期刊
DEVELOPMENT
卷 147, 期 3, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.171736
关键词
Regulatory landscape; Gene regulation; Topologically associating domains; Enhancer-promoter interactions; Pleiotropy; Neo-functionalization
资金
- European Research Council [232 790]
- Swiss National Science Foundation (Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung) [31003A 155863]
- National Institute of Child Health and Human Development of the National Institutes of Health [F32HD093555]
- Swiss National Science Foundation (SNF) [31003A_155863] Funding Source: Swiss National Science Foundation (SNF)
Regulatory landscapes have been defined in vertebrates as large DNA segments containing diverse enhancer sequences that produce coherent gene transcription. These genomic platforms integrate multiple cellular signals and hence can trigger pleiotropic expression of developmental genes. Identifying and evaluating how these chromatin regions operate may be difficult as the underlying regulatory mechanisms can be as unique as the genes they control. In this brief article and accompanying poster, we discuss some of the ways in which regulatory landscapes operate, illustrating these mechanisms using genes important for vertebrate development as examples. We also highlight some of the techniques available to researchers for analysing regulatory landscapes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据