Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level

(2019) Qiang Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Anatomical, Physiological, and Functional Diversity of Adipose Tissue

(2018) Rachel K. Zwick et al.   Cell Metabolism

Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue–kidney crosstalk

(2018) Xue-Jing Liu et al.   FASEB JOURNAL

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

(2018) George D. Mcilroy et al.   Molecular Metabolism

Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice

(2018) Huan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

Lipodystrophies, dyslipidaemias and atherosclerotic cardiovascular disease

(2018) Iram Hussain et al.   PATHOLOGY

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

(2018) George D. Mcilroy et al.   Scientific Reports

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice

(2018) Wenqiong Xu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis

(2017) Minal B. Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

(2017) Martina Schweiger et al.   Nature Communications

Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy

(2017) Canan Altay et al.   Diagnostic and Interventional Radiology

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey

(2016) Baris Akinci et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity

(2016) Mohamed Amine Lounis et al.   LIPIDS

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Molecular Mechanisms Underlying Fasting Modulated Liver Insulin Sensitivity and Metabolism in Male LipodystrophicBscl2/Seipin-Deficient Mice

(2014) Weiqin Chen et al.   ENDOCRINOLOGY

Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ

(2014) Libin Zhou et al.   HUMAN MOLECULAR GENETICS

Function of seipin: New insights from Bscl2/seipin knockout mouse models

(2013) Lucile Dollet et al.   BIOCHIMIE

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Seipin ablation in mice results in severe generalized lipodystrophy

(2011) X. Cui et al.   HUMAN MOLECULAR GENETICS

Reduced adipogenic gene expression in fibroblasts from a patient with type 2 congenital generalized lipodystrophy

(2010) B. Victoria et al.   DIABETIC MEDICINE

Resistance to leptin-replacement therapy in Berardinelli–Seip congenital lipodystrophy: an immunological origin

(2010) Jacques Beltrand et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy

(2010) Beatrice C. Lupsa et al.   MEDICINE

Efficacy of leptin therapy in the different forms of human lipodystrophy

(2009) A. Y. Chong et al.   DIABETOLOGIA

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES