期刊
BRAIN IMPAIRMENT
卷 18, 期 1, 页码 117-129出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/BrImp.2016.21
关键词
Progressive non-fluent aphasia; logopenic progressive aphasia; interpersonal reactivity index; empathy; carer burden; empathic concern; perspective taking; personal distress
资金
- National Health and Medical Research Council (NHMRC) of Australia programme [APP1037746]
- Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Node [CE110001021]
- Australian Research Council Discovery Early Career Researcher Award [DE130100463]
- NHMRC Senior Research Fellowship [APP1103258]
- NHMRC-ARC Dementia Research Development Fellowship [APP1097026]
Empathy involves being able to understand and respond to others' emotional experiences. Whilst deficits in empathy have been observed in frontotemporal dementia, the extent to which empathy is disrupted in dementia syndromes with predominant language impairment remains unclear. The current study investigated cognitive and affective empathy in the two non-fluent primary progressive aphasia syndromes: progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA). Informants of 23 PNFA and 16 LPA patients completed the Interpersonal Reactivity Index (IRI), regarding patients' capacity for empathy preand post-disease onset. Twenty-four healthy control participants completed the self-rated IRI for comparison of post-disease empathy capabilities. Within-group analyses revealed reduced cognitive empathy and increased personal distress in both patient groups. In addition, lowered affective empathy was reported in PNFA, with a similar trend observed in LPA. Interestingly, reduced affective empathy was associated with greater carer burden in LPA. Between-group analyses revealed reduced cognitive empathy in both patient groups relative to controls. The current study is the first to document empathy changes in PNFA and LPA, offering insight into the social cognitive deficits experienced in these syndromes. Future neuroimaging studies are needed to identify the underlying neural correlates and mechanisms driving empathy deficits in PNFA and LPA.
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