Article
Biochemistry & Molecular Biology
Yi Zhang, Huan Gui, Zikun Duan, Tian Yu, Jie Zhang, Xiaoli Liang, Chengxi Liu
Summary: Systemic activation of D1 receptors has been found to promote emergence from propofol-induced unconsciousness, with the nucleus accumbens (NAc) showing disinhibited neuronal activity during the recovery phase. D1 receptor modulation on the activity of NAc MSNs plays a vital role in facilitating the emergence from propofol-induced unconsciousness, as shown by whole-cell patch clamp recordings and pharmacological intervention experiments.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Michael D. Flood, Erika D. Eggers
Summary: The retina must adapt to a wide range of light intensities, with dopamine playing a crucial role in this process by activating D1 and D4 receptors. Activation of these receptors decreases excitation in ON-sustained ganglion cells, with both D1Rs and D4Rs affecting spontaneous activity.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Michael Gray, Joseph M. Santin
Summary: Whole-cell patch clamp is a useful technique for studying voltage-gated ion channels in central neurons, but voltage errors caused by electrode resistance limit its application to small ionic currents. The commonly used Ohm's law-based correction for voltage errors was found to overestimate the actual errors in this study, leading to erroneous current-voltage relationships.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Biology
Irina Ignatova, Roman Frolov, Soile Nymark
Summary: Recent studies have found voltage-activated Na+ channels in the retinal pigment epithelium (RPE), which are important for the phagocytosis of photoreceptor outer segments and maintaining retinal homeostasis.
Article
Biochemistry & Molecular Biology
Arturo Ponce, Isabel Larre, Lidia Jimenez, Maria Luisa Roldan, Liora Shoshani, Marcelino Cereijido
Summary: This study investigates the effects of ouabain on TRPV4 channels, finding that it affects the activity and expression of the channels. Ouabain has a short-term modulatory effect on TRPV4 channel activity and a long-term effect on the synthesis of new TRPV4 channel units. The action of ouabain is dependent on intercellular contacts and involves multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kuang- Cheng, Kan-Ting Yang, Chien-Lun Kung, Yu-Chi Cheng, Jwu-Lai Yeh, Zen-Kong Dai, Bin-Nan Wu
Summary: This study demonstrated that KMUP-1 improved chronic constriction injury-induced BKCa current inhibition in DRG neurons by regulating BKCa mRNA levels and channel activity. KMUP-1 also prevented neuropathic pain induced by CCI, suggesting its potential therapeutic role in controlling neuropathic pain.
Article
Biochemistry & Molecular Biology
Hiroyuki Inoue, Hidetaka Kuroda, Wataru Ofusa, Sadao Oyama, Maki Kimura, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Summary: The ionotropic P2X receptor P2X(7) is believed to play a role in regulating and generating nociceptive pain in neuropathological diseases. Detailed examination of its functional properties in trigeminal ganglion (TG) neurons revealed that P2X(7) may interact with other P2X receptors and pannexin-1 (PANX1) channels to influence pain sensing pathways through autocrine or paracrine signaling. The complex formed by P2X(7)-PANX1-P2X receptor/channel may be involved in long-lasting neuronal activity driven by extracellular high-concentration ATP following tissue damage in the orofacial area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Gabriela Tavares, Fatima O. Martins, Bernardete F. Melo, Paulo Matafome, Silvia Conde
Summary: Peripheral dopamine plays a role in regulating glucose uptake in insulin-sensitive tissues, with dopamine receptors having differential involvement. Dopamine also affects lipid metabolism in white adipose tissue. The modulation of the dopaminergic system in the periphery could be a potential therapeutic approach for metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chenhao Li, Yang Li, Wenwen Zhang, Zhenjie Ma, Shaobo Xiao, Wei Xie, Shuai Miao, Bozhi Li, Guangshuang Lu, Yingyuan Liu, Wenhao Bai, Shengyuan Yu
Summary: Clinical imaging studies have shown that the hypothalamus is activated in migraine patients before and during headache, and has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system in the hypothalamus, particularly the A11 nucleus, may play a crucial role in the pathogenesis of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Iina Korkka, Heli Skottman, Soile Nymark
Summary: Research shows that human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) has functional potassium (K+) channels and ion channels, which are essential for its therapeutic effectiveness.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Han Zhou, Tao Hou, Zhenhua Gao, Xiujie Guo, Chaoran Wang, Jixia Wang, Yanfang Liu, Xinmiao Liang
Summary: This study isolated eight alkaloids from lotus leaves and evaluated them on dopamine receptors. These alkaloids acted as antagonists for D1 and D2 receptors, with O-nornuciferine being the most potent among the eight on both receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Baoyu Shen, Dongxian Zhang, Xiaofeng Zeng, Lina Guan, Genmeng Yang, Liu Liu, Jian Huang, Yuanyuan Li, Shijun Hong, Lihua Li
Summary: This study reveals that METH induces DA release via the DRD1-MeCP2-BDNF-TrkB signaling pathway, and CBD significantly inhibits DA release induced by METH through modulation of this pathway.
PSYCHOPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Lingyun Li, Huan Zhao, Haohuan Xie, Tasneem Akhtar, Yichuan Yao, Yuan Cai, Kai Dong, Yonghao Gu, Jin Bao, Jutao Chen, Mei Zhang, Kai Zhong, Weiping Xu, Tian Xue
Summary: This study comprehensively characterized the physiological maturation of photoreceptor-like cells derived from hiPSCs in ROs, revealing progressive maturation of ion channels associated with photoreceptor function during differentiation. The inward-outward current ratio was identified as a sensitive indicator of photoreceptor maturity and pathological state, providing a potential biomarker for quality control during RO differentiation.
Article
Biochemistry & Molecular Biology
Jing Yu, Jiabing Zhu, Jian Deng, Jing Shen, Fukuan Du, Xu Wu, Yu Chen, Mingxing Li, Qinglian Wen, Zhangang Xiao, Yueshui Zhao
Summary: The study demonstrates that activation of DRD1 signaling can promote lipolysis and browning of adipocytes, reducing adipocyte size and increasing the release of fatty acids, providing new strategies for obesity treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Alan Jung Park
Summary: Novelty enhances the ability of mice to overcome established behavioral bias and adapt to new rules by impacting connectivity within the VTA-HPC-mPFC circuit. Blocking dopamine D1-receptors in the vHPC abolishes the effects of novelty.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Qian Li, Peng Cui, Yanying Miao, Feng Gao, Xue-Yan Li, Wen-Jing Qian, Shu-Xia Jiang, Na Wu, Xing-Huai Sun, Zhongfeng Wang
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Peng Cui, Xue-Yan Li, Yuan Zhao, Qian Li, Feng Gao, Ling-Zhu Li, Ning Yin, Xing-Huai Sun, Zhongfeng Wang
Article
Neurosciences
Yuan Zhao, Qian Li, Xue-Yan Li, Peng Cui, Feng Gao, Ke Zhu, Ling-Zhu Li, Xing-Huai Sun, Zhongfeng Wang
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.