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Biochemistry & Molecular Biology
Minkyoung Sung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun Woo Lee, Hyo-Deog Rim, Seunghee Won, Byung-Soo Kim, Kyungmin Kim, Seoyoung Jang, Sang Gyu Kwak, Jungmin Woo, Min-Soo Seo
Summary: Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by symptoms like eczema and itching. Psychological stress can trigger neuroinflammation in the brain in AD patients, leading to changes in microRNAs (miRNAs) in neuronal exosomes (nEVs). This study found that certain miRNAs in nEVs may serve as stress-related biomarkers associated with AD and stress-induced depression.
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Claudia Sacchetto, Zenab Mohseni, Robin M. W. Colpaert, Libero Vitiello, Marzia De Bortoli, Indira G. C. Vonhogen, Ke Xiao, Giulia Poloni, Alessandra Lorenzon, Chiara Romualdi, Riccardo Bariani, Elisa Mazzotti, Luciano Daliento, Barbara Bauce, Domenico Corrado, Thomas Thum, Alessandra Rampazzo, Leon J. de Windt, Martina Calore
Summary: The study identified miR-185-5p as significantly upregulated in ARVC patients compared to healthy controls, with a confirmed link to ARVC pathophysiology based on receiver operating characteristic analysis.
Review
Medicine, General & Internal
Angel Earle, Madison Bessonny, Josh Benito, Kun Huang, Hannah Parker, Emily Tyler, Brittany Crawford, Nabeeha Khan, Bridget Armstrong, Alexis Stamatikos, Sudha Garimella, Alyssa Clay-Gilmour
Summary: The early detection of chronic kidney disease is crucial, and there is growing interest in finding new biomarkers. Currently, there is no single effective biomarker, but there is evidence supporting the use of urinary exosomal microRNAs as biomarkers for kidney fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Jose Pedro Sequeira, Vera Constancio, Joao Lobo, Rui Henrique, Carmen Jeronimo
Summary: Liquid biopsies have emerged as a new tool for early diagnosis, with circulating or exosome miRNAs showing great potential in renal cell carcinoma. The study of these miRNAs in liquid biopsies has experienced exponential growth, signaling a promising development in clinical applications.
Article
Oncology
Shichao Cui, Jiayu Zhang, Jingwei Li, Haiwang Wu, Huimin Zhang, Qingying Yu, Yuexi Zhou, Xiaoli Lv, Yanlan Zhong, Songping Luo, Jie Gao
Summary: The study investigated the feasibility of using serum exosomal miRNAs as novel biomarkers for spontaneous abortion (SA). Analysis found altered expression of specific miRNAs in SA patients, potentially serving as biomarkers. Targetscan and KEGG pathway analysis revealed high-risk pathways associated with SA. Single or combined miRNA markers demonstrated varying specificity and sensitivity for SA diagnosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jorge Armando Jimenez-Avalos, Juan Carlos Fernandez-Macias, Ana Karen Gonzalez-Palomo
Summary: Exosomes, particularly the miRs within them, have the potential to serve as non-invasive biomarkers for the diagnosis and prognosis of various diseases, making them valuable tools for disease management and early detection.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Review
Oncology
Elmira Gheytanchi, Fatemeh Tajik, Mahdieh Razmi, Sadegh Babashah, William Chi Shing Cho, Kiarash Tanha, Maryam Sahlolbei, Roya Ghods, Zahra Madjd
Summary: This meta-analysis suggests that circulating exosomal microRNAs have prognostic value in gastrointestinal cancers. Both up-regulated and down-regulated exomiRs are associated with differentiation, TNM stage, lymph node metastasis, distant metastasis, overall survival, and disease/relapse/progression-free survival in GI cancer patients. These findings indicate that circulating exomiRs could serve as potential prognostic biomarkers in GI cancers.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Maha M. Itani, Farah J. Nassar, Arafat H. Tfayli, Rabih S. Talhouk, Ghada K. Chamandi, Abdul Rahman S. Itani, Joelle Makoukji, Rose-Mary N. Boustany, Lifang Hou, Nathalie K. Zgheib, Rihab R. Nasr
Summary: The combination of miR-145/miR-425-5p/miR-139-5p/miR-130a as a panel of microRNAs shows the highest diagnostic accuracy for early-stage breast cancer detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Roberta Resaz, Davide Cangelosi, Daniela Segalerba, Martina Morini, Paolo Uva, Maria Carla Bosco, Giuseppe Banderali, Ana Estrella, Corbinian Wanner, David A. Weinstein, Annalisa Sechi, Sabrina Paci, Daniela Melis, Maja Di Rocco, Young Mok Lee, Alessandra Eva
Summary: This study analyzed the expression of exosomal microRNAs in the plasma of glycogen storage disease type Ia patients, and found that altered expression of several microRNAs correlates with the pathological state of the patients, potentially serving as biomarkers for monitoring disease progression and the development of late complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fahimeh Ghasemi, Effat Alemzadeh, Leila Allahqoli, Esmat Alemzadeh, Afrooz Mazidimoradi, Hamid Salehiniya, Ibrahim Alkatout
Summary: Endometriosis is a chronic disease characterized by the presence of endometrial tissue outside the uterus, causing pelvic pain and infertility. The gold standard for diagnosis is laparoscopy, but a non-invasive and more accurate test is urgently needed. miRNAs have been suggested as potential biomarkers, but there is no consensus.
Review
Biochemistry & Molecular Biology
Katiusse Alves dos Santos, Isabelle Cristina Clemente dos Santos, Carollyne Santos Silva, Heriks Gomes Ribeiro, Igor de Farias Domingos, Vivian Nogueira Silbiger
Summary: Colorectal cancer is a common malignant tumor in the gastrointestinal tract, involving multiple factors such as environmental, genetic, and lifestyle factors. The lack of specific and sensitive biomarkers leads to late diagnosis and poor prognosis for CRC patients. Exosomal miRNAs are considered potential biomarkers for the diagnosis and prognosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hongli Shi, Xin Jiang, Cuidi Xu, Qun Cheng
Summary: This study investigated the differences in miRNA expression profiles in postmenopausal osteoporosis patients with fragility fractures and identified several miRNAs associated with bone mineral density. The study also explored the potential role of these miRNAs in the pathophysiology of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Lu Zhang, Zitong Yu, Qingxi Qu, Xiao Li, Xue Lu, Hui Zhang
Summary: Exosomal HOTAIR promotes the progression and angiogenesis of endometriosis by regulating the miR-761/HDAC1 axis and activating STAT3-mediated inflammation, both in vitro and in vivo, providing a potential treatment for endometriosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)