Article
Plant Sciences
Xiugui Chen, Zhe Wu, Zujun Yin, Yuexin Zhang, Cun Rui, Jing Wang, Waqar Afzal Malik, Xuke Lu, Delong Wang, Junjuan Wang, Lixue Guo, Shuai Wang, Lanjie Zhao, Bobokhonova Zebinisso Qaraevna, Chao Chen, Xiuping Wang, Wuwei Ye
Summary: In this study, the authors conducted a genome-wide analysis of CAT genes in cotton and found that these genes play important roles in plant metabolic functions and response to abiotic stress. They found that the expression of GhCAT genes is induced by salt, drought, cold, and heat stresses, and the promoters of GhCAT genes contain responsive elements to plant hormones and abiotic stress. Silencing the expression of GhCAT10D decreased cotton's resistance to salt stress. These findings lay a foundation for further research on the regulation mechanism of CAT genes in cationic amino acid transport and distribution in response to abiotic stress.
Review
Biology
Maryam Alfalasi, Sarah Alzaabi, Linda Ostlundh, Rami H. Al-Rifai, Suhail Al-Salam, Paul Michel Mertes, Seth L. Alper, Elhadi H. Aburawi, Abdelouahab Bellou
Summary: This systematic review assessed the effect of inhibiting nitric oxide pathways on blood pressure and survival in animal models of anaphylactic shock (AS). The results showed that inhibition of nitric oxide pathways improved survival and/or blood pressure in some experimental conditions. However, there is insufficient evidence to support the use of this approach as a definitive treatment for AS in humans.
Article
Agronomy
Songchong Lu, Xuan Ji, Xinshuang Zhang, Hao Wu, Yan Sun, Ying Zhu, Shanshan Su, Shumin Wei, Xin Liu
Summary: The cationic amino acid transporter NtCAT1 plays an important role in leaf senescence in tobacco. Overexpression of NtCAT1 accelerates leaf senescence, while the mutant ntcAT1-36 shows delayed senescence phenotype. NtCAT1 is involved in leaf senescence through regulating ABA biosynthesis and TOR kinase gene expression. Moreover, NtCAT1 transgenic plants exhibit significant changes in amino acid concentrations during leaf senescence.
Article
Physiology
Anna E. Stanhewicz, Rowan L. Schlarmann, Kaila M. Brustkern, Diana I. Jalal
Summary: The study demonstrates that women who have had gestational diabetes during pregnancy are at higher risk for cardiovascular disease and type 2 diabetes in the decade following pregnancy. Microvascular dysfunction, mediated by increased oxidative stress, persists after pregnancy in women who had gestational diabetes.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maral Afshinpour, Hamid Mahdiuni
Summary: This study investigates the transportation mechanism of arginine in CAT-1 and finds that water molecules play a leading role in forming the transportation channel. Understanding the arginine transportation mechanism is essential for developing CAT-1 blockers and potential medications for certain types of cancers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Physiology
Maria Amparo Bayarri, Javier Milara, Cristina Estornut, Julio Cortijo
Summary: The airway epithelium acts as a physical barrier protecting the lungs but can be disrupted by harmful agents, leading to dysfunction and various lung diseases. Nitric oxide plays a role in bronchial epithelial barrier function, yet its role in pathological conditions remains largely unknown.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Parasitology
Matthew Pinch, Theodore Muka, Yashoda Kandel, Mahesh Lamsal, Nathan Martinez, Marialuisa Teixeira, Dmitri Y. Boudko, Immo A. Hansen
Summary: This study identified a putative interacting protein GCN1 for the mosquito's CAT1 protein, which is important for egg development. The results suggest that GCN1 is part of the nutrient sensor mechanism in mosquitoes.
PARASITES & VECTORS
(2022)
Article
Medicine, General & Internal
Carla Sala, Marta Rescaldani, Elisa Gherbesi, Gianni Bolla, Cesare Cuspidi, Massimiliano Ruscica, Stefano Carugo
Summary: The present study found that chronic aldosterone excess impairs the platelet nitric oxide/cGMP pathway in humans, possibly due to potassium depletion caused by aldosterone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
T. Michael De Silva, Mary L. Modrick, Justin L. Grobe, Frank M. Faraci
Summary: The activation of central and cerebrovascular RAS impairs endothelial signaling in the brain through AT1R expression and activation, leading to impaired cerebral artery function and showing sex-dependent effects.
Article
Chemistry, Inorganic & Nuclear
N. A. Sanina, I. V. Sulimenkov, N. S. Emel'yanova, A. S. Konyukhova, T. S. Stupina, A. A. Balakina, A. A. Terent'ev, S. M. Aldoshin
Summary: The cytotoxic activity of dinitrosyl iron complexes (DNICs) with thioureas against cells has been studied, and the results show that the cytotoxicity depends on the complex structure and cell line. The release of NO during the decomposition of DNICs does not correlate with their cytotoxic effects, suggesting that the formation of long-lived nitrosyl iron-sulfur intermediates is responsible for the cytotoxic activity. The structures of the decomposition products have been analyzed, and stable high-molecular cluster ions containing NO groups have been detected.
DALTON TRANSACTIONS
(2022)
Article
Engineering, Electrical & Electronic
Ye Chen, Bingyan Yang, Yuqing Liu, Lixin Xu, Zhongfang Shi, Yixiao Liu, Ruoyu Han, Fang Yuan, Jiting Ouyang, Xu Yan, Kostya (Ken) Ostrikov
Summary: This study found that treatment with atmospheric pressure plasma jet (APPJ) could improve neurological function, enhance blood flow, reduce brain infarction, and decrease brain cell apoptosis in a rat model of ischemic stroke (IS). These findings provide a novel potential strategy for IS treatment using atmospheric pressure plasma inhalation.
Article
Multidisciplinary Sciences
Slobodan Tepic, Daniel Arens, Tim Buchholz, Dirk Nehrbass, Olivera Cvetkovic, Martin J. Stoddart, R. G. Richards, Stephan Zeiter
Summary: Pneumonia, especially during the COVID-19 pandemic, has become a major public health and economic disaster. This study suggests that lung metabolism in inflammation may have common features regardless of the underlying cause. By comparing mice with bleomycin-induced lung inflammation to control groups, it was found that certain amino acids had significantly lower concentrations in the arterial blood, indicating that arginine replacement therapy may be beneficial in pneumonia.
Article
Pharmacology & Pharmacy
Behnam Ghorbanzadeh, Mohammad Amin Behmanesh, Roya Mahmoudinejad, Mehdi Zamaniyan, Shadi Ekhtiar, Yousef Paridar
Summary: In this study, researchers found that the leukotriene receptor antagonist, montelukast, reduced colonic tissue damage induced by acetic acid and decreased inflammatory levels. The study also revealed that the NO-cGMP-KATP channel pathway is involved in the protective effect of montelukast.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aileen Jehle, Olga Garaschuk
Summary: Cyclic guanosine monophosphate (cGMP) plays a key role in many important signaling cascades in the body and brain, including phototransduction, olfaction, vasodilation, and functional hyperemia. Recent studies suggest that cGMP may act as a modulator in Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sana Latif, Young-Sook Kang
Summary: The transport of arginine is associated with system y(+), with neuroprotection by L-arginine potentially serving as a therapeutic target in the treatment of ALS.
Article
Oncology
Moshe Elkabets, Evangelos Pazarentzos, Dejan Juric, Qing Sheng, Raphael A. Pelossof, Samuel Brook, Ana Oaknin Benzaken, Jordi Rodon, Natasha Morse, Jenny Jiacheng Yan, Manway Liu, Rita Das, Yan Chen, Angela Tam, Huiqin Wang, Jinsheng Liang, Joseph M. Gurski, Darcy A. Kerr, Rafael Rosell, Cristina Teixido, Alan Huang, Ronald A. Ghossein, Neal Rosen, Trever G. Bivona, Maurizio Scaltriti, Jose Baselga
Biographical-Item
Biochemistry & Molecular Biology
A-L Mahul-Mellier, L. Huc, A. Lemarie, S. Irshad, M. Hwang, C. Datler, E. Pazarentzos
CELL DEATH AND DIFFERENTIATION
(2015)
Article
Genetics & Heredity
Luping Lin, Amit J. Sabnis, Elton Chan, Victor Olivas, Lindsay Cade, Evangelos Pazarentzos, Saurabh Asthana, Dana Neel, Jenny Jiacheng Yan, Xinyuan Lu, Luu Pham, Mingxue M. Wang, Niki Karachaliou, Maria Gonzalez Cao, Jose Luis Manzano, Jose Luis Ramirez, Jose Miguel Sanchez Torres, Fiamma Buttitta, Charles M. Rudin, Eric A. Collisson, Alain Algazi, Eric Robinson, Iman Osman, Eva Munoz-Couselo, Javier Cortes, Dennie T. Frederick, Zachary A. Cooper, Martin McMahon, Antonio Marchetti, Rafael Rosell, Keith T. Flaherty, Jennifer A. Wargo, Trever G. Bivona
Article
Biochemistry & Molecular Biology
Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos, Asmin Tulpule, Saurabh Asthana, Collin M. Blakely, Ross A. Okimoto, Luping Lin, Dana S. Neel, Amit Sabnis, Jennifer Flanagan, Elton Chan, Marileila Varella-Garcia, Dara L. Aisner, Aria Vaishnavi, Sai-Hong I. Ou, Eric A. Collisson, Eiki Ichihara, Philip C. Mack, Christine M. Lovly, Niki Karachaliou, Rafael Rosell, Jonathan W. Riess, Robert C. Doebele, Trever G. Bivona
Article
Biochemistry & Molecular Biology
E. Pazarentzos, P. Giannikopoulos, G. Hrustanovic, J. St John, V. R. Olivas, M. A. Gubens, R. Balassanian, J. Weissman, W. Polkinghorn, T. G. Bivona
Article
Medicine, Research & Experimental
Alexander N. Comninos, Matthew B. Wall, Lysia Demetriou, Amar J. Shah, Sophie A. Clarke, Shakunthala Narayanaswamy, Alexander Nesbitt, Chioma Izzi-Engbeaya, Julia K. Prague, Ali Abbara, Risheka Ratnasabapathy, Victoria Salem, Gurjinder M. Nijher, Channa N. Jayasena, Mark Tanner, Paul Bassett, Amrish Mehta, Eugenii A. Rabiner, Christoph Honigsperger, Meire Ribeiro Silva, Ole Kristian Brandtzaeg, Elsa Lundanes, Steven Ray Wilson, Rachel C. Brown, Sarah A. Thomas, Stephen R. Bloom, Waljit S. Dhillo
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Vanessa D. Jonsson, Collin M. Blakely, Luping Lin, Saurabh Asthana, Nikolai Matni, Victor Olivas, Evangelos Pazarentzos, Matthew A. Gubens, Boris C. Bastian, Barry S. Taylor, John C. Doyle, Trever G. Bivona
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Gayathri N. Sekhar, Ana R. Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C. Brown, Paula Muresan, Roland A. Fleck, Sarah A. Thomas
Article
Cell Biology
Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K. Mayekar, Philippe Gui, David V. Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R. Johnson, Matan Hofree, Jenny J. Yan, Billy W. Newton, John V. Dollen, Charles H. Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh Asthana, Trey Ideker, Wei Wu, Junji Suzuki, Benjamin A. Barad, Yuriy Kirichok, James S. Fraser, William A. Weiss, Nevan J. Krogan, Asmin Tulpule, Amit J. Sabnis, Trever G. Bivona
Article
Neurosciences
Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B. Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas
FLUIDS AND BARRIERS OF THE CNS
(2019)
Article
Infectious Diseases
Lisa Sanderson, Marcelo da Silva, Gayathri N. Sekhar, Rachel C. Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cecile A. Dreiss, Chris Lorenz, Mark Christie, Shanta J. Persaud, Vanessa Yardley, Simon L. Croft, Margarita Valero, Sarah A. Thomas
Summary: Sleeping sickness, caused by a parasite transferred by tsetse flies, has two stages affecting the blood and the brain, with the brain stage being fatal if untreated. The blood-brain barrier makes treating the brain stage difficult. Pluronic was not found to improve delivery of pentamidine to the brain.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Oncology
Evangelos Pazarentzos
Summary: The protein I kappa B alpha, known for inhibiting the anti-apoptotic factor NF kappa B, has also been found to have a strong anti-apoptotic activity at the outer mitochondria membrane. It binds to VDAC1 and HK2, stabilizes the complex, and prevents mitochondria outer membrane permeabilisation and apoptosis.
MOLECULAR & CELLULAR ONCOLOGY
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.