Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

(2019) Vimal Parkash et al.   Nature Communications

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

(2019) Xuanxuan Xing et al.   Nature Communications

Structures and operating principles of the replisome

(2019) Yang Gao et al.   SCIENCE

Lesion Bypass and the Reactivation of Stalled Replication Forks

(2018) Kenneth J. Marians   Annual Review of Biochemistry

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein

(2018) Alfredo J. Hernandez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

(2018) Hao-Dong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

The Yeast Mitochondrial RNA Polymerase and Transcription Factor Complex Catalyzes Efficient Priming of DNA Synthesis on Single-stranded DNA

(2016) Aparna Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into the Mechanism of DNA Duplication by the Eukaryotic Replisome

(2016) Luca Pellegrini et al.   TRENDS IN BIOCHEMICAL SCIENCES

Processive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Klenow Fragment) Nanocircuits

(2015) Kaitlin M. Pugliese et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other

(2015) Divya Nandakumar et al.   eLife

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Kinetic Mechanism at the Branchpoint between the DNA Synthesis and Editing Pathways in Individual DNA Polymerase Complexes

(2014) Kate R. Lieberman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Helicase and Polymerase Move Together Close to the Fork Junction and Copy DNA in One-Nucleotide Steps

(2014) Manjula Pandey et al.   Cell Reports

Single-Molecule Fluorescence Reveals the Unwinding Stepping Mechanism of Replicative Helicase

(2014) Salman Syed et al.   Cell Reports

Dynamics of Site Switching in DNA Polymerase

(2013) Rajan Lamichhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-Molecule Förster Resonance Energy Transfer Reveals an Innate Fidelity Checkpoint in DNA Polymerase I

(2012) Svitlana Y. Berezhna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein

(2012) Ramanagouda Ramanagoudr-Bhojappa et al.   NUCLEIC ACIDS RESEARCH

RNA Transcript 3′-Proximal Sequence Affects Translocation Bias of RNA Polymerase

(2011) Pyae P. Hein et al.   BIOCHEMISTRY

The kinetic and chemical mechanism of high-fidelity DNA polymerases

(2010) Kenneth A. Johnson   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Yeast mitochondrial DNA polymerase is a highly processive single-subunit enzyme

(2010) Katrin Viikov et al.   MITOCHONDRION

Motors, Switches, and Contacts in the Replisome

(2009) Samir M. Hamdan et al.   Annual Review of Biochemistry

DNA polymerase proofreading: Multiple roles maintain genome stability

(2009) Linda J. Reha-Krantz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Proofreading dynamics of a processive DNA polymerase

(2009) Borja Ibarra et al.   EMBO JOURNAL

Coordinating DNA replication by means of priming loop and differential synthesis rate

(2009) Manjula Pandey et al.   NATURE

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Coupling of DNA unwinding to nucleotide hydrolysis in a ring-shaped helicase

(2008) Ilker Donmez et al.   EMBO JOURNAL

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH