Article
Microbiology
Muhammad Usman Qamar, Muhammad Ismail Chughtai, Hasan Ejaz, Bi Bi Zainab Mazhari, Uzma Maqbool, Awadh Alanazi, Yasir Alruwaili, Kashaf Junaid
Summary: This study aimed to identify the pathogens, genes, and antimicrobial residues present in raw milk and meat. Samples were collected from different parts of Faisalabad metropolis in Pakistan. The beef samples showed polymicrobial contamination with Escherichia coli and Klebsiella pneumoniae predominating, while the milk samples showed polymicrobial contamination with E. coli, K. pneumoniae, and Staphylococcus aureus forming the majority. Antimicrobial resistance genes were identified in both beef and milk samples, with high tetracycline residue levels posing a serious health risk to consumers.
Review
Biochemistry & Molecular Biology
Jagjit Singh Dhaliwal, Said Moshawih, Khang Wen Goh, Mei Jun Loy, Md Sanower Hossain, Andi Hermansyah, Vijay Kotra, Nurolaini Kifli, Hui Poh Goh, Sachinjeet Kaur Sodhi Dhaliwal, Hayati Yassin, Long Chiau Ming
Summary: Chalcones and their derivatives have various pharmacological properties, including antibacterial, antifungal, anti-inflammatory, and anticancer effects. Modifying the structure can enhance their potency and reduce toxicity. Chalcone compounds can inhibit antibiotic-resistance development pathways and exhibit higher activity than conventional antibiotics. Chalcone derivatives can block inflammation-related signaling pathways and show potent inhibitory activity.
Review
Biochemistry & Molecular Biology
Rajeev Shrestha, Anusree Thenissery, Rahul Khupse, Gireesh Rajashekara, Agnieszka Ewa Wiacek
Summary: This article reviews the recent chemical modifications of chitosan and its derivatives. By using various synthetic methods, chitosan can be modified to produce different derivatives with potential applications in areas such as antimicrobial activities, targeted drug delivery, and plant agriculture.
Article
Biochemistry & Molecular Biology
Zhenting Zhang, Zhimei Zhong, Zhihong Zhao
Summary: Six cyclic substituted chitosan derivatives were synthesized and characterized by various methods, showing greater antibacterial efficacy against Gram-positive bacteria compared to chitosan. The results suggest that these derivatives have potential as new pesticides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Environmental Sciences
Mohamed E. Abd El-Hack, Nahed A. El-Shall, Nagwa I. El-Kasrawy, Mohamed T. El-Saadony, Manal E. Shafi, Nidal M. Zabermawi, Mashaeal S. Alshilawi, Mahmoud Alagawany, Asmaa F. Khafaga, Rana M. Bilal, Shaaban S. Elnesr, Lotfi Aleya, Synan F. AbuQamar, Khaled A. El-Tarabily
Summary: Consumers' demand for clean-label food products has led to the search for new natural antimicrobials. This review investigates the antimicrobial properties of black pepper and highlights consumers' desire for clean-label products and additives-free food.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Ourania Misiou, Konstantinos Koutsoumanis
Summary: This paper provides an overview of the potential impact of climate change on food safety and microbial spoilage. Global warming is projected to increase the risk of microbial spoilage in food, such as contamination by mycotoxins and marine biotoxins, as well as environmental residuals and zoonotic diseases. The paper emphasizes the need for multidisciplinary approaches to study the potential effects of climate change on food and highlights the importance of preparedness by the food industry and policy makers.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dazhong Yan, Yanzhen Li, Yinling Liu, Na Li, Xue Zhang, Chen Yan
Summary: Chitosan, a natural antimicrobial polymer, has potential as an alternative for antibiotics in therapy and disinfection due to its ability to kill microbes by neutralizing their negative charges on the surface. Chemically modified chitosan derivatives have better water solubility and antimicrobial properties, offering promise for improvement in the treatment of enteric infections.
Article
Chemistry, Medicinal
Dawei Yu, Jiayao Feng, Huimin You, Shipeng Zhou, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: Chitosan oligosaccharides, derived from abundant marine resources, have been proven to exhibit various biological activities. Their properties can be further enhanced through the formation of different derivatives, making them superior to chitosan itself. This review provides an overview of the key structures and synthesis methods of chitosan oligosaccharide derivatives, as well as discussing their applications in antimicrobial and antitumor fields.
Review
Chemistry, Multidisciplinary
Iyyakkannu Sivanesan, Nazim Hasan, Syed Kashif Ali, Juhyun Shin, Judy Gopal, Manikandan Muthu, Jae-Wook Oh
Summary: This review comprehensively lists the available novel chitosan derivatives and summarizes their biological applications. It points out the selective focus on bio functions and the lack of exploration in other biomedical and antiviral applications, while highlighting the profound impact of synthesized chitosan derivatives on unexplored biological aspects.
APPLIED SCIENCES-BASEL
(2022)
Article
Materials Science, Multidisciplinary
Mirela Roman (Iana-Roman), Petronela Nechita, Mihaela-Aida Vasile, Alina-Mihaela Cantaragiu Ceoromila
Summary: This study analyzes the potential of coatings based on xylan derivatives and chitosan for paper food packaging, finding that the addition of chitosan significantly improves the performance of the coatings.
Article
Chemistry, Applied
Dongkun Yu, Indra Bhusan Basumatary, You Liu, Xingyan Zhang, Santosh Kumar, Fei Ye, Joydeep Dutta
Summary: This study reports a method to enhance the antimicrobial properties of chitosan coating by loading photocatalyst ZnO-SnOx nanoparticles onto chitosan matrix. The results show that ZnO-SnOx has a better inhibitory effect on bacteria compared to chitosan alone, making the chitosan nanocomposite coating a potential material for food packaging.
PROGRESS IN ORGANIC COATINGS
(2024)
Article
Energy & Fuels
Sawsan Affes, Inmaculada Aranaz, Niuris Acosta, Angeles Heras, Moncef Nasri, Hana Maalej
Summary: Chitosan derivatives with improved functional and biological properties were prepared by chemical depolymerization. The resulting products showed enhanced solubility and antioxidant properties, and their antibacterial and antifungal potentials were related to their molecular weight.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Review
Biochemistry & Molecular Biology
Luminita Georgeta Confederat, Cristina Gabriela Tuchilus, Maria Dragan, Mousa Sha'at, Oana Maria Dragostin
Summary: Biodegradable biopolymers, such as chitosan, have gained significant attention for their environmentally friendly properties and wide range of applications in various economic sectors and medicine. Chitosan, with its biodegradability, biocompatibility, low cost, and multiple pharmacological properties, has sparked strong interest among researchers.
Article
Biochemistry & Molecular Biology
Mehran Babaee, Farhad Garavand, Abdur Rehman, Shima Jafarazadeh, Elahe Amini, Ilaria Cacciotti
Summary: The study developed a PS/CNPs composite film with good antimicrobial properties against both S. aureus and E. coli. The mechanical and barrier properties of the film improved with the increase in CNPs percentage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Materials Science, Multidisciplinary
Sheng Ding, Yuanfeng Wang, Jianna Li, Shiguo Chen
Summary: Chitosan is a natural alkaline polysaccharide derived from marine organisms with broad-spectrum antimicrobial activity and good water solubility. However, its poor solubility under physiological conditions limits its applications, thus systematic summarization of modification strategies for CS derivatives is highly necessary. Current research has improved the properties of CS derivatives through chemical reactions and physical integration, providing more possibilities for medical applications.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
F. Chamorro, M. Carpena, M. Fraga-Corral, J. Echave, Muhammad Shahid Riaz Rajoka, Francisco J. Barba, Hui Cao, Jianbo Xiao, M. A. Prieto, J. Simal-Gandara
Summary: Agricultural production and food industry wastes can be revalued by utilizing kiwifruit by-products as natural sources of ingredients, rich in nutrients such as vitamin C and phenolic compounds, for various applications in food, cosmetic, and pharmaceutical industries.
Review
Microbiology
Aqsa Shahid, Mohsin Khurshid, Bilal Aslam, Saima Muzammil, Hafiza Mahreen Mehwish, Muhammad Shahid Riaz Rajoka, Hafiz Fakhar Hayat, Muhammad Hassan Sarfraz, Muhammad Khuram Razzaq, Muhammad Atif Nisar, Muhammad Waseem
Summary: Cyanobacterial metabolites have shown potential in inducing apoptosis and inhibiting cancer cell growth through various mechanisms, making them promising candidates for developing novel anticancer drugs. This study summarizes the role of cyanobacterial metabolites in cytotoxicity induction, growth inhibition of cancer cells, and their anticancer mechanisms, while also discussing ongoing trials and future developments in cancer therapy implications.
JOURNAL OF BASIC MICROBIOLOGY
(2022)
Article
Microbiology
Y. Suda, K. Kagawa, K. Fukuyama, M. Elean, B. Zhou, M. Tomokiyo, M. Aminul Islam, M. S. R. Rajoka, A. K. M. Humayun Kober, T. Shimazu, S. Egusa, Y. Terashima, H. Aso, W. Ikeda-Ohtsubo, J. Villena, H. Kitazawa
Summary: This study found that soymilk fermented with L. delbrueckii subsp. delbrueckii TUA4408L reduced inflammation and regulated cytokine expression in the intestinal mucosa of pigs. These immunological changes were associated with improved resistance to pathogenic Escherichia coli and enhanced growth performance and meat quality.
BENEFICIAL MICROBES
(2022)
Article
Engineering, Chemical
Sana Tabassum, Hafiz Rameez Khalid, Waqar ul Haq, Sidra Aslam, Abdulrahman Alshammari, Metab Alharbi, Muhammad Shahid Riaz Rajoka, Mohsin Khurshid, Usman Ali Ashfaq
Summary: This study investigated the potential role of holy basil (Tulsi) in the treatment of tuberculosis using a network pharmacology approach. The results showed that Tulsi contains eight active ingredients that target 776 potential therapeutic targets. There were 72 common potential targets between tuberculosis and Tulsi, and ten core protein-protein interactions were identified through topological analysis. Molecular docking analysis revealed that the active compounds have strong binding ability to potential targets for suppressing tuberculosis.
Review
Microbiology
A. K. M. Humayun Kober, Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Julio Villena, Haruki Kitazawa
Summary: In the past decade, the use of probiotics as feed supplements in animal production has significantly increased due to the ban on antibiotic growth promoters. Probiotics have been suggested to improve the health, immunity, growth performance, nutritional digestibility, and intestinal microbial balance of livestock. Furthermore, they can help balance the beneficial microbial population and turnover in animals by stimulating the host immune response and excluding potentially pathogenic bacteria.
Review
Environmental Sciences
Ayesha Javaid, Shoomaila Latif, Muhammad Imran, Nazim Hussain, Muhammad Shahid Riaz Rajoka, Hafiz M. N. Iqbal, Muhammad Bilal
Summary: Advancement in medication has increased the chemical burden on our natural ecosystem, with pharmaceutical residuals becoming a serious health hazard in wastewater. Efficient materials, such as nanohybrid photocatalysts, have been explored to mitigate pharmaceuticals in wastewater. Metal-based and carbon-based nanohybrids have been widely studied for the removal of pharmaceutical drugs. This review discusses the sources of pharmaceuticals in wastewater, their health risks, and the use of efficient nanohybrids as photocatalysts for their reduction.
Article
Biochemistry & Molecular Biology
Mubarak A. Alamri, Muhammad Tahir ul Qamar, Alhumaidi B. Alabbas, Safar M. Alqahtani, Manal A. Alossaimi, Sikandar Azam, Muhammad Harris Hashmi, Muhammad Shahid Riaz Rajoka
Summary: The COVID-19 pandemic has caused significant stress on the global health system, resulting in high morbidity and mortality. Efforts are needed to develop new therapeutics to manage SARS-CoV-2 and other emerging viruses. This study focused on the impact of SARS-CoV-2 RdRp mutations collected from Saudi Arabia on protein structure and function. The results suggest that certain mutations may affect protein stability.
Article
Biotechnology & Applied Microbiology
Ahitsham Umar, Sadia Liaquat, Israr Fatima, Abdur Rehman, Danish Rasool, Abdulrahman Alshammari, Metab Alharbi, Muhammad Shahid Riaz Rajoka, Mohsin Khurshid, Usman Ali Ashfaq, Asma Haque
Summary: Legionella pneumophila is a bacterium found in natural aquatic environments, able to withstand different environmental conditions. It is responsible for Legionnaires' disease, a dangerous form of pneumonia, and there is currently no authorized vaccine available. Through immunoinformatics and proteomic techniques, potential antigen candidates for a multi-epitope-based vaccine were identified. A vaccine was constructed in silico, combining selected epitopes with MHC and TLR4 molecules and a 50S ribosomal adjuvant. Experimental validation is needed to confirm the vaccine's efficacy in preventing L. pneumophila infections.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Mikado Tomokiyo, Fernanda Raya Tonetti, Hikari Yamamuro, Ryoko Shibata, Kohtaro Fukuyama, Nadia Gobbato, Leonardo Albarracin, Muhammad Shahid Riaz Rajoka, A. K. M. Humayun Kober, Wakako Ikeda-Ohtsubo, Julio Villena, Haruki Kitazawa
Summary: The study found that postimmunobiotics derived from Lactobacillus gasseri can alter the antiviral immune response of alveolar macrophages and have a protective effect against lung inflammatory damage caused by TLR3 activation.
Article
Pharmacology & Pharmacy
Aqsa Kanwal, Farrukh Azeem, Habibullah Nadeem, Usman Ali Ashfaq, Rana Muhammad Aadil, A. K. M. Humayun Kober, Muhammad Shahid Riaz Rajoka, Ijaz Rasul
Summary: This study evaluated the potential of Cassia fistula for the treatment of epithelial ovarian cancer (EOC) using network pharmacology and molecular docking. Key targets for EOC were identified from 98 potential targets of Cassia fistula, including AKT1, CTNNB1, ESR1, and CASP3. Enriched pathways of these targets were also investigated.
Article
Chemistry, Analytical
Francesc Ramon-Mascarell, Francisco J. Marti-Quijal, Juan Manuel Castagnini, Yuthana Phimolsiripol, Warintorn Ruksiriwanich, Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Francisco J. Barba
Summary: This study evaluated the extraction of bioactive compounds from different geographical strains of Spirulina using pulsed electric fields (PEF) and binary solvents. The results showed that PEF treatment combined with EtOH/H2O extraction for 180 minutes resulted in higher recovery of total phenolic content and carotenoids, with higher chlorophyll recovery in Spirulina from China and highest extraction of total antioxidant compounds in Spirulina from Costa Rica.
Review
Microbiology
A. K. M. Humayun Kober, Sudeb Saha, Md. Aminul Islam, Muhammad Shahid Riaz Rajoka, Kohtaro Fukuyama, Hisashi Aso, Julio Villena, Haruki Kitazawa
Summary: This review article provides an overview of recent advances in the use of probiotics for the prevention and treatment of bovine mastitis. Research has shown that probiotics can suppress mammary pathogens through competitive exclusion or the production of antimicrobial compounds. Additionally, evidence suggests that probiotics can modulate the immune response of mammary glands to inflammation. These findings indicate that probiotics can be used as a preventive strategy for managing mastitis and antimicrobial resistance, while also improving milk production and animal and human health.
Review
Food Science & Technology
Yan-Yan Huang, Yun-Hui Lu, Xin-Tong Liu, Wei-Tong Wu, Wen-Qi Li, Shu-Qin Lai, Rana Muhammad Aadil, Muhammad Shahid Riaz Rajoka, Lang-Hong Wang, Xin-An Zeng
Summary: Lactic acid bacteria (LAB) are non-respiring, non-spore-forming bacteria that produce lactic acid as the main product of carbohydrate fermentation. Some strains of LAB are probiotics that play important roles in food processing and safety, as well as in maintaining human health. This article summarizes the isolation and identification, safety assessments, and metabolic properties of Streptococcus thermophilus, a species of LAB, and discusses its functional properties, applications in fermented product production, new perspectives, and limitations, in order to facilitate future research and application of S. thermophilus.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biology
Abdelrahman M. Sedeek, Israa Salah, Hasnaa L. Kamel, Mohamed A. Soltan, Eman Nour, Abdulrahman Alshammari, Muhammad Shahid Riaz Rajoka, Tarek R. Elsayed
Summary: The problem of antimicrobial resistance poses a serious threat to humanity, and it is crucial to search for new antibiotics. Advances in sequencing techniques and bioinformatics provide important tools for discovering hidden biosynthetic capabilities and novel active secondary metabolites within bacterial genomes. This study successfully recovered the Streptomyces vinaceusdrappus strain AC-40, which exhibited potent and broad-spectrum antimicrobial activity. Whole genome sequencing and analysis revealed the presence of gene clusters associated with beneficial traits such as secondary metabolite production and plant growth promotion.
Review
Food Science & Technology
Muhammad Umair, Tayyaba Sultana, Song Xun, Saqib Jabbar, Muhammad Shahid Riaz Rajoka, Amgad Albahi, Muhammad Abid, Muhammad Modassar Ali Nawaz Ranjha, Hesham R. R. El-Seedi, Fengwei Xie, Kashif Ur Rehman Khan, Liqing Zhao, Zhendan He
Summary: This review discusses the recent advancements in cold sterilization of food and fresh-keeping packaging. Functional nanoparticles, such as TiO2 and Fe2O3, with photocatalytic activity have gained attention but raise concerns about their toxicity and safety. The bacteriostatic and fresh-keeping properties of these nanoparticles and their packaging strategies using ultraviolet photo-catalysis effect are emphasized. The innovative method of cold sterilizing food using high-voltage electric field cold plasma (HVEF-CP) is also discussed.
FOOD SCIENCE & NUTRITION
(2023)
