Article
Cell Biology
Guangxi Wang, Mantang Qiu, Xudong Xing, Juntuo Zhou, Hantao Yao, Mingru Li, Rong Yin, Yan Hou, Yang Li, Shuli Pan, Yuqing Huang, Fan Yang, Fan Bai, Honggang Nie, Shuangshuang Di, Limei Guo, Zhu Meng, Jun Wang, Yuxin Yin
Summary: Lung cancer, the leading cause of cancer-related deaths, can be improved by early detection. A study found dysregulated lipid metabolism in different cell types of early-stage lung cancers. By identifying nine important lipids, a targeted assay was developed with high specificity in detecting early-stage lung cancer. This method demonstrated high sensitivity and specificity in screening and clinical cohorts. Overall, this method shows promise in early lung cancer detection and cancer prevention for high-risk populations.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemical Research Methods
Xingze Wang, Guoxian Yu, Jun Wang, Azlan Mohd Zain, Wei Guo
Summary: Diagnosing lung cancer subtypes accurately is crucial for precise treatment. This study introduces an interpretable and flexible solution called LungDWM, which utilizes weakly paired multiomics data to diagnose lung cancer subtypes. By extracting important diagnostic features, imputing missing data, and fusing information from different omics, LungDWM outperforms other competitive methods in terms of performance, authenticity, and interpretability.
Article
Medicine, General & Internal
Xiaoshuang Feng, David C. Muller, Hana Zahed, Karine Alcala, Florence Guida, Karl Smith-Byrne, Jian-Min Yuan, Woon-Puay Koh, Renwei Wang, Roger L. Milne, Julie K. Bassett, Arnulf Langhammer, Kristian Hveem, Victoria L. Stevens, Ying Wang, Mikael Johansson, Anne Tjonneland, Rosario Tumino, Mahdi Sheikh, Mattias Johansson, Hilary A. Robbins
Summary: This study aimed to evaluate the association between circulating proteins and survival after lung cancer diagnosis, as well as their potential for improving prognosis prediction. The results showed that only CDCP1 remained statistically significant after accounting for multiple testing. In conclusion, blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival and did not significantly improve prognosis prediction beyond clinical information.
Article
Oncology
He-Guo Jiang, Chun-Hua Dai, Ya-Ping Xu, Qian Jiang, Xian-Bin Xia, Yang Shu, Jian Li
Summary: This study investigated the diagnostic and prognostic value of four plasma miRNAs in non-small cell lung cancer (NSCLC), confirming that miR-210, miR-1290, miR-150, and miR-21-5p were highly expressed in NSCLC patients. The four-miRNA panel showed high accuracy in distinguishing NSCLC patients from healthy controls and those with benign lung disease, suggesting their potential as useful biomarkers for early diagnosis and prognosis of NSCLC.
Article
Nutrition & Dietetics
Ola Hysaj, Nena Karavasiloglou, Manuela Limam, Miriam Wanner, Dimitri Korol, Sabine Rohrmann
Summary: In Switzerland, there is a seasonal variation in sunlight, with winter being associated with vitamin D deficiency. A study found that being diagnosed with cancer in summer and/or autumn was associated with better survival rates, possibly due to the seasonal variation of sun-induced vitamin D.
Article
Oncology
Shaoyan Lin, Hongnan Mo, Yiqun Li, Xiuwen Guan, Yimeng Chen, Zijing Wang, Binghe Xu
Summary: The study revealed significant associations between incidence of lung metastases and factors such as age, ECOG grade, tumor subtype in the Chinese Han population; BCLM patients had a median survival of 41.7 months, with the worst prognosis seen in triple-negative subtype patients.
Article
Oncology
Yang Liu, Libo He, Wang Wang
Summary: The importance of physical exercise in reducing cancer risk and improving treatment efficacy in tumor patients, especially those with lung cancer, has long been known. Though several molecular mechanisms have been identified, the role of microRNAs (miRNAs) in relation to these processes is still unclear. This study aimed to identify and analyze miRNAs associated with lung cancer and exercise intervention. The results identified 42 marker miRNAs, of which three core miRNAs (has-miR-195, has-miR-26b, and has-miR-126) were found to be co-regulated by exercise and cancer, with involvement in cell cycle and immunity. This study supports the potential of exercise intervention as adjuvant therapy for lung cancer patients, with the identified core miRNAs potentially serving as non-invasive biomarkers for cancer prevention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Chih-Hsiung Su, Wan-Ming Chen, Ming-Chih Chen, Ben-Chang Shia, Szu-Yuan Wu
Summary: This study found that the presence of sarcopenia before cancer diagnosis may be associated with reduced survival outcomes in cancer patients.
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Ji Li, Wang Jing, Xiaoyang Zhai, Wenxiao Jia, Hui Zhu, Jinming Yu
Summary: This study validates the feasibility of the Lung-molGPA tool in predicting survival of patients with non-small-cell lung cancer, providing evidence for its usefulness in determining treatment strategies and prognosis. Patients in the adenocarcinoma group with higher Lung-molGPA scores had longer median survival times, while a similar trend was observed in the non-adenocarcinoma group.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Multidisciplinary Sciences
Shi-Ang Qi, Qian Wu, Zhenpu Chen, Wei Zhang, Yongchun Zhou, Kaining Mao, Jia Li, Yuanyuan Li, Jie Chen, Youguang Huang, Yunchao Huang
Summary: This study identified key metabolites for early lung cancer screening through plasma metabolomic analysis, which could potentially be transferred onto point-of-care devices for lung cancer diagnosis and prognosis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Monu Pandey, Abhirup Mukhopadhyay, Surender K. Sharawat, Sachin Kumar
Summary: SCLC, a smoking-related aggressive cancer, shows universal loss of TP53 and RB1 tumor suppressor genes, with miRNAs playing a key role in regulating cell processes and potential clinical applications in monitoring chemotherapy responses and predicting survival outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Pathology
Ghazale Faraji, Pedram Moeini, Mohammad Hasan Ranjbar
Summary: The significance of exosomal microRNAs in breast cancer diagnosis and treatment prediction is important but requires further research.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Engineering, Electrical & Electronic
Rajesh Kumar, Sachin Kumar, Binod Kumar Kanaujia
Summary: This paper proposes a Doherty power amplifier (DPA) structure based on Class-J power amplifier (PA) and Class-J(-1) PA for configurable Internet of Things (IoT) transmitters. The proposed DPA structure achieves wider bandwidth performance, high efficiency, and power gain flatness. Compared to existing DPAs, the proposed DPA exhibits higher efficiency, output power, and compact size.
INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sachin Kumar, Vikas Gaur, Ishfaq A. Mir, Jyoutishman Saikia, Sunil Kumar
Summary: Overexpression of miR-3692-3p is observed in the tumors and tissue biopsies of lung cancer patients, but it is not associated with survival outcomes or therapeutic response. Therapeutic response is identified as an independent prognostic biomarker. Further mechanistic studies are needed to elucidate the role of miR-3692-3p in lung carcinogenesis.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Computer Science, Information Systems
Ghanshyam Singh, Sachin Kumar, Ajay Abrol, Binod Kumar Kanaujia, Vijay Kumar Pandey, Mohamed Marey, Hala Mostafa
Summary: In this paper, a frequency reconfigurable multiband MIMO antenna is developed for 5G communication systems. The antenna element consists of a microstrip line, a divided monopole, and a ground plane. The antenna design includes a split-ring resonator (SRR) for multiple 5G application bands and an RF PIN diode for frequency diversity. The MIMO antenna is designed with improved inter-element isolation by orthogonally locating four antenna elements with connected ground planes. The prototype antenna, developed on an FR-4 substrate, matches the simulated outcomes and has an overall footprint of 70 x 70 x 1.6 mm(3).
Article
Computer Science, Information Systems
Divya Upadhyay, Puneet Garg, Sultan Mesfer Aldossary, Jana Shafi, Sachin Kumar
Summary: In recent years, the IoT and wireless sensor networks have been widely used in healthcare applications, aiming to reduce human errors and improve the accuracy of illness analysis. This paper proposes an IoT-based health monitoring system that can monitor various parameters and provide timely advice to parents or guardians through SMS or emails. The system also employs a clock synchronisation technique to improve the performance and accuracy of the monitoring system.
Review
Immunology
Kiran Singh, Deepa Mehta, Shaurya Dumka, Aditya Singh Chauhan, Sachin Kumar
Summary: Viral quasispecies are distinct but closely related mutants formed by recombination, mutations, competition, and selection pressure. Their origin is attributed to the error-prone replication by polymerase and mutants of RNA replicators. The impact of quasispecies for major human pathogens is reviewed, and the rapid changes in geographical landscapes favor the origin and selection of mutants, posing a significant risk to public health.
Correction
Materials Science, Multidisciplinary
Sachin Kumar, Shiv Brat Singh
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Sachin Kumar, Shiv Brat Singh
Summary: A low-carbon low-alloy steel suitable for Q&P processing was designed by considering the influence of alloying elements on various aspects of transformation and microstructure. The designed steel showed improved strength and elongation due to a more effective exploitation of the TRIP effect. The TRIP behavior depended not only on the amount and carbon content of retained austenite, but also on the morphology of austenite and the characteristics of the surrounding phases.
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Meznah M. Alanazi, Loubna Ouahid, Jameelah S. Al Shahrani, M. A. Abdou, Sachin Kumar
Summary: This paper presents new soliton solutions for ion sound and Langmuir waves (ISALWs) using the Atangana-Baleanu (AB) fractional. The extended sub-equation method (ESEM) is applied to obtain various soliton solutions in trigonometric functions, hyperbolic functions, and other functional forms. The obtained soliton solutions show different shapes, including bell-shaped, single-soliton-shaped, and mixed-type solitons, which are examined using three-dimensional graphics.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Sachin Kumar, Monika Niwas
Summary: In this work, the perturbed Chen-Lee-Liu (CLL) equation is studied using the generalized Riccati equation mapping method. Soliton solutions are obtained by applying the traveling wave transformation and analyzing the real and imaginary parts of the perturbed CLL equation. The obtained solutions exhibit various dynamic behaviors such as solitary wave solitons, mixed periodic solitons, anti-bell shape solitons, solitary wave with lump solitons, singular type solitons, and periodic wave solitons.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Oncology
Shefali Singh, Deevanshu Goyal, Karthikeyan Raman, Sachin Kumar, Prabhat Singh Malik, Ravikrishnan Elangovan
Summary: This study used a rapid immunomagnetic enrichment approach to isolate lung cancer cell-derived exosomes from human plasma and analyzed their RNA content using high throughput sequencing. Differential expression analysis between patients and healthy controls identified cancer-related genes, and functional enrichment analysis revealed their association with cancer-related pathways. In conclusion, this approach provides a feasible option for focused disease-specific transcriptome analysis to identify exosome biomarkers for detecting non-small lung cancer.
Article
Regional & Urban Planning
Sachin Kumar, Neeraj Dhiman, Honey Kanojia, Richa Joshi
Summary: This study aims to explore the factors influencing the discontinuance intentions of millennials to use hotel booking apps. A quantitative technique was used to collect data from tourists, and partial least square structural equation modeling (PLS-SEM) was used to validate the proposed model. The study found that significant predictors of discontinuance intentions include usage barrier, values barrier, risk barrier, lack of facilitating conditions, and digital self-efficacy. The findings provide valuable insights for tourism stakeholders and app developers to understand the challenges faced by users of such hotel booking apps.
Article
Biology
Preeti Saini, Bharti Nagpal, Puneet Garg, Sachin Kumar
Summary: This study aims to assess the accuracy of a prediction model for sugarcane yield based on remote sensing-derived products and climate data. By using regression analysis on historical sugarcane yield, climatic parameters, and vegetation condition index (VCI) of 75 districts in six major sugar-producing states of India, a highly accurate empirical model was developed. The results show that incorporating maximum and minimum temperature parameters with remote sensing-derived vegetation indices significantly improves the coefficient of determination of the prediction model.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2023)
Article
Oncology
S. Verma, S. Chitikela, V. Singh, S. Khurana, D. Pushpam, D. Jain, S. Kumar, Y. Gupta, P. S. Malik
Summary: This study investigated the efficacy of metformin combined with pemetrexed-carboplatin in the treatment of driver mutation-negative non-squamous NSCLC. The results showed that the combination treatment did not improve the 6-month progression-free survival rate, but was safe.
Article
Engineering, Civil
Xindi Ma, Qi Jiang, Mohammad Shojafar, Mamoun Alazab, Sachin Kumar, Saru Kumari
Summary: This paper introduces the challenges of using federated learning in IoT-enabled Maritime Transportation System (MTS) for intelligent control and routing planning. It proposes a mechanism called DisBezant to achieve secure and Byzantine-robust federated learning. The mechanism includes a credibility-based mechanism to resist Byzantine attacks and a privacy-preserving gradient aggregation protocol based on a secure two-party calculation protocol. The effectiveness of DisBezant is verified through experiments.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Oncology
Dan Hu, Ying Wang, Genxin Ji, Yu Liu
Summary: This study constructed prognostic models for advanced NPC patients treated with IMRT using machine learning algorithms. Random forest (RF) showed the best predictive performance and identified the most important predictors. RF was proposed as a simple and accurate tool for evaluating the prognosis of advanced NPC patients.
CURRENT PROBLEMS IN CANCER
(2024)
Article
Oncology
Leena Gupta, Pratibha Suku, Aishwarya Dash, Parveen Bose, Praveen Sharma, Nabhajit Mallik, Sreejesh Sreedharanunni, Neelam Varma, Aditya Jandial, Pankaj Malhotra, Man Updesh Singh Sachdeva
Summary: This study evaluated the load and characteristics of circulating tumor plasma cells (CTPCs) and circulating normal plasma cells (CNPCs) in newly diagnosed multiple myeloma patients using flow cytometry. Increased burden of CTPCs was associated with poor prognostic markers and poor response to therapy. CNPCs were lower in patients with thrombocytopenia and hypoalbuminemia.
CURRENT PROBLEMS IN CANCER
(2024)
