Article
Immunology
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The International Working Group on the Diabetic Foot has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. This updated guideline uses the GRADE framework and provides recommendations for healthcare professionals involved in diabetes-related foot care. The recommendations cover various aspects of foot infections in diabetes patients, including diagnosis, treatment, and adjunctive therapies. The guideline aims to improve patient care, reduce amputations, and lessen the burden of diabetes-related foot disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Nicolaas J. Schaper, Jaap van Netten, Jan A. Apelqvist, Sicco Bus, Robert Fitridge, Fran Game, Matilde Monteiro-Soares, Eric Senneville, IWGDF Editorial Board
Summary: The International Working Group on the Diabetic Foot (IWGDF) has updated their practical guidelines on the prevention and management of diabetes-related foot disease. These guidelines aim to reduce the frequency of lower-extremity amputations caused by diabetes-related foot disease and provide better care for patients worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Sicco Bus, Matilde Monteiro-Soares, Fran J. Game, Jaap van Netten, Jan Apelqvist, Robert Fitridge, Eric C. Senneville, Nicolaas Schaper
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published updated guidelines in 2023 on the prevention and management of diabetes-related foot disease. These guidelines cover various aspects such as prevention, classification, offloading, peripheral artery disease, infection, wound healing interventions, and Charcot neuro-osteoarthropathy. Implementing these guidelines by healthcare providers, public health agencies, and policymakers is expected to improve the management of diabetes-related foot disease and reduce the burden caused by this condition worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Alana C. Keegan, Sanuja Bose, Katherine M. McDermott, Midori P. Starks White, David P. Stonko, Danielle Jeddah, Eilat Lev-Ari, Joanna Rutkowski, Ronald Sherman, Christopher J. Abularrage, Elizabeth Selvin, Caitlin W. Hicks
Summary: This study assessed the feasibility of a remote wound monitoring system (Healthy.io Minuteful for Wound Digital Management System) for lower extremity wounds. The results showed that the system is feasible for use by patients and/or their caregivers, providing accurate and effective wound monitoring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Urology & Nephrology
Jean-Baptiste Bonnet, Ariane Sultan
Summary: Diabetic foot ulcer (DFU) and chronic kidney disease (CKD) are two significant complications of diabetes mellitus (DM). This review examines the epidemiologic and pathophysiological links between DFU and CKD, as well as the actions taken to improve management in the end-stage renal disease (ESRD) population. Specific measures for patients undergoing dialysis have been found to improve the prognosis of DFU and reduce the rate of major amputations.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Endocrinology & Metabolism
Li Yang, Gui-Chuan Rong, Qi-Nan Wu
Summary: Diabetic foot ulcers (DFUs) have become a significant burden for patients with diabetes and society, requiring multidisciplinary management. This review discusses recent progress in DFU treatment, highlighting new technologies and measurements, as well as future challenges and directions.
WORLD JOURNAL OF DIABETES
(2022)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Matthew Malone, Adriaan Erasmus, Saskia Schwarzer, Namson S. Lau, Mehtab Ahmad, Hugh G. Dickson
Summary: The study used the 2019 IWGDF guidelines as an audit tool in clinical practice for patients with diabetes attending a High-Risk Foot Service, identifying deficits in performance in areas such as diagnosis, treatment, and culture. Further improvements and enhancements are needed in clinical practice and service delivery.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Racha El Hage, Uwe Knippschild, Tobias Arnold, Irene Hinterseher
Summary: Stem cell-based therapy shows promising potential in treating diabetic foot ulcers by promoting tissue repair through various mechanisms. However, there are still unknown factors that require further research to determine the optimal type of stem cells, administration route, and dosage.
Article
Endocrinology & Metabolism
Jaap J. A. van Netten, Sicco A. Bus, Jan Apelqvist, Pam Chen, Vivienne Chuter, Robert Fitridge, Frances J. Game, Robert J. A. Hinchliffe, Peter A. Lazzarini, Joseph Mills, Matilde Monteiro-Soares, Edgar J. G. M. Peters, Katherine M. Raspovic, Eric K. Senneville, Dane K. C. Wukich, Nicolaas C. Schaper
Summary: In order to facilitate clear communication between individuals with diabetes-related foot disease and professionals worldwide, the International Working Group on the Diabetic Foot (IWGDF) has developed a set of definitions and criteria for diabetes-related foot disease based on systematic reviews of the literature. This document describes the 2023 update of these definitions and criteria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Moreno D'Amico, Edyta Kinel, Piero Roncoletta, Andrea Gnaldi, Celeste Ceppitelli, Federico Belli, Giuseppe Murdolo, Cristiana Vermigli
Summary: The study aimed to develop a novel quantitative-statistical framework (QSF) for evaluating and designing custom-made insoles for offloading, and compared the pressure-relieving efficiency of traditional shape-based insoles with a CAD-CAM approach. The CAD-CAM approach showed better offloading performance than the traditional method.
Editorial Material
Endocrinology & Metabolism
Jennifer A. Pallin, Jaap J. Van Netten, Patricia M. Kearney, Sean F. Dinneen, Claire M. Buckley
Article
Endocrinology & Metabolism
Yuqi Zhang, Hannah E. Carter, Peter A. Lazzarini, Susanna Cramb, Rosana Pacella, Jaap J. van Netten, Qinglu Cheng, Patrick H. Derhy, Ewan M. Kinnear, Steven M. McPhail
Summary: The provision of guideline-based care for patients with diabetes-related foot ulcers is currently suboptimal. This study shows that increasing the proportion of patients receiving guideline-based care can lead to cost savings and improved patient outcomes. Strategies to increase the uptake of guideline-based care are necessary.
Review
Endocrinology & Metabolism
Peter A. Lazzarini, Susanna M. Cramb, Jonathan Golledge, Jedidiah I. Morton, Dianna J. Magliano, Jaap J. Van Netten
Summary: Diabetic foot disease (DFD) is a major cause of hospital admissions and amputations. This review analyzed the incidence of hospital admissions for DFD conditions and diabetes-related amputations in representative populations. The findings suggest that hospital admission rates for DFD conditions are higher than amputation rates, and the hospital admission rates for DFD conditions are not decreasing in many populations. Consistent definitions and data from low- and middle-income countries should be included in future studies.
Article
Endocrinology & Metabolism
Sicco Bus, Matilde Monteiro-Soares, Fran J. Game, Jaap van Netten, Jan Apelqvist, Robert Fitridge, Eric C. Senneville, Nicolaas Schaper
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published updated guidelines in 2023 on the prevention and management of diabetes-related foot disease. These guidelines cover various aspects such as prevention, classification, offloading, peripheral artery disease, infection, wound healing interventions, and Charcot neuro-osteoarthropathy. Implementing these guidelines by healthcare providers, public health agencies, and policymakers is expected to improve the management of diabetes-related foot disease and reduce the burden caused by this condition worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Jaap J. A. van Netten, Sicco A. Bus, Jan Apelqvist, Pam Chen, Vivienne Chuter, Robert Fitridge, Frances J. Game, Robert J. A. Hinchliffe, Peter A. Lazzarini, Joseph Mills, Matilde Monteiro-Soares, Edgar J. G. M. Peters, Katherine M. Raspovic, Eric K. Senneville, Dane K. C. Wukich, Nicolaas C. Schaper
Summary: In order to facilitate clear communication between individuals with diabetes-related foot disease and professionals worldwide, the International Working Group on the Diabetic Foot (IWGDF) has developed a set of definitions and criteria for diabetes-related foot disease based on systematic reviews of the literature. This document describes the 2023 update of these definitions and criteria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Jaap J. van Netten, Anita Raspovic, Lawrence A. Lavery, Matilde Monteiro-Soares, Joanne Paton, Anne Rasmussen, Isabel C. N. Sacco, Sicco A. Bus
Summary: Prevention of foot ulcers in persons with diabetes is important, and a comprehensive analysis is needed to inform healthcare professionals about effective prevention. This systematic review and meta-analysis aimed to assess the effectiveness of interventions to prevent foot ulcers in persons with diabetes at risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Sicco A. Bus, Isabel C. N. Sacco, Matilde Monteiro-Soares, Anita Raspovic, Joanne Paton, Anne Rasmussen, Lawrence A. Lavery, Jaap J. van Netten
Summary: This is the 2023 International Working Group on the Diabetic Foot guideline on the prevention of foot ulcers in persons with diabetes. It provides recommendations for clinicians and other healthcare professionals to screen and educate patients with diabetes in order to prevent foot ulcers.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Nicolaas J. Schaper, Jaap van Netten, Jan A. Apelqvist, Sicco Bus, Robert Fitridge, Fran Game, Matilde Monteiro-Soares, Eric Senneville, IWGDF Editorial Board
Summary: The International Working Group on the Diabetic Foot (IWGDF) has updated their practical guidelines on the prevention and management of diabetes-related foot disease. These guidelines aim to reduce the frequency of lower-extremity amputations caused by diabetes-related foot disease and provide better care for patients worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Editorial Material
Endocrinology & Metabolism
Wouter B. aan de Stegge, Jaap J. Van Netten, Sicco A. Bus
Summary: This study aimed to investigate if foot ulcers in people with diabetes and foot ulcer history are preceded by increased skin temperature. The results showed that the majority of the ulcers did not heat up before the occurrence, questioning the association between foot temperature increase and ulcer development.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Jaap J. van Netten, Isabel C. N. Sacco, Lawrence Lavery, Matilde Monteiro-Soares, Joanne Paton, Anne Rasmussen, Anita Raspovic, Sicco A. Bus
Summary: This study aimed to summarize and analyze the effectiveness of foot-ankle exercise programs for people with diabetes at risk of foot ulceration. The results showed that an 8-12 week foot-ankle exercise program may improve ankle joint and first metatarsal-phalangeal joint range of motion and alleviate neuropathy symptoms. However, this exercise program may not prevent or cause diabetes-related foot ulceration.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Chemistry, Analytical
Anas Ababneh, Kathleen Finlayson, Helen Edwards, David G. Armstrong, Bijan Najafi, Jaap J. van Netten, Peter A. Lazzarini
Summary: This study aimed to assess the validity and reliability of self-reported adherence to using removable cast walker (RCW) offloading treatment among people with diabetes-related foot ulcers (DFUs). The results showed that self-reported adherence was higher than objectively measured adherence, indicating poor agreement between the two measures. Therefore, clinicians and researchers should use objective measures to assess offloading adherence in patients.
Article
Chemistry, Analytical
Bernd Ploderer, Damien Clark, Ross Brown, Joel Harman, Peter A. Lazzarini, Jaap J. Van Netten
Summary: People with DFUs need to consistently perform self-care to promote healing, but it can be difficult to detect improvements. To address this, a mobile app called MyFootCare was developed to self-monitor DFU healing progression. The study evaluates the engagement and perceived value of MyFootCare over 3 months for people with plantar DFUs. Results showed that most participants found MyFootCare valuable for monitoring progress and reflecting on self-care events, but engagement varied due to facilitators and barriers. Further improvements and clinical outcome testing are needed.
Article
Medicine, Research & Experimental
M. A. Mens, T. E. Busch-Westbroekb, S. A. Bus, J. J. van Nettenb, R. H. H. Wellenberg, G. J. Streekstrac, M. Maas, M. Nieuwdorpd, G. M. M. J. Kerkhoffse, S. A. S. Stufkense
Summary: Foot ulcers are a significant issue in diabetes patients, often leading to amputations. This study aims to evaluate the effectiveness of tendon tenotomy in preventing toe ulcer recurrence in patients with diabetes and a history of toe ulcers.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: Early diagnosis and ongoing monitoring and treatment of peripheral artery disease (PAD) is crucial for reducing the risk of foot ulcer development, non-healing of wounds, infection, amputation, and cardiovascular complications in patients with diabetes. Various non-invasive bedside tests are available for diagnosing PAD, but the most accurate test and its reliability for ongoing monitoring are still uncertain. This systematic review aimed to determine the diagnostic accuracy of non-invasive bedside tests for identifying PAD and their reliability in adults with diabetes. The review included 40 studies on diagnostic accuracy and 7 studies on reliability. Ankle-brachial index (ABI) was the most investigated test. The review found that an ABI <0.9 increases the likelihood of disease, while an ABI within the normal range (≥0.90 and <1.3) does not exclude PAD. Toe-brachial index (TBI) and Doppler waveforms in the pedal arteries were also associated with PAD presence. Several bedside tests showed acceptable reliability, but the margin of error was wide. No single or combination of bedside tests demonstrated superior diagnostic accuracy for PAD in patients with diabetes. However, an ABI of 1.3, TBI <0.70, and absent or monophasic pedal Doppler waveforms can help identify the presence of disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Robert Hinchliffe, Joseph Mills, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Russell David, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: This systematic review aimed to determine the performance of non-invasive bedside tests for predicting the outcomes of DFU healing, minor amputation, and major amputation in people with diabetes and DFU or gangrene. The results showed that a toe pressure of ≥30 mmHg, TcPO2 of ≥25 mmHg, and skin perfusion pressure of ≥40 mmHg were associated with a moderate to large increase in the likelihood of DFU healing. However, there is limited research on the prognostic capacity of bedside testing for healing post-minor amputation or major amputation in people with DFU. Current evidence suggests that an ABI <0.4 may be associated with a large increase in the risk of major amputation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)