Article
Biochemistry & Molecular Biology
Ping Guo, Shijia Zu, Shilong Han, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin, Xinrui Zhao, Haibo Lu, Chunyu Hua, Xinyu Wan, Liyuan Ru, Ziyue Guo, Hanxiao Ge, Kuan Lv, Guohui Zhang, Wuguo Deng, Cheng Luo, Wei Guo
Summary: This study revealed that Bromodomain PHD Finger Transcription Factor (BPTF) promotes colorectal cancer (CRC) progression by targeting Cdc25A under the regulation of c-Myc. Inhibition of BPTF could be a promising strategy for CRC treatment, and the c-Myc/BPTF/Cdc25A signaling axis may serve as candidate biomarkers for CRC diagnosis and prognosis prediction.
Article
Oncology
Homa Fatma, Santosh K. Maurya, Hifzur R. Siddique
Summary: Both genetic and epigenetic mechanisms play crucial roles in cancer development and chemoresistance, with the reversible nature of epigenetic modifications being an attractive target for cancer prevention and therapy. c-MYC is a key transcription factor implicated in multiple cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Lu Jin, Yibin Zhou, Guangqiang Chen, Guangcheng Dai, Kai Fu, Dongrong Yang, Jin Zhu
Summary: TROAP is overexpressed in prostate cancer and is associated with tumor progression and poor patient survival. Knockdown of TROAP inhibits proliferation and invasion of DU145 and PC3 cells, potentially through modulation of MMP-9 and E-Cadherin. TROAP is identified as a driver of prostate cancer development and progression, providing a new target for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xufen Ding, Tianwei Chen, Qian Shi, Peng Nan, Xiang Wang, Dong Xie, Jingjing Li
Summary: INTS6 has been found to be overexpressed in colorectal cancer (CRC) tissues, and its downregulation can induce cell cycle arrest and inhibit the growth of CRC cells and tumors. The oncogenic role of INTS6 in CRC has been revealed, providing a potential therapeutic target for this malignant cancer.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Min Zhang, Luyang Zhang, Minghe Zhou, Enze Wang, Bo Meng, Qingjun Li, Xiaoqian Wang, Yunjian Wang, Qiong Li
Summary: The present study found that ASF1B plays an important regulatory role in pancreatic cancer by activating c-Myc through CBP-mediated H3K56 acetylation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Zuolei Jing, Qianmei Liu, Xinyuan He, Zhirong Jia, Zhizhong Xu, Bolin Yang, Ping Liu
Summary: Our study demonstrates that NCAPD3 promotes glucose metabolism reprogramming and enhances the Warburg effect in colorectal tumorigenesis and CRC progression. We found that NCAPD3 is overexpressed in CRC tissues and is associated with poor prognosis in CRC patients. Knockout of NCAPD3 suppressed CRC development in mouse models and we identified the underlying molecular mechanism by which NCAPD3 regulates glucose metabolism.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Zijian Wu, Jin Xu, Chen Liang, Qingcai Meng, Jie Hua, Wei Wang, Bo Zhang, Jiang Liu, Xianjun Yu, Si Shi
Summary: Pancreatic cancer is a deadly gastrointestinal tumor with limited improvements in patient prognosis despite advances in surgical procedures. Solute carriers (SLCs) play important roles in regulating cellular functions, with significant implications for pancreatic cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jun-Xian Du, Yi-Hong Luo, Si-Jia Zhang, Biao Wang, Cong Chen, Gui-Qi Zhu, Ping Zhu, Cheng-Zhe Cai, Jing-Lei Wan, Jia-Liang Cai, Shi-Ping Chen, Zhi Dai, Wei Zhu
Summary: The study revealed that SRSF1 is upregulated in breast cancer and correlates with tumor grade, Ki-67 index, and poor prognosis in HR+ patients. By regulating PTPMT1 AS, SRSF1 exerts oncogenic roles in breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Beibei Cao, Kailun Zhang, Changjie Pan, Yifei Dong, Feng Lu
Summary: Radiotherapy and chemotherapy are the main treatment methods for colorectal cancer, but their effectiveness is limited. Understanding the molecular mechanisms of colorectal cancer progression could lead to the development of new therapies. NEK8 positively regulates CRC progression by phosphorylating c-MYC protein at serine 405, enhancing its stability through polyubiquitination. This study highlights the role of NEK8/MYC signaling as a potential target for colorectal cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Tong-peng Xu, Tao Yu, Meng-yan Xie, Yuan Fang, Ting-ting Xu, Yu-tian Pan, Pei Ma, Yong-qian Shu
Summary: This study reveals that LIN28B can stabilize c-MYC mRNA by recognizing its m6A modification, thereby promoting the Warburg effect in gastric cancer. The study also identifies an interaction between LOC101929709 and LIN28B/IGF2BP3, with LOC101929709 enriching in the cytoplasm to stabilize c-MYC mRNA and promote the proliferation, migration, and glycolysis of gastric cancer. Additionally, LOC101929709 is found to activate the PI3K/AKT pathway. This study provides a novel potential target for the treatment of gastric cancer.
Article
Biochemistry & Molecular Biology
Zhe Qiao, Yu Li, Yao Cheng, Shaomin Li, Shiyuan Liu
Summary: The study revealed that SHMT2 is upregulated in EC and associated with poor prognosis. Silencing SHMT2 suppressed c-myc expression in an m6A-dependent manner, inhibiting proliferation, migration, invasion, and immune evasion abilities of EC cells. SHMT2 mediates c-myc expression through m6A-methylation modification, promoting EC tumorigenesis.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jie Xu, Pengfei Shi, Fanwei Xia, Xuan Zhao, Junfan Chen, Rui Geng, Hongjuan Cui, Liqun Yang
Summary: Melanoma, a highly fatal skin cancer, is influenced by RAI14, which is associated with prognosis and affects the growth and invasive capabilities of melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Qing Huang, Chunlan Pu, Lun Tan, Shirui Wang, Hongjia Zhang, Su Yu, Rui Deng, Dan Luo, Xinyu Ma, Rui Li
Summary: c-Myc protein, aberrantly expressed in colorectal cancer, can be effectively inhibited by a compound called B13. B13 not only suppresses the proliferation and migration of CRC cells, but also interferes with the expression of apoptosis pathway-related proteins. Additionally, B13 shows strong inhibition of tumor growth in animal models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Lijun An, Huiyuan Gong, Xiaojing Yu, Wangming Zhang, Xiaohua Liu, Xiaomin Yang, Liping Shu, Jielin Liu, Liuqi Yang
Summary: This study found that MAL2 is significantly upregulated in breast cancer tissues and is associated with poor prognosis. Functional experiments showed that MAL2 knockdown can inhibit migration and invasion of breast cancer cells, increase apoptosis, and reduce metastatic capacity. Mechanistically, MAL2 interacts with beta-catenin in breast cancer cells and regulates the EMT and beta-catenin/c-Myc axis to promote tumor progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Shengxian Xu, Zhenpeng Lian, Siyang Zhang, Yong Xu, Hongtuan Zhang
Summary: The circGNG4/miR-223/EYA3/c-Myc regulatory pathway was shown to promote the malignant progression of prostate cancer. Research on circGNG4 and its interactions could provide new directions for the treatment of prostate cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pallabi Sengupta, Nilanjan Banerjee, Tanaya Roychowdhury, Anindya Dutta, Samit Chattopadhyay, Subhrangsu Chatterjee
NUCLEIC ACIDS RESEARCH
(2018)
Article
Oncology
Aftab Alam, Nandaraj Taye, Sonal Patel, Milind Thube, Jayati Mullick, Vibhuti Kumar Shah, Richa Pant, Tanaya Roychowdhurey, Nilanjan Banerjee, Subhranosu Chatterjee, Rittwika Bhattachatya, Rini Roy, Ashis Mukhopadhyay, Devraj Mogare, Samit Chattopadhyay
Article
Biochemistry & Molecular Biology
Apoorva Bhattacharya, Shravanti Mukherjee, Poulami Khan, Shruti Banerjee, Apratim Dutta, Nilanjan Banerjee, Debomita Sengupta, Udit Basak, Sourio Chakraborty, Abhishek Dutta, Samit Chattopadhyay, Kuladip Jana, Diptendra K. Sarkar, Subhrangsu Chatterjee, Tanya Das
Article
Biochemistry & Molecular Biology
Debasmita Sinha, Debabrata Sinha, Nilanjan Banerjee, Priya Rai, Soham Seal, Tushar Chakraborty, Subhrangsu Chatterjee, Subrata Sau
Summary: In this study, the impact of the critical residue Arg 23 in RsbW on its structure and function was investigated. By altering the amino acid at Arg 23, we found that rRsbW[R23A] was unable to interact and phosphorylate RsbV, and its stability and structure were significantly altered. However, rRsbW[R23A] still interacted with sigma(B). These results reveal the importance of Arg 23 in RsbW.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Anindya Dutta, Nilanjana Maji, Pallabi Sengupta, Nilanjan Banerjee, Swarnali Kar, Gopeswar Mukherjee, Subhrangsu Chatterjee, Moitri Basu
Summary: Our study identified the crucial role of nucleolin in facilitating SP1 transcription factor binding to the ZEB1 promoter, leading to the activation of ZEB1 transcription. Stabilization of G-quadruplex with TMPyP4 represses ZEB1 transcription and inhibits cell invasiveness. These findings suggest that small molecule induced G-quadruplex stabilization may serve as a potential molecular switch to regulate gene expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Biochemistry & Molecular Biology
Nilanjan Banerjee, Suman Panda, Subhrangsu Chatterjee
Summary: G-Quadruplex, a unique secondary structure in nucleic acids found throughout the human genome, plays a crucial role in regulating oncogenes. Targeting G-Quadruplex structures for therapeutic research has shown promising results and may provide new insights for the next-generation cancer treatment.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Ananya Roy, Oishika Chatterjee, Nilanjan Banerjee, Tanaya Roychowdhury, Gopa Dhar, Gopeswar Mukherjee, Subhrangsu Chatterjee
Summary: The deregulation of c-MYC in TNBC suggests it as a potential biomarker for breast cancer treatment, with Curcumin showing promise in stabilizing G-quadruplex to repress MYC expression. Curcumin also triggers apoptosis in cancer cells through a new pathway involving MYC, E2F-1, and BCL-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Meghomukta Mukherjee, Debajyoti Das, Jit Sarkar, Nilanjan Banerjee, Jagannath Jana, Jyotsna Bhat, Jithender G. Reddy, Jagadeesh Bharatam, Samit Chattopadhyay, Subhrangsu Chatterjee, Partha Chakrabarti
Summary: A new tetrapeptide VYYR has been found to effectively inhibit insulin fibrillation and maintain its bioactivity, providing good blood sugar control in mouse models of diabetes. The critical interaction between insulin and IS1 has been elucidated through nuclear magnetic resonance spectroscopy, and a non-canonical dimer-mediated conformational trapping mechanism has been demonstrated for insulin stabilization. This study introduces a class of tetrapeptides for developing thermostable insulin formulations with therapeutic relevance.
Article
Biochemistry & Molecular Biology
Soham Seal, Nilanjan Banerjee, Rohit Mahato, Tanmoy Kundu, Debabrata Sinha, Tushar Chakraborty, Debasmita Sinha, Keya Sau, Subhrangsu Chatterjee, Subrata Sau
Summary: The study identifies the serine residue at position 106 of SaCyp as crucial for maintaining its tertiary structure, function, and stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Nilanjan Banerjee, Oishika Chatterjee, Tanaya Roychowdhury, Debadrita Basu, Anindya Dutta, Madhurima Chowdhury, Shubhra Ghosh Dastidar, Subhrangsu Chatterjee
Summary: This study presents a peptide that can bind to the c-MYC quadruplex and induce a substantially different structure than canonical G-quadruplexes. This destabilizes the quadruplex and reduces c-MYC expression, increasing cancer cell sensitivity to apoptotic cascades. The findings provide insights into the peptide-quadruplex interface and encourage better pharmacophore design for targeting dynamic quadruplex structures.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Biochemistry & Molecular Biology
Tushar Chakraborty, Nilanjan Banerjee, Debasmita Sinha, Soham Seal, Subhrangsu Chatterjee, Subrata Sau
Summary: CapF, a staphylococcal capsule-producing enzyme, utilizes its C-terminal domain (CTD) and N-terminal domain (NTD) to bind Zn2+ ion and NADPH, respectively. The presence of Zn2+ plays a crucial role in maintaining the conformation and stability of the enzyme. The different recombinant proteins, rCapF, rCTD, rNTD, and Apo-rCapF/Apo-rCTD, exhibit distinct structural and functional characteristics, suggesting the importance of domains and cofactors in CapF's function.
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Soma Roy, Bappa Maiti, Nilanjan Banerjee, Mangesh H. Kaulage, Kalappa Muniyappa, Subhrangsu Chatterjee, Santanu Bhattacharya
Summary: Xanthone is a significant scaffold for designing cytotoxic agents against cancer cells by stabilizing G-quadruplex nucleic acids. We synthesized xanthone-based derivatives with various side-arm substituents that showed selectivity for G4 DNA over dsDNA, verified through biophysical experiments. These compounds exhibit end-stacking mode of binding with G4 DNA and induce conformational changes in flanking nucleotides, suggesting their potential as potent anti-cancer agents.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Meghomukta Mukherjee, Nilanjan Banerjee, Subhrangsu Chatterjee
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
