期刊
BRAIN RESEARCH
卷 1641, 期 -, 页码 101-110出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.09.025
关键词
Schwann cell; Myelin; Transcription factors; Regulatory circuits; Neofunctionalization; Sox proteins
资金
- DFG [We1326/8, We1326/11]
- Bavarian State Ministry of Education and Culture, Science and Arts [D2-F2412.26]
- IZKF [TP E18]
As derivatives of the neural crest, Schwann cells represent a vertebrate invention. Their development and differentiation is under control of a newly constructed, vertebrate-specific regulatory network that contains Sox10, Oct6 and Krox20 as cornerstones and central regulators of peripheral myelination. In this review, we discuss the function and relationship of these transcription factors among each other and in the context of their regulatory network, and present ideas of how neofunctionalization may have helped to recruit them to their novel task in Schwann cells. This article is part of a Special Issue entitled SI: Myelin Evolution. (C) 2015 Elsevier B.V. All rights reserved.
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