期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 59, 期 -, 页码 19-28出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.01.006
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资金
- National Institutes of Health [R21DK114607, R01090260]
Mechanisms for making and breaking the heme b cofactor (heme) are more diverse than previously expected. Biosynthetic pathways have diverged at least twice along taxonomic lines, reflecting differences in membrane organization and O-2 utilization among major groups of organisms. At least three families of heme degradases are now known, again differing in whether and how O-2 is used by the organism and possibly the purpose for turning over the tetrapyrrole. Understanding these enzymes and pathways offers a handle for antimicrobial development and for monitoring heme use in organismal and ecological systems.
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