlink, Iva Prihodova, Veronika Ibarburu Lorenzo y Losada, Jiri Trnka, David Zogala, Ondrej Bezdicek, Tomas Nikolai, Pavla Perinova, Irene Dall'Antonia, Evzen Ruzicka, Karel Sonka
Summary: Abnormal motor manifestations in idiopathic REM sleep behavior disorder are closely related to disease severity, with violent motor events potentially indicating a higher risk of phenoconversion. Additionally, motor events are associated with nigrostriatal degeneration, suggesting their potential as predictive markers for disease progression.
Article
Clinical Neurology
Jirada Sringean, Ambra Stefani, Kathrin Marini, Melanie Bergmann, Mario Werkmann, Evi Holzknecht, Roberto De Marzi, Elisabeth Brandauer, Heinz Hackner, Atbin Djamshidian, Heike Stockner, Carles Gaig, Alex Iranzo, Joan Santamaria, Eduardo Tolosa, Klaus Seppi, Werner Poewe, Birgit Hoegl
Summary: The study found that early-stage PD patients had shorter REM sleep latency compared to advanced-stage PD patients. In advanced-stage PD patients, there was a higher incidence and intensity of rapid eye movement (REM) sleep without atonia (RWA), indicating that RWA worsens or becomes more intense with disease progression.
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Behavioral Sciences
Eva Schaeffer, Daniela Berg
Summary: REM sleep behavior disorder (RBD) is increasingly recognized as an important prodromal marker for neurodegenerative disorders like Parkinson's Disease. However, its clinical relevance and association with other prodromal markers are often underestimated in clinical practice. This case highlights the importance of recognizing RBD as a multisystem disease.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Jean-Baptiste Maranci, Milan Nigam, Luc Masset, Eva-Flore Msika, Marie Charlotte Vionnet, Charlotte Chaumereil, Marie Vidailhet, Smaranda Leu-Semenescu, Isabelle Arnulf
Summary: Growing evidence suggests that sleep plays a crucial role in regulating emotions. This study found an association between REM sleep and slow eye movements (SEMs), as well as dream emotions.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Carlos H. Schenck, Valerie Cochen de Cock, Simon J. G. Lewis, Naoko Tachibana, Clete Kushida, Raffaele Ferri
Summary: Updated guidelines for diagnosing RBD using vPSG procedures have been proposed, but a survey found that most health systems and medical communities in WSS member countries cannot implement the stricter guidelines, which would interfere with RBD diagnosis for many patients.
Article
Clinical Neurology
John C. Feemster, Tyler A. Steele, Kyle P. Palermo, Christy L. Ralston, Yumeng Tao, David A. Bauer, Liam Edgar, Sonia Rivera, Maxwell Walters-Smith, Thomas R. Gossard, Luke N. Teigen, Paul C. Timm, Jarrett W. Richardson, R. Robert Auger, Bhanuprakash Kolla, Stuart J. McCarter, Bradley F. Boeve, Michael H. Silber, Erik K. St Louis
Summary: This study comparatively analyzed REM sleep without atonia (RSWA) in chronic PTSD patients with and without dream enactment behavior (DEB), isolated RBD patients, and controls. The results show that PTSD patients have higher RSWA than controls, indicating abnormal REM sleep atonia control in chronic PTSD. More studies are needed to determine if neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients.
Article
Clinical Neurology
Elena Antelmi, Marco Filardi, Fabio Pizza, Stefano Vandi, Monica Moresco, Christian Franceschini, Michele Tinazzi, Raffaele Ferri, Giuseppe Plazzi
Summary: The study showed that stable treatment with sodium oxybate (SO) significantly improved RBD and RSWA in children with type 1 narcolepsy (NT1), indicating a direct role of the drug in modulating motor control during REM sleep.
Article
Clinical Neurology
Simon F. Eskildsen, Alex Iranzo, Morten G. Stokholm, Kristian Staer, Karen Ostergaard, Monica Serradell, Marit Otto, Kristina B. Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Moller, Carles Gaig, David J. Brooks, Eduardo Tolosa, Leif Ostergaard, Nicola Pavese
Summary: The study revealed that patients with isolated REM sleep behavior disorder exhibit significant cortical blood flow abnormalities and microvascular flow disturbances, which are associated with cognitive impairment. This suggests that pharmacological restoration of perivascular neurotransmitter levels may help preserve cognitive function in patients with this prodromal phenotype of parkinsonism.
Article
Clinical Neurology
Avi Gadoth, Michelle F. Devine, Sean J. Pittock, Andrew McKeon, W. Oliver Tobin, Thomas R. Gossard, Elena F. D. Cattaneo, Stuart J. McCarter, Erik K. St. Louis
Summary: This study aimed to describe prominent sleep disturbances and polysomnography findings in six patients with dipeptidyl-peptidase-like protein-6 (DPPX) autoimmunity syndrome. The patients exhibited significant gastrointestinal disturbances, a range of neuropsychiatric disturbances, and various sleep disorders including insomnia, obstructive sleep apnea, periodic leg movements, and REM sleep behavior disorder. Polysomnography indicated REM sleep-atonia loss and mixed features of wakefulness, NREM, and REM sleep. Immunotherapy led to neurological improvement and partial improvement in sleep disturbances in most patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Yi-Qun Wang, Wen-Ying Liu, Lei Li, Wei-Min Qu, Zhi-Li Huang
Summary: REM sleep is believed to be associated with dreaming, but the mechanisms of its generation are still unclear. Several models have been established to explain REM sleep. REM sleep behavior disorder and narcolepsy are two common disorders related to REM sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Madan Parajuli, Amy W. W. Amara, Mohamed Shaban
Summary: In this study, deep-learning based approaches were proposed to detect mild cognitive impairment in Parkinson's disease by analyzing sleep Electroencephalography signals. The proposed models achieved accurate prediction and identification of mild cognitive impairment, providing a promising computer-aided diagnostic tool for monitoring the progression of Parkinson's disease.
Article
Clinical Neurology
Jun-Sang Sunwoo, Kwang Su Cha, Jung-Ick Byun, Jin-Sun Jun, Tae-Joon Kim, Jung-Won Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Han-Joon Kim, Carlos H. Schenck, Ki-Young Jung
Summary: Abnormal EEG oscillations were found during NREM sleep in patients with iRBD in this study, with impaired temporal coupling between SOs and SSs possibly reflecting early neurodegenerative changes in iRBD.
Article
Clinical Neurology
Yu-Heng Zhong, Shan Jiang, Wei-Min Qu, Wen Zhang, Zhi-Li Huang, Chang-Rui Chen
Summary: This study found that the active component SSa of Radix Bupleuri can promote sleep by shortening sleep latency, increasing the duration of non-rapid eye movement sleep, and reducing locomotor activities. The mechanism of action may involve modulation of neuronal activity in the lateral hypothalamus.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mustafa Korkutata, Lokesh Agrawal, Michael Lazarus
Summary: Targeting adenosine A(2A) receptors has immense therapeutic potential due to their broad expression and involvement in various physiological functions. Allosteric modulators, which can selectively elicit a physiological response and reduce adverse effects, have shown promise in recent research on A(2A) receptor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Li, Meng-Qi Zhang, Xiao Sun, Wen-Ying Liu, Zhi-Li Huang, Yi-Qun Wang
Summary: Good sleep quality is essential for maintaining attention during wakefulness. Through experiments on mice, it was found that gamma-aminobutyric acid (GABA)ergic neurons in the dorsomedial hypothalamus (DMH) play an important role in regulating sleep-wake behaviors in response to changes in ambient temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yi-Chen Shen, Xiao Sun, Lei Li, Hu-Yunlong Zhang, Zhi-Li Huang, Yi-Qun Wang
Summary: Sleep and wakefulness are fundamental behavioral states that involve coordination between brain regions and multiple neurochemical systems, including neuropeptides. Neuropeptides, produced by neurons and neuroendocrine cells, can bind to specific receptors and regulate neuronal activities. Different neuropeptides play distinct roles in sleep-wake regulation, promoting sleep, inducing wakefulness, or having bidirectional effects. This review provides an overview of the distribution of neuropeptides in the brain and summarizes their roles in sleep-wake regulation, aiming to lay the foundation for further studies on the mechanisms underlying sleep-wake states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ya-Dong Li, Yan-Jia Luo, Ze-Ka Chen, Luis Quintanilla, Yoan Cherasse, Libo Zhang, Michael Lazarus, Zhi-Li Huang, Juan Song
Summary: Adult hippocampal neurogenesis is critical for memory and emotion processing. Researchers have found that chronic patterned optogenetic stimulation of SuM neurons in the hypothalamus promotes neurogenesis and modulates behavior. SuM neurons are highly responsive to environmental novelty.
NATURE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xixi Tao, Ronglu Du, Shumin Guo, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu, Yujun Shen
Summary: The PGE(2)-EP3 axis plays a protective role in interscapular BAT development by stabilizing WTAP/Zfp410 signaling.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Wei-Wei Bao, Shan Jiang, Wei-Min Qu, Wen-Xian Li, Chang-Hong Miao, Zhi-Li Huang
Summary: This review summarized the current knowledge about the cell subtypes and neural circuits that control wakefulness, REM sleep, non-REM sleep, and GA, and discussed their interactions as well as unresolved questions and challenges in this field.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Zhao-yi Chen, Yao-lian Yang, Mai Li, Lu Gao, Wei-min Qu, Zhi-li Huang, Xiang-shan Yuan
Summary: The cholinergic neurons in the nucleus basalis of Meynert (NBM) play a crucial role in cognition and are associated with various neurological disorders. This study used a transgenic mouse model and tracing techniques to investigate the neural connectivity of NBM cholinergic neurons. The results revealed specific inputs from the caudate putamen and the posterior limb of the anterior commissure, as well as widespread axon projections to the cortex mantle. Interestingly, while NBM cholinergic neurons received input projections from certain regions, they sparsely sent axon projections back to these areas. Furthermore, specific cortical regions received abundant inputs from the NBM but sent few outputs back. These findings provide important insights into the connectivity and function of cholinergic neurons in the NBM.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Tadaaki Nishioka, Suthinee Attachaipanich, Kosuke Hamaguchi, Michael Lazarus, Alban de Kerchove d'Exaerde, Tom Macpherson, Takatoshi Hikida
Summary: Learned associations between environmental cues and outcomes play a crucial role in behavioral control, and D2-MSNs in the NAc are involved in inhibiting inappropriate responses. Error-signaling by NAc D2-MSNs contributes to the ability to use environmental cues to inhibit inappropriate behavior.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Han Guo, Jian-Bo Jiang, Wei Xu, Mu-Tian Zhang, Hui Chen, Huan-Ying Shi, Lu Wang, Miao He, Michael Lazarus, Shan-Qun Li, Zhi-Li Huang, Wei-Min Qu
Summary: In this study, the authors found that neurons expressing calretinin in the parasubthalamic nucleus play a key role in the induction and maintenance of wakefulness associated with exploration. They demonstrate that these neurons regulate wakefulness by innervating the ventral tegmental area. These findings provide new insights into the neural circuits regulating wakefulness.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Wei-Xiang Ma, Lei Li, Ling-Xi Kong, Hui Zhang, Ping-Chuan Yuan, Zhi-Li Huang, Yi-Qun Wang
Summary: This study investigates the monosynaptic inputs to glutamatergic neurons in the lateral periaqueductal gray (LPAG), which is involved in social responses, pain, and offensive and defensive behaviors. Using retrograde tracing systems and immunofluorescence analysis, the study reveals that 59 nuclei project monosynaptic inputs to LPAG glutamatergic neurons, with the hypothalamus being the most densely connected. Furthermore, the input neurons are colocalized with markers related to physiological behaviors.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Yasutaka Mukai, Tatsuo S. Okubo, Michael Lazarus, Daisuke Ono, Kenji F. Tanaka, Akihiro Yamanaka
Summary: This study established an efficient screening method for identifying substances that modulate the activity of LC-NA neurons. Five novel substances were discovered, with neuromedin U showing the strongest response in female mice. Prostaglandin E2 was identified as a substance that can suppress LC-NA neuronal activity and modulate behavioral response to stress.
JOURNAL OF NEUROSCIENCE
(2023)