Editorial Material
Microbiology
Jan Claesen, J. Mark Brown
Summary: This study comprehensively cataloged pathways involved in trimethylamine metabolism and identified key bacterial players in the process. It also discovered new TMA-reducing genera that have potential for probiotic strategies or targeted microbiome interventions.
Review
Biochemistry & Molecular Biology
Sanna Lensu, Satu Pekkala
Summary: A physically active lifestyle and exercise are associated with a healthy gut microbiota, benefiting from medium-intensity endurance exercise. However, this connection varies depending on study population and exercise protocol, and improvements induced by exercise may disappear in previously sedentary subjects. Controlling for diet in future longitudinal studies on the gut microbiota and physical performance is essential.
Review
Biochemistry & Molecular Biology
Hao-Jian Zhang, Yan Wang, Jian-Dong Jiang
Summary: This review explores the relationship between the gut microbiome and the development of atherosclerosis, as well as the interactions between atherosclerosis-related drugs and the intestinal microbiome. It provides further insights into the development of microbiome-based drugs for the treatment of atherosclerosis.
CURRENT DRUG METABOLISM
(2023)
Review
Microbiology
Edyta Bulanda, Tomasz P. Wypych
Summary: The interaction between the gut microbiome and the immune system plays a crucial role in determining health and disease. Modifying the microbiome through diet interventions and probiotics can help prevent or treat chronic respiratory diseases. Additionally, microbial products are emerging as a new class of potential therapeutics for communication along the gut-lung axis.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Panagiotis D. Papadopoulos, Christina Tsigalou, Pipitsa N. Valsamaki, Theocharis G. Konstantinidis, Chrysoula Voidarou, Eugenia Bezirtzoglou
Summary: The collection of normal microorganisms in our gut plays a significant role in our health, while dysbiosis in the gut microbial pool has been proven to be crucial in the pathophysiology of various diseases, including cardiovascular disease. In addition to traditional risk factors, research has also highlighted the involvement of gut bacteria and their metabolites in the pathogenesis of CVD.
Review
Infectious Diseases
Brandilyn A. A. Peters, Robert D. D. Burk, Robert C. C. Kaplan, Qibin Qi
Summary: Recent studies have explored the link between the gut microbiome and microbial metabolites and cardiovascular disease in people living with HIV. However, there is insufficient and inconsistent evidence regarding specific microbial species and metabolites associated with cardiovascular outcomes in this population.
CURRENT HIV/AIDS REPORTS
(2023)
Article
Critical Care Medicine
Daphne M. Moutsoglou, Jasmine Tatah, Sasha Z. Prisco, Kurt W. Prins, Christopher Staley, Sharon Lopez, Madelyn Blake, Levi Teigen, Felipe Kazmirczak, E. Kenneth Weir, Amanda J. Kabage, Weihua Guan, Alexander Khoruts, Thenappan Thenappan
Summary: Inflammation drives pulmonary arterial hypertension (PAH). This study found that patients with PAH have less diverse gut microbiome, with fewer copies of genes that produce anti-inflammatory short-chain fatty acids and secondary bile acids, and enrichment of species with genes encoding the proinflammatory metabolite trimethylamine. These findings support investigating modulation of the gut microbiome as a potential treatment for PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Neurosciences
Carol L. Cheatham, David C. Nieman, Andrew P. Neilson, Mary Ann Lila
Summary: Age-related cognitive changes may be an early indication of dementia progression, and these changes are driven by complex interactions among factors such as diet, activity levels, genetics, and environment. Recent studies have found that flavonoid-rich foods can inhibit neuroinflammation and enhance cognitive performance. Improved cognition is also correlated with a physically active lifestyle and a diverse gut microbiome. This article suggests that a combination of flavonoid intake and physical exertion may have potential impacts on cognitive function, mediated by the gut microbiome. Further research is needed to explore this hypothesis through animal studies and clinical interventions.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Kaplina, Svetlana Kononova, Ekaterina Zaikova, Tatiana Pervunina, Natalia Petrova, Stanislav Sitkin
Summary: This review summarizes the impact of necrotizing enterocolitis (NEC) on very low birth weight preterm infants and the potential complications from surgical treatment. It discusses the unclear pathogenesis, prevention, and treatment of NEC, including prenatal risk factors and the role of the intestinal microbiome. The review also highlights promising approaches for preventing and treating NEC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Bei Gao, Atoosa Emami, Shilpa Nath, Bernd Schnabl
Summary: Alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and gut microbiota, communicating with the liver through the gut-liver axis. Some microbial products and metabolites reviewed in this article may serve as therapeutic targets for alcohol-related liver disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Medicine, General & Internal
Yue Ma, Xiaolin Liu, Jun Wang
Summary: Research on the gut microbiome and related diseases is expanding rapidly, and new perspectives on disease development and treatment are being offered. This review explores the changes in gut microbial metabolites within complex diseases and discusses the potential causal effects of these metabolites on diseases.
Review
Microbiology
Yi Xia, Mengting Ren, Jinpu Yang, Changzhou Cai, Weixin Cheng, Xinxin Zhou, Dan Lu, Feng Ji
Summary: Obesity is a major risk factor for non-alcoholic fatty liver disease (NAFLD), and weight loss can be an effective therapeutic solution. Bariatric surgery (BS) can achieve long-term weight loss and improve the overall health of patients with NAFLD. Studies have found alterations in the gut microbiome in NAFLD patients, suggesting a correlation between gut microbiome and NAFLD.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Malgorzata Anna Marc, Rafal Jastrzab, Jennifer Mytych
Summary: This article summarizes the latest knowledge on the correlation between gut microbiota dysbiosis and neurodegenerative and brain-related diseases such as Alzheimer's and Parkinson's. It emphasizes the importance of gut-derived metabolites and gut metabolic status as key factors in gut-brain crosstalk and their impact on the severity of neural conditions.
Article
Nutrition & Dietetics
Kristina S. Petersen, Mansi Chandra, Jeremy R. Chen See, Jillian Leister, Fatemeh Jafari, Alyssa Tindall, Penny M. Kris-Etherton, Regina Lamendella
Summary: This study aimed to investigate the effect of walnut-related modulation of gut microbiota composition on microbiota functionality. The results showed that walnut intake increased the alpha-diversity of actively expressed genes and led to the upregulation of certain genes. Additionally, walnut intake may increase the endogenous production of homoarginine through gut microbiota-mediated mechanisms.
CLINICAL NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Jin Guo, Chun-Xia Shi, Qing-Qi Zhang, Wei Deng, Lu-Yi Zhang, Qian Chen, Dan-Mei Zhang, Zuo-Jiong Gong
Summary: This review explores the interaction between microbial products and non-alcoholic fatty liver disease (NAFLD), as well as the regulatory role of existing NAFLD therapies on metabolite levels. It is found that microbial metabolites can regulate host lipid, glucose, and bile acid metabolic homeostasis through various pathways, and have the potential to alleviate NAFLD. Therefore, targeting these metabolites may be beneficial in relieving NAFLD.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)