期刊
BRAIN RESEARCH
卷 1649, 期 -, 页码 158-165出版社
ELSEVIER
DOI: 10.1016/j.brainres.2016.02.049
关键词
Brain; Autophagy; Metabolism; Neurodegenerative disease; Hormone; Nutrient
资金
- National Research Foundation, South Korea [2013M3C7A1056099]
- Daegu Gyeongbuk Institute of Science and Technology (DGIST) R&D Program of the Ministry of Science, Information and Communication Technology, and Future Planning [15-BD-0402]
- National Research Foundation of Korea [2013M3C7A1056099] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases are accompanied by altered metabolism and autophagy in the brain. In this review, we discuss how hormones and nutrients regulate autophagy in the brain and affect neurodegeneration. This article is part of a Special Issue entitled SI:Autophagy. (C) 2016 Elsevier B.V. All rights reserved.
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