Article
Oncology
Ichiaki Ito, Abdelrahman M. G. Yousef, Saikat Chowdhury, Princess N. Dickson, Zahra A. Naini, Michael G. White, Karianne G. Fleten, Kjersti Flatmark, Keith F. Fournier, Natalie W. Fowlkes, John Paul Shen
Summary: The activity and safety of intraperitoneal paclitaxel in orthotopic PDX models of mucinous appendiceal adenocarcinoma supports the evaluation of intraperitoneal paclitaxel in a prospective clinical trial of this rare tumor type.
Article
Oncology
Victor Kung, Megan Delisle, Sue Alves, Faheez Mohamed, Tom Cecil, Brendan Moran
Summary: This study investigated the long-term health-related quality of life (HRQOL) of patients with appendiceal PMP who underwent CRS and HIPEC. The results showed that patients who had complete cytoreduction (CC0/1) without recurrence had excellent and maintained global HRQOL over a period of 17 years.
Article
Oncology
Christopher W. Mangieri, Cristian D. Valenzuela, Richard A. Erali, Konstantinos Votanopoulos, Perry Shen, Edward A. Levine
Summary: This study examined the conversion of low-grade appendiceal neoplasms to high-grade disease following multiple CRS/HIPEC surgeries. Conversion rate was 16.92%, associated with elevated CEA levels, splenectomy, and adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xin Zhao, Xinbao Li, Yulin Lin, Ru Ma, Ying Zhang, Dazhao Xu, Yan Li
Summary: This study established a survival prognostic model for PMP patients treated with CRS + HIPEC based on Bayesian network. The model showed reasonable predictive performance with an accuracy of 70.3% and an AUC of 73.5%.
Article
Surgery
David N. Hanna, Cameron Schlegel, Muhammad O. Ghani, Andrew Hermina, Alexander S. Mina, Katlyn McKay, Christina E. Bailey, Deepa Magge, Kamran Idrees
Summary: This study evaluated the use of a linear cutting stapler for full-thickness diaphragm resection (FT-DR) in cytoreductive surgery. The stapled group showed improved postoperative pulmonary outcomes compared to the conventional group.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Oncology
Mikael L. Soucisse, Oliver Fisher, Winston Liauw, Lana Ghanipour, Peter Cashin
Summary: This study analyzed patients with appendiceal origin PM treated with CRS + HIPEC between 2004 and 2012 at Uppsala University Hospital. The results suggest that EPIC did not provide any survival benefit in these patients and led to longer hospital and ICU stays.
Article
Oncology
Suk Jun Lee, Youngbae Jeon, Hae Won Lee, Jeonghyun Kang, Seung Hyuk Baik, Eun Jung Park
Summary: This study evaluated the clinical manifestations and impact of MMC-induced neutropenia after CRS and HIPEC in colorectal cancer patients. Severe neutropenia occurred earlier and lasted longer than mild neutropenia, with a higher rate of major postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Bing Wang, Ruiqing Ma, Guanjun Shi, Zhenpeng Yang, Huazhen Tang, Shuai Lu, Yuying Wang, Jinxiu Qu, Benqiang Rao, Hongbin Xu
Summary: This study retrospectively analyzed the preoperative nutritional status of 165 patients with Low-grade Appendiceal Mucinous Neoplasms (LAMNs) and identified prognostic factors for survival. The results showed that preoperative nutritional status, prior surgical score, completeness of cytoreduction, and hyperthermic intraperitoneal chemotherapy were independent predictors of prognosis. Complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy can benefit patients in terms of survival.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Andrei Nikiforchin, Armando Sardi, Mary Caitlin King, Ekaterina Baron, Felipe Lopez-Ramirez, Luis Felipe Falla-Zuniga, Philipp Barakat, Sergei Iugai, Kathleen Pawlikowski, Carol Nieroda, Vadim Gushchin
Summary: This study aimed to assess the recurrence patterns of low-grade and high-grade appendiceal cancer. The results showed that low-grade appendiceal cancer mainly recurred intraperitoneally, while high-grade appendiceal cancer recurred both intra- and extraperitoneally. Understanding the recurrence patterns of appendiceal cancer can help to understand its biology and plan follow-up and post-relapse management.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Felipe Lopez-Ramirez, Vadim Gushchin, Michelle Sittig, Mary Caitlin King, Ekaterina Baron, Andrei Nikiforchin, Carol Nieroda, Armando Sardi
Summary: This study analyzed the recurrence of mucinous carcinomatosis peritonei (MCP) after the first cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for appendiceal tumors (AT) and compared the outcomes between patients who underwent iterative CRS/HIPEC and those who did not. The study found that selected low- and high-grade appendiceal cancer patients with MCP recurrence who were able to undergo iterative CRS/HIPEC procedures showed favorable outcomes. However, there was no evidence supporting a survival benefit with iterative CRS/HIPEC in recurrent MCP with signet ring cell morphology.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Joel M. Baumgartner, Amitabh Srivastava, Nelya Melnitchouk, Michael G. Drage, Aaron R. Huber, Raul S. Gonzalez, Phoenix Bell, Elizabeth Wu, Murray Resnick, Kiran Turaga, Elizabeth Poli, Jesus Esquivel, Jeremiah Deneve, Kaitlyn J. Kelly, Jula Veerapong, Andrew M. Lowy
Summary: In the absence of perforation or presence of extra-appendiceal mucin or cells, recurrence of localized LAMNs is extremely rare; however, patients with any of these pathologic findings require careful follow-up.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Gang Liu, Zhong-he Ji, Xin-bao Li, Song-lin An, Yan-bin Zhang, Bing Li, Yang Yu, Xin Zhao, Rui Yang, Yan Li
Summary: The safety and efficacy of hyperthermic intraoperative thoraco-abdominal chemotherapy (HITAC) and cytoreductive surgery (CRS) for patients with peritoneal carcinomatosis (PC) who underwent diaphragm resection were evaluated in this study. The results showed that HITAC can be performed without worsening the safety profile and may have a beneficial effect on pleural progression in carefully selected patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ekaterina Baron, Armando Sardi, Mary Caitlin King, Andrei Nikiforchin, Felipe Lopez-Ramirez, Carol Nieroda, Vadim Gushchin, Panayotis Ledakis
Summary: This study evaluated the efficacy of systemic chemotherapy in improving the overall survival of high-grade mucinous appendiceal cancer patients with unresectable peritoneal metastases, and found that systemic chemotherapy was associated with improved survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Eric A. Hanse, Tianhong Wang, Delia Tifrea, Maheswari Senthil, Alex C. Kim, Mei Kong, Oliver S. Eng
Summary: This study aims to compare the phenotypic differences between peritoneal metastases (PM) derived from low-grade appendiceal mucinous neoplasms (LAMNs) and adenocarcinoma. It was found that the levels of metabolites in PM from LAMNs were different from adenocarcinoma, particularly in lipid metabolism pathways. Additionally, the differential gene expression mainly involved lipid metabolism pathways, and a potential top-level modulation candidate in IL1B signaling was identified.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
John Paul Shen, Abdelrahman M. Yousef, Fadl A. Zeineddine, Mohammad A. Zeineddine, Rebecca S. Tidwell, Karen A. Beaty, Lisa C. Scofield, Safia Rafeeq, Nicholas Hornstein, Elizabeth Lano, Cathy Eng, Aurelio Matamoros, Wai Chin Foo, Abhineet Uppal, Christopher Scally, Paul Mansfield, Melissa Taggart, Kanwal P. Raghav, Michael J. Overman, Keith Fournier
Summary: In this study, the effectiveness of fluoropyrimidine-based systemic chemotherapy in patients with inoperable low-grade mucinous appendiceal adenocarcinoma was evaluated. The results showed that patients did not derive clinical benefit from chemotherapy, with no objective responses, no difference in overall survival when treatment was delayed, and no difference in tumor growth rate during chemotherapy.
Review
Oncology
Miguel Enrique Alberto Vilchez, Eva Pachmayr, Alexander Arnold, Safak Guel-Klein, Andreas Brandl, Beate Rau
Summary: Malignant mesotheliomas are rare diseases, and cases with synchronous involvement of both the pleura and peritoneum are even scarcer. There is no standardized treatment recommendation for children with mesothelioma. Studies have found that mesothelioma can spread between the pleura and peritoneum. A radical two-stage surgical approach in combination with locoregional chemotherapy has shown effectiveness in treating patients.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Lilian Roth, Dilmurodjon Eshmuminov, Linda Russo, Felix Laminger, Friedrich Kober, Sebastian Roka, Kuno Lehmann
Summary: This study aimed to assess the sensitivity and specificity of blood and serum markers after CRS/HIPEC. It found that HIPEC alters the diagnostic sensitivity and specificity of these markers, with PCT identified as a highly specific marker for diagnosing infectious complications after CRS/HIPEC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Frederic Schell, Amaniel Kefleyesus, Nazim Benzerdjeb, Guillaume Passot, Pascal Rousset, Alhadeedi Omar, Laurent Villeneuve, Julien Peron, Olivier Glehen, Vahan Kepenekian
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Vahan Kepenekian, Amaniel Kefleyesus, Guillaume Passot, Pascal Rousset, Nazim Benzerdjeb, Benoit You, Julien Peron, Olivier Glehen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Frederic Schell, Amaniel Kefleyesus, Nazim Benzerdjeb, Guillaume Passot, Pascal Rousset, Alhadeedi Omar, Laurent Villeneuve, Julien Peron, Olivier Glehen, Vahan Kepenekian
Summary: In patients with colorectal cancer peritoneal metastasis, limited extraperitoneal disease involving one site, notably the liver, does not significantly impair postoperative results. However, lymph node invasion is a poor prognostic factor in this population.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Frederic Dumont, Vahan Kepenekian, Valeria De Franco, Clarisse Eveno, Patrick Rat, Charles Sabbagh, Jean-Jacques Tuech, Jean-Marc Bereder, Maxime Gerard, Cecile Loaec, Elodie Martin, Loic Campion, Olivier Glehen
Summary: Multimodal treatment, including perioperative chemotherapy and complete resection, improves survival in patients with peritoneal metastases from colorectal cancer. However, the impact of treatment delays on oncologic outcomes remains uncertain.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Vahan Kepenekian, Amaniel Kefleyesus, Guillaume Passot, Pascal Rousset, Julien Peron, Olivier Glehen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Florian Fanget, Amaniel Kefleyesus, Julien Peron, Isabelle Bonnefoy, Laurent Villeneuve, Guillaume Passot, Pascal Rousset, Benoit You, Nazim Benzerdjeb, Olivier Glehen, Vahan Kepenekian
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Pamela Funk-Debleds, Julien Rossi, Lorraine Bernard, Alexandre Galan, Vahan Kepenekian, Olivier Glehen, Cecile Chambrier
Summary: Patients with advanced gastric adenocarcinoma undergoing gastrectomy and HIPEC with or without CR are at high risk of malnutrition. Post-operative weight loss has a negative impact on patient outcomes.
Editorial Material
Surgery
Matylda Sofia Kuzinska, Beate Rau, Safak Guel-Klein
ZENTRALBLATT FUR CHIRURGIE
(2023)
Article
Oncology
Vahan Kepenekian, Olivia Sgarbura, Frederic Marchal, Laurent Villeneuve, Shigeki Kusamura, Marcello Deraco
Summary: Through an international consensus, it was confirmed that hyperthermic intraperitoneal chemotherapy (HIPEC) following complete cytoreductive surgery (CRS) is the first-line treatment for diffuse malignant peritoneal mesothelioma (DMPM), and the combination of cisplatin and doxorubicin is recommended as the preferred HIPEC regimen.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Vahan Kepenekian, Olivia Sgarbura, Frederic Marchal, Laurent Villeneuve, Shigeki Kusamura, Marcello Deraco
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Vahan Kepenekian, Olivia Sgarbura, Frederic Marchal, Laurent Villeneuve, Shigeki Kusamura, Marcello Deraco
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Mark Lawler, Lynne Davis, Simon Oberst, Kathy Oliver, Alexander Eggermont, Anna Schmutz, Carlo La Vecchia, Claudia Allemani, Yolande Lievens, Peter Naredi, Tanja Cufer, Ajay Aggarwal, Matti Aapro, Kathi Apostolidis, Anne-Marie Baird, Fatima Cardoso, Andreas Charalambous, Michel P. Coleman, Alberto Costa, Mirjam Crul, Csaba L. Degi, Federica Di Nicolantonio, Sema Erdem, Marius Geanta, Jan Geissler, Jacek Jassem, Beata Jagielska, Bengt Jonsson, Daniel Kelly, Olaf Kelm, Teodora Kolarova, Tezer Kutluk, Grant Lewison, Francoise Meunier, Jana Pelouchova, Thierry Philip, Richard Price, Beate Rau, Isabel T. Rubio, Peter Selby, Maja Juznic Sotlar, Gilliosa Spurrier-Bernard, Jolanda C. van Hoeve, Eduard Vrdoljak, Willien Westerhuis, Urszula Wojciechowska, Richard Sullivan
Summary: Cancer research is vital for improving cancer care, and patients treated in research-active hospitals have better outcomes. However, the COVID-19 pandemic has negatively impacted cancer outcomes in Europe and set back progress by almost a decade. The Lancet Oncology European Groundshot Commission aims to use detailed data on cancer research to inform future cancer care strategies in Europe.
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
